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NCOA2 (nuclear receptor coactivator 2)

Identity

Other namesGRIP1
KAT13C
MGC138808
NCoA-2
SRC2
TIF2
bHLHe75
HGNC (Hugo) NCOA2
Location 8q13.3
Location_base_pair Starts at 71186821 and ends at 71478574 bp from pter ( according to hg18-March_2006)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)NCOA2   7669
Entrez_Gene (NCBI)NCOA2  10499  nuclear receptor coactivator 2
Cards
GeneCards (Weizmann)NCOA2
Ensembl (Hinxton)ENSG00000140396 [Gene_View]  NCOA2 [Vega]
AceView (NCBI)NCOA2
Genatlas (Paris)NCOA2
euGene (Indiana)10499
SOURCE (Stanford)NM_006540
Gene Expression (Array Express) ENSG00000140396
Genomic and cartography
GoldenPath (UCSC)NCOA2  -  8q13.3   chr8:71186821-71478574 -  8q13.3   [Description]    (hg18-March_2006)
EnsemblNCOA2 - 8q13.3 [CytoView]
Mapping of homologs : NCBINCOA2 [Mapview]
OMIM601993   
Gene and transcription
Gene : Genbank (Entrez)AK298528 AK308426 AW504723 BC092442 BC114383
Reference sequence (RefSeq transcript) :SRSNM_006540
Reference transcript : EntrezNM_006540
RefSeq genomic : SRSAC_000051 AC_000140 NC_000008 NT_008183 NW_001839132 NW_923929
RefSeq genomic : EntrezAC_000051 AC_000140 NC_000008 NT_008183 NW_001839132 NW_923929
Consensus coding sequences : CCDS NCBINCOA2
Cluster EST : UnigeneHs.446678 [ SRS ] Hs.446678 [ NCBI ]
Alternative Splicing : Fast-db (Paris)5964
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtQ15596 (SRS) Q15596 (Expasy) Q15596 (Uniprot)
With graphics : InterProQ15596
Splice isoforms : VarSplice FASTAQ15596(VarSplice FASTA)
Domaine pattern : Prosite (SRS)HLH (PS50888)    PAS (PS50112)   
Domain pattern : Prosite (Expaxy)HLH (PS50888)    PAS (PS50112)   
Domains : Interpro (SRS)DUF1518    HLH_DNA-bd_dom    HLH_DNA_bd    Nuc_rcpt_coact    Nuc_rcpt_coact_Ncoa-typ    Nuclear_rcpt_coactivator    PAC    PAS    PAS_fold    SRC-1   
Domains : Interpro (EBI)DUF1518    HLH_DNA-bd_dom    HLH_DNA_bd    Nuc_rcpt_coact    Nuc_rcpt_coact_Ncoa-typ    Nuclear_rcpt_coactivator    PAC    PAS    PAS_fold    SRC-1   
Related proteins : CluSTrQ15596
Domain families : Pfam SRSDUF1518 (PF07469)    Nuc_rec_co-act (PF08815)    PAS (PF00989)    SRC-1 (PF08832)   
Domain families : Pfam SangerDUF1518 (PF07469)    Nuc_rec_co-act (PF08815)    PAS (PF00989)    SRC-1 (PF08832)   
Domain families : Pfam NCBIpfam07469    pfam08815    pfam00989    pfam08832   
Domain families : Smart EMBLHLH (SM00353)  PAC (SM00086)  PAS (SM00091)  
Blocks (Seattle)Q15596
Crystal structure of protein : PDB SRS1GWQ    1GWR    1M2Z    1MV9    1MVC    1MZN    1P93    1T63    1T65    1UHL    1YOK    1ZDT    1ZDU    1ZKY    2AO6    2B1V    2B1Z    2B23    2FAI    2G44    2G5O    2P15    2P1T    2P1U    2P1V    2Q7J    2Q7L    2ZXZ    2ZY0    3CLD    3DZU    3DZY    3E00    3E7C    3E94    3FUG    3GN8   
Crystal structure of protein : PDBSum1GWQ    1GWR    1M2Z    1MV9    1MVC    1MZN    1P93    1T63    1T65    1UHL    1YOK    1ZDT    1ZDU    1ZKY    2AO6    2B1V    2B1Z    2B23    2FAI    2G44    2G5O    2P15    2P1T    2P1U    2P1V    2Q7J    2Q7L    2ZXZ    2ZY0    3CLD    3DZU    3DZY    3E00    3E7C    3E94    3FUG    3GN8   
Crystal structure of protein : IMB1GWQ    1GWR    1M2Z    1MV9    1MVC    1MZN    1P93    1T63    1T65    1UHL    1YOK    1ZDT    1ZDU    1ZKY    2AO6    2B1V    2B1Z    2B23    2FAI    2G44    2G5O    2P15    2P1T    2P1U    2P1V    2Q7J    2Q7L    2ZXZ    2ZY0    3CLD    3DZU    3DZY    3E00    3E7C    3E94    3FUG    3GN8   
Crystal structure of protein : PDB RSDB1GWQ    1GWR    1M2Z    1MV9    1MVC    1MZN    1P93    1T63    1T65    1UHL    1YOK    1ZDT    1ZDU    1ZKY    2AO6    2B1V    2B1Z    2B23    2FAI    2G44    2G5O    2P15    2P1T    2P1U    2P1V    2Q7J    2Q7L    2ZXZ    2ZY0    3CLD    3DZU    3DZY    3E00    3E7C    3E94    3FUG    3GN8   
HPRD09066
Protein Interaction databases
DIP (DOE-UCLA)Q15596
IntAct (EBI)Q15596
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBINCOA2
SNP : GeneSNP UtahNCOA2
SNP : HGBaseNCOA2
Genetic variants : HAPMAPNCOA2
Cancer Gene: CensusNCOA2 
Somatic Mutations in Cancer : COSMICNCOA2 
Translocation Breakpoints in Cancer : TICdbnegative 
Mutations and Diseases : HGMDNCOA2
Hereditary diseases : OMIM601993   
Hereditary diseases : GENETests601993   
Diseases : Genetic AssociationNCOA2
General knowledge
Homologs : HomoloGeneNCOA2
Homology/Alignments : Family Browser UCSCNCOA2
Phylogenetic Trees/Animal Genes : TreeFamNCOA2
Chemical/Protein Interactions : CTD10499
Keywords Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  signal transducer activity  receptor binding  nucleus  cytoplasm  regulation of transcription, DNA-dependent  signal transduction  transcription repressor activity  cerebellum development  thyroid hormone receptor coactivator activity  androgen receptor signaling pathway  nuclear hormone receptor binding  positive regulation of transcription from RNA polymerase II promoter  
Keywords Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  signal transducer activity  receptor binding  nucleus  cytoplasm  regulation of transcription, DNA-dependent  signal transduction  transcription repressor activity  cerebellum development  thyroid hormone receptor coactivator activity  androgen receptor signaling pathway  nuclear hormone receptor binding  positive regulation of transcription from RNA polymerase II promoter  
Pathways : BIOCARTARole of PPAR-gamma Coactivators in Obesity and Thermogenesis [Genes]    Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells [Genes]    Control of Gene Expression by Vitamin D Receptor [Genes]   
Pathways : KEGG
Other databases
Probes
Probes : ImagenesNCOA2 Related clones (RZPD - Berlin)
Literature
PubMed93 Pubmed reference(s) in Entrez
PubGeneNCOA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated03-2009Dessen P

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indexed on : Sat Feb 27 10:32:58 CET 2010
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