Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

NBR1 (NBR1, autophagy cargo receptor)

Identity

Alias_namesM17S2
membrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125)
neighbor of BRCA1 gene 1
Alias_symbol (synonym)CA125
KIAA0049
1A1-3B
Other aliasIAI3B
MIG19
HGNC (Hugo) NBR1
LocusID (NCBI) 4077
Atlas_Id 41224
Location 17q21.31  [Link to chromosome band 17q21]
Location_base_pair Starts at 43170970 and ends at 43209857 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NBR1 (17q21.31) / MYH11 (16p13.11)NBR1 (17q21.31) / RUNDC3A (17q21.31)WSB1 (17q11.1) / NBR1 (17q21.31)
NBR1 17q21.31 / RUNDC3A 17q21.31WSB1 17q11.1 / NBR1 17q21.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NBR1   6746
Cards
Entrez_Gene (NCBI)NBR1  4077  NBR1, autophagy cargo receptor
Aliases1A1-3B; IAI3B; M17S2; MIG19
GeneCards (Weizmann)NBR1
Ensembl hg19 (Hinxton)ENSG00000188554 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000188554 [Gene_View]  chr17:43170970-43209857 [Contig_View]  NBR1 [Vega]
ICGC DataPortalENSG00000188554
TCGA cBioPortalNBR1
AceView (NCBI)NBR1
Genatlas (Paris)NBR1
WikiGenes4077
SOURCE (Princeton)NBR1
Genetics Home Reference (NIH)NBR1
Genomic and cartography
GoldenPath hg38 (UCSC)NBR1  -     chr17:43170970-43209857 +  17q21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NBR1  -     17q21.31   [Description]    (hg19-Feb_2009)
EnsemblNBR1 - 17q21.31 [CytoView hg19]  NBR1 - 17q21.31 [CytoView hg38]
Mapping of homologs : NCBINBR1 [Mapview hg19]  NBR1 [Mapview hg38]
OMIM166945   
Gene and transcription
Genbank (Entrez)AF227189 AK128512 AK290005 AK297425 AK299328
RefSeq transcript (Entrez)NM_001291571 NM_001291572 NM_005899 NM_031858 NM_031862
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NBR1
Cluster EST : UnigeneHs.708158 [ NCBI ]
CGAP (NCI)Hs.708158
Alternative Splicing GalleryENSG00000188554
Gene ExpressionNBR1 [ NCBI-GEO ]   NBR1 [ EBI - ARRAY_EXPRESS ]   NBR1 [ SEEK ]   NBR1 [ MEM ]
Gene Expression Viewer (FireBrowse)NBR1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4077
GTEX Portal (Tissue expression)NBR1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14596   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14596  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14596
Splice isoforms : SwissVarQ14596
PhosPhoSitePlusQ14596
Domaine pattern : Prosite (Expaxy)PB1 (PS51745)    UBA (PS50030)    ZF_ZZ_1 (PS01357)    ZF_ZZ_2 (PS50135)   
Domains : Interpro (EBI)N_BRCA1_central    NBR1    PB1_dom    UBA    UBA-like    Znf_ZZ   
Domain families : Pfam (Sanger)N_BRCA1_IG (PF16158)    PB1 (PF00564)    ZZ (PF00569)   
Domain families : Pfam (NCBI)pfam16158    pfam00564    pfam00569   
Domain families : Smart (EMBL)PB1 (SM00666)  ZnF_ZZ (SM00291)  
Conserved Domain (NCBI)NBR1
DMDM Disease mutations4077
Blocks (Seattle)NBR1
PDB (SRS)1WJ6    2BKF    2CP8    2G4S    2L8J    2MGW    2MJ5    4OLE   
PDB (PDBSum)1WJ6    2BKF    2CP8    2G4S    2L8J    2MGW    2MJ5    4OLE   
PDB (IMB)1WJ6    2BKF    2CP8    2G4S    2L8J    2MGW    2MJ5    4OLE   
PDB (RSDB)1WJ6    2BKF    2CP8    2G4S    2L8J    2MGW    2MJ5    4OLE   
Structural Biology KnowledgeBase1WJ6    2BKF    2CP8    2G4S    2L8J    2MGW    2MJ5    4OLE   
SCOP (Structural Classification of Proteins)1WJ6    2BKF    2CP8    2G4S    2L8J    2MGW    2MJ5    4OLE   
CATH (Classification of proteins structures)1WJ6    2BKF    2CP8    2G4S    2L8J    2MGW    2MJ5    4OLE   
