NAGK (N-acetylglucosamine kinase)

2014-11-01  

Identity

HGNC
LOCATION
2p13.3
LOCUSID
ALIAS
GNK,HSA242910
FUSION GENES

Other Information

Locus ID:

NCBI: 55577
MIM: 606828
HGNC: 17174
Ensembl: ENSG00000124357

Variants:

dbSNP: 55577
ClinVar: 55577
TCGA: ENSG00000124357
COSMIC: NAGK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124357ENST00000244204Q9UJ70
ENSG00000124357ENST00000244204A0A384N6G7
ENSG00000124357ENST00000418807C9JEV6
ENSG00000124357ENST00000443872H7C286
ENSG00000124357ENST00000443938H7C3G9
ENSG00000124357ENST00000450272H7C1L7
ENSG00000124357ENST00000455197C9JMR7
ENSG00000124357ENST00000455662Q9UJ70
ENSG00000124357ENST00000524537H0YF44
ENSG00000124357ENST00000524736H0YEB7
ENSG00000124357ENST00000529236H0YC94
ENSG00000124357ENST00000531934E9PPU6
ENSG00000124357ENST00000533981H0YE82
ENSG00000124357ENST00000613852Q9UJ70

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Amino sugar and nucleotide sugar metabolismKEGGko00520
Amino sugar and nucleotide sugar metabolismKEGGhsa00520
Metabolic pathwaysKEGGhsa01100
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinREACTOMER-HSA-446193
Synthesis of substrates in N-glycan biosythesisREACTOMER-HSA-446219
Synthesis of UDP-N-acetyl-glucosamineREACTOMER-HSA-446210

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
159879572005Use of a cell-free system to determine UDP-N-acetylglucosamine 2-epimerase and N-acetylmannosamine kinase activities in human hereditary inclusion body myopathy.21
170103752006Structures of human N-Acetylglucosamine kinase in two complexes with N-Acetylglucosamine and with ADP/glucose: insights into substrate specificity and regulation.20
225077502012Heterozygous UDP-GlcNAc 2-epimerase and N-acetylmannosamine kinase domain mutations in the GNE gene result in a less severe GNE myopathy phenotype compared to homozygous N-acetylmannosamine kinase domain mutations.16
259216062015N-acetyl-D-glucosamine kinase is a component of nuclear speckles and paraspeckles.6
276466882016N-Acetyl-D-Glucosamine Kinase Interacts with Dynein-Lis1-NudE1 Complex and Regulates Cell Division.1
309045942019Developmental regulation of Wnt signaling by Nagk and the UDP-GlcNAc salvage pathway.1

Citation

Dessen P

NAGK (N-acetylglucosamine kinase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70673/nagk