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NAV3 (neuron navigator 3)

Identity

Alias (NCBI)POMFIL1
STEERIN3
unc53H3
HGNC (Hugo) NAV3
HGNC Alias symbKIAA0938
POMFIL1
HGNC Alias namepore membrane and/or filament interacting like protein 1
 steerin 3
LocusID (NCBI) 89795
Atlas_Id 46629
Location 12q21.2  [Link to chromosome band 12q21]
Location_base_pair Starts at 77830894 and ends at 78213010 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CPSF6 (12q15)::NAV3 (12q21.2)LRP1B (2q22.1)::NAV3 (12q21.2)NAV3 (12q21.2)::NAV3 (12q21.2)
NELL1 (11p15.1)::NAV3 (12q21.2)PDK3 (Xp22.11)::NAV3 (12q21.2)WDFY3 (4q21.23)::NAV3 (12q21.2)
CPSF6 12q15::NAV3 12q21.2PDK3 Xp22.11::NAV3 12q21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  Subcutaneous panniculitis-like T-cell lymphoma


External links

 

Nomenclature
HGNC (Hugo)NAV3   15998
Cards
Entrez_Gene (NCBI)NAV3    neuron navigator 3
AliasesPOMFIL1; STEERIN3; unc53H3
GeneCards (Weizmann)NAV3
Ensembl hg19 (Hinxton)ENSG00000067798 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000067798 [Gene_View]  ENSG00000067798 [Sequence]  chr12:77830894-78213010 [Contig_View]  NAV3 [Vega]
ICGC DataPortalENSG00000067798
TCGA cBioPortalNAV3
AceView (NCBI)NAV3
Genatlas (Paris)NAV3
SOURCE (Princeton)NAV3
Genetics Home Reference (NIH)NAV3
Genomic and cartography
GoldenPath hg38 (UCSC)NAV3  -     chr12:77830894-78213010 +  12q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NAV3  -     12q21.2   [Description]    (hg19-Feb_2009)
GoldenPathNAV3 - 12q21.2 [CytoView hg19]  NAV3 - 12q21.2 [CytoView hg38]
ImmunoBaseENSG00000067798
Genome Data Viewer NCBINAV3 [Mapview hg19]  
OMIM611629   
Gene and transcription
Genbank (Entrez)AB023155 AF397731 AJ488201 AK022070 AK294988
RefSeq transcript (Entrez)NM_001024383 NM_014903
Consensus coding sequences : CCDS (NCBI)NAV3
Gene ExpressionNAV3 [ NCBI-GEO ]   NAV3 [ EBI - ARRAY_EXPRESS ]   NAV3 [ SEEK ]   NAV3 [ MEM ]
Gene Expression Viewer (FireBrowse)NAV3 [ Firebrowse - Broad ]
GenevisibleExpression of NAV3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)89795
GTEX Portal (Tissue expression)NAV3
Human Protein AtlasENSG00000067798-NAV3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IVL0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IVL0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IVL0
PhosPhoSitePlusQ8IVL0
Domaine pattern : Prosite (Expaxy)CH (PS50021)   
Domains : Interpro (EBI)AAA+_ATPase    ATPase_AAA_core    CH-domain    CH_dom_sf    Nav/unc-53    P-loop_NTPase   
Domain families : Pfam (Sanger)AAA (PF00004)    CH (PF00307)   
Domain families : Pfam (NCBI)pfam00004    pfam00307   
Domain families : Smart (EMBL)AAA (SM00382)  CH (SM00033)  
Conserved Domain (NCBI)NAV3
SuperfamilyQ8IVL0
AlphaFold pdb e-kbQ8IVL0   
Human Protein Atlas [tissue]ENSG00000067798-NAV3 [tissue]
HPRD10114
Protein Interaction databases
DIP (DOE-UCLA)Q8IVL0
IntAct (EBI)Q8IVL0
BioGRIDNAV3
STRING (EMBL)NAV3
ZODIACNAV3
Ontologies - Pathways
QuickGOQ8IVL0
Ontology : AmiGOATP binding  nuclear outer membrane  negative regulation of microtubule depolymerization  nervous system development  microtubule binding  ATP hydrolysis activity  neurogenesis  negative regulation of cell migration  positive regulation of microtubule polymerization  negative regulation of interleukin-2 production  microtubule end  
Ontology : EGO-EBIATP binding  nuclear outer membrane  negative regulation of microtubule depolymerization  nervous system development  microtubule binding  ATP hydrolysis activity  neurogenesis  negative regulation of cell migration  positive regulation of microtubule polymerization  negative regulation of interleukin-2 production  microtubule end  
NDEx NetworkNAV3
Atlas of Cancer Signalling NetworkNAV3
Wikipedia pathwaysNAV3
Orthology - Evolution
OrthoDB89795
GeneTree (enSembl)ENSG00000067798
Phylogenetic Trees/Animal Genes : TreeFamNAV3
Homologs : HomoloGeneNAV3
Homology/Alignments : Family Browser (UCSC)NAV3
Gene fusions - Rearrangements
Fusion : MitelmanCPSF6::NAV3 [12q15/12q21.2]  
Fusion : MitelmanNELL1::NAV3 [11p15.1/12q21.2]  
Fusion : MitelmanPDK3::NAV3 [Xp22.11/12q21.2]  
Fusion : QuiverNAV3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNAV3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NAV3
dbVarNAV3
ClinVarNAV3
MonarchNAV3
1000_GenomesNAV3 
Exome Variant ServerNAV3
GNOMAD BrowserENSG00000067798
Varsome BrowserNAV3
ACMGNAV3 variants
VarityQ8IVL0
Genomic Variants (DGV)NAV3 [DGVbeta]
DECIPHERNAV3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNAV3 
Mutations
ICGC Data PortalNAV3 
TCGA Data PortalNAV3 
Broad Tumor PortalNAV3
OASIS PortalNAV3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNAV3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNAV3
Mutations and Diseases : HGMDNAV3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNAV3
DgiDB (Drug Gene Interaction Database)NAV3
DoCM (Curated mutations)NAV3
CIViC (Clinical Interpretations of Variants in Cancer)NAV3
Cancer3DNAV3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611629   
Orphanet
DisGeNETNAV3
MedgenNAV3
Genetic Testing Registry NAV3
NextProtQ8IVL0 [Medical]
GENETestsNAV3
Target ValidationNAV3
Huge Navigator NAV3 [HugePedia]
ClinGenNAV3
Clinical trials, drugs, therapy
MyCancerGenomeNAV3
Protein Interactions : CTDNAV3
Pharm GKB GenePA31453
PharosQ8IVL0
Clinical trialNAV3
Miscellaneous
canSAR (ICR)NAV3
HarmonizomeNAV3
ARCHS4NAV3
DataMed IndexNAV3
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNAV3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:48:39 CET 2022

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