Identity
HGNC
LOCATION
5p13.2
LOCUSID
ALIAS
C5orf33,DECRD,MNADK,NADKD1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 133686
MIM: 615787
HGNC: 26404
Ensembl: ENSG00000152620
Variants:
dbSNP: 133686
ClinVar: 133686
TCGA: ENSG00000152620
COSMIC: NADK2
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Nicotinate and nicotinamide metabolism | KEGG | ko00760 |
| Nicotinate and nicotinamide metabolism | KEGG | hsa00760 |
| Metabolic pathways | KEGG | hsa01100 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35868311 | 2022 | Crystal structure of human NADK2 reveals a dimeric organization and active site occlusion by lysine acetylation. | 7 |
| 35944895 | 2022 | The mitochondrial NAD kinase functions as a major metabolic regulator upon increased energy demand. | 3 |
| 35944895 | 2022 | The mitochondrial NAD kinase functions as a major metabolic regulator upon increased energy demand. | 3 |
| 35868311 | 2022 | Crystal structure of human NADK2 reveals a dimeric organization and active site occlusion by lysine acetylation. | 7 |
| 35944895 | 2022 | The mitochondrial NAD kinase functions as a major metabolic regulator upon increased energy demand. | 3 |
| 35944895 | 2022 | The mitochondrial NAD kinase functions as a major metabolic regulator upon increased energy demand. | 3 |
| 33888598 | 2021 | Mitochondrial NADP(H) generation is essential for proline biosynthesis. | 43 |
| 33888598 | 2021 | Mitochondrial NADP(H) generation is essential for proline biosynthesis. | 43 |
| 29388319 | 2018 | Clinical heterogeneity of mitochondrial NAD kinase deficiency caused by a NADK2 start loss variant. | 17 |
| 29388319 | 2018 | Clinical heterogeneity of mitochondrial NAD kinase deficiency caused by a NADK2 start loss variant. | 17 |
| 27940755 | 2016 | Lysine Restriction and Pyridoxal Phosphate Administration in a NADK2 Patient. | 12 |
| 27940755 | 2016 | Lysine Restriction and Pyridoxal Phosphate Administration in a NADK2 Patient. | 12 |
| 24847004 | 2014 | Mitochondrial NADP(H) deficiency due to a mutation in NADK2 causes dienoyl-CoA reductase deficiency with hyperlysinemia. | 31 |
| 24847004 | 2014 | Mitochondrial NADP(H) deficiency due to a mutation in NADK2 causes dienoyl-CoA reductase deficiency with hyperlysinemia. | 31 |
| 23616928 | 2013 | MNADK, a novel liver-enriched mitochondrion-localized NAD kinase. | 23 |
Citation
Dessen P
NADK2 (NAD kinase 2, mitochondrial)
Atlas Genet Cytogenet Oncol Haematol. 2013-05-01
Online version: http://atlasgeneticsoncology.org/gene/53303/nadk2
