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NABP1 (nucleic acid binding protein 1)

Identity

Alias (NCBI)OBFC2A
SOSS-B2
SSB2
HGNC (Hugo) NABP1
HGNC Alias symbFLJ22833
DKFZp667M1322
FLJ13624
MGC111163
SSB2
hSSB2
SOSS-B2
HGNC Alias namesingle-stranded DNA-binding protein 2
 sensor of single-strand DNA complex subunit B2
HGNC Previous nameOBFC2A
HGNC Previous nameoligonucleotide/oligosaccharide-binding fold containing 2A
LocusID (NCBI) 64859
Atlas_Id 51114
Location 2q32.3  [Link to chromosome band 2q32]
Location_base_pair Starts at 191678072 and ends at 191690151 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NABP1 (2q32.3) / RARA (17q21.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  M3/M3v acute myeloid leukemia (AML M3/M3v)
::Acute promyelocytic leukemia (APL)
::Acute promyelocytic leukemia (APL) PML/RARA

t(2;17)(q32;q21) NABP1/RARA
t(5;17)(q35;q21) NPM1/RARA


External links

 

Nomenclature
HGNC (Hugo)NABP1   26232
Cards
Entrez_Gene (NCBI)NABP1    nucleic acid binding protein 1
AliasesOBFC2A; SOSS-B2; SSB2
GeneCards (Weizmann)NABP1
Ensembl hg19 (Hinxton)ENSG00000173559 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000173559 [Gene_View]  ENSG00000173559 [Sequence]  chr2:191678072-191690151 [Contig_View]  NABP1 [Vega]
ICGC DataPortalENSG00000173559
TCGA cBioPortalNABP1
AceView (NCBI)NABP1
Genatlas (Paris)NABP1
SOURCE (Princeton)NABP1
Genetics Home Reference (NIH)NABP1
Genomic and cartography
GoldenPath hg38 (UCSC)NABP1  -     chr2:191678072-191690151 +  2q32.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NABP1  -     2q32.3   [Description]    (hg19-Feb_2009)
GoldenPathNABP1 - 2q32.3 [CytoView hg19]  NABP1 - 2q32.3 [CytoView hg38]
ImmunoBaseENSG00000173559
Genome Data Viewer NCBINABP1 [Mapview hg19]  
OMIM612103   
Gene and transcription
Genbank (Entrez)AK023686 AK026486 AL832659 AL833684 BC017114
RefSeq transcript (Entrez)NM_001031716 NM_001254736 NM_022837
Consensus coding sequences : CCDS (NCBI)NABP1
Gene ExpressionNABP1 [ NCBI-GEO ]   NABP1 [ EBI - ARRAY_EXPRESS ]   NABP1 [ SEEK ]   NABP1 [ MEM ]
Gene Expression Viewer (FireBrowse)NABP1 [ Firebrowse - Broad ]
GenevisibleExpression of NABP1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64859
GTEX Portal (Tissue expression)NABP1
Human Protein AtlasENSG00000173559-NABP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96AH0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96AH0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96AH0
PhosPhoSitePlusQ96AH0
Domains : Interpro (EBI)NA-bd_OB-fold   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)NABP1
SuperfamilyQ96AH0
AlphaFold pdb e-kbQ96AH0   
Human Protein Atlas [tissue]ENSG00000173559-NABP1 [tissue]
HPRD08009
Protein Interaction databases
DIP (DOE-UCLA)Q96AH0
IntAct (EBI)Q96AH0
BioGRIDNABP1
STRING (EMBL)NABP1
ZODIACNABP1
Ontologies - Pathways
QuickGOQ96AH0
Ontology : AmiGOdouble-strand break repair via homologous recombination  double-strand break repair via homologous recombination  chromosome, telomeric region  DNA binding  single-stranded DNA binding  RNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytosol  DNA repair  cellular response to DNA damage stimulus  mitotic cell cycle checkpoint signaling  response to ionizing radiation  response to ionizing radiation  site of double-strand break  snRNA transcription by RNA polymerase II  mitotic G2/M transition checkpoint  SOSS complex  SOSS complex  
Ontology : EGO-EBIdouble-strand break repair via homologous recombination  double-strand break repair via homologous recombination  chromosome, telomeric region  DNA binding  single-stranded DNA binding  RNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytosol  DNA repair  cellular response to DNA damage stimulus  mitotic cell cycle checkpoint signaling  response to ionizing radiation  response to ionizing radiation  site of double-strand break  snRNA transcription by RNA polymerase II  mitotic G2/M transition checkpoint  SOSS complex  SOSS complex  
NDEx NetworkNABP1
Atlas of Cancer Signalling NetworkNABP1
Wikipedia pathwaysNABP1
Orthology - Evolution
OrthoDB64859
GeneTree (enSembl)ENSG00000173559
Phylogenetic Trees/Animal Genes : TreeFamNABP1
Homologs : HomoloGeneNABP1
Homology/Alignments : Family Browser (UCSC)NABP1
Gene fusions - Rearrangements
Fusion : MitelmanNABP1/RARA [2q32.3/17q21.2]  
Fusion : QuiverNABP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNABP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NABP1
dbVarNABP1
ClinVarNABP1
MonarchNABP1
1000_GenomesNABP1 
Exome Variant ServerNABP1
GNOMAD BrowserENSG00000173559
Varsome BrowserNABP1
ACMGNABP1 variants
VarityQ96AH0
Genomic Variants (DGV)NABP1 [DGVbeta]
DECIPHERNABP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNABP1 
Mutations
ICGC Data PortalNABP1 
TCGA Data PortalNABP1 
Broad Tumor PortalNABP1
OASIS PortalNABP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNABP1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNABP1
Mutations and Diseases : HGMDNABP1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNABP1
DgiDB (Drug Gene Interaction Database)NABP1
DoCM (Curated mutations)NABP1
CIViC (Clinical Interpretations of Variants in Cancer)NABP1
Cancer3DNABP1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612103   
Orphanet8559   
DisGeNETNABP1
MedgenNABP1
Genetic Testing Registry NABP1
NextProtQ96AH0 [Medical]
GENETestsNABP1
Target ValidationNABP1
Huge Navigator NABP1 [HugePedia]
ClinGenNABP1
Clinical trials, drugs, therapy
MyCancerGenomeNABP1
Protein Interactions : CTDNABP1
Pharm GKB GenePA143485566
PharosQ96AH0
Clinical trialNABP1
Miscellaneous
canSAR (ICR)NABP1
HarmonizomeNABP1
DataMed IndexNABP1
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNABP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:21:59 CEST 2021

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