NCAPD3 (non-SMC condensin II complex subunit D3)

2008-03-01 Affiliation

Identity

HGNC

NCAPD3

LOCATION

11q25

LOCUSID

23310

ALIAS

CAP-D3,CAPD3,MCPH22,hCAP-D3,hHCP-6,hcp-6

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 23310
MIM: 609276
HGNC: 28952
Ensembl: ENSG00000151503

Variants:

dbSNP: 23310
ClinVar: 23310
TCGA: ENSG00000151503
COSMIC: NCAPD3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000151503	ENST00000525485	E9PR72
ENSG00000151503	ENST00000525964	E9PKK4
ENSG00000151503	ENST00000526422	E9PJM8
ENSG00000151503	ENST00000527944	E9PQA3
ENSG00000151503	ENST00000530396	E9PLE0
ENSG00000151503	ENST00000532445	E9PJ63
ENSG00000151503	ENST00000533155	E9PL95
ENSG00000151503	ENST00000534227	E9PL84
ENSG00000151503	ENST00000534532	G3V1A9
ENSG00000151503	ENST00000534548	P42695

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
M Phase	REACTOME	R-HSA-68886
Mitotic Prophase	REACTOME	R-HSA-68875
Condensation of Prophase Chromosomes	REACTOME	R-HSA-2299718

References

Pubmed ID	Year	Title	Citations
14532007	2003	Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells.	212
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
21498573	2011	The initial phase of chromosome condensation requires Cdk1-mediated phosphorylation of the CAP-D3 subunit of condensin II.	55
19915589	2009	The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A.	26
18223322	2008	hCAP-D3 expression marks a prostate cancer subtype with favorable clinical behavior and androgen signaling signature.	13
25701737	2015	Chromosome-associated protein D3 promotes bacterial clearance in human intestinal epithelial cells by repressing expression of amino acid transporters.	9
29028794	2017	Condensin II and GAIT complexes cooperate to restrict LINE-1 retrotransposition in epithelial cells.	5
31885422	2019	Non-SMC condensin I complex subunit D2 and non-SMC condensin II complex subunit D3 induces inflammation via the IKK/NF-κB pathway in ulcerative colitis.	0

Citation

Dessen P

NCAPD3 (non-SMC condensin II complex subunit D3)

Atlas Genet Cytogenet Oncol Haematol. 2008-03-01

Online version: http://atlasgeneticsoncology.org/gene/50064/ncapd3