NAT8L (N-acetyltransferase 8 like)

2014-08-01  

Identity

HGNC
NAT8L
LOCATION
4p16.3
LOCUSID
339983
ALIAS
CML3,NACED,NAT8-LIKE
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 339983
MIM: 610647
HGNC: 26742
Ensembl: ENSG00000185818

Variants:

dbSNP: 339983
ClinVar: 339983
TCGA: ENSG00000185818
COSMIC: NAT8L

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185818ENST00000423729Q8N9F0

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Alanine, aspartate and glutamate metabolismKEGGko00250
Alanine, aspartate and glutamate metabolismKEGGhsa00250
Metabolic pathwaysKEGGhsa01100

References

Pubmed IDYearTitleCitations
198076912009Molecular identification of aspartate N-acetyltransferase and its mutation in hypoacetylaspartia.33
219367732012Determinants of the enzymatic activity and the subcellular localization of aspartate N-acetyltransferase.0
241552402013NAT8L (N-acetyltransferase 8-like) accelerates lipid turnover and increases energy expenditure in brown adipocytes.0
242462742014Deletion of SHATI/NAT8L increases dopamine D1 receptor on the cell surface in the nucleus accumbens, accelerating methamphetamine dependence.0
265114902016Cancer-Specific Production of N-Acetylaspartate via NAT8L Overexpression in Non-Small Cell Lung Cancer and Its Potential as a Circulating Biomarker.0
265509432016Purification and characterization of aspartate N-acetyltransferase: A critical enzyme in brain metabolism.0
273485322016Decreased DNA Methylation in the Shati/Nat8l Promoter in Both Patients with Schizophrenia and a Methamphetamine-Induced Murine Model of Schizophrenia-Like Phenotype.0

Citation

Dessen P

NAT8L (N-acetyltransferase 8 like)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54488/nat8l