Atlas of Genetics and Cytogenetics in Oncology and Haematology

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NAV2 (neuron navigator 2)

Identity

Alias (NCBI)HELAD1
POMFIL2
RAINB1
STEERIN2
UNC53H2
HGNC (Hugo) NAV2
HGNC Alias symbFLJ10633
FLJ11030
HELAD1
KIAA1419
POMFIL2
RAINB1
FLJ23707
HGNC Alias namepore membrane and/or filament interacting like protein 2
 retinoic acid inducible gene in neuroblastoma 1
 helicase, APC down-regulated 1
LocusID (NCBI) 89797
Atlas_Id 41499
Location 11p15.1  [Link to chromosome band 11p15]
Location_base_pair Starts at 19712837 and ends at 20121601 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MOV10L1 (22q13.33) / NAV2 (11p15.1)NAV2 (11p15.1) / C8A (1p32.2)NAV2 (11p15.1) / CBX5 (12q13.13)
NAV2 (11p15.1) / CNTN5 (11q22.1)NAV2 (11p15.1) / DGKA (12q13.2)NAV2 (11p15.1) / EHF (11p13)
NAV2 (11p15.1) / HNRNPH1 (5q35.3)NAV2 (11p15.1) / PACSIN3 (11p11.2)NAV2 (11p15.1) / SLC33A1 (3q25.31)
NAV2 (11p15.1) / TCF7L1 (2p11.2)NAV2 (11p15.1) / WDFY1 (2q36.1)MOV10L1 22q13.33 / NAV2 11p15.1
NAV2 11p15.1 / CNTN5 11q22.1NAV2 11p15.1 / EHF 11p13NAV2 11p15.1 / PACSIN3 11p11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 6 ]
  t(2;11)(p11;p15) NAV2/TCF7L1
t(2;11)(q36;p15) NAV2/WDFY1
t(11;11)(p11;p15) NAV2/PACSIN3
t(11;11)(p13;p15) NAV2/EHF
t(11;11)(p15;q22) NAV2/CNTN5
t(11;22)(p15;q13) MOV10L1/NAV2

