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NCK1 (NCK adaptor protein 1)

Identity

Alias_namesNCK
Alias_symbol (synonym)NCKalpha
Other aliasnck-1
HGNC (Hugo) NCK1
LocusID (NCBI) 4690
Atlas_Id 41505
Location 3q22.3  [Link to chromosome band 3q22]
Location_base_pair Starts at 136930475 and ends at 136951610 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
IBTK (6q14.1) / NCK1 (3q22.3)IL20RB (3q22.3) / NCK1 (3q22.3)NCK1 (3q22.3) / IL20RB (3q22.3)
NCK1 (3q22.3) / RAB6B (3q22.1)NCK1 (3q22.3) / ZFAND4 (10q11.22)RAB11FIP3 (16p13.3) / NCK1 (3q22.3)
ZZZ3 (1p31.1) / NCK1 (3q22.3)IL20RB 3q22.3 / NCK1 3q22.3NCK1 3q22.3 / RAB6B 3q22.1
ZZZ3 1p31.1 / NCK1 3q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NCK1   7664
Cards
Entrez_Gene (NCBI)NCK1  4690  NCK adaptor protein 1
AliasesNCK; NCKalpha; nck-1
GeneCards (Weizmann)NCK1
Ensembl hg19 (Hinxton)ENSG00000158092 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000158092 [Gene_View]  chr3:136930475-136951610 [Contig_View]  NCK1 [Vega]
ICGC DataPortalENSG00000158092
TCGA cBioPortalNCK1
AceView (NCBI)NCK1
Genatlas (Paris)NCK1
WikiGenes4690
SOURCE (Princeton)NCK1
Genetics Home Reference (NIH)NCK1
Genomic and cartography
GoldenPath hg38 (UCSC)NCK1  -     chr3:136930475-136951610 +  3q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NCK1  -     3q22.3   [Description]    (hg19-Feb_2009)
EnsemblNCK1 - 3q22.3 [CytoView hg19]  NCK1 - 3q22.3 [CytoView hg38]
Mapping of homologs : NCBINCK1 [Mapview hg19]  NCK1 [Mapview hg38]
OMIM600508   
Gene and transcription
Genbank (Entrez)AK095534 AK301460 AK312692 BC006403 BP339594
RefSeq transcript (Entrez)NM_001190796 NM_001291999 NM_006153
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NCK1
Cluster EST : UnigeneHs.477693 [ NCBI ]
CGAP (NCI)Hs.477693
Alternative Splicing GalleryENSG00000158092
Gene ExpressionNCK1 [ NCBI-GEO ]   NCK1 [ EBI - ARRAY_EXPRESS ]   NCK1 [ SEEK ]   NCK1 [ MEM ]
Gene Expression Viewer (FireBrowse)NCK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4690
GTEX Portal (Tissue expression)NCK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP16333   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP16333  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP16333
Splice isoforms : SwissVarP16333
PhosPhoSitePlusP16333
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)NCK    SH2    SH3_domain   
Domain families : Pfam (Sanger)SH2 (PF00017)    SH3_1 (PF00018)    SH3_9 (PF14604)   
Domain families : Pfam (NCBI)pfam00017    pfam00018    pfam14604   
Domain families : Smart (EMBL)SH2 (SM00252)  SH3 (SM00326)  
Conserved Domain (NCBI)NCK1
DMDM Disease mutations4690
Blocks (Seattle)NCK1
PDB (SRS)2CI8    2CI9    2CUB    2JS0    2JS2    2JW4   
PDB (PDBSum)2CI8    2CI9    2CUB    2JS0    2JS2    2JW4   
PDB (IMB)2CI8    2CI9    2CUB    2JS0    2JS2    2JW4   
PDB (RSDB)2CI8    2CI9    2CUB    2JS0    2JS2    2JW4   
Structural Biology KnowledgeBase2CI8    2CI9    2CUB    2JS0    2JS2    2JW4   
SCOP (Structural Classification of Proteins)2CI8    2CI9    2CUB    2JS0    2JS2    2JW4   
CATH (Classification of proteins structures)2CI8    2CI9    2CUB    2JS0    2JS2    2JW4   
SuperfamilyP16333
Human Protein AtlasENSG00000158092
Peptide AtlasP16333
HPRD02740
IPIIPI00028065   IPI00793968   IPI00797459   IPI00945303   IPI00798394   IPI00946941   IPI00944972   IPI00947429   
Protein Interaction databases
DIP (DOE-UCLA)P16333
IntAct (EBI)P16333
FunCoupENSG00000158092
BioGRIDNCK1
STRING (EMBL)NCK1
ZODIACNCK1
Ontologies - Pathways
QuickGOP16333
Ontology : AmiGOprotein phosphatase type 1 complex  protein kinase inhibitor activity  SH3/SH2 adaptor activity  receptor binding  protein binding  nucleus  cytoplasm  cytoplasm  endoplasmic reticulum  cytosol  ribosome  plasma membrane  cell-cell junction  negative regulation of protein kinase activity  substrate-dependent cell migration, cell extension  actin filament organization  signal complex assembly  cytoskeletal adaptor activity  positive regulation of neuron projection development  vesicle membrane  protein domain specific binding  lamellipodium assembly  receptor signaling complex scaffold activity  regulation of cell migration  protein binding, bridging  positive regulation of actin filament polymerization  receptor tyrosine kinase binding  negative regulation of peptidyl-serine phosphorylation  positive regulation of translation in response to endoplasmic reticulum stress  Fc-gamma receptor signaling pathway involved in phagocytosis  positive regulation of T cell proliferation  T cell activation  cadherin binding  positive regulation of transcription from RNA polymerase II promoter  ephrin receptor binding  vascular endothelial growth factor receptor signaling pathway  ephrin receptor signaling pathway  T cell receptor signaling pathway  response to other organism  negative regulation of cell death  peptidyl-serine dephosphorylation  eukaryotic initiation factor eIF2 binding  positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  positive regulation of cap-dependent translational initiation  positive regulation of cap-independent translational initiation  negative regulation of PERK-mediated unfolded protein response  negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation  negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  