SuperfamilyQ14596
Human Protein AtlasENSG00000188554
Peptide AtlasQ14596
HPRD01326
IPIIPI00871941   IPI00793935   IPI01009112   IPI01010483   IPI01026527   IPI01014897   
Protein Interaction databases
DIP (DOE-UCLA)Q14596
IntAct (EBI)Q14596
FunCoupENSG00000188554
BioGRIDNBR1
STRING (EMBL)NBR1
ZODIACNBR1
Ontologies - Pathways
QuickGOQ14596
Ontology : AmiGOpre-autophagosomal structure  protein binding  nucleoplasm  mitochondrion  lysosome  late endosome  autophagosome  autophagosome  cytosol  zinc ion binding  membrane  macroautophagy  nuclear body  regulation of bone mineralization  M band  regulation of stress-activated MAPK cascade  ubiquitin binding  intracellular membrane-bounded organelle  negative regulation of osteoblast differentiation  mitogen-activated protein kinase binding  protein oligomerization  extracellular exosome  
Ontology : EGO-EBIpre-autophagosomal structure  protein binding  nucleoplasm  mitochondrion  lysosome  late endosome  autophagosome  autophagosome  cytosol  zinc ion binding  membrane  macroautophagy  nuclear body  regulation of bone mineralization  M band  regulation of stress-activated MAPK cascade  ubiquitin binding  intracellular membrane-bounded organelle  negative regulation of osteoblast differentiation  mitogen-activated protein kinase binding  protein oligomerization  extracellular exosome  
NDEx NetworkNBR1
Atlas of Cancer Signalling NetworkNBR1
Wikipedia pathwaysNBR1
Orthology - Evolution
OrthoDB4077
GeneTree (enSembl)ENSG00000188554
Phylogenetic Trees/Animal Genes : TreeFamNBR1
HOVERGENQ14596
HOGENOMQ14596
Homologs : HomoloGeneNBR1
Homology/Alignments : Family Browser (UCSC)NBR1
Gene fusions - Rearrangements
Fusion : MitelmanNBR1/RUNDC3A [17q21.31/17q21.31]  
Fusion : MitelmanWSB1/NBR1 [17q11.1/17q21.31]  [t(17;17)(q11;q21)]  
Fusion: TCGANBR1 17q21.31 RUNDC3A 17q21.31 BRCA
Fusion: TCGAWSB1 17q11.1 NBR1 17q21.31 LAML
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNBR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NBR1
dbVarNBR1
ClinVarNBR1
1000_GenomesNBR1 
Exome Variant ServerNBR1
ExAC (Exome Aggregation Consortium)NBR1 (select the gene name)
Genetic variants : HAPMAP4077
Genomic Variants (DGV)NBR1 [DGVbeta]
DECIPHERNBR1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNBR1 
Mutations
ICGC Data PortalNBR1 
TCGA Data PortalNBR1 
Broad Tumor PortalNBR1
OASIS PortalNBR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNBR1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNBR1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NBR1
DgiDB (Drug Gene Interaction Database)NBR1
DoCM (Curated mutations)NBR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NBR1 (select a term)
intoGenNBR1
Cancer3DNBR1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM166945   
Orphanet
MedgenNBR1
Genetic Testing Registry NBR1
NextProtQ14596 [Medical]
TSGene4077
GENETestsNBR1
Huge Navigator NBR1 [HugePedia]
snp3D : Map Gene to Disease4077
BioCentury BCIQNBR1
ClinGenNBR1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4077
Chemical/Pharm GKB GenePA30510
Clinical trialNBR1
Miscellaneous
canSAR (ICR)NBR1 (select the gene name)
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNBR1
EVEXNBR1
GoPubMedNBR1
iHOPNBR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:28:06 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.