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NACA (nascent polypeptide-associated complex alpha subunit)

Identity

Alias_namesnascent-polypeptide-associated complex alpha polypeptide
Alias_symbol (synonym)NACA1
Other aliasHSD48
NAC-alpha
skNAC
HGNC (Hugo) NACA
LocusID (NCBI) 4666
Atlas_Id 41491
Location 12q13.3  [Link to chromosome band 12q13]
Location_base_pair Starts at 57106211 and ends at 57119076 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ARGLU1 (13q33.3) / NACA (12q13.3)BCL6 (3q27.3) / NACA (12q13.3)FAM135A (6q13) / NACA (12q13.3)
GLTSCR2 (19q13.33) / NACA (12q13.3)NACA (12q13.3) / ANK2 (4q25)NACA (12q13.3) / BCL6 (3q27.3)
NACA (12q13.3) / HLA-B (6p21.33)NACA (12q13.3) / NACAP1 (8q22.3)NACA (12q13.3) / TUBB2B (6p25.2)
NFE2L2 (2q31.2) / NACA (12q13.3)PRIM1 (12q13.3) / NACA (12q13.3)PTGES3 (12q13.3) / NACA (12q13.3)
RPL41 (12q13.2) / NACA (12q13.3)TSPAN5 (4q23) / NACA (12q13.3)PTGES3 12q13.3 / NACA 12q13.3
RPL41 12q13.2 / NACA 12q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NACA   7629
Cards
Entrez_Gene (NCBI)NACA  4666  nascent polypeptide-associated complex alpha subunit
AliasesHSD48; NAC-alpha; NACA1; skNAC
GeneCards (Weizmann)NACA
Ensembl hg19 (Hinxton)ENSG00000196531 [Gene_View]  chr12:57106211-57119076 [Contig_View]  NACA [Vega]
Ensembl hg38 (Hinxton)ENSG00000196531 [Gene_View]  chr12:57106211-57119076 [Contig_View]  NACA [Vega]
ICGC DataPortalENSG00000196531
TCGA cBioPortalNACA
AceView (NCBI)NACA
Genatlas (Paris)NACA
WikiGenes4666
SOURCE (Princeton)NACA
Genetics Home Reference (NIH)NACA
Genomic and cartography
GoldenPath hg19 (UCSC)NACA  -     chr12:57106211-57119076 -  12q13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NACA  -     12q13.3   [Description]    (hg38-Dec_2013)
EnsemblNACA - 12q13.3 [CytoView hg19]  NACA - 12q13.3 [CytoView hg38]
Mapping of homologs : NCBINACA [Mapview hg19]  NACA [Mapview hg38]
OMIM601234   
Gene and transcription
Genbank (Entrez)AF054187 AK090650 AK096699 AK223085 AK293209
RefSeq transcript (Entrez)NM_001113201 NM_001113202 NM_001113203 NM_001320193 NM_001320194 NM_005594
RefSeq genomic (Entrez)NC_000012 NC_018923 NG_030341 NT_029419 NW_004929384
Consensus coding sequences : CCDS (NCBI)NACA
Cluster EST : UnigeneHs.505735 [ NCBI ]
CGAP (NCI)Hs.505735
Alternative Splicing GalleryENSG00000196531
Gene ExpressionNACA [ NCBI-GEO ]   NACA [ EBI - ARRAY_EXPRESS ]   NACA [ SEEK ]   NACA [ MEM ]
Gene Expression Viewer (FireBrowse)NACA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4666
GTEX Portal (Tissue expression)NACA
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13765   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13765  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13765
Splice isoforms : SwissVarQ13765
PhosPhoSitePlusQ13765
Domaine pattern : Prosite (Expaxy)NAC_AB (PS51151)   
Domains : Interpro (EBI)EGD2/NACA    Nas_poly-pep-assoc_cplx_dom   
Domain families : Pfam (Sanger)NAC (PF01849)   
Domain families : Pfam (NCBI)pfam01849   
Conserved Domain (NCBI)NACA
DMDM Disease mutations4666
Blocks (Seattle)NACA
PDB (SRS)3LKX    3MCB    3MCE   
PDB (PDBSum)3LKX    3MCB    3MCE   
PDB (IMB)3LKX    3MCB    3MCE   
PDB (RSDB)3LKX    3MCB    3MCE   
Structural Biology KnowledgeBase3LKX    3MCB    3MCE   
SCOP (Structural Classification of Proteins)3LKX    3MCB    3MCE   
CATH (Classification of proteins structures)3LKX    3MCB    3MCE   
SuperfamilyQ13765
Human Protein AtlasENSG00000196531
Peptide AtlasQ13765
HPRD03137
IPIIPI00023748   IPI00797126   IPI01022622   IPI01022244   IPI01022398   IPI01021955   IPI01022112   IPI01021585   IPI01021748   IPI01021457   IPI01020959   IPI01021109   
Protein Interaction databases
DIP (DOE-UCLA)Q13765
IntAct (EBI)Q13765
FunCoupENSG00000196531
BioGRIDNACA
STRING (EMBL)NACA
ZODIACNACA
Ontologies - Pathways
QuickGOQ13765
