Atlas of Genetics and Cytogenetics in Oncology and Haematology

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NAIP (NLR family apoptosis inhibitory protein)

Identity

Alias (NCBI)BIRC1
NLRB1
psiNAIP
HGNC (Hugo) NAIP
HGNC Alias symbNLRB1
HGNC Alias namenucleotide-binding oligomerization domain, leucine rich repeat and BIR domain containing 1
 NLR family, BIR domain containing 1
HGNC Previous nameBIRC1
HGNC Previous namebaculoviral IAP repeat-containing 1
LocusID (NCBI) 4671
Atlas_Id 43168
Location 5q13.2  [Link to chromosome band 5q13]
Location_base_pair Starts at 70968166 and ends at 71025339 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NAIP (5q13.2) / NFIL3 (9q22.31)NAIP (5q13.2) / OCLN (5q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Lung: Translocations in Small Cell Carcinoma
NAIP/OCLN (5q13)

External links

Nomenclature
HGNC (Hugo)NAIP   7634
Cards
Entrez_Gene (NCBI)NAIP  4671  NLR family apoptosis inhibitory protein
AliasesBIRC1; NLRB1; psiNAIP
GeneCards (Weizmann)NAIP
Ensembl hg19 (Hinxton)ENSG00000249437 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000249437 [Gene_View]  ENSG00000249437 [Sequence]  chr5:70968166-71025339 [Contig_View]  NAIP [Vega]
ICGC DataPortalENSG00000249437
TCGA cBioPortalNAIP
AceView (NCBI)NAIP
Genatlas (Paris)NAIP
WikiGenes4671
SOURCE (Princeton)NAIP
Genetics Home Reference (NIH)NAIP
Genomic and cartography
GoldenPath hg38 (UCSC)NAIP  -     chr5:70968166-71025339 -  5q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NAIP  -     5q13.2   [Description]    (hg19-Feb_2009)
GoldenPathNAIP - 5q13.2 [CytoView hg19]  NAIP - 5q13.2 [CytoView hg38]
ImmunoBaseENSG00000249437
genome Data Viewer NCBINAIP [Mapview hg19]  
OMIM600355   
Gene and transcription
Genbank (Entrez)AB048534 AB209123 AK124511 AK295115 AK309627
RefSeq transcript (Entrez)NM_001346870 NM_004536 NM_022892
RefSeq genomic (Entrez)NC_000005 NG_008724 NT_187651 NW_003315917
Consensus coding sequences : CCDS (NCBI)NAIP
Alternative Splicing GalleryENSG00000249437
Gene ExpressionNAIP [ NCBI-GEO ]   NAIP [ EBI - ARRAY_EXPRESS ]   NAIP [ SEEK ]   NAIP [ MEM ]
Gene Expression Viewer (FireBrowse)NAIP [ Firebrowse - Broad ]
GenevisibleExpression of NAIP in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4671
GTEX Portal (Tissue expression)NAIP
Human Protein AtlasENSG00000249437-NAIP [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13075   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13075  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13075
Splice isoforms : SwissVarQ13075
PhosPhoSitePlusQ13075
Domaine pattern : Prosite (Expaxy)BIR_REPEAT_1 (PS01282)    BIR_REPEAT_2 (PS50143)    NACHT (PS50837)   
Domains : Interpro (EBI)AAA+_ATPase    BIR_rpt    LRR_dom_sf    NACHT_NTPase    Naip    NLRC4_HD    NOD2_WH    P-loop_NTPase   
Domain families : Pfam (Sanger)BIR (PF00653)    NACHT (PF05729)    NLRC4_HD (PF17889)    NOD2_WH (PF17779)   
Domain families : Pfam (NCBI)pfam00653    pfam05729    pfam17889    pfam17779   
Domain families : Smart (EMBL)AAA (SM00382)  BIR (SM00238)  
Conserved Domain (NCBI)NAIP
DMDM Disease mutations4671
Blocks (Seattle)NAIP
PDB (RSDB)2VM5   
PDB Europe2VM5   
PDB (PDBSum)2VM5   
PDB (IMB)2VM5   
Structural Biology KnowledgeBase2VM5   
SCOP (Structural Classification of Proteins)2VM5   
CATH (Classification of proteins structures)2VM5   
SuperfamilyQ13075
Human Protein Atlas [tissue]ENSG00000249437-NAIP [tissue]
Peptide AtlasQ13075
IPIIPI00011547   IPI00291585   IPI00982449   IPI00981369   IPI00983594   IPI00981791   
Protein Interaction databases
DIP (DOE-UCLA)Q13075
IntAct (EBI)Q13075
FunCoupENSG00000249437
BioGRIDNAIP
STRING (EMBL)NAIP
ZODIACNAIP
Ontologies - Pathways
QuickGOQ13075
Ontology : AmiGOprotein binding  ATP binding  ATP binding  cytoplasm  apoptotic process  inflammatory response  nervous system development  detection of bacterium  basolateral plasma membrane  defense response to bacterium  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of neuron apoptotic process  innate immune response  metal ion binding  pyroptosis  IPAF inflammasome complex  
Ontology : EGO-EBIprotein binding  ATP binding  ATP binding  cytoplasm  apoptotic process  inflammatory response  nervous system development  detection of bacterium  basolateral plasma membrane  defense response to bacterium  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of neuron apoptotic process  innate immune response  metal ion binding  pyroptosis  IPAF inflammasome complex  
Pathways : KEGGNOD-like receptor signaling pathway    Legionellosis   
NDEx NetworkNAIP
Atlas of Cancer Signalling NetworkNAIP
Wikipedia pathwaysNAIP
Orthology - Evolution
OrthoDB4671
GeneTree (enSembl)ENSG00000249437
Phylogenetic Trees/Animal Genes : TreeFamNAIP
HOGENOMQ13075
Homologs : HomoloGeneNAIP
Homology/Alignments : Family Browser (UCSC)NAIP
Gene fusions - Rearrangements
Fusion : MitelmanNAIP/OCLN [5q13.2/5q13.2]  
Fusion : QuiverNAIP
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNAIP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NAIP
dbVarNAIP
ClinVarNAIP
MonarchNAIP
1000_GenomesNAIP 
Exome Variant ServerNAIP
GNOMAD BrowserENSG00000249437
Varsome BrowserNAIP
Genetic variants : HAPMAP4671
Genomic Variants (DGV)NAIP [DGVbeta]
DECIPHERNAIP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNAIP 
Mutations
ICGC Data PortalNAIP 
TCGA Data PortalNAIP 
Broad Tumor PortalNAIP
OASIS PortalNAIP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNAIP  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNAIP
Mutations and Diseases : HGMDNAIP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NAIP
DgiDB (Drug Gene Interaction Database)NAIP
DoCM (Curated mutations)NAIP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NAIP (select a term)
intoGenNAIP
Cancer3DNAIP(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600355   
Orphanet11563    11566    11565   
DisGeNETNAIP
MedgenNAIP
Genetic Testing Registry NAIP
NextProtQ13075 [Medical]
TSGene4671
GENETestsNAIP
Target ValidationNAIP
Huge Navigator NAIP [HugePedia]
snp3D : Map Gene to Disease4671
BioCentury BCIQNAIP
ClinGenNAIP
Clinical trials, drugs, therapy
Protein Interactions : CTD4671
Pharm GKB GenePA162396805
Clinical trialNAIP
Miscellaneous
canSAR (ICR)NAIP (select the gene name)
HarmonizomeNAIP
DataMed IndexNAIP
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNAIP
EVEXNAIP
GoPubMedNAIP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:23:32 CEST 2020
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