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NCOA1 (Nuclear receptor coactivator 1)

Written2018-02Hasan Huseyin Kazan, Ufuk Gunduz
Department of Biological Sciences, Middle East Technical University, Ankara, Turkey, hasanhuseyinkazan@gmail.com (HHK); Department of Biological Sciences, Middle East Technical University, Ankara, Turkey ufukg@metu.edu.tr (UG)

Abstract Review on NCOA1, with data on DNA, on the protein encoded, and where the gene is implicated.

Keywords Nuclear receptor coactivator 1 (NCOA1), transcription regulation, nuclear hormone receptors

(Note : for Links provided by Atlas : click)

Identity

Alias_symbol (synonym)SRC1
F-SRC-1
NCoA-1
KAT13A
RIP160
bHLHe74
Other aliasbHLHe42
HGNC (Hugo) NCOA1
LocusID (NCBI) 8648
Atlas_Id 44097
Location 2p23.3 (Carapeti et al., 1998); Start: 24,492,050 bp; End: 24,770,702 bp; 278,652 bp; Orientation: Plus strand (GRCh38.p7)  [Link to chromosome band 2p23]
Location_base_pair Starts at 24584477 and ends at 24770701 bp from pter ( according to hg19-Feb_2009)  [Mapping NCOA1.png]
 
  Local order of NCOA1. Local order is shown together with leading and subsequent genes on chromosome 2. The direction of arrows indicates transcriptional directions on the chromosome and arrow sizes approximate gene sizes.
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PAX3/NCOA1

DNA/RNA

Note NCOA1 is the firstly cloned nuclear hormone receptor co-activator (Onate et al., 1995; Xu et al., 2009). The canonical transcript (ENST00000348332.7; NM_003743) includes 21 exons, 19 of which are encoded (GRCh38.p10; http://www.ensembl.org).
 
  Numbers and illustrative sizes of exons of human NCOA1. Red boxes are the coding region and black boxes are the non-coding ones.
Transcription Four alternatively spliced isoforms of NCOA1 have firstly been illustrated (Kamei et al., 1996). Compared to NCOA1a, NCOA1b lacks the N-termial domain, and NCOA1c, d and e have unique C-terminal sequences. NCOA1a and b have been shown to display diverse abilities to increase the estrogen receptor α ( ESR1 (Erα)) activity in cell lines (Kalkhoven et al., 1998; Xu et al., 2009). According to Ensembl database, there are eleven different transcripts of NCOA1 gene. Six of these transcripts encode two different proteins while five of them cannot encode protein. Lengths of the transcripts vary between 7405-501 bp (GRCh38.p10; http://www.ensembl.org).

Protein

Note NCOA1 gene encodes two similar proteins. The length of the canonical protein is 1441 amino acids with a molecular mass of 156,757 Da (UniPort ID: Q15788) and the length of the second protein is 1248 amino acids with a molecular mass of 135,621 Da (UniProt ID: B5MCN7). Like the other SRCs (NCOA2 and NCOA3 (SRC-2 and 3)), NCOA1 consists of three structural domains. The protein-protein interaction is performed via an N-terminal basic helix-loop-helix-Per/ARNT/Sim (bHLH-PAS) domain. This domain is highly conserved amongst p160 SRC family and promotes interaction with the transcription factors, such as myogenin, MEF-2C and TEF. The central domain which consists of LXXLL motifs forming amphipathic alpha-helices supports interaction with nuclear hormone receptors. The C-terminal domain includes two transcription activation domains, AD1 and AD2. AD1 binds and recruits CREBBP and EP300 (CBP and p300 histone acetyltransferase (HAT)) for chromatin remodeling, which is critical for SRC-mediated transcriptional activation. AD2 interacts with histone methyltransferases, coactivator-associated arginine methyltransferase 1 ( CARM1) and protein arginine methyltransferases ( PRMT1). The C-terminus of NCOA1, like SRC-3, also includes a HAT activity domain (Torchia et al., 1997; Xu et al., 2009).
Expression Chen et al. showed that NCOA1 was expressed in placental labyrinth (Chen et al., 2010). According to The Human Protein Atlas database, NCOA1 is highly expressed in cerebral cortex, hippocampus, cerebellum, thyroid gland, parathyroid gland, adrenal gland, lymph node, nasopharynx, bronchus, gallbladder, pancreas, oral mucosa, esophagus, stomach, duodenum, small intestine, colon, rectum, kidney, urinary bladder, testis, fallopian tube, breast, vagina and placenta.
 
  Expression profile of NCOA1 in human tissues. Data taken from The Human Protein Atlas (http://www.proteinatlas.org) in February, 2018.
Localisation NCOA1 is synthesized in cytoplasm and imported into nucleus, and localized as speckles in both cytoplasm and nucleus. Localization to nucleus is performed thanks to nuclear localization signal located in between amino acids 18 and 36. After it display its function, it is exported to cytoplasm back, which is thought to inhibition of hormone action via NCOA1 degradation in cytoplasm. Exportation to cytoplasm back occurs owing to nuclear export signal located between amino acids 990 and 1038 (Amazit et al., 2003).
 