Ontology : AmiGOcardiac ventricle development  DNA binding  transcription coactivator activity  protein binding  nucleus  nucleus  cytoplasm  cytoplasm  nascent polypeptide-associated complex  transcription, DNA-templated  regulation of transcription, DNA-templated  translation  negative regulation of striated muscle cell apoptotic process  protein transport  viral process  skeletal muscle tissue regeneration  positive regulation of skeletal muscle tissue growth  regulation of skeletal muscle fiber development  heart trabecula morphogenesis  extracellular exosome  negative regulation of transcription from RNA polymerase II promoter involved in heart development  positive regulation of transcription from RNA polymerase II promoter involved in heart development  positive regulation of cell proliferation involved in heart morphogenesis  
Ontology : EGO-EBIcardiac ventricle development  DNA binding  transcription coactivator activity  protein binding  nucleus  nucleus  cytoplasm  cytoplasm  nascent polypeptide-associated complex  transcription, DNA-templated  regulation of transcription, DNA-templated  translation  negative regulation of striated muscle cell apoptotic process  protein transport  viral process  skeletal muscle tissue regeneration  positive regulation of skeletal muscle tissue growth  regulation of skeletal muscle fiber development  heart trabecula morphogenesis  extracellular exosome  negative regulation of transcription from RNA polymerase II promoter involved in heart development  positive regulation of transcription from RNA polymerase II promoter involved in heart development  positive regulation of cell proliferation involved in heart morphogenesis  
NDEx NetworkNACA
Atlas of Cancer Signalling NetworkNACA
Wikipedia pathwaysNACA
Orthology - Evolution
OrthoDB4666
GeneTree (enSembl)ENSG00000196531
Phylogenetic Trees/Animal Genes : TreeFamNACA
HOVERGENQ13765
HOGENOMQ13765
Homologs : HomoloGeneNACA
Homology/Alignments : Family Browser (UCSC)NACA
Gene fusions - Rearrangements
Fusion : MitelmanPRIM1/NACA [12q13.3/12q13.3]  [t(12;12)(q13;q13)]  
Fusion : MitelmanPTGES3/NACA [12q13.3/12q13.3]  [t(12;12)(q13;q13)]  
Fusion : MitelmanRPL41/NACA [12q13.2/12q13.3]  [t(12;12)(q13;q13)]  
Fusion: TCGAPTGES3 12q13.3 NACA 12q13.3 HNSC
Fusion: TCGARPL41 12q13.2 NACA 12q13.3 GBM
Fusion Cancer (Beijing)NACA [12q13.3]  -  NACAP1 [8q22.3]  [FUSC004209]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNACA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NACA
dbVarNACA
ClinVarNACA
1000_GenomesNACA 
Exome Variant ServerNACA
ExAC (Exome Aggregation Consortium)NACA (select the gene name)
Genetic variants : HAPMAP4666
Genomic Variants (DGV)NACA [DGVbeta]
DECIPHER (Syndromes)12:57106211-57119076  ENSG00000196531
CONAN: Copy Number AnalysisNACA 
Mutations
ICGC Data PortalNACA 
TCGA Data PortalNACA 
Broad Tumor PortalNACA
OASIS PortalNACA [ Somatic mutations - Copy number]
Cancer Gene: CensusNACA 
Somatic Mutations in Cancer : COSMICNACA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNACA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NACA
DgiDB (Drug Gene Interaction Database)NACA
DoCM (Curated mutations)NACA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NACA (select a term)
intoGenNACA
Cancer3DNACA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601234   
Orphanet
MedgenNACA
Genetic Testing Registry NACA
NextProtQ13765 [Medical]
TSGene4666
GENETestsNACA
Huge Navigator NACA [HugePedia]
snp3D : Map Gene to Disease4666
BioCentury BCIQNACA
ClinGenNACA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4666
Chemical/Pharm GKB GenePA31433
Clinical trialNACA
Miscellaneous
canSAR (ICR)NACA (select the gene name)
Probes
Litterature
PubMed79 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNACA
EVEXNACA
GoPubMedNACA
iHOPNACA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:11:36 CEST 2017

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