NCEH1 (neutral cholesterol ester hydrolase 1)

2009-08-01  

Identity

HGNC
LOCATION
3q26.31
LOCUSID
ALIAS
AADACL1,NCEH
FUSION GENES

Other Information

Locus ID:

NCBI: 57552
MIM: 613234
HGNC: 29260
Ensembl: ENSG00000144959

Variants:

dbSNP: 57552
ClinVar: 57552
TCGA: ENSG00000144959
COSMIC: NCEH1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144959ENST00000421723F8WE33
ENSG00000144959ENST00000424772H7C046
ENSG00000144959ENST00000475381Q6PIU2
ENSG00000144959ENST00000538775A0A0A0MTJ9
ENSG00000144959ENST00000543711Q6PIU2

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Bile secretionKEGGko04976
Bile secretionKEGGhsa04976
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
LDL-mediated lipid transportREACTOMER-HSA-171052

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
170526082006An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling.77
187827672008Identification of neutral cholesterol ester hydrolase, a key enzyme removing cholesterol from macrophages.31
209478312010The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages.31
201983152010Association of genetic variants with hemorrhagic stroke in Japanese individuals.11
270154522016Psoriasis Skin Inflammation-Induced microRNA-26b Targets NCEH1 in Underlying Subcutaneous Adipose Tissue.8
289343922017NCEH-1 modulates cholesterol metabolism and protects against α-synuclein toxicity in a C. elegans model of Parkinson's disease.6
239934622013Chemoproteomic discovery of AADACL1 as a regulator of human platelet activation.4
198512962010Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.3
203538152010Investigation of low-dose ritonavir on human peripheral blood mononuclear cells using gene expression whole genome microarrays.3
252803982015Pioglitazone reduces lipid droplets in cholesterolosis of the gallbladder by increasing ABCA1 and NCEH1 expression.1

Citation

Dessen P

NCEH1 (neutral cholesterol ester hydrolase 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51009/nceh1