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NCOA2 (nuclear receptor coactivator 2)

Identity

Other namesGRIP1
KAT13C
NCoA-2
SRC2
TIF2
bHLHe75
HGNC (Hugo) NCOA2
LocusID (NCBI) 10499
Atlas_Id 141
Location 8q13.3  [Link to chromosome band 8q13]
Location_base_pair Starts at 71024267 and ends at 71316020 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AHRR (5p15.33) / NCOA2 (8q13.3)AKAP13 (15q25.3) / NCOA2 (8q13.3)ETV6 (12p13.2) / NCOA2 (8q13.3)
GTF2I (7q11.23) / NCOA2 (8q13.3)HEY1 (8q21.13) / NCOA2 (8q13.3)HMGN3 (6q14.1) / NCOA2 (8q13.3)
KAT6A (8p11.21) / NCOA2 (8q13.3)NCOA2 (8q13.3) / ARFGEF1 (8q13.2)NCOA2 (8q13.3) / CAPZB (1p36.13)
NCOA2 (8q13.3) / HEY1 (8q21.13)NCOA2 (8q13.3) / KAT6A (8p11.21)NCOA2 (8q13.3) / KLHL28 (14q21.2)
NCOA2 (8q13.3) / LEPROTL1 (8p12)NCOA2 (8q13.3) / MAP2K3 (17p11.2)NCOA2 (8q13.3) / NCALD (8q22.3)
NCOA2 (8q13.3) / NCOA2 (8q13.3)NCOA2 (8q13.3) / PTPRE (10q26.2)NCOA2 (8q13.3) / RHOB (2p24.1)
NCOA2 (8q13.3) / RUNXBP2 ()NCOA2 (8q13.3) / SLC35B4 (7q33)NCOA2 (8q13.3) / SLC7A1 (13q12.3)
NCOA2 (8q13.3) / SNTG1 (8q11.21)NCOA2 (8q13.3) / ST18 (8q11.23)NCOA2 (8q13.3) / XKR9 (8q13.3)
NCOA2 (8q13.3) / ZNF704 (8q21.13)PAX3 (2q36.1) / NCOA2 (8q13.3)SH2D6 (2p11.2) / NCOA2 (8q13.3)
SRF (6p21.1) / NCOA2 (8q13.3)TEAD1 (11p15.3) / NCOA2 (8q13.3)THSD7B (2q22.1) / NCOA2 (8q13.3)
PAX3 2q36.1 / NCOA2 8q13.3NCOA2 8q13.3 / ARFGEF1 8q13.2NCOA2 8q13.3 / LEPROTL1 8p12
NCOA2 8q13.3 / NCALD 8q22.3NCOA2 8q13.3 / ST18 8q11.23NCOA2 8q13.3 / XKR9 8q13.3
SH2D6 2p11.2 / NCOA2 8q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Breakpoints

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  inv(8)(p11q13) KAT6A/NCOA2
t(8;12)(q13;p13) ETV6/NCOA2
t(8;16)(p11;p13) KAT6A/CREBBP

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  Soft Tissues: Alveolar rhabdomyosarcoma
Soft Tissues: Angiofibroma
Soft Tissues: Rhabdomyosarcoma
Soft tissue tumors: an overview
Soft Tissues: Alveolar rhabdomyosarcoma with t(2;2)(p23;q35) PAX3/NCOA1

External links

Nomenclature
HGNC (Hugo)NCOA2   7669
Cards
Entrez_Gene (NCBI)NCOA2  10499  nuclear receptor coactivator 2
AliasesGRIP1; KAT13C; NCoA-2; SRC2; 
TIF2; bHLHe75
GeneCards (Weizmann)NCOA2
Ensembl hg19 (Hinxton)ENSG00000140396 [Gene_View]  chr8:71024267-71316020 [Contig_View]  NCOA2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000140396 [Gene_View]  chr8:71024267-71316020 [Contig_View]  NCOA2 [Vega]
ICGC DataPortalENSG00000140396
TCGA cBioPortalNCOA2
AceView (NCBI)NCOA2
Genatlas (Paris)NCOA2
WikiGenes10499
SOURCE (Princeton)NCOA2
Genomic and cartography
GoldenPath hg19 (UCSC)NCOA2  -     chr8:71024267-71316020 -  8q13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NCOA2  -     8q13.3   [Description]    (hg38-Dec_2013)
EnsemblNCOA2 - 8q13.3 [CytoView hg19]  NCOA2 - 8q13.3 [CytoView hg38]
Mapping of homologs : NCBINCOA2 [Mapview hg19]  NCOA2 [Mapview hg38]
OMIM601993   
Gene and transcription
Genbank (Entrez)AI652063 AK298528 AK308426 AL712418 AW504723
RefSeq transcript (Entrez)NM_001321703 NM_001321707 NM_001321711 NM_001321712 NM_001321713 NM_006540
RefSeq genomic (Entrez)NC_000008 NC_018919 NT_008183 NW_004929339
Consensus coding sequences : CCDS (NCBI)NCOA2
Cluster EST : UnigeneHs.595378 [ NCBI ]
CGAP (NCI)Hs.595378
Alternative Splicing GalleryENSG00000140396
Gene ExpressionNCOA2 [ NCBI-GEO ]   NCOA2 [ EBI - ARRAY_EXPRESS ]   NCOA2 [ SEEK ]   NCOA2 [ MEM ]
