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NAALADL2 (N-acetylated alpha-linked acidic dipeptidase like 2)

Identity

Alias (NCBI)-
HGNC (Hugo) NAALADL2
HGNC Alias nameglutamate carboxypeptidase II-type non-peptidase homologue
LocusID (NCBI) 254827
Atlas_Id 55209
Location 3q26.31  [Link to chromosome band 3q26]
Location_base_pair Starts at 174859334 and ends at 175810548 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATP13A4 (3q29) / NAALADL2 (3q26.31)CACNA2D1 (7q21.11) / NAALADL2 (3q26.31)FNDC3B (3q26.31) / NAALADL2 (3q26.31)
MBNL1 (3q25.1) / NAALADL2 (3q26.31)MECR (1p35.3) / NAALADL2 (3q26.31)NAALADL2 (3q26.31) / ABCC5 (3q27.1)
NAALADL2 (3q26.31) / CAMK2N1 (1p36.12)NAALADL2 (3q26.31) / CORO1C (12q24.11)NAALADL2 (3q26.31) / DRD3 (3q13.31)
NAALADL2 (3q26.31) / FBXO45 (3q29)NAALADL2 (3q26.31) / LYZ (12q15)NAALADL2 (3q26.31) / NCKAP5 (2q21.2)
NAALADL2 (3q26.31) / NLGN1 (3q26.31)NAALADL2 (3q26.31) / PEX5L (3q26.33)NAALADL2 (3q26.31) / SMC5 (9q21.12)
RBM28 (7q32.1) / NAALADL2 (3q26.31)SERPINI1 (3q26.1) / NAALADL2 (3q26.31)SLC22A23 (6p25.2) / NAALADL2 (3q26.31)
ATP13A4 3q29 / NAALADL2 3q26.31CACNA2D1 7q21.11 / NAALADL2 3q26.31FNDC3B 3q26.31 / NAALADL2 3q26.31
MBNL1 3q25.1 / NAALADL2 3q26.31MECR 1p35.3 / NAALADL2 3q26.31NAALADL2 3q26.31 / ABCC5 3q27.1
NAALADL2 3q26.31 / DRD3 3q13.31NAALADL2 3q26.31 / FBXO45 3q29NAALADL2 3q26.31 / NCKAP5 2q21.2
NAALADL2 3q26.31 / NLGN1 3q26.31NAALADL2 3q26.31 / PEX5L 3q26.33NAALADL2 3q26.31 / SMC5 9q21.12
SERPINI1 3q26.1 / NAALADL2 3q26.31SLC22A23 6p25.2 / NAALADL2 3q26.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)NAALADL2   23219
Cards
Entrez_Gene (NCBI)NAALADL2    N-acetylated alpha-linked acidic dipeptidase like 2
Aliases
GeneCards (Weizmann)NAALADL2
Ensembl hg19 (Hinxton)ENSG00000177694 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000177694 [Gene_View]  ENSG00000177694 [Sequence]  chr3:174859334-175810548 [Contig_View]  NAALADL2 [Vega]
ICGC DataPortalENSG00000177694
TCGA cBioPortalNAALADL2
AceView (NCBI)NAALADL2
Genatlas (Paris)NAALADL2
SOURCE (Princeton)NAALADL2
Genetics Home Reference (NIH)NAALADL2
Genomic and cartography
GoldenPath hg38 (UCSC)NAALADL2  -     chr3:174859334-175810548 +  3q26.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NAALADL2  -     3q26.31   [Description]    (hg19-Feb_2009)
GoldenPathNAALADL2 - 3q26.31 [CytoView hg19]  NAALADL2 - 3q26.31 [CytoView hg38]
ImmunoBaseENSG00000177694
Genome Data Viewer NCBINAALADL2 [Mapview hg19]  
OMIM608806   
Gene and transcription
Genbank (Entrez)AJ607396 AJ607397 AJ607398 AJ607399 AJ607400
RefSeq transcript (Entrez)NM_207015
Consensus coding sequences : CCDS (NCBI)NAALADL2
Gene ExpressionNAALADL2 [ NCBI-GEO ]   NAALADL2 [ EBI - ARRAY_EXPRESS ]   NAALADL2 [ SEEK ]   NAALADL2 [ MEM ]
Gene Expression Viewer (FireBrowse)NAALADL2 [ Firebrowse - Broad ]
GenevisibleExpression of NAALADL2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)254827
GTEX Portal (Tissue expression)NAALADL2
Human Protein AtlasENSG00000177694-NAALADL2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ58DX5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ58DX5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ58DX5
PhosPhoSitePlusQ58DX5
Domains : Interpro (EBI)Peptidase_M28    Peptidase_M28B    TFR-like_dimer_dom_sf   
Domain families : Pfam (Sanger)Peptidase_M28 (PF04389)   