  Structure and functions of NCOA1 protein. When hormone (H) is bound to nuclear hormone receptors (NR), they recruit NCOA1 and interact with it via LXXLL motif in NCOA1. NCOA1 interacts with CBP, p300, KAT2B (p/ CAF), CARM1 and PRMT1 and recruits these coactivators to the chromatin for chromatin remodeling. Remodeling of chromatin enables binding of transcription factors and RNA polymerase II on the promoter region. NR interacts with NCOA1 via not only NRID domain but bHLH/PAS domain, which is also important for function of NCOA1. Data adapted from Xu et al., 2009.
Function NCOA1 increases the transcriptional activities of nuclear hormone receptors in a hormone-dependent manner. In addition to nuclear hormone receptors, NCOA1 and other SRCs are the coactivators of other transcription factors including NF-kB, Smads, E2F1, STATs, HIF1A, TP53, RB1, ETV4 (polyoma enhancer activator 3 (PEA3)) and ETS2. They support gene transcription by interacting with kinases, ubiquitin/sumoligases, phosphatases, histone acetyltransferases and histone methyltransferases (Qin et al., 2009; McBryan et al., 2012; Xu et al., 2009). Due to its role in transcription, NCOA1 and other SRCs have a role in different physiological functions, including cell cycle and energy metabolism. NCOA1 itself is critical for organ physiology. It has been showed that NCOA1 deficiency strongly influenced mice reproductive organ development (Xu et al., 1998). NCOA1-/- mice also displayed partial resistance to sex steroids and thyroid hormone (Weiss et al., 1999; Kamiya et al., 2003). NCOA1 is also important for the gluconeogenesis. In liver, it is a coactivator of CEBPA (CEBPα) which regulates the pyruvate carboxylase gene, the limiting enzyme for gluconeogenesis, together with PPARG (PPARγ). Activated PPARγ recruits NCOA1 and other coregulators, such as PGC-1 and CBP/p300 in brown fat, and deficiency in NCOA1 results in drawbacks in activity of PGC-1. This drawback further decreases energy expenditure and causes obesity with high fat diet (Xu et al., 2009).
Phosphorylation is critical in the functioning of SRC family proteins. Phosphorylation of SRCs alters their affinities for certain nuclear hormone receptors (Lopez et al., 2001; Rowan et al., 2000; Wu et al., 2004; Giamas et al., 2009). Moreover, phosphorylation by different kinases via different Ser/Thr amino acids results in determination of down-stream processes. NCOA1 could be phosphorylated by EGF, IL6, CAMP, CCNA2 (cyclin A2)/ CDK2, CDK1 and MAPK. Cyclin A2/Cdk2- and EGF-mediated phosphorylation increases progesterone receptor ( PGR)-dependent transcription while IL-6-induced phosphorylation supports androgen receptor ( AR)-dependent transcription via ligand independency. Additionally, cAMP-mediated phosphorylation of NCOA1 recruits p300 and CBP and activates PR-dependent transcription via ligand independency and MAPK-induced NCOA1 phosphorylation enhances the affinity of NCOA1 towards AR in prostate cancer cells (Rowan et al., 2000; Wu et al., 2004; Giamas et al., 2009; Ueda et al., 2002; Rowan et al., 2000b; Gregory et al., 2004; Xu et al., 2009; Moore and Weigel, 2011). In addition to phosphorylation, sumoylation of NCOA1 at Lys731 and Lys774 by SUMO1 was showed to increase the interaction between PR and NCOA1, and upregulate PR-mediated transcription (Chauchereau et al., 2003).
In hormone-dependent progesterone receptor activity, NCOA1 was shown to be down-regulated in hormone-dependent manner like PR to activate the transcription of target genes. NCOA1 down-regulation was illustrated to be predominantly in cytoplasmic compartment via proteasomal degradation and the down-regulation of NCOA1 together with PR is critical for the regulation of transcription (Amazit et al., 2011).
The interaction of NCOA1 with PR to regulate gene expression was partly underlined in a study where KAT7 (HBO1) (a member of the MYST acetylase family) was illustrated to modulate interaction of NCOA1 and PR in a hormone-dependent manner in human testis cell line, CV1 and human embryonic kidney cell line, HEK293 (Georgiakaki et al., 2006).
NCOA1 has been shown to affect developmental processes. NCOA1 and NCOA3 double knockout mice died at early embryonic stage while single knockout mice lived normally, pointing a cooperative role of NCOA1 and NCOA2 in embryo survival. Moreover, morphologies of labyrinths of NCOA1 (together with NCOA3) knockout mice embryos were abnormal via altered expression of genes responsible for placental morphogenesis, and glucose metabolism (Chen et al., 2010).
Baldwin et al. showed that high-risk human papillomavirus type 16 (HPV16) E7 oncoprotein affected the localization and function of NCOA1; relocalized NCOA1 into cytoplasm and decreased NCOA1-mediated gene expression and NCOA1-dependent histone acetyltransferase (HAT) activity in vivo and in vitro in cervical cancer cell line, HeLa (Baldwin et al., 2006).
NCOA1 has also been linked to glucose metabolism. Under glucose deprivation, NCOA1 was proved to stabilize 26S proteasome and affect the expression of complex I of the mitochondrial electron transport chain (Motamed et al., 2014).
Homology NCOA2 (SRC-2, TIF2 or GRIP1) and NCOA3 (SRC-3, p/CIP, RAC3, AIB1, ACTR or TRAM-1) are homologous to NCOA1 and these three proteins are included in a family, called p160 SRC (Torchia et al., 1997; Xu et al., 2009).

Mutations

Note A single nucleotide polymorphism (SNP) in NCOA1 (rs1804645; P1272S) was demonstrated to decrease ER activation while it increase protein life-time via blocking phosphorylation by glycogen synthase 3 ( GSK3B) in bone. Moreover, this SNP was linked to a decrease in hip and lumbar bone mineral density in women receiving tamoxifen (Hartmaier et al., 2011).
Another SNP in NCOA1 (rs7948087) was associated to multiple myeloma phenotype in Chinese Han population (Peng et al., 2017).
Four different SNPs in NCOA1 (rs11894248, rs17791703, rs7572475 and rs9309308) were linked to Kawasaki disease in Taiwanese people (Chen et al., 2014).
Two chromosomal rearrangements affecting NCOA1 in patients with sarcoma subtypes were identified. In one study, a novel t(2;2)(q35;p23) translocation generating PAX3/NCOA1 fusion protein has been shown (Wachtel et al., 2004). Similar fusion protein was proved to be a result of inv(2)(q35p23) mutation (Huang et al., 2016).
According to ClinVar database, huge chromosomal deletions and duplications in regions including NCOA1 gene have been submitted. These mutations showed to be pathogenic, benign or with uncertain significance.

Implicated in

Note NCOA1 has widely been studied particularly in breast and prostate cancer through its interaction status with estrogen receptor alpha, progesterone receptor and androgen receptor.
  
