NAB2 (NGFI-A binding protein 2)

2013-04-01  

Identity

HGNC
LOCATION
12q13.3
LOCUSID
ALIAS
MADER
FUSION GENES

Other Information

Locus ID:

NCBI: 4665
MIM: 602381
HGNC: 7627
Ensembl: ENSG00000166886

Variants:

dbSNP: 4665
ClinVar: 4665
TCGA: ENSG00000166886
COSMIC: NAB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166886ENST00000300131Q15742
ENSG00000166886ENST00000342556Q15742

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
233139522013Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing.119
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
233139542013Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors.82
235758982013Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein.60
162607762005Egr-1 induces the expression of its corepressor nab2 by activation of the nab2 promoter thereby establishing a negative feedback loop.45
124277502003NAB2, a corepressor of EGR-1, inhibits vascular endothelial growth factor-mediated gene induction and angiogenic responses of endothelial cells.33
205061192010EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin.32
237613232013Comprehensive genetic analysis identifies a pathognomonic NAB2/STAT6 fusion gene, nonrandom secondary genomic imbalances, and a characteristic gene expression profile in solitary fibrous tumor.31
245132612014Solitary fibrous tumors/hemangiopericytomas with different variants of the NAB2-STAT6 gene fusion are characterized by specific histomorphology and distinct clinicopathological features.30
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27

Citation

Dessen P

NAB2 (NGFI-A binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2013-04-01

Online version: http://atlasgeneticsoncology.org/gene/53246/nab2