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NCK1 (NCK adaptor protein 1)

Identity

Other namesMGC12668
NCK
NCKalpha
HGNC (Hugo) NCK1
Location 3q22.3
Location_base_pair Starts at 138063763 and ends at 138150658 bp from pter ( according to hg18-March_2006)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)NCK1   7664
Entrez_Gene (NCBI)NCK1  4690  NCK adaptor protein 1
Cards
GeneCards (Weizmann)NCK1
Ensembl (Hinxton)ENSG00000158092 [Gene_View]  NCK1 [Vega]
AceView (NCBI)NCK1
Genatlas (Paris)NCK1
euGene (Indiana)4690
SOURCE (Stanford)NM_006153
Gene Expression (Array Express) ENSG00000158092
Genomic and cartography
GoldenPath (UCSC)NCK1  -  3q22.3   chr3:138063763-138150658 +  3q22.3   [Description]    (hg18-March_2006)
EnsemblNCK1 - 3q22.3 [CytoView]
Mapping of homologs : NCBINCK1 [Mapview]
OMIM600508   
Gene and transcription
Gene : Genbank (Entrez)AK301460 AK312692 BC006403 DQ893094 EU832672
Reference sequence (RefSeq transcript) :SRSNM_006153
Reference transcript : EntrezNM_006153
RefSeq genomic : SRSAC_000046 AC_000135 NC_000003 NT_005612 NW_001838884 NW_921807
RefSeq genomic : EntrezAC_000046 AC_000135 NC_000003 NT_005612 NW_001838884 NW_921807
Consensus coding sequences : CCDS NCBINCK1
Cluster EST : UnigeneHs.477693 [ SRS ] Hs.477693 [ NCBI ]
Alternative Splicing : Fast-db (Paris)13340
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtP16333 (SRS) P16333 (Expasy) P16333 (Uniprot)
With graphics : InterProP16333
Splice isoforms : VarSplice FASTAP16333(VarSplice FASTA)
Domaine pattern : Prosite (SRS)SH2 (PS50001)    SH3 (PS50002)   
Domain pattern : Prosite (Expaxy)SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (SRS)Cytoplasmic_NCK    SH2    SH3_domain    SH3_region   
Domains : Interpro (EBI)Cytoplasmic_NCK    SH2    SH3_domain    SH3_region   
Related proteins : CluSTrP16333
Domain families : Pfam SRSSH2 (PF00017)    SH3_1 (PF00018)   
Domain families : Pfam SangerSH2 (PF00017)    SH3_1 (PF00018)   
Domain families : Pfam NCBIpfam00017    pfam00018   
Domain families : Smart EMBLSH2 (SM00252)  SH3 (SM00326)  
Blocks (Seattle)P16333
Crystal structure of protein : PDB SRS2CI8    2CI9    2CUB    2JS0    2JS2    2JW4   
Crystal structure of protein : PDBSum2CI8    2CI9    2CUB    2JS0    2JS2    2JW4   
Crystal structure of protein : IMB2CI8    2CI9    2CUB    2JS0    2JS2    2JW4   
Crystal structure of protein : PDB RSDB2CI8    2CI9    2CUB    2JS0    2JS2    2JW4   
HPRD02740
Protein Interaction databases
DIP (DOE-UCLA)P16333
IntAct (EBI)P16333
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBINCK1
SNP : GeneSNP UtahNCK1
SNP : HGBaseNCK1
Genetic variants : HAPMAPNCK1
Somatic Mutations in Cancer : COSMICNCK1 
Mutations and Diseases : HGMDNCK1
Hereditary diseases : OMIM600508   
Hereditary diseases : GENETests600508   
Diseases : Genetic AssociationNCK1
General knowledge
Homologs : HomoloGeneNCK1
Homology/Alignments : Family Browser UCSCNCK1
Phylogenetic Trees/Animal Genes : TreeFamNCK1
Chemical/Protein Interactions : CTD4690
Keywords Ontology : AmiGOreceptor binding  nucleus  cytoplasm  endoplasmic reticulum  cytosol  regulation of translation  actin filament organization  signal complex assembly  cytoskeletal adaptor activity  vesicle membrane  cell migration  protein domain specific binding  lamellipodium assembly  receptor signaling complex scaffold activity  positive regulation of actin filament polymerization  positive regulation of T cell proliferation  T cell activation  
Keywords Ontology : EGO-EBIreceptor binding  nucleus  cytoplasm  endoplasmic reticulum  cytosol  regulation of translation  actin filament organization  signal complex assembly  cytoskeletal adaptor activity  vesicle membrane  cell migration  protein domain specific binding  lamellipodium assembly  receptor signaling complex scaffold activity  positive regulation of actin filament polymerization  positive regulation of T cell proliferation  T cell activation  
Pathways : BIOCARTAY branching of actin filaments [Genes]   
Pathways : KEGGAxon guidanceT cell receptor signaling pathway
Other databases
Probes
Probes : ImagenesNCK1 Related clones (RZPD - Berlin)
Literature
PubMed115 Pubmed reference(s) in Entrez
PubGeneNCK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated03-2009Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 27 10:28:56 CET 2010
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