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NADK2 (NAD kinase 2, mitochondrial)

Identity

Alias_namesC5orf33
NADKD1
chromosome 5 open reading frame 33
NAD kinase domain containing 1
Alias_symbol (synonym)FLJ30596
MNADK
Other aliasDECRD
HGNC (Hugo) NADK2
LocusID (NCBI) 133686
Atlas_Id 53303
Location 5p13.2  [Link to chromosome band 5p13]
Location_base_pair Starts at 36192589 and ends at 36241798 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AKAP9 (7q21.2) / NADK2 (5p13.2)NADK2 (5p13.2) / BRD2 (6p21.32)NADK2 (5p13.2) / CMIP (16q23.2)
NADK2 (5p13.2) / DONSON (21q22.11)NADK2 (5p13.2) / TPRN (9q34.3)SPEF2 (5p13.2) / NADK2 (5p13.2)
TRIB3 (20p13) / NADK2 (5p13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NADK2   26404
Cards
Entrez_Gene (NCBI)NADK2  133686  NAD kinase 2, mitochondrial
AliasesC5orf33; DECRD; MNADK; NADKD1
GeneCards (Weizmann)NADK2
Ensembl hg19 (Hinxton)ENSG00000152620 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000152620 [Gene_View]  chr5:36192589-36241798 [Contig_View]  NADK2 [Vega]
ICGC DataPortalENSG00000152620
TCGA cBioPortalNADK2
AceView (NCBI)NADK2
Genatlas (Paris)NADK2
WikiGenes133686
SOURCE (Princeton)NADK2
Genetics Home Reference (NIH)NADK2
Genomic and cartography
GoldenPath hg38 (UCSC)NADK2  -     chr5:36192589-36241798 -  5p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NADK2  -     5p13.2   [Description]    (hg19-Feb_2009)
EnsemblNADK2 - 5p13.2 [CytoView hg19]  NADK2 - 5p13.2 [CytoView hg38]
Mapping of homologs : NCBINADK2 [Mapview hg19]  NADK2 [Mapview hg38]
OMIM615787   616034   
Gene and transcription
Genbank (Entrez)AA332693 AI377881 AK055158 AK057950 AK304009
RefSeq transcript (Entrez)NM_001085411 NM_001287340 NM_001287341 NM_153013
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NADK2
Cluster EST : UnigeneHs.81907 [ NCBI ]
CGAP (NCI)Hs.81907
Alternative Splicing GalleryENSG00000152620
Gene ExpressionNADK2 [ NCBI-GEO ]   NADK2 [ EBI - ARRAY_EXPRESS ]   NADK2 [ SEEK ]   NADK2 [ MEM ]
Gene Expression Viewer (FireBrowse)NADK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)133686
GTEX Portal (Tissue expression)NADK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ4G0N4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ4G0N4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ4G0N4
Splice isoforms : SwissVarQ4G0N4
Catalytic activity : Enzyme2.7.1.23 [ Enzyme-Expasy ]   2.7.1.232.7.1.23 [ IntEnz-EBI ]   2.7.1.23 [ BRENDA ]   2.7.1.23 [ KEGG ]   
PhosPhoSitePlusQ4G0N4
Domains : Interpro (EBI)ATP-NAD_kinase_dom_1    ATP-NAD_kinase_PpnK-typ_all-b    NAD/diacylglycerol_kinase    NADK    NADK_euk   
Domain families : Pfam (Sanger)NAD_kinase (PF01513)   
Domain families : Pfam (NCBI)pfam01513   
Conserved Domain (NCBI)NADK2
DMDM Disease mutations133686
Blocks (Seattle)NADK2
SuperfamilyQ4G0N4
Human Protein AtlasENSG00000152620
Peptide AtlasQ4G0N4
HPRD08088
IPIIPI00845432   IPI00431405   IPI00654793   IPI00964640   IPI00964333   IPI00968110   
Protein Interaction databases
DIP (DOE-UCLA)Q4G0N4
IntAct (EBI)Q4G0N4
FunCoupENSG00000152620
BioGRIDNADK2
STRING (EMBL)NADK2
ZODIACNADK2
Ontologies - Pathways
QuickGOQ4G0N4
Ontology : AmiGONAD+ kinase activity  ATP binding  mitochondrion  NADP biosynthetic process  phosphorylation  NAD metabolic process  protein homodimerization activity  
Ontology : EGO-EBINAD+ kinase activity  ATP binding  mitochondrion  NADP biosynthetic process  phosphorylation  NAD metabolic process  protein homodimerization activity  
NDEx NetworkNADK2
Atlas of Cancer Signalling NetworkNADK2
Wikipedia pathwaysNADK2
Orthology - Evolution
OrthoDB133686
GeneTree (enSembl)ENSG00000152620
Phylogenetic Trees/Animal Genes : TreeFamNADK2
HOVERGENQ4G0N4
HOGENOMQ4G0N4
Homologs : HomoloGeneNADK2
Homology/Alignments : Family Browser (UCSC)NADK2
Gene fusions - Rearrangements
Fusion : MitelmanSPEF2/NADK2 [5p13.2/5p13.2]  [t(5;5)(p13;p13)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNADK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NADK2
dbVarNADK2
ClinVarNADK2
1000_GenomesNADK2 
Exome Variant ServerNADK2
ExAC (Exome Aggregation Consortium)NADK2 (select the gene name)
Genetic variants : HAPMAP133686
Genomic Variants (DGV)NADK2 [DGVbeta]
DECIPHERNADK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNADK2 
Mutations
ICGC Data PortalNADK2 
TCGA Data PortalNADK2 
Broad Tumor PortalNADK2
OASIS PortalNADK2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDNADK2
BioMutasearch NADK2
DgiDB (Drug Gene Interaction Database)NADK2
DoCM (Curated mutations)NADK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NADK2 (select a term)
intoGenNADK2
Cancer3DNADK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615787    616034   
Orphanet23249   
MedgenNADK2
Genetic Testing Registry NADK2
NextProtQ4G0N4 [Medical]
TSGene133686
GENETestsNADK2
Target ValidationNADK2
Huge Navigator NADK2 [HugePedia]
snp3D : Map Gene to Disease133686
BioCentury BCIQNADK2
ClinGenNADK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD133686
Chemical/Pharm GKB GenePA162380039
Clinical trialNADK2
Miscellaneous
canSAR (ICR)NADK2 (select the gene name)
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNADK2
EVEXNADK2
GoPubMedNADK2
iHOPNADK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:01:06 CEST 2017

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