Entity Breast Cancer
Note NCOA1 has been shown to be generally over-expressed in breast cancer. Moreover, its over-expression has been correlated with ERBB2 expression, metastasis, cancer recurrence and poor disease-free survival (Wang et al., 2006; Fleming et al., 2004; Myers et al., 2004; Hudelist et al., 2003; McBryan et al., 2012; Qin et al., 2014; 2015). Furthermore, NCOA1 has also been demonstrated to be a predictor of breast cancer recurrence after therapy (Redmond et al., 2009). In a cohort study, NCOA1 was found to be over-expressed in 155 of 312 breast cancer patients underwent radical resection, and NCOA1 expression was demonstrated to be correlated with Ki-67 and HER-2 expression. Moreover, NCOA1 and NANOG coexpression was showed to be significantly poorer postoperative disease-specific survival than those with no expression in the HER-2-positive group (Jin et al., 2016). In a study, NCOA1 expression has also been correlated with a favorable response to tamoxifen in patients with recurrent breast cancer (Berns et al., 1998). However, it has been showed that protein kinase A (PKA)-mediated of phosphorylation of estrogen receptor alpha at S305 caused alteration in orientation between ERα and NCOA1 leading to active transcription complex even in the presence of tamoxifen, resulting tamoxifen resistance in T47D and MCF7 breast cancer cell lines (Zwart et al., 2007). Not only tamoxifen response, NCOA1 was shown to be involved in resistance to aromatase inhibitors in patient with breast cancer and breast cancer cell model. NCOA1 was proved to be over-expressed in aromatase-resistant cells and patient tumors. NCOA1 was demonstrated to interact with transcription factor Ets2 and regulate transcription of MYC and MMP9 by which it affected tumor aggressiveness (McBryan et al., 2012). In breast adenocarcinoma cell line, MCF7, NCOA1 has been illustrated to have a role in ERα-mediated cell growth (Tai et al., 2000; Cavarretta et al., 2002). What is more, NCOA1 was shown to co-operate with MUC1, an ERα interactive protein (Wei et al., 2006). NCOA1 has been also involved in cell proliferation and invasion via autocrine/paracrine activity of the SDF-1α- CXCL12 signaling pathway in MCF7 cell lines (Kishimoto et al., 2005). In another study, NCOA1 has been proved to support epithelial-mesenchymal transition (EMT), invasion, migration and metastasis of breast tumor cells via activating PEA3-mediated Twist ( TWIST1) expression (Qin et al., 2009; Xu et al., 2009). In human ductal breast epithelial cell line, T47D, cyclin A2/Cdk2 was proved to phosphorylate NCOA1 and thus increase NCOA1/PR interaction and PR activity. Cyclin A2/Cdk2 as well as Cdk1 was further showed to phosphorylate seventeen sites in NCOA1 protein (Moore and Weigel, 2011). In vivo animal model studies have also proved the function of NCOA1 in breast tumorigenesis. Importantly, in vivo NCOA1 knockdown was showed to cause reduction in expression of ERBB2, activation of Akt, inhibition of colony stimulating factor 1 ( CSF1) and prevention of macrophage recruitment to the tumor environment (Wang et al., 2009). Metastasis-focused study in mice figured out that NCOA1, together with FOS, up-regulated macrophage attractant CSF1 and increased macrophage recruitment, and metastasis (Qin et al., 2014). In a study conducted by Qin et al. NCOA1 was determined to up-regulate VEGFA by associating with FOS and HIF1α, potentiating angiogenesis in breast cancer mice models (Qin et al., 2015). Wang et al. proposed cardiac glycoside bufalin as an inhibitor of both SRC-3 and NCOA1, and showed that bufalin treatment decreased tumor growth in a mouse xenograft model of breast cancer (Wang et al., 2014).
  
  
Entity Prostate Cancer
Note The expression profile of NCOA1 was not high in human tumors in general (Maki et al., 2006). Still, some studies proposed the expression of NCOA1 was correlated with tumor grade (Agoulnik et al., 2005; Gregory et al., 2001; Fujimoto et al., 2001). In one study, NCOA1 was shown to be more located to nucleus in androgen-independent prostate tumors (Maki et al., 2006). NCOA1 was demonstrated to increase AR-dependent cell proliferation in prostate cancer cell lines. Thus, NCOA1 knockdown was parallel to inhibition of proliferation in androgen-dependent prostate cancer cell lines, LNCaP and C4-2 while it did not affect the proliferation of AR-negative prostate cancer cell lines, PC-3 and DU145 (Agoulnik et al., 2005). This effect was further characterized by Luef et al. and proved that the effect was a result of upregulation of protein kinase D1 ( PRKD1) which was negatively regulated by AR. They also showed that the expression of NCOA1 was high in patients with prostate cancer (Luef et al., 2016). Overall, NCOA1 supports prostate carcinogenesis in an androgen-dependent and -independent manner (Xu et al., 2009). However, in vivo murine studies have showed that NCOA1 did not affect the prostate cancer tumorigenesis while other SRC family member, SRC-3 was critically affected (Tien et al., 2006).
  
  
Entity Endometrial Cancer
Note NCOA1 phosporylation was demonstrated to significantly enhance agonistic activity of tamoxifen in endometrial cancer, pointing a possible function of NCOA1 in tamoxifen-induced proliferation and enhancement in risk of endometrial cancer via tamoxifen therapy (Shang and Brown, 2002; Shah and Rowan, 2005).
  
  
Entity Hepatoma
Note NCOA1 together with PPARGC1A (PGC1α) was proved to be down-regulated in hepatoma cell line, HepG2 where it critically coactivates hepatocyte nuclear factor 4α ( HNF4A) which is fundamental for liver development and hepatic gene expression. Overexpression of both NCOA1 and PCG1α increase the expression of HNF4α-regulated genes and triggered differentiation of HepG2 cells (Martinez-Himenez et al., 2006). Ma et al. showed thatMIR105-1 targeted NCOA1 in hepatocellular carcinoma. They checked the expression levels of miR-105-1 and demonstrated that it was down-regulated in samples from patients with hepatocellular carcinoma compared to those of normal individuals. Moreover, down-regulation of miR-105-1 and up-regulation of NCOA1, as a result, were correlated with shorter overall survival (OS) and progression free survival (PFS) in hepatocellular carcinoma (Ma et al., 2017).
  
  
Entity Colon cancer
Note In colorectal cancer-derived cell lines, DLD-1, HT29 and HCT116, leptin and insulin signaling, via ERK1/2, were showed to increase MIR4443 targeting and down-regulating both TRAF4 and NCOA1. Down-regulation of TRAF4 and NCOA1 was illustrated to suppress invasion and proliferation of these cell lines (Meerson and Yehuda, 2016).
  
  
Entity Cervical cancer
Note In cervical cancer cell line, HeLa overexpressing HPV16 E7, this epitope has been shown to relocalize NCOA1 into cytoplasm and decrease NCOA1-dependent transcription via disrupting association with HAT (Baldwin et al., 2006).
  
  
Entity Myeloma
Note In a cohort study with multiple myeloma patients in China, single nucleotide polymorphism in NCOA1 gene (rs7948087) was shown to strongly associate with multiple myeloma phenotype, pointing NCOA1 as a susceptibility gene for multiple myeloma patients in Chinese Han population (Peng et al., 2017).
  
  
Entity Head and neck squamous cell carcinoma
Note In a clinical study, Pavon et al. showed that expression of NCOA1 and creatine kinase mitochondrial 1(CKMT1) had prognostic significance in advanced-stage head and neck carcinoma (Pavon et al., 2015).
  
  
Entity Sarcoma
Note Rhabdomyosarcoma is a soft sarcoma and is able to subclassified in to two groups: embryonal rhabdomyosarcoma ID: 5193> and alveolar rhabdomyosarcoma. In a microarray-based study, a novel translocation t(2;2)(q35;p23) causing a fusion PAX3/NCOA1 protein (Wachtel et al., 2004). In another study, in biphenotypic sinonasal sarcoma cases where t(2;4)(q36;q31) PAX3/ MAML3 fusion has already been known, novel PAX3/NCOA1 fusion has been demonstrated via inv(2)(q35p23). These cases were underlined to display desmin reactivity and a small component of rhabdomyoblastic cells (Huang et al., 2016).
  
  
Entity Endometriosis
Note Endometriosis (EMS; ectopic endometrium) is an estrogen-dependent and inflammatory complex disease where immunological factors and angiogenesis play a pivotal role in its pathogenesis (Gazvani and Templeton, 2006; Rizner 2009). Shi et al. showed that the expression of NCOA1 was greater in ectopic endometrium than that of normal endometrium, and NCOA1 was involved in the expression of stromal cell-derived factor 1 (SCDF1/CXCL12) whose expression was induced by estradiol (Shi et al., 2014).
  