Gene Expression Viewer (FireBrowse)NCOA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10499
GTEX Portal (Tissue expression)NCOA2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15596 (Uniprot)
NextProtQ15596  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15596
Splice isoforms : SwissVarQ15596 (Swissvar)
PhosPhoSitePlusQ15596
Domaine pattern : Prosite (Expaxy)BHLH (PS50888)    PAS (PS50112)   
Domains : Interpro (EBI)bHLH_dom    DUF1518    DUF4927    NCOA2    Nuc_rcpt_coact    Nuc_rcpt_coact_Ncoa-typ    Nuclear_rcpt_coactivator    PAC    PAS    PAS_fold    SRC-1    Src1_rcpt_coact   
Domain families : Pfam (Sanger)DUF1518 (PF07469)    DUF4927 (PF16279)    Nuc_rec_co-act (PF08815)    PAS (PF00989)    SRC-1 (PF08832)   
Domain families : Pfam (NCBI)pfam07469    pfam16279    pfam08815    pfam00989    pfam08832   
Domain families : Smart (EMBL)HLH (SM00353)  PAC (SM00086)  PAS (SM00091)  
DMDM Disease mutations10499
Blocks (Seattle)NCOA2
PDB (SRS)1GWQ    1GWR    1M2Z    1MV9    1MVC    1MZN    1P93    1T63    1T65    1UHL    1YOK    1ZDT    1ZDU    1ZKY    2AO6    2B1V    2B1Z    2B23    2FAI    2G44    2G5O    2LDC    2P15    2P1T    2P1U    2P1V    2Q7J    2Q7L    2YJD    2ZXZ    2ZY0    3A9E    3CLD    3DZU    3DZY    3E00    3E7C    3E94    3ERD    3FUG    3GN8    3K22    3K23    3KWY    3KYT    3L0E    3L0J    3L0L    3O1D    3O1E    3OAP    3OZJ    3PCU    3PLZ    3Q95    3Q97    3R5M    3UP0    3UP3    4CSJ    4DOS    4E2J    4FHH    4FHI    4IA1    4IA2    4IA3    4IA7    4IQR    4IU7    4IUI    4IV2    4IV4    4IVW    4IVY    4IW6    4IW8    4IWC    4IWF    4K4J    4K6I    4M8E    4M8H    4NIE    4NQA    4OC7    4P6W    4P6X    4PLD    4PLE    4POH    4POJ    4PP3    4PP5    4PP6    4PPP    4PPS    4PXM    4Q0A    4QE6    4QE8    4RFW    4RMC    4RMD    4RME    4RUO    4UDC    4UDD    4WG0    4ZN9    4ZO1   
PDB (PDBSum)1GWQ    1GWR    1M2Z    1MV9    1MVC    1MZN    1P93    1T63    1T65    1UHL    1YOK    1ZDT    1ZDU    1ZKY    2AO6    2B1V    2B1Z    2B23    2FAI    2G44    2G5O    2LDC    2P15    2P1T    2P1U    2P1V    2Q7J    2Q7L    2YJD    2ZXZ    2ZY0    3A9E    3CLD    3DZU    3DZY    3E00    3E7C    3E94    3ERD    3FUG    3GN8    3K22    3K23    3KWY    3KYT    3L0E    3L0J    3L0L    3O1D    3O1E    3OAP    3OZJ    3PCU    3PLZ    3Q95    3Q97    3R5M    3UP0    3UP3    4CSJ    4DOS    4E2J    4FHH    4FHI    4IA1    4IA2    4IA3    4IA7    4IQR    4IU7    4IUI    4IV2    4IV4    4IVW    4IVY    4IW6    4IW8    4IWC    4IWF    4K4J    4K6I    4M8E    4M8H    4NIE    4NQA    4OC7    4P6W    4P6X    4PLD    4PLE    4POH    4POJ    4PP3    4PP5    4PP6    4PPP    4PPS    4PXM    4Q0A    4QE6    4QE8    4RFW    4RMC    4RMD    4RME    4RUO    4UDC    4UDD    4WG0    4ZN9    4ZO1   
PDB (IMB)1GWQ    1GWR    1M2Z    1MV9    1MVC    1MZN    1P93    1T63    1T65    1UHL    1YOK    1ZDT    1ZDU    1ZKY    2AO6    2B1V    2B1Z    2B23    2FAI    2G44    2G5O    2LDC    2P15    2P1T    2P1U    2P1V    2Q7J    2Q7L    2YJD    2ZXZ    2ZY0    3A9E    3CLD    3DZU    3DZY    3E00    3E7C    3E94    3ERD    3FUG    3GN8    3K22    3K23    3KWY    3KYT    3L0E    3L0J    3L0L    3O1D    3O1E    3OAP    3OZJ    3PCU    3PLZ    3Q95    3Q97    3R5M    3UP0    3UP3    4CSJ    4DOS    4E2J    4FHH    4FHI    4IA1    4IA2    4IA3    4IA7    4IQR    4IU7    4IUI    4IV2    4IV4    4IVW    4IVY    4IW6    4IW8    4IWC    4IWF    4K4J    4K6I    4M8E    4M8H    4NIE    4NQA    4OC7    4P6W    4P6X    4PLD    4PLE    4POH    4POJ    4PP3    4PP5    4PP6    4PPP    4PPS    4PXM    4Q0A    4QE6    4QE8    4RFW    4RMC    4RMD    4RME    4RUO    4UDC    4UDD    4WG0    4ZN9    4ZO1   
