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NCL (nucleolin)

Identity

Alias_symbol (synonym)C23
Other alias
HGNC (Hugo) NCL
LocusID (NCBI) 4691
Atlas_Id 46574
Location 2q37.1  [Link to chromosome band 2q37]
Location_base_pair Starts at 231454748 and ends at 231464494 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ANP32A (15q23) / NCL (2q37.1)ANP32B (9q22.33) / NCL (2q37.1)ARID1B (6q25.3) / NCL (2q37.1)
BGN (Xq28) / NCL (2q37.1)CFB (6p21.33) / NCL (2q37.1)EIF3D (22q12.3) / NCL (2q37.1)
GTF2I (7q11.23) / NCL (2q37.1)HADH (4q25) / NCL (2q37.1)IDH1 (2q34) / NCL (2q37.1)
KRT86 (12q13.13) / NCL (2q37.1)LOC100996476 () / NCL (2q37.1)MYH9 (22q12.3) / NCL (2q37.1)
NCL (2q37.1) / ARIH2 (3p21.31)NCL (2q37.1) / ASPH (8q12.3)NCL (2q37.1) / EEF1DP3 (13q13.1)
NCL (2q37.1) / EIF5B (2q11.2)NCL (2q37.1) / FOXJ3 (1p34.2)NCL (2q37.1) / HSPA8 (11q24.1)
NCL (2q37.1) / IGF2BP1 (17q21.32)NCL (2q37.1) / KAT6A (8p11.21)NCL (2q37.1) / MAP4K4 (2q11.2)
NCL (2q37.1) / NAP1L1 (12q21.2)NCL (2q37.1) / NCL (2q37.1)NCL (2q37.1) / NPY (7p15.3)
NCL (2q37.1) / PLXNB1 (3p21.31)NCL (2q37.1) / PSMA7 (20q13.33)NCL (2q37.1) / PSMG2 (18p11.21)
NCL (2q37.1) / PTMA (2q37.1)NCL (2q37.1) / PTMS (12p13.31)NCL (2q37.1) / RBM25 (14q24.2)
NCL (2q37.1) / SLC4A5 (2p13.1)NCL (2q37.1) / SQSTM1 (5q35.3)NCL (2q37.1) / SRRM1 (1p36.11)
NCL (2q37.1) / WDR26 (1q42.11)NME4 (16p13.3) / NCL (2q37.1)NPM1 (5q35.1) / NCL (2q37.1)
PPP4R2 (3p13) / NCL (2q37.1)PTMS (12p13.31) / NCL (2q37.1)RAPGEFL1 (17q21.1) / NCL (2q37.1)
RSPH6A (19q13.32) / NCL (2q37.1)SDHA (5p15.33) / NCL (2q37.1)TMEM259 (19p13.3) / NCL (2q37.1)
TSPYL2 (Xp11.22) / NCL (2q37.1)USMG5 (10q24.33) / NCL (2q37.1)ZC3H11A (1q32.1) / NCL (2q37.1)
NCL 2q37.1 / RBM25 14q24.2NCL 2q37.1 / SQSTM1 5q35.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NCL   7667
Cards
Entrez_Gene (NCBI)NCL  4691  nucleolin
AliasesC23
GeneCards (Weizmann)NCL
Ensembl hg19 (Hinxton)ENSG00000115053 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115053 [Gene_View]  chr2:231454748-231464494 [Contig_View]  NCL [Vega]
ICGC DataPortalENSG00000115053
TCGA cBioPortalNCL
AceView (NCBI)NCL
Genatlas (Paris)NCL
WikiGenes4691
SOURCE (Princeton)NCL
Genetics Home Reference (NIH)NCL
Genomic and cartography
GoldenPath hg38 (UCSC)NCL  -     chr2:231454748-231464494 -  2q37.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NCL  -     2q37.1   [Description]    (hg19-Feb_2009)
EnsemblNCL - 2q37.1 [CytoView hg19]  NCL - 2q37.1 [CytoView hg38]
Mapping of homologs : NCBINCL [Mapview hg19]  NCL [Mapview hg38]
OMIM164035   
Gene and transcription
Genbank (Entrez)AK000221 AK000250 AK001314 AK091742 AK095897
RefSeq transcript (Entrez)NM_005381
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NCL
Cluster EST : UnigeneHs.79110 [ NCBI ]
CGAP (NCI)Hs.79110
Alternative Splicing GalleryENSG00000115053
Gene ExpressionNCL [ NCBI-GEO ]   NCL [ EBI - ARRAY_EXPRESS ]   NCL [ SEEK ]   NCL [ MEM ]
Gene Expression Viewer (FireBrowse)NCL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4691
GTEX Portal (Tissue expression)NCL
Protein : pattern, domain, 3D structure
UniProt/SwissProtP19338   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP19338  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP19338
Splice isoforms : SwissVarP19338
PhosPhoSitePlusP19338
Domaine pattern : Prosite (Expaxy)RRM (PS50102)   
Domains : Interpro (EBI)Nucleolin_RRM1    Nucleolin_RRM2    Nucleolin_RRM3    Nucleolin_RRM4    Nucleotide-bd_a/b_plait    RRM_dom    RRM_dom_euk   
Domain families : Pfam (Sanger)RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00076   
Domain families : Smart (EMBL)RRM (SM00360)  RRM_1 (SM00361)  
Conserved Domain (NCBI)NCL
DMDM Disease mutations4691
Blocks (Seattle)NCL
PDB (SRS)2FC8    2FC9    2KRR   
PDB (PDBSum)2FC8    2FC9    2KRR   
PDB (IMB)2FC8    2FC9    2KRR   
PDB (RSDB)2FC8    2FC9    2KRR   
Structural Biology KnowledgeBase2FC8    2FC9    2KRR   