  
Entity Obesity
Note NCOA1 together with p/CIP was demonstrated to control insulin signaling in vitro and in vivo. Knockout of these genes resulted in increase in glucose uptake and insulin sensitivity in both regular chow- and high fat diet-fed mice. Moreover, knockouts also brought about resistance to age-related obesity and glucose intolerance through increase in the levels of insulin receptor substrate 1 ( IRS1; Wang et al., 2012).
  
  
Entity Inflammation
Note Isoflavone biochanin A treatment of thymoma cell line, EL4 increased the levels ofIL7 which was linked to autoimmunity, chronic inflammation and protection against infections. This function of Biochanin A was proved to be a result of enhanced interaction between retinoic acid receptor-related orphan receptor RORC and NCOA1 via phosphorylation of signal transducer and activator of transcription 3 (STAT3; Takahashi et al., 2017).
  
  
Entity Kawasaki disease
Note Kawasaki disease is a self-limited, acute and systemic vasculitis. Chen et al. showed that four SNPs (rs11894248, rs17791703, rs7572475 and rs9309308) in NCOA1 were associated with Kawasaki disease in 327 Taiwanese people (Chen et al., 2014).
  

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Regulation of progesterone receptor activity by cyclin dependent kinases 1 and 2 occurs in part by phosphorylation of the SRC-1 carboxyl-terminus
Moore NL, Weigel NL
Int J Biochem Cell Biol 2011 Aug;43(8):1157-67
PMID 21550420
 
Steroid receptor coactivator 1 is an integrator of glucose and NAD+/NADH homeostasis
Motamed M, Rajapakshe KI, Hartig SM, Coarfa C, Moses RE, Lonard DM, O'Malley BW
Mol Endocrinol 2014 Mar;28(3):395-405
PMID 24438340
 
Inverse relationship between ER-beta and SRC-1 predicts outcome in endocrine-resistant breast cancer
Myers E, Fleming FJ, Crotty TB, Kelly G, McDermott EW, O'higgins NJ, Hill AD, Young LS
Br J Cancer 2004 Nov 1;91(9):1687-93
PMID 15477868
 
Sequence and characterization of a coactivator for the steroid hormone receptor superfamily
Oñate SA, Tsai SY, Tsai MJ, O'Malley BW
Science 1995 Nov 24;270(5240):1354-7
PMID 7481822
 
CKMT1 and NCOA1 expression as a predictor of clinical outcome in patients with advanced-stage head and neck squamous cell carcinoma
Pavón MA, Parreño M, Téllez-Gabriel M, León X, Arroyo-Solera I, López M, Céspedes MV, Casanova I, Gallardo A, López-Pousa A, Mangues MA, Quer M, Barnadas A, Mangues R
Head Neck 2016 Apr;38 Suppl 1:E1392-403
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NCOA1 is a novel susceptibility gene for multiple myeloma in the Chinese population: A case-control study
Peng M, Zhao G, Yang F, Cheng G, Huang J, Qin X, Liu Y, Wang Q, Li Y, Qin D
PLoS One 2017 Mar 6;12(3):e0173298
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The steroid receptor coactivator-1 regulates twist expression and promotes breast cancer metastasis
Qin L, Liu Z, Chen H, Xu J
Cancer Res 2009 May 1;69(9):3819-27
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NCOA1 Directly Targets M-CSF1 Expression to Promote Breast Cancer Metastasis
Qin L, Wu YL, Toneff MJ, Li D, Liao L, Gao X, Bane FT, Tien JC, Xu Y, Feng Z, Yang Z, Xu Y, Theissen SM, Li Y, Young L, Xu J
Cancer Res 2014 Jul 1;74(13):3477-88
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NCOA1 promotes angiogenesis in breast tumors by simultaneously enhancing both HIF1α- and AP-1-mediated VEGFa transcription
Qin L, Xu Y, Xu Y, Ma G, Liao L, Wu Y, Li Y, Wang X, Wang X, Jiang J, Wang J, Xu J
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Coassociation of estrogen receptor and p160 proteins predicts resistance to endocrine treatment; SRC-1 is an independent predictor of breast cancer recurrence
Redmond AM, Bane FT, Stafford AT, McIlroy M, Dillon MF, Crotty TB, Hill AD, Young LS
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Estrogen metabolism and action in endometriosis
Rizner TL
Mol Cell Endocrinol 2009 Aug 13;307(1-2):8-18
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8-Bromo-cyclic AMP induces phosphorylation of two sites in SRC-1 that facilitate ligand-independent activation of the chicken progesterone receptor and are critical for functional cooperation between SRC-1 and CREB binding protein
Rowan BG, Garrison N, Weigel NL, O'Malley BW
Mol Cell Biol 2000 Dec;20(23):8720-30
PMID 11073973
 
Phosphorylation of steroid receptor coactivator-1
Rowan BG, Weigel NL, O'Malley BW
Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway J Biol Chem
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The Src kinase pathway promotes tamoxifen agonist action in Ishikawa endometrial cells through phosphorylation-dependent stabilization of estrogen receptor (alpha) promoter interaction and elevated steroid receptor coactivator 1 activity
Shah YM, Rowan BG
Mol Endocrinol 2005 Mar;19(3):732-48
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Molecular determinants for the tissue specificity of SERMs
Shang Y, Brown M
Science 2002 Mar 29;295(5564):2465-8
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The role of SRC1 and SRC2 in steroid-induced SDF1 expression in normal and ectopic endometrium
Shi X, Xu W, Dai HH, Sun Y, Wang XL
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Biochem Biophys Res Commun 2000 Jan 7;267(1):311-6
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Biochanin A enhances RORγ activity through STAT3-mediated recruitment of NCOA1
Takahashi M, Muromoto R, Kojima H, Takeuchi S, Kitai Y, Kashiwakura JI, Matsuda T
Biochem Biophys Res Commun 2017 Aug 5;489(4):503-508
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Tien JC, Zhou S, Xu J
Int J Biol Sci 2009;5(3):256-64
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J Biol Chem 2002 Oct 11;277(41):38087-94
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MUC1 oncoprotein stabilizes and activates estrogen receptor alpha
Wei X, Xu H, Kufe D
Mol Cell 2006 Jan 20;21(2):295-305
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Mice deficient in the steroid receptor co-activator 1 (SRC-1) are resistant to thyroid hormone
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Citation

This paper should be referenced as such :
Kazan HH, Gunduz U.
NCOA1 (Nuclear receptor coactivator 1);
Atlas Genet Cytogenet Oncol Haematol. in press
On line version : http://AtlasGeneticsOncology.org/Genes/NCOA1ID44097ch2p23.html


