Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NCOA1 (nuclear receptor coactivator 1)

Identity

Alias_symbol (synonym)SRC1
F-SRC-1
NCoA-1
KAT13A
RIP160
bHLHe74
Other aliasbHLHe42
HGNC (Hugo) NCOA1
LocusID (NCBI) 8648
Atlas_Id 44097
Location 2p23.3  [Link to chromosome band 2p23]
Location_base_pair Starts at 24584477 and ends at 24770701 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NCOA1 (2p23.3) / GOLGB1 (3q13.33)NCOA1 (2p23.3) / MAGI1 (3p14.1)NCOA1 (2p23.3) / NCOA1 (2p23.3)
NCOA1 (2p23.3) / NOVA1 (14q12)NCOA1 (2p23.3) / PAX3 (2q36.1)NCOA1 (2p23.3) / PSD2 (5q31.2)
NCOA1 (2p23.3) / SPTBN1 (2p16.2)PAX3 (2q36.1) / NCOA1 (2p23.3)PCGF3 (4p16.3) / NCOA1 (2p23.3)
RAB10 (2p23.3) / NCOA1 (2p23.3)PAX3 2q36.1 / NCOA1 2p23.3NCOA1 2p23.3 / GOLGB1 3q13.33
NCOA1 2p23.3 / PSD2 5q31.2RAB10 2p23.3 / NCOA1 2p23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  Soft Tissues: Alveolar rhabdomyosarcoma
Soft Tissues: Rhabdomyosarcoma
Soft tissue tumors: an overview
Soft Tissues: Alveolar rhabdomyosarcoma with t(2;2)(p23;q35) PAX3/NCOA1


