Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NCF1 (neutrophil cytosolic factor 1)

Identity

Other namesNCF1A
NOXO2
SH3PXD1A
p47phox
HGNC (Hugo) NCF1
LocusID (NCBI) 653361
Location 7q11.23
Location_base_pair Starts at 74188309 and ends at 74203720 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)NCF1   7660
Cards
Entrez_Gene (NCBI)NCF1  653361  neutrophil cytosolic factor 1
GeneCards (Weizmann)NCF1
Ensembl (Hinxton)ENSG00000158517 [Gene_View]  chr7:74188309-74203720 [Contig_View]  NCF1 [Vega]
ICGC DataPortalENSG00000158517
cBioPortalNCF1
AceView (NCBI)NCF1
Genatlas (Paris)NCF1
WikiGenes653361
SOURCE (Princeton)NM_000265
Genomic and cartography
GoldenPath (UCSC)NCF1  -  7q11.23   chr7:74188309-74203720 +  7q11.23   [Description]    (hg19-Feb_2009)
EnsemblNCF1 - 7q11.23 [CytoView]
Mapping of homologs : NCBINCF1 [Mapview]
OMIM233700   608512   
Gene and transcription
Genbank (Entrez)AF330625 AF330626 AK127905 AK223217 AK292094
RefSeq transcript (Entrez)NM_000265
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_009078 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)NCF1
Cluster EST : UnigeneHs.655201 [ NCBI ]
CGAP (NCI)Hs.655201
Alternative Splicing : Fast-db (Paris)GSHG0027451
Alternative Splicing GalleryENSG00000158517
Gene ExpressionNCF1 [ NCBI-GEO ]     NCF1 [ SEEK ]   NCF1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP14598 (Uniprot)
NextProtP14598  [Medical]
With graphics : InterProP14598
Splice isoforms : SwissVarP14598 (Swissvar)
Domaine pattern : Prosite (Expaxy)PX (PS50195)    SH3 (PS50002)   
Domains : Interpro (EBI)NADPH_oxidase_p47Phox_C [organisation]   P47PHOX [organisation]   Phox [organisation]   SH3_domain [organisation]  
Related proteins : CluSTrP14598
Domain families : Pfam (Sanger)p47_phox_C (PF08944)    PX (PF00787)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam08944    pfam00787    pfam00018   
Domain families : Smart (EMBL)PX (SM00312)  SH3 (SM00326)  
DMDM Disease mutations653361
Blocks (Seattle)P14598
PDB (SRS)1GD5    1K4U    1KQ6    1NG2    1O7K    1OV3    1UEC    1W70    1WLP   
PDB (PDBSum)1GD5    1K4U    1KQ6    1NG2    1O7K    1OV3    1UEC    1W70    1WLP   
PDB (IMB)1GD5    1K4U    1KQ6    1NG2    1O7K    1OV3    1UEC    1W70    1WLP   
PDB (RSDB)1GD5    1K4U    1KQ6    1NG2    1O7K    1OV3    1UEC    1W70    1WLP   
Human Protein AtlasENSG00000158517 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP14598
IPIIPI00788186   IPI00902858   IPI00924484   IPI01015820   IPI00927351   IPI00926936   
Protein Interaction databases
DIP (DOE-UCLA)P14598
IntAct (EBI)P14598
FunCoupENSG00000158517
BioGRIDNCF1
InParanoidP14598
Interologous Interaction database P14598
IntegromeDBNCF1
STRING (EMBL)NCF1
Ontologies - Pathways
Ontology : AmiGOresponse to yeast  antigen processing and presentation of peptide antigen via MHC class I  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  respiratory burst involved in defense response  protein binding  rough endoplasmic reticulum  Golgi apparatus  cytosol  cytosol  protein targeting to membrane  leukotriene metabolic process  superoxide metabolic process  apoptotic process  inflammatory response  cellular defense response  cell proliferation  electron carrier activity  superoxide-generating NADPH oxidase activity  SH3 domain binding  extrinsic component of membrane  dendrite  phagolysosome  phosphatidylinositol binding  superoxide anion generation  superoxide anion generation  antigen processing and presentation of exogenous peptide antigen via MHC class I  NADPH oxidase complex  NADPH oxidase complex  neuronal cell body  phosphatidylinositol-3,4-bisphosphate binding  innate immune response  respiratory burst  negative regulation of smooth muscle contraction  hydrogen peroxide biosynthetic process  interaction with host  oxidation-reduction process  oxidation-reduction process  neutrophil mediated killing of gram-positive bacterium  neutrophil mediated killing of fungus  phagosome maturation  
Ontology : EGO-EBIresponse to yeast  antigen processing and presentation of peptide antigen via MHC class I  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  respiratory burst involved in defense response  protein binding  rough endoplasmic reticulum  Golgi apparatus  cytosol  cytosol  protein targeting to membrane  leukotriene metabolic process  superoxide metabolic process  apoptotic process  inflammatory response  cellular defense response  cell proliferation  electron carrier activity  superoxide-generating NADPH oxidase activity  SH3 domain binding  extrinsic component of membrane  dendrite  phagolysosome  phosphatidylinositol binding  superoxide anion generation  superoxide anion generation  antigen processing and presentation of exogenous peptide antigen via MHC class I  NADPH oxidase complex  NADPH oxidase complex  neuronal cell body  phosphatidylinositol-3,4-bisphosphate binding  innate immune response  respiratory burst  negative regulation of smooth muscle contraction  hydrogen peroxide biosynthetic process  interaction with host  oxidation-reduction process  oxidation-reduction process  neutrophil mediated killing of gram-positive bacterium  neutrophil mediated killing of fungus  phagosome maturation  
Pathways : BIOCARTAfMLP induced chemokine gene expression in HMC-1 cells [Genes]   
Pathways : KEGGChemokine signaling pathway    Phagosome    Osteoclast differentiation    Fc gamma R-mediated phagocytosis    Leukocyte transendothelial migration    Leishmaniasis   
Protein Interaction DatabaseNCF1
Wikipedia pathwaysNCF1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)NCF1
snp3D : Map Gene to Disease653361
SNP (GeneSNP Utah)NCF1
SNP : HGBaseNCF1
Genetic variants : HAPMAPNCF1
Exome VariantNCF1
1000_GenomesNCF1 
ICGC programENSG00000158517 
Somatic Mutations in Cancer : COSMICNCF1 
CONAN: Copy Number AnalysisNCF1 
Mutations and Diseases : HGMDNCF1
Mutations and Diseases : intOGenNCF1
Genomic VariantsNCF1  NCF1 [DGVbeta]
dbVarNCF1
ClinVarNCF1
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM233700    608512   
MedgenNCF1
GENETestsNCF1
Disease Genetic AssociationNCF1
Huge Navigator NCF1 [HugePedia]  NCF1 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneNCF1
Homology/Alignments : Family Browser (UCSC)NCF1
Phylogenetic Trees/Animal Genes : TreeFamNCF1
Chemical/Protein Interactions : CTD653361
Chemical/Pharm GKB GenePA31463
Clinical trialNCF1
Cancer Resource (Charite)ENSG00000158517
Other databases
Probes
Litterature
PubMed125 Pubmed reference(s) in Entrez
CoreMineNCF1
iHOPNCF1
OncoSearchNCF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 22 19:06:13 CEST 2014

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