NCKAP1 (NCK associated protein 1)

2012-09-01  

Identity

HGNC
LOCATION
2q32.1
LOCUSID
ALIAS
HEM2,NAP1,NAP125,p125Nap1
FUSION GENES

Other Information

Locus ID:

NCBI: 10787
MIM: 604891
HGNC: 7666
Ensembl: ENSG00000061676

Variants:

dbSNP: 10787
ClinVar: 10787
TCGA: ENSG00000061676
COSMIC: NCKAP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000061676ENST00000360982Q9Y2A7
ENSG00000061676ENST00000361354Q9Y2A7

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Regulation of actin cytoskeletonKEGGhsa04810
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate WASPs and WAVEsREACTOMER-HSA-5663213

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
276323922016The Contribution of Mosaic Variants to Autism Spectrum Disorder.31
274327942016The WASF3-NCKAP1-CYFIP1 Complex Is Essential for Breast Cancer Metastasis.15
277042672017MicroRNA-34c-3p promotes cell proliferation and invasion in hepatocellular carcinoma by regulation of NCKAP1 expression.8
308670032019Nck-associated protein 1 associates with HSP90 to drive metastasis in human non-small-cell lung cancer.5
310685752019NCKAP1 improves patient outcome and inhibits cell growth by enhancing Rb1/p53 activation in hepatocellular carcinoma.1

Citation

Dessen P

NCKAP1 (NCK associated protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52881/nckap1