External links

Nomenclature
HGNC (Hugo)NCOA1   7668
Cards
Entrez_Gene (NCBI)NCOA1  8648  nuclear receptor coactivator 1
AliasesF-SRC-1; KAT13A; RIP160; SRC1; 
bHLHe42; bHLHe74
GeneCards (Weizmann)NCOA1
Ensembl hg19 (Hinxton)ENSG00000084676 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000084676 [Gene_View]  chr2:24584477-24770701 [Contig_View]  NCOA1 [Vega]
ICGC DataPortalENSG00000084676
TCGA cBioPortalNCOA1
AceView (NCBI)NCOA1
Genatlas (Paris)NCOA1
WikiGenes8648
SOURCE (Princeton)NCOA1
Genetics Home Reference (NIH)NCOA1
Genomic and cartography
GoldenPath hg38 (UCSC)NCOA1  -     chr2:24584477-24770701 +  2p23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NCOA1  -     2p23.3   [Description]    (hg19-Feb_2009)
EnsemblNCOA1 - 2p23.3 [CytoView hg19]  NCOA1 - 2p23.3 [CytoView hg38]
Mapping of homologs : NCBINCOA1 [Mapview hg19]  NCOA1 [Mapview hg38]
OMIM602691   
Gene and transcription
Genbank (Entrez)AJ000881 AJ000882 AK226063 AK290019 BC035976
RefSeq transcript (Entrez)NM_003743 NM_147223 NM_147233
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NCOA1
Cluster EST : UnigeneHs.596314 [ NCBI ]
CGAP (NCI)Hs.596314
Alternative Splicing GalleryENSG00000084676
Gene ExpressionNCOA1 [ NCBI-GEO ]   NCOA1 [ EBI - ARRAY_EXPRESS ]   NCOA1 [ SEEK ]   NCOA1 [ MEM ]
Gene Expression Viewer (FireBrowse)NCOA1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8648
GTEX Portal (Tissue expression)NCOA1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15788   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15788  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15788
Splice isoforms : SwissVarQ15788
Catalytic activity : Enzyme2.3.1.48 [ Enzyme-Expasy ]   2.3.1.482.3.1.48 [ IntEnz-EBI ]   2.3.1.48 [ BRENDA ]   2.3.1.48 [ KEGG ]   
PhosPhoSitePlusQ15788
Domaine pattern : Prosite (Expaxy)BHLH (PS50888)    PAS (PS50112)   
Domains : Interpro (EBI)bHLH_dom    DUF1518    NCOA1    Nuc_rcpt_coact    Nuc_rcpt_coact_Ncoa-typ    Nuclear_rcpt_coactivator    PAS    PAS_fold    SRC/p160_LXXLL   
Domain families : Pfam (Sanger)DUF1518 (PF07469)    HLH (PF00010)    Nuc_rec_co-act (PF08815)    PAS (PF00989)    SRC-1 (PF08832)   
Domain families : Pfam (NCBI)pfam07469    pfam00010    pfam08815    pfam00989    pfam08832   
Domain families : Smart (EMBL)DUF1518 (SM01151)  HLH (SM00353)  PAS (SM00091)  
Conserved Domain (NCBI)NCOA1
DMDM Disease mutations8648
Blocks (Seattle)NCOA1
PDB (SRS)###############################################################################################################################################################################################################################################################   
PDB (PDBSum)###############################################################################################################################################################################################################################################################   
PDB (IMB)###############################################################################################################################################################################################################################################################   
PDB (RSDB)###############################################################################################################################################################################################################################################################   
Structural Biology KnowledgeBase###############################################################################################################################################################################################################################################################   
SCOP (Structural Classification of Proteins)###############################################################################################################################################################################################################################################################   
CATH (Classification of proteins structures)###############################################################################################################################################################################################################################################################   
SuperfamilyQ15788
Human Protein AtlasENSG00000084676
Peptide AtlasQ15788
HPRD04070
IPIIPI00470490   IPI00470492   IPI00470491   IPI00892959   
Protein Interaction databases
DIP (DOE-UCLA)Q15788
IntAct (EBI)Q15788
FunCoupENSG00000084676
BioGRIDNCOA1
STRING (EMBL)NCOA1
ZODIACNCOA1
Ontologies - Pathways
QuickGOQ15788
