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NADSYN1 (NAD synthetase 1)

Identity

Alias (NCBI)VCRL3
HGNC (Hugo) NADSYN1
HGNC Alias symbFLJ10631
LocusID (NCBI) 55191
Atlas_Id 70670
Location 11q13.4  [Link to chromosome band 11q13]
Location_base_pair Starts at 71453203 and ends at 71501816 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GSTA4 (6p12.2)::NADSYN1 (11q13.4)LRCH1 (13q14.13)::NADSYN1 (11q13.4)NADSYN1 (11q13.4)::HNRNPUL1 (19q13.2)
NADSYN1 (11q13.4)::MTL5 (11q13.3)NADSYN1 (11q13.4)::NADSYN1 (11q13.4)NADSYN1 (11q13.4)::PLET1 (11q23.1)
NADSYN1 (11q13.4)::TRIM9 (14q22.1)RELT (11q13.4)::NADSYN1 (11q13.4)SPTBN1 (2p16.2)::NADSYN1 (11q13.4)
SUPT5H (19q13.2)::NADSYN1 (11q13.4)ZNF451 (6p12.1)::NADSYN1 (11q13.4)GSTA4 NADSYN1
ZNF451 NADSYN1SUPT5H NADSYN1NADSYN1 TRIM9
NADSYN1 C11orf34

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)NADSYN1   29832
Cards
Entrez_Gene (NCBI)NADSYN1    NAD synthetase 1
AliasesVCRL3
GeneCards (Weizmann)NADSYN1
Ensembl hg19 (Hinxton)ENSG00000172890 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172890 [Gene_View]  ENSG00000172890 [Sequence]  chr11:71453203-71501816 [Contig_View]  NADSYN1 [Vega]
ICGC DataPortalENSG00000172890
TCGA cBioPortalNADSYN1
AceView (NCBI)NADSYN1
Genatlas (Paris)NADSYN1
SOURCE (Princeton)NADSYN1
Genetics Home Reference (NIH)NADSYN1
Genomic and cartography
GoldenPath hg38 (UCSC)NADSYN1  -     chr11:71453203-71501816 +  11q13.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NADSYN1  -     11q13.4   [Description]    (hg19-Feb_2009)
GoldenPathNADSYN1 - 11q13.4 [CytoView hg19]  NADSYN1 - 11q13.4 [CytoView hg38]
ImmunoBaseENSG00000172890
Genome Data Viewer NCBINADSYN1 [Mapview hg19]  
OMIM608285   618845   
Gene and transcription
Genbank (Entrez)AB091316 AK001493 AK022436 AK055452 AK094022
RefSeq transcript (Entrez)NM_018161
Consensus coding sequences : CCDS (NCBI)NADSYN1
Gene ExpressionNADSYN1 [ NCBI-GEO ]   NADSYN1 [ EBI - ARRAY_EXPRESS ]   NADSYN1 [ SEEK ]   NADSYN1 [ MEM ]
Gene Expression Viewer (FireBrowse)NADSYN1 [ Firebrowse - Broad ]
GenevisibleExpression of NADSYN1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55191
GTEX Portal (Tissue expression)NADSYN1
Human Protein AtlasENSG00000172890-NADSYN1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6IA69   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6IA69  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6IA69
PhosPhoSitePlusQ6IA69
Domaine pattern : Prosite (Expaxy)CN_HYDROLASE (PS50263)   
Domains : Interpro (EBI)C-N_Hydrolase    C-N_Hydrolase_sf    Gln-dep_NAD_synthase    NAD/GMP_synthase    NAD_synthase    Rossmann-like_a/b/a_fold   
Domain families : Pfam (Sanger)CN_hydrolase (PF00795)    NAD_synthase (PF02540)   
Domain families : Pfam (NCBI)pfam00795    pfam02540   
Conserved Domain (NCBI)NADSYN1
PDB (RSDB)6OFB   
PDB Europe6OFB   
PDB (PDBSum)6OFB   
PDB (IMB)6OFB   
Structural Biology KnowledgeBase6OFB   
SCOP (Structural Classification of Proteins)6OFB   
CATH (Classification of proteins structures)6OFB   
SuperfamilyQ6IA69
AlphaFold pdb e-kbQ6IA69   
Human Protein Atlas [tissue]ENSG00000172890-NADSYN1 [tissue]
HPRD16309
Protein Interaction databases
DIP (DOE-UCLA)Q6IA69
IntAct (EBI)Q6IA69
BioGRIDNADSYN1
STRING (EMBL)NADSYN1
ZODIACNADSYN1
Ontologies - Pathways
QuickGOQ6IA69
Ontology : AmiGONAD+ synthase (glutamine-hydrolyzing) activity  NAD+ synthase (glutamine-hydrolyzing) activity  glutaminase activity  protein binding  ATP binding  cytoplasm  cytosol  NAD biosynthetic process  NAD metabolic process  'de novo' NAD biosynthetic process  
Ontology : EGO-EBINAD+ synthase (glutamine-hydrolyzing) activity  NAD+ synthase (glutamine-hydrolyzing) activity  glutaminase activity  protein binding  ATP binding  cytoplasm  cytosol  NAD biosynthetic process  NAD metabolic process  'de novo' NAD biosynthetic process  
Pathways : KEGGKEGG_hsa00760 Nicotinate and nicotinamide metabolism    KEGG_hsa00251 Glutamate metabolism   
NDEx NetworkNADSYN1
Atlas of Cancer Signalling NetworkNADSYN1
Wikipedia pathwaysNADSYN1
Orthology - Evolution
OrthoDB55191
GeneTree (enSembl)ENSG00000172890
Phylogenetic Trees/Animal Genes : TreeFamNADSYN1
Homologs : HomoloGeneNADSYN1
Homology/Alignments : Family Browser (UCSC)NADSYN1
Gene fusions - Rearrangements
Fusion : QuiverNADSYN1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNADSYN1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NADSYN1
dbVarNADSYN1
ClinVarNADSYN1
MonarchNADSYN1
1000_GenomesNADSYN1 
Exome Variant ServerNADSYN1
GNOMAD BrowserENSG00000172890
Varsome BrowserNADSYN1
ACMGNADSYN1 variants
VarityQ6IA69
Genomic Variants (DGV)NADSYN1 [DGVbeta]
DECIPHERNADSYN1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNADSYN1 
Mutations
ICGC Data PortalNADSYN1 
TCGA Data PortalNADSYN1 
Broad Tumor PortalNADSYN1
OASIS PortalNADSYN1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNADSYN1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNADSYN1
Mutations and Diseases : HGMDNADSYN1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNADSYN1
DgiDB (Drug Gene Interaction Database)NADSYN1
DoCM (Curated mutations)NADSYN1
CIViC (Clinical Interpretations of Variants in Cancer)NADSYN1
Cancer3DNADSYN1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608285    618845   
Orphanet
DisGeNETNADSYN1
MedgenNADSYN1
Genetic Testing Registry NADSYN1
NextProtQ6IA69 [Medical]
GENETestsNADSYN1
Target ValidationNADSYN1
Huge Navigator NADSYN1 [HugePedia]
ClinGenNADSYN1
Clinical trials, drugs, therapy
MyCancerGenomeNADSYN1
Protein Interactions : CTDNADSYN1
Pharm GKB GenePA142671299
PharosQ6IA69
Clinical trialNADSYN1
Miscellaneous
canSAR (ICR)NADSYN1
HarmonizomeNADSYN1
ARCHS4NADSYN1
DataMed IndexNADSYN1
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNADSYN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 13:42:04 CET 2022

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