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NCKAP1L (NCK associated protein 1 like)

Identity

Alias_namesHEM1
hematopoietic protein 1
Other alias
HGNC (Hugo) NCKAP1L
LocusID (NCBI) 3071
Atlas_Id 56489
Location 12q13.13  [Link to chromosome band 12q13]
Location_base_pair Starts at 54498784 and ends at 54543115 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NCKAP1L   4862
Cards
Entrez_Gene (NCBI)NCKAP1L  3071  NCK associated protein 1 like
AliasesHEM1
GeneCards (Weizmann)NCKAP1L
Ensembl hg19 (Hinxton)ENSG00000123338 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000123338 [Gene_View]  chr12:54498784-54543115 [Contig_View]  NCKAP1L [Vega]
ICGC DataPortalENSG00000123338
TCGA cBioPortalNCKAP1L
AceView (NCBI)NCKAP1L
Genatlas (Paris)NCKAP1L
WikiGenes3071
SOURCE (Princeton)NCKAP1L
Genetics Home Reference (NIH)NCKAP1L
Genomic and cartography
GoldenPath hg38 (UCSC)NCKAP1L  -     chr12:54498784-54543115 +  12q13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NCKAP1L  -     12q13.13   [Description]    (hg19-Feb_2009)
EnsemblNCKAP1L - 12q13.13 [CytoView hg19]  NCKAP1L - 12q13.13 [CytoView hg38]
Mapping of homologs : NCBINCKAP1L [Mapview hg19]  NCKAP1L [Mapview hg38]
OMIM141180   
Gene and transcription
Genbank (Entrez)AI924363 AK300783 AK314012 AU100069 AW575485
RefSeq transcript (Entrez)NM_001184976 NM_005337
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NCKAP1L
Cluster EST : UnigeneHs.182014 [ NCBI ]
CGAP (NCI)Hs.182014
Alternative Splicing GalleryENSG00000123338
Gene ExpressionNCKAP1L [ NCBI-GEO ]   NCKAP1L [ EBI - ARRAY_EXPRESS ]   NCKAP1L [ SEEK ]   NCKAP1L [ MEM ]
Gene Expression Viewer (FireBrowse)NCKAP1L [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3071
GTEX Portal (Tissue expression)NCKAP1L
Protein : pattern, domain, 3D structure
UniProt/SwissProtP55160   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP55160  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP55160
Splice isoforms : SwissVarP55160
PhosPhoSitePlusP55160
Domains : Interpro (EBI)Nck-associated_protein-1   
Domain families : Pfam (Sanger)Nckap1 (PF09735)   
Domain families : Pfam (NCBI)pfam09735   
Conserved Domain (NCBI)NCKAP1L
DMDM Disease mutations3071
Blocks (Seattle)NCKAP1L
SuperfamilyP55160
Human Protein AtlasENSG00000123338
Peptide AtlasP55160
HPRD00781
IPIIPI00023407   IPI01022786   IPI01021337   IPI00793989   
Protein Interaction databases
DIP (DOE-UCLA)P55160
IntAct (EBI)P55160
FunCoupENSG00000123338
BioGRIDNCKAP1L
STRING (EMBL)NCKAP1L
ZODIACNCKAP1L
Ontologies - Pathways
QuickGOP55160
Ontology : AmiGOB cell homeostasis  myeloid cell homeostasis  GTPase activator activity  protein binding  cytosol  cytosol  plasma membrane  integral component of plasma membrane  protein complex assembly  chemotaxis  membrane  maintenance of cell polarity  protein kinase activator activity  neutrophil chemotaxis  secretory granule membrane  positive regulation of actin filament polymerization  cortical actin cytoskeleton organization  cortical actin cytoskeleton organization  positive regulation of B cell proliferation  SCAR complex  activation of protein kinase activity  protein complex binding  negative regulation of interleukin-17 production  negative regulation of interleukin-6 production  positive regulation of cell adhesion mediated by integrin  erythrocyte homeostasis  negative regulation of myosin-light-chain-phosphatase activity  Fc-gamma receptor signaling pathway involved in phagocytosis  positive regulation of T cell proliferation  positive regulation of phosphorylation  response to drug  T cell homeostasis  negative regulation of apoptotic process  neutrophil degranulation  positive regulation of CD4-positive, alpha-beta T cell differentiation  positive regulation of CD8-positive, alpha-beta T cell differentiation  positive regulation of GTPase activity  positive regulation of B cell differentiation  positive regulation of gamma-delta T cell differentiation  positive regulation of lymphocyte differentiation  positive regulation of erythrocyte differentiation  vascular endothelial growth factor receptor signaling pathway  erythrocyte development  B cell receptor signaling pathway  positive regulation of phagocytosis, engulfment  extracellular exosome  actin polymerization-dependent cell motility  positive regulation of neutrophil chemotaxis  ficolin-1-rich granule membrane  
