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NCK2 (NCK adaptor protein 2)

Identity

Alias_symbol (synonym)NCKbeta
Other aliasGRB4
HGNC (Hugo) NCK2
LocusID (NCBI) 8440
Atlas_Id 52582
Location 2q12.2  [Link to chromosome band 2q12]
Location_base_pair Starts at 105851748 and ends at 105894274 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NCK2 (2q12.2) / ATP6V0D1 (16q22.1)NCK2 (2q12.2) / DDI2 (1p36.21)NCK2 (2q12.2) / SFXN5 (2p13.2)
NCK2 2q12.2 / SFXN5 2p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NCK2   7665
Cards
Entrez_Gene (NCBI)NCK2  8440  NCK adaptor protein 2
AliasesGRB4; NCKbeta
GeneCards (Weizmann)NCK2
Ensembl hg19 (Hinxton)ENSG00000071051 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000071051 [Gene_View]  chr2:105851748-105894274 [Contig_View]  NCK2 [Vega]
ICGC DataPortalENSG00000071051
TCGA cBioPortalNCK2
AceView (NCBI)NCK2
Genatlas (Paris)NCK2
WikiGenes8440
SOURCE (Princeton)NCK2
Genetics Home Reference (NIH)NCK2
Genomic and cartography
GoldenPath hg38 (UCSC)NCK2  -     chr2:105851748-105894274 +  2q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NCK2  -     2q12.2   [Description]    (hg19-Feb_2009)
EnsemblNCK2 - 2q12.2 [CytoView hg19]  NCK2 - 2q12.2 [CytoView hg38]
Mapping of homologs : NCBINCK2 [Mapview hg19]  NCK2 [Mapview hg38]
OMIM604930   
Gene and transcription
Genbank (Entrez)AF043119 AF047487 BC000103 BC007195 BC033176
RefSeq transcript (Entrez)NM_001004720 NM_001004722 NM_003581
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NCK2
Cluster EST : UnigeneHs.735723 [ NCBI ]
CGAP (NCI)Hs.735723
Alternative Splicing GalleryENSG00000071051
Gene ExpressionNCK2 [ NCBI-GEO ]   NCK2 [ EBI - ARRAY_EXPRESS ]   NCK2 [ SEEK ]   NCK2 [ MEM ]
Gene Expression Viewer (FireBrowse)NCK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8440
GTEX Portal (Tissue expression)NCK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43639   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43639  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43639
Splice isoforms : SwissVarO43639
PhosPhoSitePlusO43639
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)NCK    SH2    SH3_domain   
Domain families : Pfam (Sanger)SH2 (PF00017)    SH3_1 (PF00018)    SH3_9 (PF14604)   
Domain families : Pfam (NCBI)pfam00017    pfam00018    pfam14604   
Domain families : Smart (EMBL)SH2 (SM00252)  SH3 (SM00326)  
Conserved Domain (NCBI)NCK2
DMDM Disease mutations8440
Blocks (Seattle)NCK2
PDB (SRS)1U5S    1WX6    1Z3K    2B86    2CIA    2FRW    2FRY    2JXB    4E6R   
PDB (PDBSum)1U5S    1WX6    1Z3K    2B86    2CIA    2FRW    2FRY    2JXB    4E6R   
PDB (IMB)1U5S    1WX6    1Z3K    2B86    2CIA    2FRW    2FRY    2JXB    4E6R   
PDB (RSDB)1U5S    1WX6    1Z3K    2B86    2CIA    2FRW    2FRY    2JXB    4E6R   
Structural Biology KnowledgeBase1U5S    1WX6    1Z3K    2B86    2CIA    2FRW    2FRY    2JXB    4E6R   
SCOP (Structural Classification of Proteins)1U5S    1WX6    1Z3K    2B86    2CIA    2FRW    2FRY    2JXB    4E6R   
CATH (Classification of proteins structures)1U5S    1WX6    1Z3K    2B86    2CIA    2FRW    2FRY    2JXB    4E6R   
SuperfamilyO43639
Human Protein AtlasENSG00000071051
Peptide AtlasO43639
HPRD05378
IPIIPI00306531   IPI00464976   IPI00915970   IPI01010193   
Protein Interaction databases
DIP (DOE-UCLA)O43639
IntAct (EBI)O43639
FunCoupENSG00000071051
BioGRIDNCK2
STRING (EMBL)NCK2
ZODIACNCK2
Ontologies - Pathways
QuickGOO43639
Ontology : AmiGOimmunological synapse formation  phosphotyrosine binding  SH3/SH2 adaptor activity  protein binding  cytoplasm  cytoplasm  endoplasmic reticulum  cytosol  actin filament organization  signal transduction  signal complex assembly  epidermal growth factor receptor signaling pathway  regulation of epidermal growth factor-activated receptor activity  cytoskeletal adaptor activity  negative regulation of cell proliferation  vesicle membrane  postsynaptic density  cell migration  lamellipodium assembly  receptor signaling complex scaffold activity  positive regulation of actin filament polymerization  