Ontology : AmiGOpositive regulation of transcription from RNA polymerase II promoter by galactose  nuclear chromatin  RNA polymerase II regulatory region DNA binding  RNA polymerase II transcription coactivator activity  regulation of thyroid hormone mediated signaling pathway  chromatin binding  transcription coactivator activity  transcription coactivator activity  histone acetyltransferase activity  protein binding  nucleoplasm  nucleoplasm  cytosol  plasma membrane  transcription, DNA-templated  lactation  male gonad development  bile acid and bile salt transport  ligand-dependent nuclear receptor binding  aryl hydrocarbon receptor binding  enzyme binding  cerebellum development  hippocampus development  hypothalamus development  cerebral cortex development  estrogen receptor binding  ligand-dependent nuclear receptor transcription coactivator activity  androgen receptor signaling pathway  intracellular receptor signaling pathway  response to estradiol  protein complex binding  response to retinoic acid  response to progesterone  cellular response to hormone stimulus  progesterone receptor binding  nuclear hormone receptor binding  neuron projection  positive regulation of apoptotic process  protein complex  histone H4 acetylation  cellular lipid metabolic process  estrous cycle  positive regulation of neuron differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of female receptivity  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  retinoid X receptor binding  protein dimerization activity  protein N-terminus binding  androgen receptor binding  male mating behavior  labyrinthine layer morphogenesis  cellular response to Thyroglobulin triiodothyronine  regulation of cellular response to drug  
Ontology : EGO-EBIpositive regulation of transcription from RNA polymerase II promoter by galactose  nuclear chromatin  RNA polymerase II regulatory region DNA binding  RNA polymerase II transcription coactivator activity  regulation of thyroid hormone mediated signaling pathway  chromatin binding  transcription coactivator activity  transcription coactivator activity  histone acetyltransferase activity  protein binding  nucleoplasm  nucleoplasm  cytosol  plasma membrane  transcription, DNA-templated  lactation  male gonad development  bile acid and bile salt transport  ligand-dependent nuclear receptor binding  aryl hydrocarbon receptor binding  enzyme binding  cerebellum development  hippocampus development  hypothalamus development  cerebral cortex development  estrogen receptor binding  ligand-dependent nuclear receptor transcription coactivator activity  androgen receptor signaling pathway  intracellular receptor signaling pathway  response to estradiol  protein complex binding  response to retinoic acid  response to progesterone  cellular response to hormone stimulus  progesterone receptor binding  nuclear hormone receptor binding  neuron projection  positive regulation of apoptotic process  protein complex  histone H4 acetylation  cellular lipid metabolic process  estrous cycle  positive regulation of neuron differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of female receptivity  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  retinoid X receptor binding  protein dimerization activity  protein N-terminus binding  androgen receptor binding  male mating behavior  labyrinthine layer morphogenesis  cellular response to Thyroglobulin triiodothyronine  regulation of cellular response to drug  
Pathways : BIOCARTA [Genes]   
Pathways : KEGGThyroid hormone signaling pathway   
NDEx NetworkNCOA1
Atlas of Cancer Signalling NetworkNCOA1
Wikipedia pathwaysNCOA1
Orthology - Evolution
OrthoDB8648
GeneTree (enSembl)ENSG00000084676
Phylogenetic Trees/Animal Genes : TreeFamNCOA1
HOVERGENQ15788
HOGENOMQ15788
Homologs : HomoloGeneNCOA1
Homology/Alignments : Family Browser (UCSC)NCOA1
Gene fusions - Rearrangements
Fusion : MitelmanNCOA1/GOLGB1 [2p23.3/3q13.33]  
Fusion : MitelmanNCOA1/MAGI1 [2p23.3/3p14.1]  [t(2;3)(p23;p14)]  
Fusion : MitelmanNCOA1/PSD2 [2p23.3/5q31.2]  [t(2;5)(p23;q31)]  
Fusion : MitelmanPAX3/NCOA1 [2q36.1/2p23.3]  [t(2;2)(p23;q36)]  
Fusion : MitelmanRAB10/NCOA1 [2p23.3/2p23.3]  [t(2;2)(p23;p23)]  
Fusion: TCGANCOA1 2p23.3 GOLGB1 3q13.33 BRCA
Fusion: TCGANCOA1 2p23.3 PSD2 5q31.2 BRCA
Fusion: TCGARAB10 2p23.3 NCOA1 2p23.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNCOA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NCOA1
dbVarNCOA1
ClinVarNCOA1
1000_GenomesNCOA1 
Exome Variant ServerNCOA1
ExAC (Exome Aggregation Consortium)NCOA1 (select the gene name)
Genetic variants : HAPMAP8648
Genomic Variants (DGV)NCOA1 [DGVbeta]
DECIPHERNCOA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNCOA1 
Mutations
ICGC Data PortalNCOA1 
TCGA Data PortalNCOA1 
Broad Tumor PortalNCOA1
OASIS PortalNCOA1 [ Somatic mutations - Copy number]
Cancer Gene: CensusNCOA1 
Somatic Mutations in Cancer : COSMICNCOA1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNCOA1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NCOA1
DgiDB (Drug Gene Interaction Database)NCOA1
DoCM (Curated mutations)NCOA1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NCOA1 (select a term)
intoGenNCOA1
Cancer3DNCOA1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602691   
Orphanet
MedgenNCOA1
Genetic Testing Registry NCOA1
NextProtQ15788 [Medical]
TSGene8648
GENETestsNCOA1
Huge Navigator NCOA1 [HugePedia]
snp3D : Map Gene to Disease8648
BioCentury BCIQNCOA1
ClinGenNCOA1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8648
Chemical/Pharm GKB GenePA31470
Clinical trialNCOA1
Miscellaneous
canSAR (ICR)NCOA1 (select the gene name)
Probes
Litterature
PubMed283 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNCOA1
EVEXNCOA1
GoPubMedNCOA1
iHOPNCOA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:28:10 CEST 2017

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