Ontology : EGO-EBIB cell homeostasis  myeloid cell homeostasis  GTPase activator activity  protein binding  cytosol  cytosol  plasma membrane  integral component of plasma membrane  protein complex assembly  chemotaxis  membrane  maintenance of cell polarity  protein kinase activator activity  neutrophil chemotaxis  secretory granule membrane  positive regulation of actin filament polymerization  cortical actin cytoskeleton organization  cortical actin cytoskeleton organization  positive regulation of B cell proliferation  SCAR complex  activation of protein kinase activity  protein complex binding  negative regulation of interleukin-17 production  negative regulation of interleukin-6 production  positive regulation of cell adhesion mediated by integrin  erythrocyte homeostasis  negative regulation of myosin-light-chain-phosphatase activity  Fc-gamma receptor signaling pathway involved in phagocytosis  positive regulation of T cell proliferation  positive regulation of phosphorylation  response to drug  T cell homeostasis  negative regulation of apoptotic process  neutrophil degranulation  positive regulation of CD4-positive, alpha-beta T cell differentiation  positive regulation of CD8-positive, alpha-beta T cell differentiation  positive regulation of GTPase activity  positive regulation of B cell differentiation  positive regulation of gamma-delta T cell differentiation  positive regulation of lymphocyte differentiation  positive regulation of erythrocyte differentiation  vascular endothelial growth factor receptor signaling pathway  erythrocyte development  B cell receptor signaling pathway  positive regulation of phagocytosis, engulfment  extracellular exosome  actin polymerization-dependent cell motility  positive regulation of neutrophil chemotaxis  ficolin-1-rich granule membrane  
Pathways : KEGGRegulation of actin cytoskeleton   
NDEx NetworkNCKAP1L
Atlas of Cancer Signalling NetworkNCKAP1L
Wikipedia pathwaysNCKAP1L
Orthology - Evolution
OrthoDB3071
GeneTree (enSembl)ENSG00000123338
Phylogenetic Trees/Animal Genes : TreeFamNCKAP1L
HOVERGENP55160
HOGENOMP55160
Homologs : HomoloGeneNCKAP1L
Homology/Alignments : Family Browser (UCSC)NCKAP1L
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNCKAP1L [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NCKAP1L
dbVarNCKAP1L
ClinVarNCKAP1L
1000_GenomesNCKAP1L 
Exome Variant ServerNCKAP1L
ExAC (Exome Aggregation Consortium)NCKAP1L (select the gene name)
Genetic variants : HAPMAP3071
Genomic Variants (DGV)NCKAP1L [DGVbeta]
DECIPHERNCKAP1L [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNCKAP1L 
Mutations
ICGC Data PortalNCKAP1L 
TCGA Data PortalNCKAP1L 
Broad Tumor PortalNCKAP1L
OASIS PortalNCKAP1L [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNCKAP1L  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNCKAP1L
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NCKAP1L
DgiDB (Drug Gene Interaction Database)NCKAP1L
DoCM (Curated mutations)NCKAP1L (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NCKAP1L (select a term)
intoGenNCKAP1L
Cancer3DNCKAP1L(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM141180   
Orphanet
MedgenNCKAP1L
Genetic Testing Registry NCKAP1L
NextProtP55160 [Medical]
TSGene3071
GENETestsNCKAP1L
Target ValidationNCKAP1L
Huge Navigator NCKAP1L [HugePedia]
snp3D : Map Gene to Disease3071
BioCentury BCIQNCKAP1L
ClinGenNCKAP1L
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3071
Chemical/Pharm GKB GenePA29239
Clinical trialNCKAP1L
Miscellaneous
canSAR (ICR)NCKAP1L (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNCKAP1L
EVEXNCKAP1L
GoPubMedNCKAP1L
iHOPNCKAP1L
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:46:20 CEST 2017

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