NCAPG (non-SMC condensin I complex subunit G)

2018-02-01  

Identity

HGNC
LOCATION
4p15.31
LOCUSID
ALIAS
CAPG,CHCG,NY-MEL-3,YCG1
FUSION GENES

Other Information

Locus ID:

NCBI: 64151
MIM: 606280
HGNC: 24304
Ensembl: ENSG00000109805

Variants:

dbSNP: 64151
ClinVar: 64151
TCGA: ENSG00000109805
COSMIC: NCAPG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109805ENST00000251496Q9BPX3
ENSG00000109805ENST00000510063H0Y9Z8
ENSG00000109805ENST00000514176D6RA93

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Condensation of Prometaphase ChromosomesREACTOMER-HSA-2514853

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
269338222016Downregulation of miR-137 and miR-6500-3p promotes cell proliferation in pediatric high-grade gliomas.25
287378232017Overexpression of non‑SMC condensin I complex subunit G serves as a promising prognostic marker and therapeutic target for hepatocellular carcinoma.20
205466122010The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.19
296082472018Regulation of NCAPG by miR-99a-3p (passenger strand) inhibits cancer cell aggressiveness and is involved in CRPC.11
300892162018Silencing non-SMC chromosome-associated polypeptide G inhibits proliferation and induces apoptosis in hepatocellular carcinoma cells.8
189771992008Phosphorylation of CAP-G is required for its chromosomal DNA localization during mitosis.7
310223572019Genome-wide CRISPR knockout screens identify NCAPG as an essential oncogene for hepatocellular carcinoma tumor growth.4

Citation

Dessen P

NCAPG (non-SMC condensin I complex subunit G)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57324/ncapg