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NARS2 (asparaginyl-tRNA synthetase 2, mitochondrial)

Identity

Alias (NCBI)DFNB94
SLM5
asnRS
HGNC (Hugo) NARS2
HGNC Alias symbFLJ23441
SLM5
HGNC Alias nameasparagine tRNA ligase 2, mitochondrial (putative)
HGNC Previous nameDFNB94
HGNC Previous namedeafness, autosomal recessive 94
 asparaginyl-tRNA synthetase 2, mitochondrial (putative)
LocusID (NCBI) 79731
Atlas_Id 54487
Location 11q14.1  [Link to chromosome band 11q14]
Location_base_pair Starts at 78435968 and ends at 78574864 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ALG8 (11q14.1)::NARS2 (11q14.1)COL4A2 (13q34)::NARS2 (11q14.1)ERBB2 (17q12)::NARS2 (11q14.1)
GAB2 (11q14.1)::NARS2 (11q14.1)GTF2E2 (8p12)::NARS2 (11q14.1)INTS4 (11q14.1)::NARS2 (11q14.1)
NARS2 (11q14.1)::HMGB2 (4q34.1)NARS2 (11q14.1)::ME3 (11q14.2)NARS2 (11q14.1)::MMP10 (11q22.2)
NARS2 (11q14.1)::PAK1 (11q13.5)NARS2 (11q14.1)::RSF1 (11q14.1)NARS2 (11q14.1)::VTI1A (10q25.2)
ORAOV1 (11q13.3)::NARS2 (11q14.1)PAK1 (11q13.5)::NARS2 (11q14.1)PPME1 (11q13.4)::NARS2 (11q14.1)
RARA (17q21.2)::NARS2 (11q14.1)RP11-360L9.4 ()::NARS2 (11q14.1)RPS6 (9p22.1)::NARS2 (11q14.1)
SCFD2 (4q12)::NARS2 (11q14.1)ALG8 11q14.1::NARS2 11q14.1ERBB2 17q12::NARS2 11q14.1
GTF2E2 8p12::NARS2 11q14.1INTS4 11q14.1::NARS2 11q14.1NARS2 11q14.1::ME3 11q14.2
ORAOV1 11q13.3::NARS2 11q14.1PAK1 11q13.5::NARS2 11q14.1PPME1 11q13.4::NARS2 11q14.1
RP11-360L9.4 NARS2 11q14.1SCFD2 4q12::NARS2 11q14.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)NARS2   26274
Cards
Entrez_Gene (NCBI)NARS2    asparaginyl-tRNA synthetase 2, mitochondrial
AliasesDFNB94; SLM5; asnRS
GeneCards (Weizmann)NARS2
Ensembl hg19 (Hinxton)ENSG00000137513 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137513 [Gene_View]  ENSG00000137513 [Sequence]  chr11:78435968-78574864 [Contig_View]  NARS2 [Vega]
ICGC DataPortalENSG00000137513
TCGA cBioPortalNARS2
AceView (NCBI)NARS2
Genatlas (Paris)NARS2
SOURCE (Princeton)NARS2
Genetics Home Reference (NIH)NARS2
Genomic and cartography
GoldenPath hg38 (UCSC)NARS2  -     chr11:78435968-78574864 -  11q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NARS2  -     11q14.1   [Description]    (hg19-Feb_2009)
GoldenPathNARS2 - 11q14.1 [CytoView hg19]  NARS2 - 11q14.1 [CytoView hg38]
ImmunoBaseENSG00000137513
Genome Data Viewer NCBINARS2 [Mapview hg19]  
OMIM612803   616239   618434   
Gene and transcription
Genbank (Entrez)AK027094 AK056980 AK225444 AK315425 AW968557
RefSeq transcript (Entrez)NM_001243251 NM_024678
Consensus coding sequences : CCDS (NCBI)NARS2
Gene ExpressionNARS2 [ NCBI-GEO ]   NARS2 [ EBI - ARRAY_EXPRESS ]   NARS2 [ SEEK ]   NARS2 [ MEM ]
Gene Expression Viewer (FireBrowse)NARS2 [ Firebrowse - Broad ]
GenevisibleExpression of NARS2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79731
GTEX Portal (Tissue expression)NARS2
Human Protein AtlasENSG00000137513-NARS2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96I59   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96I59  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96I59
Catalytic activity : Enzyme6.1.1.22 [ Enzyme-Expasy ]   6.1.1.226.1.1.22 [ IntEnz-EBI ]   6.1.1.22 [ BRENDA ]   6.1.1.22 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ96I59
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_II (PS50862)   
