Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NCF2 (neutrophil cytosolic factor 2)

Identity

Other namesNCF-2
NOXA2
P67-PHOX
P67PHOX
HGNC (Hugo) NCF2
LocusID (NCBI) 4688
Location 1q25.3
Location_base_pair Starts at 183524697 and ends at 183559739 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)NCF2   7661
Cards
Entrez_Gene (NCBI)NCF2  4688  neutrophil cytosolic factor 2
GeneCards (Weizmann)NCF2
Ensembl (Hinxton)ENSG00000116701 [Gene_View]  chr1:183524697-183559739 [Contig_View]  NCF2 [Vega]
ICGC DataPortalENSG00000116701
AceView (NCBI)NCF2
Genatlas (Paris)NCF2
WikiGenes4688
SOURCE (Princeton)NM_000433 NM_001127651 NM_001190789 NM_001190794
Genomic and cartography
GoldenPath (UCSC)NCF2  -  1q25.3   chr1:183524697-183559739 -  1q25.3   [Description]    (hg19-Feb_2009)
EnsemblNCF2 - 1q25.3 [CytoView]
Mapping of homologs : NCBINCF2 [Mapview]
OMIM233710   608515   
Gene and transcription
Genbank (Entrez)AB209647 AF527950 AK296672 AK298713 AK312666
RefSeq transcript (Entrez)NM_000433 NM_001127651 NM_001190789 NM_001190794
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_007267 NT_004487 NW_001838533 NW_004929293
Consensus coding sequences : CCDS (NCBI)NCF2
Cluster EST : UnigeneHs.587558 [ NCBI ]
CGAP (NCI)Hs.587558
Alternative Splicing : Fast-db (Paris)GSHG0002796
Alternative Splicing GalleryENSG00000116701
Gene ExpressionNCF2 [ NCBI-GEO ]     NCF2 [ SEEK ]   NCF2 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP19878 (Uniprot)
NextProtP19878  [Medical]
With graphics : InterProP19878
Splice isoforms : SwissVarP19878 (Swissvar)
Domaine pattern : Prosite (Expaxy)SH3 (PS50002)    TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)OPR_PB1    SH3_domain    TPR-contain_dom    TPR-like_helical    TPR_1    TPR_repeat   
Related proteins : CluSTrP19878
Domain families : Pfam (Sanger)PB1 (PF00564)    SH3_1 (PF00018)    TPR_1 (PF00515)   
Domain families : Pfam (NCBI)pfam00564    pfam00018    pfam00515   
Domain families : Smart (EMBL)PB1 (SM00666)  SH3 (SM00326)  TPR (SM00028)  
DMDM Disease mutations4688
Blocks (Seattle)P19878
PDB (SRS)1E96    1HH8    1K4U    1OEY    1WM5    2DMO   
PDB (PDBSum)1E96    1HH8    1K4U    1OEY    1WM5    2DMO   
PDB (IMB)1E96    1HH8    1K4U    1OEY    1WM5    2DMO   
PDB (RSDB)1E96    1HH8    1K4U    1OEY    1WM5    2DMO   
Human Protein AtlasENSG00000116701
Peptide AtlasP19878
HPRD01991
IPIIPI00021070   IPI00815773   IPI00641875   IPI00910100   IPI00641413   
Protein Interaction databases
DIP (DOE-UCLA)P19878
IntAct (EBI)P19878
FunCoupENSG00000116701
BioGRIDNCF2
InParanoidP19878
Interologous Interaction database P19878
IntegromeDBNCF2
STRING (EMBL)NCF2
Ontologies - Pathways
Ontology : AmiGOacrosomal vesicle  antigen processing and presentation of peptide antigen via MHC class I  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  nucleolus  cytoplasm  cytosol  superoxide metabolic process  cellular defense response  aging  protein C-terminus binding  electron carrier activity  response to glucose  response to activity  phagolysosome  response to lipopolysaccharide  response to progesterone  cellular response to hormone stimulus  response to laminar fluid shear stress  response to drug  superoxide anion generation  antigen processing and presentation of exogenous peptide antigen via MHC class I  NADPH oxidase complex  positive regulation of neuron apoptotic process  innate immune response  respiratory burst  positive regulation of blood pressure  Rac GTPase binding  interaction with host  response to hyperoxia  phagosome maturation  
Ontology : EGO-EBIacrosomal vesicle  antigen processing and presentation of peptide antigen via MHC class I  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  nucleolus  cytoplasm  cytosol  superoxide metabolic process  cellular defense response  aging  protein C-terminus binding  electron carrier activity  response to glucose  response to activity  phagolysosome  response to lipopolysaccharide  response to progesterone  cellular response to hormone stimulus  response to laminar fluid shear stress  response to drug  superoxide anion generation  antigen processing and presentation of exogenous peptide antigen via MHC class I  NADPH oxidase complex  positive regulation of neuron apoptotic process  innate immune response  respiratory burst  positive regulation of blood pressure  Rac GTPase binding  interaction with host  response to hyperoxia  phagosome maturation  
Pathways : BIOCARTAfMLP induced chemokine gene expression in HMC-1 cells [Genes]    Rac 1 cell motility signaling pathway [Genes]   
Pathways : KEGGPhagosome    Osteoclast differentiation    Leukocyte transendothelial migration    Leishmaniasis   
Protein Interaction DatabaseNCF2
Wikipedia pathwaysNCF2
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)NCF2
SNP (GeneSNP Utah)NCF2
SNP : HGBaseNCF2
Genetic variants : HAPMAPNCF2
1000_GenomesNCF2 
ICGC programENSG00000116701 
CONAN: Copy Number AnalysisNCF2 
Somatic Mutations in Cancer : COSMICNCF2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
Mutations and Diseases : HGMDNCF2
OMIM233710    608515   
MedgenNCF2
GENETestsNCF2
Disease Genetic AssociationNCF2
Huge Navigator NCF2 [HugePedia]  NCF2 [HugeCancerGEM]
Genomic VariantsNCF2  NCF2 [DGVbeta]
Exome VariantNCF2
dbVarNCF2
ClinVarNCF2
snp3D : Map Gene to Disease4688
General knowledge
Homologs : HomoloGeneNCF2
Homology/Alignments : Family Browser (UCSC)NCF2
Phylogenetic Trees/Animal Genes : TreeFamNCF2
Chemical/Protein Interactions : CTD4688
Chemical/Pharm GKB GenePA31464
Clinical trialNCF2
Cancer Resource (Charite)ENSG00000116701
Other databases
Probes
Litterature
PubMed112 Pubmed reference(s) in Entrez
CoreMineNCF2
iHOPNCF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 13:03:32 CEST 2014

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