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 8 ]
  Soft Tissues: Alveolar rhabdomyosarcoma
Soft Tissues: Rhabdomyosarcoma
Soft tissue tumors: an overview
Soft Tissues: Alveolar rhabdomyosarcoma with t(2;2)(p23;q35) PAX3/NCOA1
RAB10/NCOA1 (2p23)
t(2;3)(p23;p14) NCOA1/MAGI1
t(2;3)(p23;q13) NCOA1/GOLGB1
t(2;5)(p23;q31) NCOA1/PSD2


External links

Nomenclature
HGNC (Hugo)NCOA1   7668
Cards
AtlasNCOA1ID44097ch2p23.txt
Entrez_Gene (NCBI)NCOA1  8648  nuclear receptor coactivator 1
AliasesF-SRC-1; KAT13A; RIP160; SRC1; 
bHLHe42; bHLHe74
GeneCards (Weizmann)NCOA1
Ensembl hg19 (Hinxton)ENSG00000084676 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000084676 [Gene_View]  ENSG00000084676 [Sequence]  chr2:24584477-24770701 [Contig_View]  NCOA1 [Vega]
ICGC DataPortalENSG00000084676
TCGA cBioPortalNCOA1
AceView (NCBI)NCOA1
Genatlas (Paris)NCOA1
WikiGenes8648
SOURCE (Princeton)NCOA1
Genetics Home Reference (NIH)NCOA1
Genomic and cartography
GoldenPath hg38 (UCSC)NCOA1  -     chr2:24584477-24770701 +  2p23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NCOA1  -     2p23.3   [Description]    (hg19-Feb_2009)
EnsemblNCOA1 - 2p23.3 [CytoView hg19]  NCOA1 - 2p23.3 [CytoView hg38]
Mapping of homologs : NCBINCOA1 [Mapview hg19]  NCOA1 [Mapview hg38]
OMIM602691   
Gene and transcription
Genbank (Entrez)AJ000881 AJ000882 AK226063 AK290019 BC035976
RefSeq transcript (Entrez)NM_001362950 NM_001362952 NM_001362954 NM_001362955 NM_003743 NM_147223 NM_147233
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NCOA1
Cluster EST : UnigeneHs.596314 [ NCBI ]
CGAP (NCI)Hs.596314
Alternative Splicing GalleryENSG00000084676
Gene ExpressionNCOA1 [ NCBI-GEO ]   NCOA1 [ EBI - ARRAY_EXPRESS ]   NCOA1 [ SEEK ]   NCOA1 [ MEM ]
Gene Expression Viewer (FireBrowse)NCOA1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8648
GTEX Portal (Tissue expression)NCOA1
Human Protein AtlasENSG00000084676-NCOA1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15788   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15788  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15788
Splice isoforms : SwissVarQ15788
Catalytic activity : Enzyme2.3.1.48 [ Enzyme-Expasy ]   2.3.1.482.3.1.48 [ IntEnz-EBI ]   2.3.1.48 [ BRENDA ]   2.3.1.48 [ KEGG ]   
PhosPhoSitePlusQ15788
Domaine pattern : Prosite (Expaxy)BHLH (PS50888)    PAS (PS50112)   
Domains : Interpro (EBI)bHLH_dom    DUF1518    HLH_DNA-bd_sf    NCOA1    Nuc_rcpt_coact    Nuc_rcpt_coact_Ncoa-typ    Nuc_rcpt_coact_Ncoa_int_sf    Nuclear_rcpt_coactivator    PAS    PAS-like_dom_sf    PAS_fold    SRC/p160_LXXLL   
Domain families : Pfam (Sanger)DUF1518 (PF07469)    HLH (PF00010)    Nuc_rec_co-act (PF08815)    PAS (PF00989)    SRC-1 (PF08832)   
Domain families : Pfam (NCBI)pfam07469    pfam00010    pfam08815    pfam00989    pfam08832   
Domain families : Smart (EMBL)DUF1518 (SM01151)  HLH (SM00353)  PAS (SM00091)  
Conserved Domain (NCBI)NCOA1
DMDM Disease mutations8648
Blocks (Seattle)NCOA1
PDB (SRS)1FM6    1FM9    1K4W    1K74    1K7L    1KV6    1N4H    1NQ7    1NRL    1P8D    1PZL    1RDT    1TFC    1U3R    1U3S    1X76    1X78    1X7B    1X7J    1XIU    1XV9    1XVP    1YY4    1YYE    1ZAF    2A3I    2C52    2FVJ    2GTK    2HBH    2HC4    2HCD    2HFP    2NPA    2NV7    2P54    2PRG    3BEJ    3BQD    3CTB    3CWD    3DCT    3DCU    3DR1    3ET1    3ET3    3FEI    3FEJ    3FUR    3FXV    3G8I    3G9E    3GYT    3GYU    3H0A    3HC5    3HC6    3HVL    3IPQ    3IPS    3IPU    3KMR    3LMP    3OKH    3OKI    3OLF    3OLL    3OLS    3OMK    3OMM    3OMO    3OMP    3OMQ    3OOF    3OOK    3P88    3P89    3QT0    3RUT    3RUU    3RVF    3S9S    3T03    3UU7    3UUA    3UUD    3V9Y    3VN2    4DK7    4DK8    4DM6    4DM8    4DQM    4F9M    4FGY    4G1D    4G1Y    4G1Z    4G20    4G21    4G2H    4HEE    4J5X    4JYG    4JYH    4JYI    4MG5    4MG6    4MG7    4MG8    4MG9    4MGA    4MGB    4MGC    4MGD    4RUJ    4RUP    4TUZ    4TV1    4UDA    4UDB    4Y29    5A86    5AVI    5AVL    5AZT    5DSH    5DV3    5DV6    5DV8    5DVC    5DWL    5E7V    5GTN    5GTO    5GTP    5HJS    5JI0    5JMM    5L7E    5L7G    5L7H    5MX7    5NKY    5NMA    5NMB    5NWM    5OW7    5OW9    5OWD    5Q0J    5Q0K    5Q0L    5Q0M    5Q0N    5Q0O    5Q0P    5Q0Q    5Q0R    5Q0S    5Q0T    5Q0U    5Q0V    5Q0W    5Q0X    5Q0Y    5Q0Z    5Q10    5Q11    5Q12    5Q13    5Q14    5Q15    5Q16    5Q18    5Q19    5Q1A    5Q1B    5Q1C    5Q1D    5Q1E    5Q1F    5Q1G    5Q1H    5Q1I    5X0R    5X8U    5X8W    6BNS   
