Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

NCKAP1 (NCK associated protein 1)

Identity

Alias_symbol (synonym)Nap1
HEM2
NAP125
Other aliasNAP1
p125Nap1
HGNC (Hugo) NCKAP1
LocusID (NCBI) 10787
Atlas_Id 52881
Location 2q32.1  [Link to chromosome band 2q32]
Location_base_pair Starts at 182924851 and ends at 183038858 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
C20orf196 (20p12.3) / NCKAP1 (2q32.1)GULP1 (2q32.1) / NCKAP1 (2q32.1)NCKAP1 (2q32.1) / FAM107A (3p14.3)
NCKAP1 (2q32.1) / LYPD6B (2q23.2)NCKAP1 (2q32.1) / NCKAP1 (2q32.1)NCKAP1 (2q32.1) / PARD3 (10p11.22)
OXA1L (14q11.2) / NCKAP1 (2q32.1)RRM2 (2p25.1) / NCKAP1 (2q32.1)C20orf196 20p12.3 / NCKAP1 2q32.1
GULP1 2q32.1 / NCKAP1 2q32.1NCKAP1 2q32.1 / LYPD6B 2q23.1NCKAP1 2q32.1 / PARD3 10p11.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NCKAP1   7666
Cards
Entrez_Gene (NCBI)NCKAP1  10787  NCK associated protein 1
AliasesHEM2; NAP1; NAP125; p125Nap1
GeneCards (Weizmann)NCKAP1
Ensembl hg19 (Hinxton)ENSG00000061676 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000061676 [Gene_View]  chr2:182924851-183038858 [Contig_View]  NCKAP1 [Vega]
ICGC DataPortalENSG00000061676
TCGA cBioPortalNCKAP1
AceView (NCBI)NCKAP1
Genatlas (Paris)NCKAP1
WikiGenes10787
SOURCE (Princeton)NCKAP1
Genetics Home Reference (NIH)NCKAP1
Genomic and cartography
GoldenPath hg38 (UCSC)NCKAP1  -     chr2:182924851-183038858 -  2q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NCKAP1  -     2q32.1   [Description]    (hg19-Feb_2009)
EnsemblNCKAP1 - 2q32.1 [CytoView hg19]  NCKAP1 - 2q32.1 [CytoView hg38]
Mapping of homologs : NCBINCKAP1 [Mapview hg19]  NCKAP1 [Mapview hg38]
OMIM604891   
Gene and transcription
Genbank (Entrez)AB011159 AB014509 AI215133 AK001291 AK002153
RefSeq transcript (Entrez)NM_013436 NM_205842
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NCKAP1
Cluster EST : UnigeneHs.708541 [ NCBI ]
CGAP (NCI)Hs.708541
Alternative Splicing GalleryENSG00000061676
Gene ExpressionNCKAP1 [ NCBI-GEO ]   NCKAP1 [ EBI - ARRAY_EXPRESS ]   NCKAP1 [ SEEK ]   NCKAP1 [ MEM ]
Gene Expression Viewer (FireBrowse)NCKAP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10787
GTEX Portal (Tissue expression)NCKAP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y2A7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y2A7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y2A7
Splice isoforms : SwissVarQ9Y2A7
PhosPhoSitePlusQ9Y2A7
Domains : Interpro (EBI)Nck-associated_protein-1   
Domain families : Pfam (Sanger)Nckap1 (PF09735)   
Domain families : Pfam (NCBI)pfam09735   
Conserved Domain (NCBI)NCKAP1
DMDM Disease mutations10787
Blocks (Seattle)NCKAP1
PDB (SRS)3P8C    4N78   
PDB (PDBSum)3P8C    4N78   
PDB (IMB)3P8C    4N78   
PDB (RSDB)3P8C    4N78   
Structural Biology KnowledgeBase3P8C    4N78   
SCOP (Structural Classification of Proteins)3P8C    4N78   
CATH (Classification of proteins structures)3P8C    4N78   
SuperfamilyQ9Y2A7
Human Protein AtlasENSG00000061676
Peptide AtlasQ9Y2A7
HPRD05353
IPIIPI00031982   IPI00409684   IPI00902825   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y2A7
IntAct (EBI)Q9Y2A7
FunCoupENSG00000061676
BioGRIDNCKAP1
STRING (EMBL)NCKAP1
ZODIACNCKAP1
Ontologies - Pathways
QuickGOQ9Y2A7
