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NALCN (sodium leak channel, non-selective)

Identity

Alias_namesVGCNL1
voltage gated channel like 1
Alias_symbol (synonym)bA430M15.1
CanIon
Other aliasCLIFAHDD
IHPRF
IHPRF1
INNFD
HGNC (Hugo) NALCN
LocusID (NCBI) 259232
Atlas_Id 70678
Location 13q32.3  [Link to chromosome band 13q32]
Location_base_pair Starts at 101053778 and ends at 101416462 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARSB (5q14.1) / NALCN (13q33.1)FARP1 (13q32.2) / NALCN (13q33.1)LOC344595 () / NALCN (13q33.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NALCN   19082
Cards
Entrez_Gene (NCBI)NALCN  259232  sodium leak channel, non-selective
AliasesCLIFAHDD; CanIon; IHPRF; IHPRF1; 
INNFD; VGCNL1; bA430M15.1
GeneCards (Weizmann)NALCN
Ensembl hg19 (Hinxton)ENSG00000102452 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000102452 [Gene_View]  chr13:101053778-101416462 [Contig_View]  NALCN [Vega]
ICGC DataPortalENSG00000102452
TCGA cBioPortalNALCN
AceView (NCBI)NALCN
Genatlas (Paris)NALCN
WikiGenes259232
SOURCE (Princeton)NALCN
Genetics Home Reference (NIH)NALCN
Genomic and cartography
GoldenPath hg38 (UCSC)NALCN  -     chr13:101053778-101416462 -  13q32.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NALCN  -     13q32.3   [Description]    (hg19-Feb_2009)
EnsemblNALCN - 13q32.3 [CytoView hg19]  NALCN - 13q32.3 [CytoView hg38]
Mapping of homologs : NCBINALCN [Mapview hg19]  NALCN [Mapview hg38]
OMIM611549   615419   616266   
Gene and transcription
Genbank (Entrez)AF339780 AK002089 AK055506 AK094390 AK094669
RefSeq transcript (Entrez)NM_001350748 NM_001350749 NM_001350750 NM_001350751 NM_052867
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NALCN
Cluster EST : UnigeneHs.525146 [ NCBI ]
CGAP (NCI)Hs.525146
Alternative Splicing GalleryENSG00000102452
Gene ExpressionNALCN [ NCBI-GEO ]   NALCN [ EBI - ARRAY_EXPRESS ]   NALCN [ SEEK ]   NALCN [ MEM ]
Gene Expression Viewer (FireBrowse)NALCN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)259232
GTEX Portal (Tissue expression)NALCN
Human Protein AtlasENSG00000102452-NALCN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IZF0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IZF0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IZF0
Splice isoforms : SwissVarQ8IZF0
PhosPhoSitePlusQ8IZF0
Domains : Interpro (EBI)Channel_four-helix_dom    Ion_trans_dom    NALCN   
Domain families : Pfam (Sanger)Ion_trans (PF00520)   
Domain families : Pfam (NCBI)pfam00520   
Conserved Domain (NCBI)NALCN
DMDM Disease mutations259232
Blocks (Seattle)NALCN
SuperfamilyQ8IZF0
Human Protein Atlas [tissue]ENSG00000102452-NALCN [tissue]
Peptide AtlasQ8IZF0
HPRD15647
IPIIPI00217996   IPI00827756   IPI01011084   IPI00878301   IPI00940313   
Protein Interaction databases
DIP (DOE-UCLA)Q8IZF0
IntAct (EBI)Q8IZF0
FunCoupENSG00000102452
BioGRIDNALCN
STRING (EMBL)NALCN
ZODIACNALCN
Ontologies - Pathways
QuickGOQ8IZF0
Ontology : AmiGOvoltage-gated ion channel activity  cation channel activity  cation channel activity  sodium channel activity  protein binding  plasma membrane  plasma membrane  calcium ion transport  integral component of membrane  leak channel activity  ion transmembrane transport  ion transmembrane transport  regulation of ion transmembrane transport  sodium ion transmembrane transport  regulation of resting membrane potential  calcium ion transmembrane transport  potassium ion transmembrane transport  membrane depolarization during action potential  
Ontology : EGO-EBIvoltage-gated ion channel activity  cation channel activity  cation channel activity  sodium channel activity  protein binding  plasma membrane  plasma membrane  calcium ion transport  integral component of membrane  leak channel activity  ion transmembrane transport  ion transmembrane transport  regulation of ion transmembrane transport  sodium ion transmembrane transport  regulation of resting membrane potential  calcium ion transmembrane transport  potassium ion transmembrane transport  membrane depolarization during action potential  
NDEx NetworkNALCN
Atlas of Cancer Signalling NetworkNALCN
Wikipedia pathwaysNALCN
Orthology - Evolution
OrthoDB259232
GeneTree (enSembl)ENSG00000102452
Phylogenetic Trees/Animal Genes : TreeFamNALCN
HOVERGENQ8IZF0
HOGENOMQ8IZF0
Homologs : HomoloGeneNALCN
Homology/Alignments : Family Browser (UCSC)NALCN
Gene fusions - Rearrangements
Tumor Fusion PortalNALCN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNALCN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NALCN
dbVarNALCN
ClinVarNALCN
1000_GenomesNALCN 
Exome Variant ServerNALCN
ExAC (Exome Aggregation Consortium)ENSG00000102452
GNOMAD BrowserENSG00000102452
Genetic variants : HAPMAP259232
Genomic Variants (DGV)NALCN [DGVbeta]
DECIPHERNALCN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNALCN 
Mutations
ICGC Data PortalNALCN 
TCGA Data PortalNALCN 
Broad Tumor PortalNALCN
OASIS PortalNALCN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNALCN  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNALCN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NALCN
DgiDB (Drug Gene Interaction Database)NALCN
DoCM (Curated mutations)NALCN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NALCN (select a term)
intoGenNALCN
Cancer3DNALCN(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611549    615419    616266   
Orphanet22538   
DisGeNETNALCN
MedgenNALCN
Genetic Testing Registry NALCN
NextProtQ8IZF0 [Medical]
TSGene259232
GENETestsNALCN
Target ValidationNALCN
Huge Navigator NALCN [HugePedia]
snp3D : Map Gene to Disease259232
BioCentury BCIQNALCN
ClinGenNALCN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD259232
Chemical/Pharm GKB GenePA162396840
Clinical trialNALCN
Miscellaneous
canSAR (ICR)NALCN (select the gene name)
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNALCN
EVEXNALCN
GoPubMedNALCN
iHOPNALCN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 13:28:44 CET 2017

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