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NAP1L1 (nucleosome assembly protein 1 like 1)

Identity

Alias_namesnucleosome assembly protein 1-like 1
Alias_symbol (synonym)NRP
NAP1
NAP1L
MGC8688
MGC23410
Other alias
HGNC (Hugo) NAP1L1
LocusID (NCBI) 4673
Atlas_Id 52770
Location 12q21.2  [Link to chromosome band 12q21]
Location_base_pair Starts at 76044745 and ends at 76085033 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DNAJB2 (2q35) / NAP1L1 (12q21.2)EXOC7 (17q25.1) / NAP1L1 (12q21.2)LGMN (14q32.12) / NAP1L1 (12q21.2)
NAP1L1 (12q21.2) / LDHAL6A (11p15.1)NAP1L1 (12q21.2) / MLLT10 (10p12.31)NAP1L1 (12q21.2) / NAP1L1 (12q21.2)
NAP1L1 (12q21.2) / STK38L (12p11.23)NAP1L1 (12q21.2) / WHSC1 (4p16.3)NAP1L1 (12q21.2) / WNT7A (3p25.1)
NAP1L1 (12q21.2) / ZNF644 (1p22.2)NCL (2q37.1) / NAP1L1 (12q21.2)PATJ (1p31.3) / NAP1L1 (12q21.2)
UBAC1 (9q34.3) / NAP1L1 (12q21.2)NAP1L1 12q21.2 / STK38L 12p11.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(10;12)(p12;q21) NAP1L1/MLLT10
t(10;12)(p12;q21) NAP1L1/MLLT10


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(12;12)(p11;q21) NAP1L1/STK38L
t(12;14)(q21;q32) LGMN/NAP1L1


