NCAPH2 (non-SMC condensin II complex subunit H2)

2014-11-01  

Identity

HGNC
LOCATION
22q13.33
LOCUSID
ALIAS
CAPH2
FUSION GENES

Other Information

Locus ID:

NCBI: 29781
MIM: 611230
HGNC: 25071
Ensembl: ENSG00000025770

Variants:

dbSNP: 29781
ClinVar: 29781
TCGA: ENSG00000025770
COSMIC: NCAPH2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000025770ENST00000299821Q6IBW4
ENSG00000025770ENST00000395698Q6IBW4
ENSG00000025770ENST00000395701A0A0A6YYG7
ENSG00000025770ENST00000418794F8WAR3
ENSG00000025770ENST00000420993Q6IBW4
ENSG00000025770ENST00000518394E5RJL4
ENSG00000025770ENST00000522304H0YC55
ENSG00000025770ENST00000523045E5RJN3

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic ProphaseREACTOMER-HSA-68875
Condensation of Prophase ChromosomesREACTOMER-HSA-2299718

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
145320072003Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells.212
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
260170222015A novel role for the condensin II complex in cellular senescence.11
287172502017Plk1 phosphorylation of CAP-H2 triggers chromosome condensation by condensin II at the early phase of mitosis.6
290287942017Condensin II and GAIT complexes cooperate to restrict LINE-1 retrotransposition in epithelial cells.5
267421202016Development of Biomarkers Based on DNA Methylation in the NCAPH2/LMF2 Promoter Region for Diagnosis of Alzheimer's Disease and Amnesic Mild Cognitive Impairment.3
273562762016DNA methylation in the NCAPH2/LMF2 promoter region is associated with hippocampal atrophy in Alzheimer's disease and amnesic mild cognitive impairment patients.3
310260662019Condensin II subunit NCAPH2 associates with shelterin protein TRF1 and is required for telomere stability.1

Citation

Dessen P

NCAPH2 (non-SMC condensin II complex subunit H2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70729/ncaph2