Ontology : AmiGOprotein binding  cytosol  focal adhesion  apoptotic process  central nervous system development  positive regulation of lamellipodium assembly  integral component of membrane  viral process  Rac protein signal transduction  SCAR complex  lamellipodium membrane  protein complex binding  Fc-gamma receptor signaling pathway involved in phagocytosis  vascular endothelial growth factor receptor signaling pathway  Rac GTPase binding  extracellular exosome  positive regulation of Arp2/3 complex-mediated actin nucleation  
Ontology : EGO-EBIprotein binding  cytosol  focal adhesion  apoptotic process  central nervous system development  positive regulation of lamellipodium assembly  integral component of membrane  viral process  Rac protein signal transduction  SCAR complex  lamellipodium membrane  protein complex binding  Fc-gamma receptor signaling pathway involved in phagocytosis  vascular endothelial growth factor receptor signaling pathway  Rac GTPase binding  extracellular exosome  positive regulation of Arp2/3 complex-mediated actin nucleation  
Pathways : BIOCARTAY branching of actin filaments [Genes]   
Pathways : KEGGRegulation of actin cytoskeleton   
NDEx NetworkNCKAP1
Atlas of Cancer Signalling NetworkNCKAP1
Wikipedia pathwaysNCKAP1
Orthology - Evolution
OrthoDB10787
GeneTree (enSembl)ENSG00000061676
Phylogenetic Trees/Animal Genes : TreeFamNCKAP1
HOVERGENQ9Y2A7
HOGENOMQ9Y2A7
Homologs : HomoloGeneNCKAP1
Homology/Alignments : Family Browser (UCSC)NCKAP1
Gene fusions - Rearrangements
Fusion : MitelmanC20orf196/NCKAP1 [20p12.3/2q32.1]  [t(2;20)(q32;p12)]  
Fusion : MitelmanGULP1/NCKAP1 [2q32.1/2q32.1]  [t(2;2)(q32;q32)]  
Fusion : MitelmanNCKAP1/LYPD6B [2q32.1/2q23.1]  [t(2;2)(q23;q32)]  
Fusion : MitelmanNCKAP1/PARD3 [2q32.1/10p11.22]  [t(2;10)(q32;p11)]  
Fusion: TCGAC20orf196 20p12.3 NCKAP1 2q32.1 BRCA
Fusion: TCGAGULP1 2q32.1 NCKAP1 2q32.1 PRAD
Fusion: TCGANCKAP1 2q32.1 LYPD6B 2q23.1 PRAD
Fusion: TCGANCKAP1 2q32.1 PARD3 10p11.22 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNCKAP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NCKAP1
dbVarNCKAP1
ClinVarNCKAP1
1000_GenomesNCKAP1 
Exome Variant ServerNCKAP1
ExAC (Exome Aggregation Consortium)NCKAP1 (select the gene name)
Genetic variants : HAPMAP10787
Genomic Variants (DGV)NCKAP1 [DGVbeta]
DECIPHERNCKAP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNCKAP1 
Mutations
ICGC Data PortalNCKAP1 
TCGA Data PortalNCKAP1 
Broad Tumor PortalNCKAP1
OASIS PortalNCKAP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNCKAP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNCKAP1
intOGen PortalNCKAP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NCKAP1
DgiDB (Drug Gene Interaction Database)NCKAP1
DoCM (Curated mutations)NCKAP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NCKAP1 (select a term)
intoGenNCKAP1
Cancer3DNCKAP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604891   
Orphanet
MedgenNCKAP1
Genetic Testing Registry NCKAP1
NextProtQ9Y2A7 [Medical]
TSGene10787
GENETestsNCKAP1
Target ValidationNCKAP1
Huge Navigator NCKAP1 [HugePedia]
snp3D : Map Gene to Disease10787
BioCentury BCIQNCKAP1
ClinGenNCKAP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10787
Chemical/Pharm GKB GenePA31468
Clinical trialNCKAP1
Miscellaneous
canSAR (ICR)NCKAP1 (select the gene name)
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNCKAP1
EVEXNCKAP1
GoPubMedNCKAP1
iHOPNCKAP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:46:20 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.