PDB (RSDB)1GWQ    1GWR    1M2Z    1MV9    1MVC    1MZN    1P93    1T63    1T65    1UHL    1YOK    1ZDT    1ZDU    1ZKY    2AO6    2B1V    2B1Z    2B23    2FAI    2G44    2G5O    2LDC    2P15    2P1T    2P1U    2P1V    2Q7J    2Q7L    2YJD    2ZXZ    2ZY0    3A9E    3CLD    3DZU    3DZY    3E00    3E7C    3E94    3ERD    3FUG    3GN8    3K22    3K23    3KWY    3KYT    3L0E    3L0J    3L0L    3O1D    3O1E    3OAP    3OZJ    3PCU    3PLZ    3Q95    3Q97    3R5M    3UP0    3UP3    4CSJ    4DOS    4E2J    4FHH    4FHI    4IA1    4IA2    4IA3    4IA7    4IQR    4IU7    4IUI    4IV2    4IV4    4IVW    4IVY    4IW6    4IW8    4IWC    4IWF    4K4J    4K6I    4M8E    4M8H    4NIE    4NQA    4OC7    4P6W    4P6X    4PLD    4PLE    4POH    4POJ    4PP3    4PP5    4PP6    4PPP    4PPS    4PXM    4Q0A    4QE6    4QE8    4RFW    4RMC    4RMD    4RME    4RUO    4UDC    4UDD    4WG0    4ZN9    4ZO1   
Structural Biology KnowledgeBase1GWQ    1GWR    1M2Z    1MV9    1MVC    1MZN    1P93    1T63    1T65    1UHL    1YOK    1ZDT    1ZDU    1ZKY    2AO6    2B1V    2B1Z    2B23    2FAI    2G44    2G5O    2LDC    2P15    2P1T    2P1U    2P1V    2Q7J    2Q7L    2YJD    2ZXZ    2ZY0    3A9E    3CLD    3DZU    3DZY    3E00    3E7C    3E94    3ERD    3FUG    3GN8    3K22    3K23    3KWY    3KYT    3L0E    3L0J    3L0L    3O1D    3O1E    3OAP    3OZJ    3PCU    3PLZ    3Q95    3Q97    3R5M    3UP0    3UP3    4CSJ    4DOS    4E2J    4FHH    4FHI    4IA1    4IA2    4IA3    4IA7    4IQR    4IU7    4IUI    4IV2    4IV4    4IVW    4IVY    4IW6    4IW8    4IWC    4IWF    4K4J    4K6I    4M8E    4M8H    4NIE    4NQA    4OC7    4P6W    4P6X    4PLD    4PLE    4POH    4POJ    4PP3    4PP5    4PP6    4PPP    4PPS    4PXM    4Q0A    4QE6    4QE8    4RFW    4RMC    4RMD    4RME    4RUO    4UDC    4UDD    4WG0    4ZN9    4ZO1   
SCOP (Structural Classification of Proteins)1GWQ    1GWR    1M2Z    1MV9    1MVC    1MZN    1P93    1T63    1T65    1UHL    1YOK    1ZDT    1ZDU    1ZKY    2AO6    2B1V    2B1Z    2B23    2FAI    2G44    2G5O    2LDC    2P15    2P1T    2P1U    2P1V    2Q7J    2Q7L    2YJD    2ZXZ    2ZY0    3A9E    3CLD    3DZU    3DZY    3E00    3E7C    3E94    3ERD    3FUG    3GN8    3K22    3K23    3KWY    3KYT    3L0E    3L0J    3L0L    3O1D    3O1E    3OAP    3OZJ    3PCU    3PLZ    3Q95    3Q97    3R5M    3UP0    3UP3    4CSJ    4DOS    4E2J    4FHH    4FHI    4IA1    4IA2    4IA3    4IA7    4IQR    4IU7    4IUI    4IV2    4IV4    4IVW    4IVY    4IW6    4IW8    4IWC    4IWF    4K4J    4K6I    4M8E    4M8H    4NIE    4NQA    4OC7    4P6W    4P6X    4PLD    4PLE    4POH    4POJ    4PP3    4PP5    4PP6    4PPP    4PPS    4PXM    4Q0A    4QE6    4QE8    4RFW    4RMC    4RMD    4RME    4RUO    4UDC    4UDD    4WG0    4ZN9    4ZO1   
