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NCK2 (NCK adaptor protein 2)

Identity

Alias (NCBI)GRB4
NCKbeta
HGNC (Hugo) NCK2
HGNC Alias symbNCKbeta
LocusID (NCBI) 8440
Atlas_Id 52582
Location 2q12.2  [Link to chromosome band 2q12]
Location_base_pair Starts at 105744912 and ends at 105894272 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NCK2 (2q12.2) / ATP6V0D1 (16q22.1)NCK2 (2q12.2) / DDI2 (1p36.21)NCK2 (2q12.2) / SFXN5 (2p13.2)
NCK2 2q12.2 / SFXN5 2p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)NCK2   7665
Cards
Entrez_Gene (NCBI)NCK2    NCK adaptor protein 2
AliasesGRB4; NCKbeta
GeneCards (Weizmann)NCK2
Ensembl hg19 (Hinxton)ENSG00000071051 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000071051 [Gene_View]  ENSG00000071051 [Sequence]  chr2:105744912-105894272 [Contig_View]  NCK2 [Vega]
ICGC DataPortalENSG00000071051
TCGA cBioPortalNCK2
AceView (NCBI)NCK2
Genatlas (Paris)NCK2
SOURCE (Princeton)NCK2
Genetics Home Reference (NIH)NCK2
Genomic and cartography
GoldenPath hg38 (UCSC)NCK2  -     chr2:105744912-105894272 +  2q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NCK2  -     2q12.2   [Description]    (hg19-Feb_2009)
GoldenPathNCK2 - 2q12.2 [CytoView hg19]  NCK2 - 2q12.2 [CytoView hg38]
ImmunoBaseENSG00000071051
Genome Data Viewer NCBINCK2 [Mapview hg19]  
OMIM604930   
Gene and transcription
Genbank (Entrez)AF043119 AF047487 BC000103 BC007195 BC033176
RefSeq transcript (Entrez)NM_001004720 NM_001004722 NM_003581
Consensus coding sequences : CCDS (NCBI)NCK2
Gene ExpressionNCK2 [ NCBI-GEO ]   NCK2 [ EBI - ARRAY_EXPRESS ]   NCK2 [ SEEK ]   NCK2 [ MEM ]
Gene Expression Viewer (FireBrowse)NCK2 [ Firebrowse - Broad ]
GenevisibleExpression of NCK2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8440
GTEX Portal (Tissue expression)NCK2
Human Protein AtlasENSG00000071051-NCK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43639   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43639  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43639
PhosPhoSitePlusO43639
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)NCK    NCK2    Nck2_SH2    Nck2_SH3_1    Nck2_SH3_2    Nck2_SH3_3    SH2    SH2_dom_sf    SH3-like_dom_sf    SH3_domain   
Domain families : Pfam (Sanger)SH2 (PF00017)    SH3_1 (PF00018)    SH3_9 (PF14604)   
Domain families : Pfam (NCBI)pfam00017    pfam00018    pfam14604   
Domain families : Smart (EMBL)SH2 (SM00252)  SH3 (SM00326)  
Conserved Domain (NCBI)NCK2
PDB (RSDB)1U5S    1WX6    1Z3K    2B86    2CIA    2FRW    2FRY    2JXB    4E6R   
PDB Europe1U5S    1WX6    1Z3K    2B86    2CIA    2FRW    2FRY    2JXB    4E6R   
PDB (PDBSum)1U5S    1WX6    1Z3K    2B86    2CIA    2FRW    2FRY    2JXB    4E6R   
PDB (IMB)1U5S    1WX6    1Z3K    2B86    2CIA    2FRW    2FRY    2JXB    4E6R   
Structural Biology KnowledgeBase1U5S    1WX6    1Z3K    2B86    2CIA    2FRW    2FRY    2JXB    4E6R   
SCOP (Structural Classification of Proteins)1U5S    1WX6    1Z3K    2B86    2CIA    2FRW    2FRY    2JXB    4E6R   
CATH (Classification of proteins structures)1U5S    1WX6    1Z3K    2B86    2CIA    2FRW    2FRY    2JXB    4E6R   
SuperfamilyO43639
AlphaFold pdb e-kbO43639   
Human Protein Atlas [tissue]ENSG00000071051-NCK2 [tissue]
HPRD05378
Protein Interaction databases
DIP (DOE-UCLA)O43639
IntAct (EBI)O43639
BioGRIDNCK2
STRING (EMBL)NCK2
ZODIACNCK2
Ontologies - Pathways
QuickGOO43639
Ontology : AmiGOimmunological synapse formation  phosphotyrosine residue binding  protein binding  cytoplasm  cytoplasm  endoplasmic reticulum  cytosol  actin filament organization  signal transduction  signal complex assembly  epidermal growth factor receptor signaling pathway  regulation of epidermal growth factor-activated receptor activity  cytoskeletal anchor activity  negative regulation of cell population proliferation  vesicle membrane  postsynaptic density  cell migration  lamellipodium assembly  signaling receptor complex adaptor activity  positive regulation of actin filament polymerization  negative