Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NCF2 (neutrophil cytosolic factor 2)

Identity

Other namesNCF-2
NOXA2
P67-PHOX
P67PHOX
HGNC (Hugo) NCF2
LocusID (NCBI) 4688
Atlas_Id 46002
Location 1q25.3
Location_base_pair Starts at 183524697 and ends at 183559739 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
NCF2 (1q25.3) / PITX1 (5q31.1)NCF2 (1q25.3) / TUBA1C (12q13.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NCF2   7661
Cards
Entrez_Gene (NCBI)NCF2  4688  neutrophil cytosolic factor 2
GeneCards (Weizmann)NCF2
Ensembl hg19 (Hinxton)ENSG00000116701 [Gene_View]  chr1:183524697-183559739 [Contig_View]  NCF2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000116701 [Gene_View]  chr1:183524697-183559739 [Contig_View]  NCF2 [Vega]
ICGC DataPortalENSG00000116701
TCGA cBioPortalNCF2
AceView (NCBI)NCF2
Genatlas (Paris)NCF2
WikiGenes4688
SOURCE (Princeton)NCF2
Genomic and cartography
GoldenPath hg19 (UCSC)NCF2  -     chr1:183524697-183559739 -  1q25.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NCF2  -     1q25.3   [Description]    (hg38-Dec_2013)
EnsemblNCF2 - 1q25.3 [CytoView hg19]  NCF2 - 1q25.3 [CytoView hg38]
Mapping of homologs : NCBINCF2 [Mapview hg19]  NCF2 [Mapview hg38]
OMIM233710   608515   
Gene and transcription
Genbank (Entrez)AB209647 AF527950 AK296672 AK298713 AK312666
RefSeq transcript (Entrez)NM_000433 NM_001127651 NM_001190789 NM_001190794
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_007267 NT_004487 NW_004929293
Consensus coding sequences : CCDS (NCBI)NCF2
Cluster EST : UnigeneHs.587558 [ NCBI ]
CGAP (NCI)Hs.587558
Alternative Splicing : Fast-db (Paris)GSHG0002796
Alternative Splicing GalleryENSG00000116701
Gene ExpressionNCF2 [ NCBI-GEO ]   NCF2 [ EBI - ARRAY_EXPRESS ]   NCF2 [ SEEK ]   NCF2 [ MEM ]
Gene Expression Viewer (FireBrowse)NCF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)4688
Protein : pattern, domain, 3D structure
UniProt/SwissProtP19878 (Uniprot)
NextProtP19878  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP19878
Splice isoforms : SwissVarP19878 (Swissvar)
PhosPhoSitePlusP19878
Domaine pattern : Prosite (Expaxy)PB1 (PS51745)    SH3 (PS50002)    TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)PB1_dom    SH3_domain    TPR-contain_dom    TPR-like_helical_dom    TPR_1    TPR_repeat   
Domain families : Pfam (Sanger)PB1 (PF00564)    SH3_1 (PF00018)    TPR_1 (PF00515)   
Domain families : Pfam (NCBI)pfam00564    pfam00018    pfam00515   
Domain families : Smart (EMBL)PB1 (SM00666)  SH3 (SM00326)  TPR (SM00028)  
DMDM Disease mutations4688
Blocks (Seattle)NCF2
PDB (SRS)1E96    1HH8    1K4U    1OEY    1WM5    2DMO   
PDB (PDBSum)1E96    1HH8    1K4U    1OEY    1WM5    2DMO   
PDB (IMB)1E96    1HH8    1K4U    1OEY    1WM5    2DMO   
PDB (RSDB)1E96    1HH8    1K4U    1OEY    1WM5    2DMO   
Structural Biology KnowledgeBase1E96    1HH8    1K4U    1OEY    1WM5    2DMO   
SCOP (Structural Classification of Proteins)1E96    1HH8    1K4U    1OEY    1WM5    2DMO   
CATH (Classification of proteins structures)1E96    1HH8    1K4U    1OEY    1WM5    2DMO   
SuperfamilyP19878
Human Protein AtlasENSG00000116701
Peptide AtlasP19878
HPRD01991
IPIIPI00021070   IPI00815773   IPI00641875   IPI00910100   IPI00641413   
Protein Interaction databases
DIP (DOE-UCLA)P19878
IntAct (EBI)P19878
FunCoupENSG00000116701
BioGRIDNCF2
STRING (EMBL)NCF2
ZODIACNCF2
Ontologies - Pathways
QuickGOP19878
Ontology : AmiGOacrosomal vesicle  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  nucleolus  cytoplasm  cytosol  superoxide metabolic process  cellular defense response  protein C-terminus binding  electron carrier activity  superoxide-generating NADPH oxidase activity  phagolysosome  superoxide anion generation  NADPH oxidase complex  innate immune response  cell redox homeostasis  respiratory burst  vascular endothelial growth factor receptor signaling pathway  Rac GTPase binding  oxidation-reduction process  
Ontology : EGO-EBIacrosomal vesicle  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  nucleolus  cytoplasm  cytosol  superoxide metabolic process  cellular defense response  protein C-terminus binding  electron carrier activity  superoxide-generating NADPH oxidase activity  phagolysosome  superoxide anion generation  NADPH oxidase complex  innate immune response  cell redox homeostasis  respiratory burst  vascular endothelial growth factor receptor signaling pathway  Rac GTPase binding  oxidation-reduction process  
Pathways : BIOCARTAfMLP induced chemokine gene expression in HMC-1 cells [Genes]    Rac 1 cell motility signaling pathway [Genes]   
Pathways : KEGGPhagosome    Osteoclast differentiation    Leukocyte transendothelial migration    Leishmaniasis   
NDEx Network
Atlas of Cancer Signalling NetworkNCF2
Wikipedia pathwaysNCF2
Orthology - Evolution
OrthoDB4688
GeneTree (enSembl)ENSG00000116701
Phylogenetic Trees/Animal Genes : TreeFamNCF2
Homologs : HomoloGeneNCF2
Homology/Alignments : Family Browser (UCSC)NCF2
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerNCF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NCF2
dbVarNCF2
ClinVarNCF2
1000_GenomesNCF2 
Exome Variant ServerNCF2
ExAC (Exome Aggregation Consortium)NCF2 (select the gene name)
SNP (GeneSNP Utah)NCF2
SNP : HGBaseNCF2
Genetic variants : HAPMAPNCF2
Genomic Variants (DGV)NCF2 [DGVbeta]
Mutations
ICGC Data PortalNCF2 
TCGA Data PortalNCF2 
Broad Tumor PortalNCF2
OASIS PortalNCF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNCF2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch NCF2
DgiDB (Drug Gene Interaction Database)NCF2
DoCM (Curated mutations)NCF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NCF2 (select a term)
intoGenNCF2
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:183524697-183559739
CONAN: Copy Number AnalysisNCF2 
Mutations and Diseases : HGMDNCF2
OMIM233710    608515   
MedgenNCF2
Genetic Testing Registry NCF2
NextProtP19878 [Medical]
TSGene4688
GENETestsNCF2
Huge Navigator NCF2 [HugePedia]  NCF2 [HugeCancerGEM]
snp3D : Map Gene to Disease4688
BioCentury BCIQNCF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4688
Chemical/Pharm GKB GenePA31464
Clinical trialNCF2
Miscellaneous
canSAR (ICR)NCF2 (select the gene name)
Probes
Litterature
PubMed124 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNCF2
GoPubMedNCF2
iHOPNCF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Sat Apr 16 17:55:55 CEST 2016

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