NAPRT (nicotinate phosphoribosyltransferase)

2014-06-01 Affiliation

Identity

HGNC

NAPRT

LOCATION

8q24.3

LOCUSID

93100

ALIAS

NAPRT1,PP3856

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 93100
MIM: 611552
HGNC: 30450
Ensembl: ENSG00000147813

Variants:

dbSNP: 93100
ClinVar: 93100
TCGA: ENSG00000147813
COSMIC: NAPRT

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000147813	ENST00000340490	G5E977
ENSG00000147813	ENST00000426292	Q6XQN6
ENSG00000147813	ENST00000435154	C9J8U2
ENSG00000147813	ENST00000449291	Q6XQN6
ENSG00000147813	ENST00000460623	A0A087WUT5
ENSG00000147813	ENST00000525583	H0YF31
ENSG00000147813	ENST00000532645	H0YDA6

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Nicotinate and nicotinamide metabolism	KEGG	ko00760
Nicotinate and nicotinamide metabolism	KEGG	hsa00760
Metabolic pathways	KEGG	hsa01100
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Metabolism	REACTOME	R-HSA-1430728
Metabolism of vitamins and cofactors	REACTOME	R-HSA-196854
Metabolism of water-soluble vitamins and cofactors	REACTOME	R-HSA-196849
Nicotinate metabolism	REACTOME	R-HSA-196807
Nicotinamide salvaging	REACTOME	R-HSA-197264
Neutrophil degranulation	REACTOME	R-HSA-6798695

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
17604275	2007	Elevation of cellular NAD levels by nicotinic acid and involvement of nicotinic acid phosphoribosyltransferase in human cells.	60
22570471	2012	Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner.	28
21492230	2011	Expression patterns of nicotinamide phosphoribosyltransferase and nicotinic acid phosphoribosyltransferase in human malignant lymphomas.	20
24097869	2013	Loss of NAPRT1 expression by tumor-specific promoter methylation provides a novel predictive biomarker for NAMPT inhibitors.	20
26675378	2016	Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors.	15
28860121	2017	NAD Synthesis Pathway Interference Is a Viable Therapeutic Strategy for Chondrosarcoma.	8
31439867	2019	PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma.	6
31511522	2019	Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation.	6
28416276	2017	Synthesis and Degradation of Adenosine 5'-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases.	2

Citation

Dessen P

NAPRT (nicotinate phosphoribosyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/54027/naprt