PDB (PDBSum)1FM6    1FM9    1K4W    1K74    1K7L    1KV6    1N4H    1NQ7    1NRL    1P8D    1PZL    1RDT    1TFC    1U3R    1U3S    1X76    1X78    1X7B    1X7J    1XIU    1XV9    1XVP    1YY4    1YYE    1ZAF    2A3I    2C52    2FVJ    2GTK    2HBH    2HC4    2HCD    2HFP    2NPA    2NV7    2P54    2PRG    3BEJ    3BQD    3CTB    3CWD    3DCT    3DCU    3DR1    3ET1    3ET3    3FEI    3FEJ    3FUR    3FXV    3G8I    3G9E    3GYT    3GYU    3H0A    3HC5    3HC6    3HVL    3IPQ    3IPS    3IPU    3KMR    3LMP    3OKH    3OKI    3OLF    3OLL    3OLS    3OMK    3OMM    3OMO    3OMP    3OMQ    3OOF    3OOK    3P88    3P89    3QT0    3RUT    3RUU    3RVF    3S9S    3T03    3UU7    3UUA    3UUD    3V9Y    3VN2    4DK7    4DK8    4DM6    4DM8    4DQM    4F9M    4FGY    4G1D    4G1Y    4G1Z    4G20    4G21    4G2H    4HEE    4J5X    4JYG    4JYH    4JYI    4MG5    4MG6    4MG7    4MG8    4MG9    4MGA    4MGB    4MGC    4MGD    4RUJ    4RUP    4TUZ    4TV1    4UDA    4UDB    4Y29    5A86    5AVI    5AVL    5AZT    5DSH    5DV3    5DV6    5DV8    5DVC    5DWL    5E7V    5GTN    5GTO    5GTP    5HJS    5JI0    5JMM    5L7E    5L7G    5L7H    5MX7    5NKY    5NMA    5NMB    5NWM    5OW7    5OW9    5OWD    5Q0J    5Q0K    5Q0L    5Q0M    5Q0N    5Q0O    5Q0P    5Q0Q    5Q0R    5Q0S    5Q0T    5Q0U    5Q0V    5Q0W    5Q0X    5Q0Y    5Q0Z    5Q10    5Q11    5Q12    5Q13    5Q14    5Q15    5Q16    5Q18    5Q19    5Q1A    5Q1B    5Q1C    5Q1D    5Q1E    5Q1F    5Q1G    5Q1H    5Q1I    5X0R    5X8U    5X8W    6BNS   
PDB (IMB)1FM6    1FM9    1K4W    1K74    1K7L    1KV6    1N4H    1NQ7    1NRL    1P8D    1PZL    1RDT    1TFC    1U3R    1U3S    1X76    1X78    1X7B    1X7J    1XIU    1XV9    1XVP    1YY4    1YYE    1ZAF    2A3I    2C52    2FVJ    2GTK    2HBH    2HC4    2HCD    2HFP    2NPA    2NV7    2P54    2PRG    3BEJ    3BQD    3CTB    3CWD    3DCT    3DCU    3DR1    3ET1    3ET3    3FEI    3FEJ    3FUR    3FXV    3G8I    3G9E    3GYT    3GYU    3H0A    3HC5    3HC6    3HVL    3IPQ    3IPS    3IPU    3KMR    3LMP    3OKH    3OKI    3OLF    3OLL    3OLS    3OMK    3OMM    3OMO    3OMP    3OMQ    3OOF    3OOK    3P88    3P89    3QT0    3RUT    3RUU    3RVF    3S9S    3T03    3UU7    3UUA    3UUD    3V9Y    3VN2    4DK7    4DK8    4DM6    4DM8    4DQM    4F9M    4FGY    4G1D    4G1Y    4G1Z    4G20    4G21    4G2H    4HEE    4J5X    4JYG    4JYH    4JYI    4MG5    4MG6    4MG7    4MG8    4MG9    4MGA    4MGB    4MGC    4MGD    4RUJ    4RUP    4TUZ    4TV1    4UDA    4UDB    4Y29    5A86    5AVI    5AVL    5AZT    5DSH    5DV3    5DV6    5DV8    5DVC    5DWL    5E7V    5GTN    5GTO    5GTP    5HJS    5JI0    5JMM    5L7E    5L7G    5L7H    5MX7    5NKY    5NMA    5NMB    5NWM    5OW7    5OW9    5OWD    5Q0J    5Q0K    5Q0L    5Q0M    5Q0N    5Q0O    5Q0P    5Q0Q    5Q0R    5Q0S    5Q0T    5Q0U    5Q0V    5Q0W    5Q0X    5Q0Y    5Q0Z    5Q10    5Q11    5Q12    5Q13    5Q14    5Q15    5Q16    5Q18    5Q19    5Q1A    5Q1B    5Q1C    5Q1D    5Q1E    5Q1F    5Q1G    5Q1H    5Q1I    5X0R    5X8U    5X8W    6BNS   
PDB (RSDB)1FM6    1FM9    1K4W    1K74    1K7L    1KV6    1N4H    1NQ7    1NRL    1P8D    1PZL    1RDT    1TFC    1U3R    1U3S    1X76    1X78    1X7B    1X7J    1XIU    1XV9    1XVP    1YY4    1YYE    1ZAF    2A3I    2C52    2FVJ    2GTK    2HBH    2HC4    2HCD    2HFP    2NPA    2NV7    2P54    2PRG    3BEJ    3BQD    3CTB    3CWD    3DCT    3DCU    3DR1    3ET1    3ET3    3FEI    3FEJ    3FUR    3FXV    3G8I    3G9E    3GYT    3GYU    3H0A    3HC5    3HC6    3HVL    3IPQ    3IPS    3IPU    3KMR    3LMP    3OKH    3OKI    3OLF    3OLL    3OLS    3OMK    3OMM    3OMO    3OMP    3OMQ    3OOF    3OOK    3P88    3P89    3QT0    3RUT    3RUU    3RVF    3S9S    3T03    3UU7    3UUA    3UUD    3V9Y    3VN2    4DK7    4DK8    4DM6    4DM8    4DQM    4F9M    4FGY    4G1D    4G1Y    4G1Z    4G20    4G21    4G2H    4HEE    4J5X    4JYG    4JYH    4JYI    4MG5    4MG6    4MG7    4MG8    4MG9    4MGA    4MGB    4MGC    4MGD    4RUJ    4RUP    4TUZ    4TV1    4UDA    4UDB    4Y29    5A86    5AVI    5AVL    5AZT    5DSH    5DV3    5DV6    5DV8    5DVC    5DWL    5E7V    5GTN    5GTO    5GTP    5HJS    5JI0    5JMM    5L7E    5L7G    5L7H    5MX7    5NKY    5NMA    5NMB    5NWM    5OW7    5OW9    5OWD    5Q0J    5Q0K    5Q0L    5Q0M    5Q0N    5Q0O    5Q0P    5Q0Q    5Q0R    5Q0S    5Q0T    5Q0U    5Q0V    5Q0W    5Q0X    5Q0Y    5Q0Z    5Q10    5Q11    5Q12    5Q13    5Q14    5Q15    5Q16    5Q18    5Q19    5Q1A    5Q1B    5Q1C    5Q1D    5Q1E    5Q1F    5Q1G    5Q1H    5Q1I    5X0R    5X8U    5X8W    6BNS   