External links

Nomenclature
HGNC (Hugo)NAV2   15997
Cards
Entrez_Gene (NCBI)NAV2    neuron navigator 2
AliasesHELAD1; POMFIL2; RAINB1; STEERIN2; 
UNC53H2
GeneCards (Weizmann)NAV2
Ensembl hg19 (Hinxton)ENSG00000166833 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166833 [Gene_View]  ENSG00000166833 [Sequence]  chr11:19712837-20121601 [Contig_View]  NAV2 [Vega]
ICGC DataPortalENSG00000166833
TCGA cBioPortalNAV2
AceView (NCBI)NAV2
Genatlas (Paris)NAV2
SOURCE (Princeton)NAV2
Genetics Home Reference (NIH)NAV2
Genomic and cartography
GoldenPath hg38 (UCSC)NAV2  -     chr11:19712837-20121601 +  11p15.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NAV2  -     11p15.1   [Description]    (hg19-Feb_2009)
GoldenPathNAV2 - 11p15.1 [CytoView hg19]  NAV2 - 11p15.1 [CytoView hg38]
ImmunoBaseENSG00000166833
genome Data Viewer NCBINAV2 [Mapview hg19]  
OMIM607026   
Gene and transcription
Genbank (Entrez)AA451836 AB037840 AB063115 AB063116 AF466143
RefSeq transcript (Entrez)NM_001111018 NM_001111019 NM_001244963 NM_145117 NM_182964
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NAV2
Alternative Splicing GalleryENSG00000166833
Gene ExpressionNAV2 [ NCBI-GEO ]   NAV2 [ EBI - ARRAY_EXPRESS ]   NAV2 [ SEEK ]   NAV2 [ MEM ]
Gene Expression Viewer (FireBrowse)NAV2 [ Firebrowse - Broad ]
GenevisibleExpression of NAV2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)89797
GTEX Portal (Tissue expression)NAV2
Human Protein AtlasENSG00000166833-NAV2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IVL1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IVL1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IVL1
Splice isoforms : SwissVarQ8IVL1
Catalytic activity : Enzyme3.6.4.12 [ Enzyme-Expasy ]   3.6.4.123.6.4.12 [ IntEnz-EBI ]   3.6.4.12 [ BRENDA ]   3.6.4.12 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ8IVL1
Domaine pattern : Prosite (Expaxy)CH (PS50021)   
Domains : Interpro (EBI)AAA+_ATPase    CH-domain    CH_dom_sf    Nav/unc-53    P-loop_NTPase   
Domain families : Pfam (Sanger)CH (PF00307)   
Domain families : Pfam (NCBI)pfam00307   
Domain families : Smart (EMBL)AAA (SM00382)  CH (SM00033)  
Conserved Domain (NCBI)NAV2
Blocks (Seattle)NAV2
PDB (RSDB)2YRN   
PDB Europe2YRN   
PDB (PDBSum)2YRN   
PDB (IMB)2YRN   
Structural Biology KnowledgeBase2YRN   
SCOP (Structural Classification of Proteins)2YRN   
CATH (Classification of proteins structures)2YRN   
SuperfamilyQ8IVL1
Human Protein Atlas [tissue]ENSG00000166833-NAV2 [tissue]
Peptide AtlasQ8IVL1
HPRD07385
IPIIPI00217052   IPI00816407   IPI00816806   IPI00816570   IPI00815765   IPI00816751   IPI00815697   IPI00872269   IPI00152696   IPI00815856   IPI00879900   IPI00816020   IPI00816099   IPI00797388   IPI00977438   IPI00976287   
Protein Interaction databases
DIP (DOE-UCLA)Q8IVL1
IntAct (EBI)Q8IVL1
BioGRIDNAV2
STRING (EMBL)NAV2
ZODIACNAV2
Ontologies - Pathways
QuickGOQ8IVL1
Ontology : AmiGOregulation of systemic arterial blood pressure by baroreceptor feedback  DNA helicase activity  protein binding  ATP binding  interstitial matrix  nucleoplasm  nervous system development  sensory perception of sound  sensory perception of smell  locomotory behavior  heparin binding  optic nerve development  glossopharyngeal nerve development  vagus nerve development  neurogenesis  DNA duplex unwinding  
Ontology : EGO-EBIregulation of systemic arterial blood pressure by baroreceptor feedback  DNA helicase activity  protein binding  ATP binding  interstitial matrix  nucleoplasm  nervous system development  sensory perception of sound  sensory perception of smell  locomotory behavior  heparin binding  optic nerve development  glossopharyngeal nerve development  vagus nerve development  neurogenesis  DNA duplex unwinding  
NDEx NetworkNAV2
Atlas of Cancer Signalling NetworkNAV2
Wikipedia pathwaysNAV2
Orthology - Evolution
OrthoDB89797
GeneTree (enSembl)ENSG00000166833
Phylogenetic Trees/Animal Genes : TreeFamNAV2
HOGENOMQ8IVL1
Homologs : HomoloGeneNAV2
Homology/Alignments : Family Browser (UCSC)NAV2
Gene fusions - Rearrangements
Fusion : MitelmanMOV10L1/NAV2 [22q13.33/11p15.1]  
Fusion : MitelmanNAV2/CNTN5 [11p15.1/11q22.1]  
Fusion : MitelmanNAV2/EHF [11p15.1/11p13]  
Fusion : MitelmanNAV2/PACSIN3 [11p15.1/11p11.2]  
Fusion : MitelmanNAV2/TCF7L1 [11p15.1/2p11.2]  
Fusion : MitelmanNAV2/WDFY1 [11p15.1/2q36.1]  
Fusion PortalMOV10L1 22q13.33 NAV2 11p15.1 BRCA
Fusion PortalNAV2 11p15.1 CNTN5 11q22.1 BRCA LUAD
Fusion PortalNAV2 11p15.1 EHF 11p13 BRCA
Fusion PortalNAV2 11p15.1 PACSIN3 11p11.2 BRCA
Fusion : QuiverNAV2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNAV2 [hg38]
dbVarNAV2
ClinVarNAV2
MonarchNAV2
1000_GenomesNAV2 
Exome Variant ServerNAV2
GNOMAD BrowserENSG00000166833
Varsome BrowserNAV2
Genomic Variants (DGV)NAV2 [DGVbeta]
DECIPHERNAV2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNAV2 
Mutations
ICGC Data PortalNAV2 
TCGA Data PortalNAV2 
Broad Tumor PortalNAV2
OASIS PortalNAV2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNAV2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNAV2
Mutations and Diseases : HGMDNAV2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NAV2
DgiDB (Drug Gene Interaction Database)NAV2
DoCM (Curated mutations)NAV2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NAV2 (select a term)
intoGenNAV2
Cancer3DNAV2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607026   
Orphanet
DisGeNETNAV2
MedgenNAV2
Genetic Testing Registry NAV2
NextProtQ8IVL1 [Medical]
GENETestsNAV2
Target ValidationNAV2
Huge Navigator NAV2 [HugePedia]
ClinGenNAV2
Clinical trials, drugs, therapy
MyCancerGenomeNAV2
Protein Interactions : CTD
Pharm GKB GenePA31452
PharosQ8IVL1
Clinical trialNAV2
Miscellaneous
canSAR (ICR)NAV2 (select the gene name)
HarmonizomeNAV2
DataMed IndexNAV2
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNAV2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:28:13 CET 2021
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