External links

Nomenclature
HGNC (Hugo)NAP1L1   7637
Cards
Entrez_Gene (NCBI)NAP1L1  4673  nucleosome assembly protein 1 like 1
AliasesNAP1; NAP1L; NRP
GeneCards (Weizmann)NAP1L1
Ensembl hg19 (Hinxton)ENSG00000187109 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000187109 [Gene_View]  ENSG00000187109 [Sequence]  chr12:76044745-76085033 [Contig_View]  NAP1L1 [Vega]
ICGC DataPortalENSG00000187109
TCGA cBioPortalNAP1L1
AceView (NCBI)NAP1L1
Genatlas (Paris)NAP1L1
WikiGenes4673
SOURCE (Princeton)NAP1L1
Genetics Home Reference (NIH)NAP1L1
Genomic and cartography
GoldenPath hg38 (UCSC)NAP1L1  -     chr12:76044745-76085033 -  12q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NAP1L1  -     12q21.2   [Description]    (hg19-Feb_2009)
EnsemblNAP1L1 - 12q21.2 [CytoView hg19]  NAP1L1 - 12q21.2 [CytoView hg38]
Mapping of homologs : NCBINAP1L1 [Mapview hg19]  NAP1L1 [Mapview hg38]
OMIM164060   
Gene and transcription
Genbank (Entrez)AA057019 AF086080 AF088017 AF300335 AK021751
RefSeq transcript (Entrez)NM_001307924 NM_001330231 NM_001330232 NM_004537 NM_139207
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NAP1L1
Cluster EST : UnigeneHs.695185 [ NCBI ]
CGAP (NCI)Hs.695185
Alternative Splicing GalleryENSG00000187109
Gene ExpressionNAP1L1 [ NCBI-GEO ]   NAP1L1 [ EBI - ARRAY_EXPRESS ]   NAP1L1 [ SEEK ]   NAP1L1 [ MEM ]
Gene Expression Viewer (FireBrowse)NAP1L1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4673
GTEX Portal (Tissue expression)NAP1L1
Human Protein AtlasENSG00000187109-NAP1L1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP55209   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP55209  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP55209
Splice isoforms : SwissVarP55209
PhosPhoSitePlusP55209
Domains : Interpro (EBI)NAP-like_sf    NAP_family   
Domain families : Pfam (Sanger)NAP (PF00956)   
Domain families : Pfam (NCBI)pfam00956   
Conserved Domain (NCBI)NAP1L1
DMDM Disease mutations4673
Blocks (Seattle)NAP1L1
SuperfamilyP55209
Human Protein Atlas [tissue]ENSG00000187109-NAP1L1 [tissue]
Peptide AtlasP55209
HPRD01248
IPIIPI00023860   IPI00902909   IPI00797545   IPI01013841   IPI00922322   IPI01013371   IPI01020731   IPI00385822   IPI01021172   IPI01021323   IPI01021493   IPI01021659   IPI01026232   IPI01021840   IPI01022001   IPI01022013   IPI01022171   IPI01022332   IPI01022498   IPI01022667   IPI01022822   IPI01022994   
Protein Interaction databases
DIP (DOE-UCLA)P55209
IntAct (EBI)P55209
FunCoupENSG00000187109
BioGRIDNAP1L1
STRING (EMBL)NAP1L1
ZODIACNAP1L1
Ontologies - Pathways
QuickGOP55209
Ontology : AmiGORNA binding  protein binding  nucleus  cytoplasm  DNA replication  nucleosome assembly  positive regulation of cell proliferation  membrane  melanosome  positive regulation of neurogenesis  positive regulation of neural precursor cell proliferation  
Ontology : EGO-EBIRNA binding  protein binding  nucleus  cytoplasm  DNA replication  nucleosome assembly  positive regulation of cell proliferation  membrane  melanosome  positive regulation of neurogenesis  positive regulation of neural precursor cell proliferation  
NDEx NetworkNAP1L1
Atlas of Cancer Signalling NetworkNAP1L1
Wikipedia pathwaysNAP1L1
Orthology - Evolution
OrthoDB4673
GeneTree (enSembl)ENSG00000187109
Phylogenetic Trees/Animal Genes : TreeFamNAP1L1
HOVERGENP55209
HOGENOMP55209
Homologs : HomoloGeneNAP1L1
Homology/Alignments : Family Browser (UCSC)NAP1L1
Gene fusions - Rearrangements
Fusion : MitelmanLGMN/NAP1L1 [14q32.12/12q21.2]  [t(12;14)(q21;q32)]  
Fusion : MitelmanNAP1L1/MLLT10 [12q21.2/10p12.31]  [t(10;12)(p12;q21)]  
Fusion : MitelmanNAP1L1/STK38L [12q21.2/12p11.23]  [t(12;12)(p11;q21)]  
Fusion PortalNAP1L1 12q21.2 STK38L 12p11.23 BRCA
Fusion : QuiverNAP1L1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNAP1L1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NAP1L1
dbVarNAP1L1
ClinVarNAP1L1
1000_GenomesNAP1L1 
Exome Variant ServerNAP1L1
ExAC (Exome Aggregation Consortium)ENSG00000187109
GNOMAD BrowserENSG00000187109
Varsome BrowserNAP1L1
Genetic variants : HAPMAP4673
Genomic Variants (DGV)NAP1L1 [DGVbeta]
DECIPHERNAP1L1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNAP1L1 
Mutations
ICGC Data PortalNAP1L1 
TCGA Data PortalNAP1L1 
Broad Tumor PortalNAP1L1
OASIS PortalNAP1L1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNAP1L1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNAP1L1
intOGen PortalNAP1L1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NAP1L1
DgiDB (Drug Gene Interaction Database)NAP1L1
DoCM (Curated mutations)NAP1L1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NAP1L1 (select a term)
intoGenNAP1L1
Cancer3DNAP1L1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM164060   
Orphanet
DisGeNETNAP1L1
MedgenNAP1L1
Genetic Testing Registry NAP1L1
NextProtP55209 [Medical]
TSGene4673
GENETestsNAP1L1
Target ValidationNAP1L1
Huge Navigator NAP1L1 [HugePedia]
snp3D : Map Gene to Disease4673
BioCentury BCIQNAP1L1
ClinGenNAP1L1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4673
Chemical/Pharm GKB GenePA31439
Clinical trialNAP1L1
Miscellaneous
canSAR (ICR)NAP1L1 (select the gene name)
Probes
Litterature
PubMed93 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNAP1L1
EVEXNAP1L1
GoPubMedNAP1L1
iHOPNAP1L1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:25:00 CET 2018

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