Structural Biology KnowledgeBase1FM6    1FM9    1K4W    1K74    1K7L    1KV6    1N4H    1NQ7    1NRL    1P8D    1PZL    1RDT    1TFC    1U3R    1U3S    1X76    1X78    1X7B    1X7J    1XIU    1XV9    1XVP    1YY4    1YYE    1ZAF    2A3I    2C52    2FVJ    2GTK    2HBH    2HC4    2HCD    2HFP    2NPA    2NV7    2P54    2PRG    3BEJ    3BQD    3CTB    3CWD    3DCT    3DCU    3DR1    3ET1    3ET3    3FEI    3FEJ    3FUR    3FXV    3G8I    3G9E    3GYT    3GYU    3H0A    3HC5    3HC6    3HVL    3IPQ    3IPS    3IPU    3KMR    3LMP    3OKH    3OKI    3OLF    3OLL    3OLS    3OMK    3OMM    3OMO    3OMP    3OMQ    3OOF    3OOK    3P88    3P89    3QT0    3RUT    3RUU    3RVF    3S9S    3T03    3UU7    3UUA    3UUD    3V9Y    3VN2    4DK7    4DK8    4DM6    4DM8    4DQM    4F9M    4FGY    4G1D    4G1Y    4G1Z    4G20    4G21    4G2H    4HEE    4J5X    4JYG    4JYH    4JYI    4MG5    4MG6    4MG7    4MG8    4MG9    4MGA    4MGB    4MGC    4MGD    4RUJ    4RUP    4TUZ    4TV1    4UDA    4UDB    4Y29    5A86    5AVI    5AVL    5AZT    5DSH    5DV3    5DV6    5DV8    5DVC    5DWL    5E7V    5GTN    5GTO    5GTP    5HJS    5JI0    5JMM    5L7E    5L7G    5L7H    5MX7    5NKY    5NMA    5NMB    5NWM    5OW7    5OW9    5OWD    5Q0J    5Q0K    5Q0L    5Q0M    5Q0N    5Q0O    5Q0P    5Q0Q    5Q0R    5Q0S    5Q0T    5Q0U    5Q0V    5Q0W    5Q0X    5Q0Y    5Q0Z    5Q10    5Q11    5Q12    5Q13    5Q14    5Q15    5Q16    5Q18    5Q19    5Q1A    5Q1B    5Q1C    5Q1D    5Q1E    5Q1F    5Q1G    5Q1H    5Q1I    5X0R    5X8U    5X8W    6BNS   
SCOP (Structural Classification of Proteins)1FM6    1FM9    1K4W    1K74    1K7L    1KV6    1N4H    1NQ7    1NRL    1P8D    1PZL    1RDT    1TFC    1U3R    1U3S    1X76    1X78    1X7B    1X7J    1XIU    1XV9    1XVP    1YY4    1YYE    1ZAF    2A3I    2C52    2FVJ    2GTK    2HBH    2HC4    2HCD    2HFP    2NPA    2NV7    2P54    2PRG    3BEJ    3BQD    3CTB    3CWD    3DCT    3DCU    3DR1    3ET1    3ET3    3FEI    3FEJ    3FUR    3FXV    3G8I    3G9E    3GYT    3GYU    3H0A    3HC5    3HC6    3HVL    3IPQ    3IPS    3IPU    3KMR    3LMP    3OKH    3OKI    3OLF    3OLL    3OLS    3OMK    3OMM    3OMO    3OMP    3OMQ    3OOF    3OOK    3P88    3P89    3QT0    3RUT    3RUU    3RVF    3S9S    3T03    3UU7    3UUA    3UUD    3V9Y    3VN2    4DK7    4DK8    4DM6    4DM8    4DQM    4F9M    4FGY    4G1D    4G1Y    4G1Z    4G20    4G21    4G2H    4HEE    4J5X    4JYG    4JYH    4JYI    4MG5    4MG6    4MG7    4MG8    4MG9    4MGA    4MGB    4MGC    4MGD    4RUJ    4RUP    4TUZ    4TV1    4UDA    4UDB    4Y29    5A86    5AVI    5AVL    5AZT    5DSH    5DV3    5DV6    5DV8    5DVC    5DWL    5E7V    5GTN    5GTO    5GTP    5HJS    5JI0    5JMM    5L7E    5L7G    5L7H    5MX7    5NKY    5NMA    5NMB    5NWM    5OW7    5OW9    5OWD    5Q0J    5Q0K    5Q0L    5Q0M    5Q0N    5Q0O    5Q0P    5Q0Q    5Q0R    5Q0S    5Q0T    5Q0U    5Q0V    5Q0W    5Q0X    5Q0Y    5Q0Z    5Q10    5Q11    5Q12    5Q13    5Q14    5Q15    5Q16    5Q18    5Q19    5Q1A    5Q1B    5Q1C    5Q1D    5Q1E    5Q1F    5Q1G    5Q1H    5Q1I    5X0R    5X8U    5X8W    6BNS   
CATH (Classification of proteins structures)1FM6    1FM9    1K4W    1K74    1K7L    1KV6    1N4H    1NQ7    1NRL    1P8D    1PZL    1RDT    1TFC    1U3R    1U3S    1X76    1X78    1X7B    1X7J    1XIU    1XV9    1XVP    1YY4    1YYE    1ZAF    2A3I    2C52    2FVJ    2GTK    2HBH    2HC4    2HCD    2HFP    2NPA    2NV7    2P54    2PRG    3BEJ    3BQD    3CTB    3CWD    3DCT    3DCU    3DR1    3ET1    3ET3    3FEI    3FEJ    3FUR    3FXV    3G8I    3G9E    3GYT    3GYU    3H0A    3HC5    3HC6    3HVL    3IPQ    3IPS    3IPU    3KMR    3LMP    3OKH    3OKI    3OLF    3OLL    3OLS    3OMK    3OMM    3OMO    3OMP    3OMQ    3OOF    3OOK    3P88    3P89    3QT0    3RUT    3RUU    3RVF    3S9S    3T03    3UU7    3UUA    3UUD    3V9Y    3VN2    4DK7    4DK8    4DM6    4DM8    4DQM    4F9M    4FGY    4G1D    4G1Y    4G1Z    4G20    4G21    4G2H    4HEE    4J5X    4JYG    4JYH    4JYI    4MG5    4MG6    4MG7    4MG8    4MG9    4MGA    4MGB    4MGC    4MGD    4RUJ    4RUP    4TUZ    4TV1    4UDA    4UDB    4Y29    5A86    5AVI    5AVL    5AZT    5DSH    5DV3    5DV6    5DV8    5DVC    5DWL    5E7V    5GTN    5GTO    5GTP    5HJS    5JI0    5JMM    5L7E    5L7G    5L7H    5MX7    5NKY    5NMA    5NMB    5NWM    5OW7    5OW9    5OWD    5Q0J    5Q0K    5Q0L    5Q0M    5Q0N    5Q0O    5Q0P    5Q0Q    5Q0R    5Q0S    5Q0T    5Q0U    5Q0V    5Q0W    5Q0X    5Q0Y    5Q0Z    5Q10    5Q11    5Q12    5Q13    5Q14    5Q15    5Q16    5Q18    5Q19    5Q1A    5Q1B    5Q1C    5Q1D    5Q1E    5Q1F    5Q1G    5Q1H    5Q1I    5X0R    5X8U    5X8W    6BNS   
SuperfamilyQ15788
Human Protein Atlas [tissue]ENSG00000084676-NCOA1 [tissue]
Peptide AtlasQ15788
HPRD04070
IPIIPI00470490   IPI00470492   IPI00470491   IPI00892959   
Protein Interaction databases
DIP (DOE-UCLA)Q15788
IntAct (EBI)Q15788
FunCoupENSG00000084676
BioGRIDNCOA1
STRING (EMBL)NCOA1
ZODIACNCOA1
Ontologies - Pathways
QuickGOQ15788