Domain families : Pfam (NCBI)pfam04389   
Conserved Domain (NCBI)NAALADL2
SuperfamilyQ58DX5
AlphaFold pdb e-kbQ58DX5   
Human Protein Atlas [tissue]ENSG00000177694-NAALADL2 [tissue]
HPRD16388
Protein Interaction databases
DIP (DOE-UCLA)Q58DX5
IntAct (EBI)Q58DX5
BioGRIDNAALADL2
STRING (EMBL)NAALADL2
ZODIACNAALADL2
Ontologies - Pathways
QuickGOQ58DX5
Ontology : AmiGOprotein binding  nucleoplasm  proteolysis  metalloexopeptidase activity  response to bacterium  integral component of membrane  
Ontology : EGO-EBIprotein binding  nucleoplasm  proteolysis  metalloexopeptidase activity  response to bacterium  integral component of membrane  
NDEx NetworkNAALADL2
Atlas of Cancer Signalling NetworkNAALADL2
Wikipedia pathwaysNAALADL2
Orthology - Evolution
OrthoDB254827
GeneTree (enSembl)ENSG00000177694
Phylogenetic Trees/Animal Genes : TreeFamNAALADL2
Homologs : HomoloGeneNAALADL2
Homology/Alignments : Family Browser (UCSC)NAALADL2
Gene fusions - Rearrangements
Fusion : MitelmanATP13A4/NAALADL2 [3q29/3q26.31]  
Fusion : MitelmanCACNA2D1/NAALADL2 [7q21.11/3q26.31]  
Fusion : MitelmanFNDC3B/NAALADL2 [3q26.31/3q26.31]  
Fusion : MitelmanMBNL1/NAALADL2 [3q25.1/3q26.31]  
Fusion : MitelmanMECR/NAALADL2 [1p35.3/3q26.31]  
Fusion : MitelmanNAALADL2/ABCC5 [3q26.31/3q27.1]  
Fusion : MitelmanNAALADL2/DRD3 [3q26.31/3q13.31]  
Fusion : MitelmanNAALADL2/FBXO45 [3q26.31/3q29]  
Fusion : MitelmanNAALADL2/NCKAP5 [3q26.31/2q21.2]  
Fusion : MitelmanNAALADL2/NLGN1 [3q26.31/3q26.31]  
Fusion : MitelmanNAALADL2/PEX5L [3q26.31/3q26.33]  
Fusion : MitelmanNAALADL2/SMC5 [3q26.31/9q21.12]  
Fusion : MitelmanSERPINI1/NAALADL2 [3q26.1/3q26.31]  
Fusion : MitelmanSLC22A23/NAALADL2 [6p25.2/3q26.31]  
Fusion : QuiverNAALADL2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNAALADL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NAALADL2
dbVarNAALADL2
ClinVarNAALADL2
MonarchNAALADL2
1000_GenomesNAALADL2 
Exome Variant ServerNAALADL2
GNOMAD BrowserENSG00000177694
Varsome BrowserNAALADL2
ACMGNAALADL2 variants
VarityQ58DX5
Genomic Variants (DGV)NAALADL2 [DGVbeta]
DECIPHERNAALADL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNAALADL2 
Mutations
ICGC Data PortalNAALADL2 
TCGA Data PortalNAALADL2 
Broad Tumor PortalNAALADL2
OASIS PortalNAALADL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNAALADL2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNAALADL2
Mutations and Diseases : HGMDNAALADL2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNAALADL2
DgiDB (Drug Gene Interaction Database)NAALADL2
DoCM (Curated mutations)NAALADL2
CIViC (Clinical Interpretations of Variants in Cancer)NAALADL2
Cancer3DNAALADL2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608806   
Orphanet
DisGeNETNAALADL2
MedgenNAALADL2
Genetic Testing Registry NAALADL2
NextProtQ58DX5 [Medical]
GENETestsNAALADL2
Target ValidationNAALADL2
Huge Navigator NAALADL2 [HugePedia]
ClinGenNAALADL2 (curated)
Clinical trials, drugs, therapy
MyCancerGenomeNAALADL2
Protein Interactions : CTDNAALADL2
Pharm GKB GenePA142671295
PharosQ58DX5
Clinical trialNAALADL2
Miscellaneous
canSAR (ICR)NAALADL2
HarmonizomeNAALADL2
DataMed IndexNAALADL2
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNAALADL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:21:58 CEST 2021

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