NADK (NAD kinase)

2016-08-01  

Identity

HGNC
NADK
LOCATION
1p36.33
LOCUSID
65220
ALIAS
dJ283E3.1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 65220
MIM: 611616
HGNC: 29831
Ensembl: ENSG00000008130

Variants:

dbSNP: 65220
ClinVar: 65220
TCGA: ENSG00000008130
COSMIC: NADK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000008130ENST00000341426O95544
ENSG00000008130ENST00000341426A0A024R058
ENSG00000008130ENST00000341991O95544
ENSG00000008130ENST00000341991A0A024R058
ENSG00000008130ENST00000342348A0A0A0MR98
ENSG00000008130ENST00000378625O95544
ENSG00000008130ENST00000469045J3KSP9
ENSG00000008130ENST00000489538J3KTI3
ENSG00000008130ENST00000497186J3QR86
ENSG00000008130ENST00000498806J3QRC0

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Nicotinate and nicotinamide metabolismKEGGko00760
Nicotinate and nicotinamide metabolismKEGGhsa00760
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Nicotinate metabolismREACTOMER-HSA-196807

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
178553392007NAD kinase levels control the NADPH concentration in human cells.59
268060152016Functional annotation of rare gene aberration drivers of pancreatic cancer.20
289547332017Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers.20
308465982019Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase.8
215263402011NADPH regulates human NAD kinase, a NADP⁺-biosynthetic enzyme.7
265774082015Significance of Ser-188 in human mitochondrial NAD kinase as determined by phosphomimetic and phosphoresistant amino-acid substitutions.0

Citation

Dessen P

NADK (NAD kinase)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55853/nadk