NACA (nascent polypeptide associated complex subunit alpha)

2004-03-01 Affiliation

Identity

HGNC

NACA

LOCATION

12q13.3

LOCUSID

4666

ALIAS

HSD48,NAC-alpha,NACA1,skNAC

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4666
MIM: 601234
HGNC: 7629
Ensembl: ENSG00000196531

Variants:

dbSNP: 4666
ClinVar: 4666
TCGA: ENSG00000196531
COSMIC: NACA

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000196531	ENST00000356769	Q13765
ENSG00000196531	ENST00000356769	A0A024RB41
ENSG00000196531	ENST00000393891	Q13765
ENSG00000196531	ENST00000393891	A0A024RB41
ENSG00000196531	ENST00000454682	E9PAV3
ENSG00000196531	ENST00000546392	Q13765
ENSG00000196531	ENST00000546392	A0A024RB41
ENSG00000196531	ENST00000546862	F8W1N5
ENSG00000196531	ENST00000547914	F8W029
ENSG00000196531	ENST00000548084	F8W0C7
ENSG00000196531	ENST00000548563	F8VZJ2
ENSG00000196531	ENST00000549259	F8W0W4
ENSG00000196531	ENST00000549855	F8VZ58
ENSG00000196531	ENST00000550920	H0YHX9
ENSG00000196531	ENST00000550952	E9PAV3
ENSG00000196531	ENST00000552055	F8VNW4
ENSG00000196531	ENST00000552540	Q13765
ENSG00000196531	ENST00000552540	A0A024RB41

Expression (GTEx)

100

150

200

250

300

350

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

References

Pubmed ID	Year	Title	Citations
8698236	1996	Differential splicing-in of a proline-rich exon converts alphaNAC into a muscle-specific transcription factor.	24
19609276	2009	alphaNAC depletion as an initiator of ER stress-induced apoptosis in hypoxia.	17
20214399	2010	The crystal structure of the human nascent polypeptide-associated complex domain reveals a nucleic acid-binding region on the NACA subunit .	9
12109594	2002	Human brain nascent polypeptide-associated complex alpha subunit is decreased in patients with Alzheimer' s disease and Down syndrome.	6
21509594	2011	Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma.	6
12406326	2002	Characterization of a novel isoform of alpha-nascent polypeptide-associated complex as IgE-defined autoantigen.	5
15784678	2005	NACA is a positive regulator of human erythroid-cell differentiation.	5
12699894	2003	Expression analysis of alpha-NAC and ANX2 in juvenile myelomonocytic leukemia using SMART polymerase chain reaction and "virtual Northern" hybridization.	2
22082360	2011	Combinatorial control of ATF4-dependent gene transcription in osteoblasts.	2
30982745	2019	Dual Role of Ribosome-Binding Domain of NAC as a Potent Suppressor of Protein Aggregation and Aging-Related Proteinopathies.	2

Citation

Dessen P

NACA (nascent polypeptide associated complex subunit alpha)

Atlas Genet Cytogenet Oncol Haematol. 2004-03-01

Online version: http://atlasgeneticsoncology.org/gene/41491/naca