SCOP (Structural Classification of Proteins)2FC8    2FC9    2KRR   
CATH (Classification of proteins structures)2FC8    2FC9    2KRR   
SuperfamilyP19338
Human Protein AtlasENSG00000115053
Peptide AtlasP19338
HPRD01245
IPIIPI00604620   IPI00444262   IPI00183526   IPI00917429   IPI00916991   IPI00916036   IPI00916188   
Protein Interaction databases
DIP (DOE-UCLA)P19338
IntAct (EBI)P19338
FunCoupENSG00000115053
BioGRIDNCL
STRING (EMBL)NCL
ZODIACNCL
Ontologies - Pathways
QuickGOP19338
Ontology : AmiGOangiogenesis  RNA binding  protein binding  nucleus  nucleoplasm  nucleolus  cell cortex  protein C-terminus binding  membrane  negative regulation of translation  intracellular ribonucleoprotein complex  cytoplasmic ribonucleoprotein granule  telomeric DNA binding  identical protein binding  DNA topoisomerase binding  positive regulation of transcription from RNA polymerase II promoter  mRNA 5'-UTR binding  extracellular exosome  cellular response to epidermal growth factor stimulus  positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter  
Ontology : EGO-EBIangiogenesis  RNA binding  protein binding  nucleus  nucleoplasm  nucleolus  cell cortex  protein C-terminus binding  membrane  negative regulation of translation  intracellular ribonucleoprotein complex  cytoplasmic ribonucleoprotein granule  telomeric DNA binding  identical protein binding  DNA topoisomerase binding  positive regulation of transcription from RNA polymerase II promoter  mRNA 5'-UTR binding  extracellular exosome  cellular response to epidermal growth factor stimulus  positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter  
Pathways : BIOCARTASARS Coronavirus Protease [Genes]   
Pathways : KEGGPathogenic Escherichia coli infection   
NDEx NetworkNCL
Atlas of Cancer Signalling NetworkNCL
Wikipedia pathwaysNCL
Orthology - Evolution
OrthoDB4691
GeneTree (enSembl)ENSG00000115053
Phylogenetic Trees/Animal Genes : TreeFamNCL
HOVERGENP19338
HOGENOMP19338
Homologs : HomoloGeneNCL
Homology/Alignments : Family Browser (UCSC)NCL
Gene fusions - Rearrangements
Fusion : MitelmanNCL/RBM25 [2q37.1/14q24.2]  
Fusion : MitelmanNCL/SQSTM1 [2q37.1/5q35.3]  [t(2;5)(q37;q35)]  
Fusion: TCGANCL 2q37.1 RBM25 14q24.2 HNSC
Fusion: TCGANCL 2q37.1 SQSTM1 5q35.3 LUAD
Fusion Cancer (Beijing)NCL [2q37.1]  -  MYST3 [FUSC002462]
Fusion Cancer (Beijing)NCL [2q37.1]  -  PTMA [2q37.1]  [FUSC001210]
Fusion Cancer (Beijing)RSPH6A [19q13.32]  -  NCL [2q37.1]  [FUSC002471]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNCL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NCL
dbVarNCL
ClinVarNCL
1000_GenomesNCL 
Exome Variant ServerNCL
ExAC (Exome Aggregation Consortium)NCL (select the gene name)
Genetic variants : HAPMAP4691
Genomic Variants (DGV)NCL [DGVbeta]
DECIPHERNCL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNCL 
Mutations
ICGC Data PortalNCL 
TCGA Data PortalNCL 
Broad Tumor PortalNCL
OASIS PortalNCL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNCL  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNCL
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NCL
DgiDB (Drug Gene Interaction Database)NCL
DoCM (Curated mutations)NCL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NCL (select a term)
intoGenNCL
Cancer3DNCL(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM164035   
Orphanet
MedgenNCL
Genetic Testing Registry NCL
NextProtP19338 [Medical]
TSGene4691
GENETestsNCL
Target ValidationNCL
Huge Navigator NCL [HugePedia]
snp3D : Map Gene to Disease4691
BioCentury BCIQNCL
ClinGenNCL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4691
Chemical/Pharm GKB GenePA31469
Clinical trialNCL
Miscellaneous
canSAR (ICR)NCL (select the gene name)
Probes
Litterature
PubMed330 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNCL
EVEXNCL
GoPubMedNCL
iHOPNCL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:21:38 CEST 2017

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