regulation of peptidyl-serine phosphorylation  signaling adaptor activity  positive regulation of translation in response to endoplasmic reticulum stress  positive regulation of T cell proliferation  T cell activation  protein-containing complex binding  positive regulation of transcription by RNA polymerase II  vascular endothelial growth factor receptor signaling pathway  ephrin receptor signaling pathway  dendritic spine development  scaffold protein binding  positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  negative regulation of PERK-mediated unfolded protein response  negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation  negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  
Ontology : EGO-EBIimmunological synapse formation  phosphotyrosine residue binding  protein binding  cytoplasm  cytoplasm  endoplasmic reticulum  cytosol  actin filament organization  signal transduction  signal complex assembly  epidermal growth factor receptor signaling pathway  regulation of epidermal growth factor-activated receptor activity  cytoskeletal anchor activity  negative regulation of cell population proliferation  vesicle membrane  postsynaptic density  cell migration  lamellipodium assembly  signaling receptor complex adaptor activity  positive regulation of actin filament polymerization  negative regulation of peptidyl-serine phosphorylation  signaling adaptor activity  positive regulation of translation in response to endoplasmic reticulum stress  positive regulation of T cell proliferation  T cell activation  protein-containing complex binding  positive regulation of transcription by RNA polymerase II  vascular endothelial growth factor receptor signaling pathway  ephrin receptor signaling pathway  dendritic spine development  scaffold protein binding  positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  negative regulation of PERK-mediated unfolded protein response  negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation  negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  
Pathways : KEGGErbB signaling pathway    Axon guidance    T cell receptor signaling pathway    Pathogenic Escherichia coli infection   
NDEx NetworkNCK2
Atlas of Cancer Signalling NetworkNCK2
Wikipedia pathwaysNCK2
Orthology - Evolution
OrthoDB8440
GeneTree (enSembl)ENSG00000071051
Phylogenetic Trees/Animal Genes : TreeFamNCK2
Homologs : HomoloGeneNCK2
Homology/Alignments : Family Browser (UCSC)NCK2
Gene fusions - Rearrangements
Fusion : MitelmanNCK2/SFXN5 [2q12.2/2p13.2]  
Fusion : QuiverNCK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNCK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NCK2
dbVarNCK2
ClinVarNCK2
MonarchNCK2
1000_GenomesNCK2 
Exome Variant ServerNCK2
GNOMAD BrowserENSG00000071051
Varsome BrowserNCK2
ACMGNCK2 variants
VarityO43639
Genomic Variants (DGV)NCK2 [DGVbeta]
DECIPHERNCK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNCK2 
Mutations
ICGC Data PortalNCK2 
TCGA Data PortalNCK2 
Broad Tumor PortalNCK2
OASIS PortalNCK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNCK2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNCK2
Mutations and Diseases : HGMDNCK2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNCK2
DgiDB (Drug Gene Interaction Database)NCK2
DoCM (Curated mutations)NCK2
CIViC (Clinical Interpretations of Variants in Cancer)NCK2
Cancer3DNCK2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604930   
Orphanet
DisGeNETNCK2
MedgenNCK2
Genetic Testing Registry NCK2
NextProtO43639 [Medical]
GENETestsNCK2
Target ValidationNCK2
Huge Navigator NCK2 [HugePedia]
ClinGenNCK2
Clinical trials, drugs, therapy
MyCancerGenomeNCK2
Protein Interactions : CTDNCK2
Pharm GKB GenePA31467
PharosO43639
Clinical trialNCK2
Miscellaneous
canSAR (ICR)NCK2
HarmonizomeNCK2
DataMed IndexNCK2
Probes
Litterature
PubMed102 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNCK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:22:16 CEST 2021

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