Domains : Interpro (EBI)Aa-tRNA-synt_II    aa-tRNA-synth_II    Asn-tRNA-ligase    Asp/Asn-tRNA-synth_IIb    NA-bd_OB-fold    NA-bd_OB_tRNA   
Domain families : Pfam (Sanger)tRNA-synt_2 (PF00152)    tRNA_anti-codon (PF01336)   
Domain families : Pfam (NCBI)pfam00152    pfam01336   
Conserved Domain (NCBI)NARS2
SuperfamilyQ96I59
AlphaFold pdb e-kbQ96I59   
Human Protein Atlas [tissue]ENSG00000137513-NARS2 [tissue]
HPRD08026
Protein Interaction databases
DIP (DOE-UCLA)Q96I59
IntAct (EBI)Q96I59
BioGRIDNARS2
STRING (EMBL)NARS2
ZODIACNARS2
Ontologies - Pathways
QuickGOQ96I59
Ontology : AmiGOnucleic acid binding  asparagine-tRNA ligase activity  ATP binding  nucleoplasm  mitochondrion  mitochondrion  mitochondrial matrix  cytosol  asparaginyl-tRNA aminoacylation  
Ontology : EGO-EBInucleic acid binding  asparagine-tRNA ligase activity  ATP binding  nucleoplasm  mitochondrion  mitochondrion  mitochondrial matrix  cytosol  asparaginyl-tRNA aminoacylation  
Pathways : KEGGAminoacyl-tRNA biosynthesis   
NDEx NetworkNARS2
Atlas of Cancer Signalling NetworkNARS2
Wikipedia pathwaysNARS2
Orthology - Evolution
OrthoDB79731
GeneTree (enSembl)ENSG00000137513
Phylogenetic Trees/Animal Genes : TreeFamNARS2
Homologs : HomoloGeneNARS2
Homology/Alignments : Family Browser (UCSC)NARS2
Gene fusions - Rearrangements
Fusion : MitelmanALG8::NARS2 [11q14.1/11q14.1]  
Fusion : MitelmanERBB2::NARS2 [17q12/11q14.1]  
Fusion : MitelmanGAB2::NARS2 [11q14.1/11q14.1]  
Fusion : MitelmanGTF2E2::NARS2 [8p12/11q14.1]  
Fusion : MitelmanINTS4::NARS2 [11q14.1/11q14.1]  
Fusion : MitelmanNARS2::ME3 [11q14.1/11q14.2]  
Fusion : MitelmanORAOV1::NARS2 [11q13.3/11q14.1]  
Fusion : MitelmanPAK1::NARS2 [11q13.5/11q14.1]  
Fusion : MitelmanPPME1::NARS2 [11q13.4/11q14.1]  
Fusion : MitelmanRARA::NARS2 [17q21.2/11q14.1]  
Fusion : MitelmanSCFD2::NARS2 [4q12/11q14.1]  
Fusion : QuiverNARS2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNARS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NARS2
dbVarNARS2
ClinVarNARS2
MonarchNARS2
1000_GenomesNARS2 
Exome Variant ServerNARS2
GNOMAD BrowserENSG00000137513
Varsome BrowserNARS2
ACMGNARS2 variants
VarityQ96I59
Genomic Variants (DGV)NARS2 [DGVbeta]
DECIPHERNARS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNARS2 
Mutations
ICGC Data PortalNARS2 
TCGA Data PortalNARS2 
Broad Tumor PortalNARS2
OASIS PortalNARS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNARS2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNARS2
Mutations and Diseases : HGMDNARS2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNARS2
DgiDB (Drug Gene Interaction Database)NARS2
DoCM (Curated mutations)NARS2
CIViC (Clinical Interpretations of Variants in Cancer)NARS2
Cancer3DNARS2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612803    616239    618434   
Orphanet23489   
DisGeNETNARS2
MedgenNARS2
Genetic Testing Registry NARS2
NextProtQ96I59 [Medical]
GENETestsNARS2
Target ValidationNARS2
Huge Navigator NARS2 [HugePedia]
ClinGenNARS2
Clinical trials, drugs, therapy
MyCancerGenomeNARS2
Protein Interactions : CTDNARS2
Pharm GKB GenePA143485554
PharosQ96I59
Clinical trialNARS2
Miscellaneous
canSAR (ICR)NARS2
HarmonizomeNARS2
ARCHS4NARS2
DataMed IndexNARS2
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNARS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun Jan 16 18:24:04 CET 2022
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