protein complex binding  negative regulation of peptidyl-serine phosphorylation  positive regulation of translation in response to endoplasmic reticulum stress  positive regulation of T cell proliferation  T cell activation  positive regulation of transcription from RNA polymerase II promoter  vascular endothelial growth factor receptor signaling pathway  ephrin receptor signaling pathway  dendritic spine development  scaffold protein binding  positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  negative regulation of PERK-mediated unfolded protein response  negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation  negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  
Ontology : EGO-EBIimmunological synapse formation  phosphotyrosine binding  SH3/SH2 adaptor activity  protein binding  cytoplasm  cytoplasm  endoplasmic reticulum  cytosol  actin filament organization  signal transduction  signal complex assembly  epidermal growth factor receptor signaling pathway  regulation of epidermal growth factor-activated receptor activity  cytoskeletal adaptor activity  negative regulation of cell proliferation  vesicle membrane  postsynaptic density  cell migration  lamellipodium assembly  receptor signaling complex scaffold activity  positive regulation of actin filament polymerization  protein complex binding  negative regulation of peptidyl-serine phosphorylation  positive regulation of translation in response to endoplasmic reticulum stress  positive regulation of T cell proliferation  T cell activation  positive regulation of transcription from RNA polymerase II promoter  vascular endothelial growth factor receptor signaling pathway  ephrin receptor signaling pathway  dendritic spine development  scaffold protein binding  positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  negative regulation of PERK-mediated unfolded protein response  negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation  negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  
Pathways : KEGGErbB signaling pathway    Axon guidance    T cell receptor signaling pathway    Pathogenic Escherichia coli infection   
NDEx NetworkNCK2
Atlas of Cancer Signalling NetworkNCK2
Wikipedia pathwaysNCK2
Orthology - Evolution
OrthoDB8440
GeneTree (enSembl)ENSG00000071051
Phylogenetic Trees/Animal Genes : TreeFamNCK2
HOVERGENO43639
HOGENOMO43639
Homologs : HomoloGeneNCK2
Homology/Alignments : Family Browser (UCSC)NCK2
Gene fusions - Rearrangements
Fusion : MitelmanNCK2/SFXN5 [2q12.2/2p13.2]  
Fusion: TCGANCK2 2q12.2 SFXN5 2p13.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNCK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NCK2
dbVarNCK2
ClinVarNCK2
1000_GenomesNCK2 
Exome Variant ServerNCK2
ExAC (Exome Aggregation Consortium)NCK2 (select the gene name)
Genetic variants : HAPMAP8440
Genomic Variants (DGV)NCK2 [DGVbeta]
DECIPHERNCK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNCK2 
Mutations
ICGC Data PortalNCK2 
TCGA Data PortalNCK2 
Broad Tumor PortalNCK2
OASIS PortalNCK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNCK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNCK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NCK2
DgiDB (Drug Gene Interaction Database)NCK2
DoCM (Curated mutations)NCK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NCK2 (select a term)
intoGenNCK2
Cancer3DNCK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604930   
Orphanet
MedgenNCK2
Genetic Testing Registry NCK2
NextProtO43639 [Medical]
TSGene8440
GENETestsNCK2
Target ValidationNCK2
Huge Navigator NCK2 [HugePedia]
snp3D : Map Gene to Disease8440
BioCentury BCIQNCK2
ClinGenNCK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8440
Chemical/Pharm GKB GenePA31467
Clinical trialNCK2
Miscellaneous
canSAR (ICR)NCK2 (select the gene name)
Probes
Litterature
PubMed81 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNCK2
EVEXNCK2
GoPubMedNCK2
iHOPNCK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:46:20 CEST 2017

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