Ontology : AmiGOpositive regulation of transcription from RNA polymerase II promoter by galactose  nuclear chromatin  RNA polymerase II transcription factor activity, sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  regulation of thyroid hormone mediated signaling pathway  DNA binding  chromatin binding  transcription coactivator activity  transcription coactivator activity  histone acetyltransferase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytosol  plasma membrane  transcription, DNA-templated  bile acid and bile salt transport  nuclear receptor binding  nuclear receptor binding  aryl hydrocarbon receptor binding  regulation of lipid metabolic process  enzyme binding  estrogen receptor binding  nuclear receptor transcription coactivator activity  nuclear receptor transcription coactivator activity  androgen receptor signaling pathway  cellular response to hormone stimulus  protein-containing complex  nuclear hormone receptor binding  nuclear hormone receptor binding  positive regulation of apoptotic process  histone H4 acetylation  positive regulation of neuron differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  protein dimerization activity  protein N-terminus binding  androgen receptor binding  labyrinthine layer morphogenesis  cellular response to Thyroglobulin triiodothyronine  regulation of cellular response to drug  
Ontology : EGO-EBIpositive regulation of transcription from RNA polymerase II promoter by galactose  nuclear chromatin  RNA polymerase II transcription factor activity, sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  regulation of thyroid hormone mediated signaling pathway  DNA binding  chromatin binding  transcription coactivator activity  transcription coactivator activity  histone acetyltransferase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytosol  plasma membrane  transcription, DNA-templated  bile acid and bile salt transport  nuclear receptor binding  nuclear receptor binding  aryl hydrocarbon receptor binding  regulation of lipid metabolic process  enzyme binding  estrogen receptor binding  nuclear receptor transcription coactivator activity  nuclear receptor transcription coactivator activity  androgen receptor signaling pathway  cellular response to hormone stimulus  protein-containing complex  nuclear hormone receptor binding  nuclear hormone receptor binding  positive regulation of apoptotic process  histone H4 acetylation  positive regulation of neuron differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  protein dimerization activity  protein N-terminus binding  androgen receptor binding  labyrinthine layer morphogenesis  cellular response to Thyroglobulin triiodothyronine  regulation of cellular response to drug  
Pathways : KEGGThyroid hormone signaling pathway   
REACTOMEQ15788 [protein]
REACTOME PathwaysR-HSA-8951671 [pathway]   
NDEx NetworkNCOA1
Atlas of Cancer Signalling NetworkNCOA1
Wikipedia pathwaysNCOA1
Orthology - Evolution
OrthoDB8648
GeneTree (enSembl)ENSG00000084676
Phylogenetic Trees/Animal Genes : TreeFamNCOA1
HOVERGENQ15788
HOGENOMQ15788
Homologs : HomoloGeneNCOA1
Homology/Alignments : Family Browser (UCSC)NCOA1
Gene fusions - Rearrangements
Fusion : MitelmanNCOA1/GOLGB1 [2p23.3/3q13.33]  
Fusion : MitelmanNCOA1/MAGI1 [2p23.3/3p14.1]  [t(2;3)(p23;p14)]  
Fusion : MitelmanNCOA1/PSD2 [2p23.3/5q31.2]  [t(2;5)(p23;q31)]  
Fusion : MitelmanPAX3/NCOA1 [2q36.1/2p23.3]  [t(2;2)(p23;q36)]  
Fusion : MitelmanRAB10/NCOA1 [2p23.3/2p23.3]  [t(2;2)(p23;p23)]  
Fusion : COSMICPAX3 [NCOA1]  -  1042 [1043]  [fusion_289]  [fusion_290]  
Fusion PortalNCOA1 2p23.3 GOLGB1 3q13.33 BRCA
Fusion PortalNCOA1 2p23.3 PSD2 5q31.2 BRCA
Fusion PortalRAB10 2p23.3 NCOA1 2p23.3 BRCA
Fusion : TICdbPAX3 [2q36.1]  -  NCOA1 [2p23.3]
Fusion : QuiverNCOA1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNCOA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NCOA1
dbVarNCOA1
ClinVarNCOA1
1000_GenomesNCOA1 
Exome Variant ServerNCOA1
ExAC (Exome Aggregation Consortium)ENSG00000084676
GNOMAD BrowserENSG00000084676
Varsome BrowserNCOA1
Genetic variants : HAPMAP8648
Genomic Variants (DGV)NCOA1 [DGVbeta]
DECIPHERNCOA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNCOA1 
Mutations
ICGC Data PortalNCOA1 
TCGA Data PortalNCOA1 
Broad Tumor PortalNCOA1
OASIS PortalNCOA1 [ Somatic mutations - Copy number]
Cancer Gene: CensusNCOA1 
Somatic Mutations in Cancer : COSMICNCOA1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNCOA1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NCOA1
DgiDB (Drug Gene Interaction Database)NCOA1
DoCM (Curated mutations)NCOA1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NCOA1 (select a term)
intoGenNCOA1
NCG5 (London)NCOA1
Cancer3DNCOA1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602691   
Orphanet
DisGeNETNCOA1
MedgenNCOA1
Genetic Testing Registry NCOA1
NextProtQ15788 [Medical]
TSGene8648
GENETestsNCOA1
Target ValidationNCOA1
Huge Navigator NCOA1 [HugePedia]
snp3D : Map Gene to Disease8648
BioCentury BCIQNCOA1
ClinGenNCOA1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8648
Chemical/Pharm GKB GenePA31470
Clinical trialNCOA1
Miscellaneous
canSAR (ICR)NCOA1 (select the gene name)
Probes
Litterature
PubMed299 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNCOA1
EVEXNCOA1
GoPubMedNCOA1
iHOPNCOA1
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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