NCL (nucleolin)

2007-02-01  

Identity

HGNC
LOCATION
2q37.1
LOCUSID
ALIAS
C23,Nsr1
FUSION GENES

Other Information

Locus ID:

NCBI: 4691
MIM: 164035
HGNC: 7667
Ensembl: ENSG00000115053

Variants:

dbSNP: 4691
ClinVar: 4691
TCGA: ENSG00000115053
COSMIC: NCL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115053ENST00000322723P19338
ENSG00000115053ENST00000322723A0A024R4A0
ENSG00000115053ENST00000356936H7BY16
ENSG00000115053ENST00000417652C9J1H7
ENSG00000115053ENST00000436894C9JYW2
ENSG00000115053ENST00000453992C9JLB1
ENSG00000115053ENST00000454824C9JWL1

Expression (GTEx)

0
100
200
300
400
500
600

Pathways

PathwaySourceExternal ID
Pathogenic Escherichia coli infectionKEGGko05130
Pathogenic Escherichia coli infectionKEGGhsa05130

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
218417842011Identification of nucleolin as a cellular receptor for human respiratory syncytial virus.136
146388622003Nucleolin expressed at the cell surface is a marker of endothelial cells in angiogenic blood vessels.128
195813072009Identification and characterization of nucleolin as a c-myc G-quadruplex-binding protein.102
166017002006Nucleolin is a histone chaperone with FACT-like activity and assists remodeling of nucleosomes.85
176921222007Inactivation of nucleolin leads to nucleolar disruption, cell cycle arrest and defects in centrosome duplication.74
226178832012RNA-binding protein nucleolin in disease.72
146792092004Identification of nucleolin as an AU-rich element binding protein involved in bcl-2 mRNA stabilization.60
196570472009Plasma membrane nucleolin is a receptor for the anticancer aptamer AS1411 in MV4-11 leukemia cells.60
212034232010Surface expressed nucleolin is constantly induced in tumor cells to mediate calcium-dependent ligand internalization.57
121382092002Stress-dependent nucleolin mobilization mediated by p53-nucleolin complex formation.55

Citation

Dessen P

NCL (nucleolin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46574/ncl