Ontology : EGO-EBIprotein phosphatase type 1 complex  protein kinase inhibitor activity  SH3/SH2 adaptor activity  receptor binding  protein binding  nucleus  cytoplasm  cytoplasm  endoplasmic reticulum  cytosol  ribosome  plasma membrane  cell-cell junction  negative regulation of protein kinase activity  substrate-dependent cell migration, cell extension  actin filament organization  signal complex assembly  cytoskeletal adaptor activity  positive regulation of neuron projection development  vesicle membrane  protein domain specific binding  lamellipodium assembly  receptor signaling complex scaffold activity  regulation of cell migration  protein binding, bridging  positive regulation of actin filament polymerization  receptor tyrosine kinase binding  negative regulation of peptidyl-serine phosphorylation  positive regulation of translation in response to endoplasmic reticulum stress  Fc-gamma receptor signaling pathway involved in phagocytosis  positive regulation of T cell proliferation  T cell activation  cadherin binding  positive regulation of transcription from RNA polymerase II promoter  ephrin receptor binding  vascular endothelial growth factor receptor signaling pathway  ephrin receptor signaling pathway  T cell receptor signaling pathway  response to other organism  negative regulation of cell death  peptidyl-serine dephosphorylation  eukaryotic initiation factor eIF2 binding  positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  positive regulation of cap-dependent translational initiation  positive regulation of cap-independent translational initiation  negative regulation of PERK-mediated unfolded protein response  negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation  negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  
Pathways : BIOCARTAY branching of actin filaments [Genes]   
Pathways : KEGGErbB signaling pathway    Axon guidance    T cell receptor signaling pathway    Pathogenic Escherichia coli infection   
NDEx NetworkNCK1
Atlas of Cancer Signalling NetworkNCK1
Wikipedia pathwaysNCK1
Orthology - Evolution
OrthoDB4690
GeneTree (enSembl)ENSG00000158092
Phylogenetic Trees/Animal Genes : TreeFamNCK1
HOVERGENP16333
HOGENOMP16333
Homologs : HomoloGeneNCK1
Homology/Alignments : Family Browser (UCSC)NCK1
Gene fusions - Rearrangements
Fusion : MitelmanIBTK/NCK1 [6q14.1/3q22.3]  [t(3;6)(q22;q14)]  
Fusion : MitelmanIL20RB/NCK1 [3q22.3/3q22.3]  [t(3;3)(q22;q22)]  
Fusion : MitelmanNCK1/RAB6B [3q22.3/3q22.1]  [t(3;3)(q22;q22)]  
Fusion : MitelmanZZZ3/NCK1 [1p31.1/3q22.3]  [t(1;3)(p31;q22)]  
Fusion: TCGAIL20RB 3q22.3 NCK1 3q22.3 HNSC
Fusion: TCGANCK1 3q22.3 RAB6B 3q22.1 BRCA
Fusion: TCGAZZZ3 1p31.1 NCK1 3q22.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNCK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NCK1
dbVarNCK1
ClinVarNCK1
1000_GenomesNCK1 
Exome Variant ServerNCK1
ExAC (Exome Aggregation Consortium)NCK1 (select the gene name)
Genetic variants : HAPMAP4690
Genomic Variants (DGV)NCK1 [DGVbeta]
DECIPHERNCK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNCK1 
Mutations
ICGC Data PortalNCK1 
TCGA Data PortalNCK1 
Broad Tumor PortalNCK1
OASIS PortalNCK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNCK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNCK1
intOGen PortalNCK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NCK1
DgiDB (Drug Gene Interaction Database)NCK1
DoCM (Curated mutations)NCK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NCK1 (select a term)
intoGenNCK1
Cancer3DNCK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600508   
Orphanet
MedgenNCK1
Genetic Testing Registry NCK1
NextProtP16333 [Medical]
TSGene4690
GENETestsNCK1
Target ValidationNCK1
Huge Navigator NCK1 [HugePedia]
snp3D : Map Gene to Disease4690
BioCentury BCIQNCK1
ClinGenNCK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4690
Chemical/Pharm GKB GenePA31466
Clinical trialNCK1
Miscellaneous
canSAR (ICR)NCK1 (select the gene name)
Probes
Litterature
PubMed206 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNCK1
EVEXNCK1
GoPubMedNCK1
iHOPNCK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:21:38 CEST 2017

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