CATH (Classification of proteins structures)1GWQ    1GWR    1M2Z    1MV9    1MVC    1MZN    1P93    1T63    1T65    1UHL    1YOK    1ZDT    1ZDU    1ZKY    2AO6    2B1V    2B1Z    2B23    2FAI    2G44    2G5O    2LDC    2P15    2P1T    2P1U    2P1V    2Q7J    2Q7L    2YJD    2ZXZ    2ZY0    3A9E    3CLD    3DZU    3DZY    3E00    3E7C    3E94    3ERD    3FUG    3GN8    3K22    3K23    3KWY    3KYT    3L0E    3L0J    3L0L    3O1D    3O1E    3OAP    3OZJ    3PCU    3PLZ    3Q95    3Q97    3R5M    3UP0    3UP3    4CSJ    4DOS    4E2J    4FHH    4FHI    4IA1    4IA2    4IA3    4IA7    4IQR    4IU7    4IUI    4IV2    4IV4    4IVW    4IVY    4IW6    4IW8    4IWC    4IWF    4K4J    4K6I    4M8E    4M8H    4NIE    4NQA    4OC7    4P6W    4P6X    4PLD    4PLE    4POH    4POJ    4PP3    4PP5    4PP6    4PPP    4PPS    4PXM    4Q0A    4QE6    4QE8    4RFW    4RMC    4RMD    4RME    4RUO    4UDC    4UDD    4WG0    4ZN9    4ZO1   
SuperfamilyQ15596
Human Protein AtlasENSG00000140396
Peptide AtlasQ15596
HPRD09066
IPIIPI00018251   IPI00985123   IPI00983197   IPI00976503   IPI00974076   
Protein Interaction databases
DIP (DOE-UCLA)Q15596
IntAct (EBI)Q15596
FunCoupENSG00000140396
BioGRIDNCOA2
STRING (EMBL)NCOA2
ZODIACNCOA2
Ontologies - Pathways
QuickGOQ15596
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding  chromatin binding  transcription coactivator activity  transcription coactivator activity  histone acetyltransferase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  rough endoplasmic reticulum  Golgi apparatus  microtubule  transcription, DNA-templated  regulation of transcription, DNA-templated  male gonad development  regulation of glucose metabolic process  postsynaptic density  bile acid and bile salt transport  histone acetylation  ligand-dependent nuclear receptor binding  cerebellum development  PDZ domain binding  estrogen receptor binding  ligand-dependent nuclear receptor transcription coactivator activity  thyroid hormone receptor coactivator activity  intracellular receptor signaling pathway  protein complex binding  cellular response to hormone stimulus  circadian regulation of gene expression  progesterone receptor binding  nuclear hormone receptor binding  glucocorticoid receptor binding  neuronal cell body  dendritic spine  cellular lipid metabolic process  locomotor rhythm  positive regulation of female receptivity  positive regulation of transcription from RNA polymerase II promoter  retinoid X receptor binding  thyroid hormone receptor binding  protein dimerization activity  presynaptic active zone  DNA polymerase binding  cellular response to Thyroglobulin triiodothyronine  positive regulation of receptor activity  positive regulation of glucocorticoid receptor signaling pathway  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding  chromatin binding  transcription coactivator activity  transcription coactivator activity  histone acetyltransferase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  rough endoplasmic reticulum  Golgi apparatus  microtubule  transcription, DNA-templated  regulation of transcription, DNA-templated  male gonad development  regulation of glucose metabolic process  postsynaptic density  bile acid and bile salt transport  histone acetylation  ligand-dependent nuclear receptor binding  cerebellum development  PDZ domain binding  estrogen receptor binding  ligand-dependent nuclear receptor transcription coactivator activity  thyroid hormone receptor coactivator activity  intracellular receptor signaling pathway  protein complex binding  cellular response to hormone stimulus  circadian regulation of gene expression  progesterone receptor binding  nuclear hormone receptor binding  glucocorticoid receptor binding  neuronal cell body  dendritic spine  cellular lipid metabolic process  locomotor rhythm  positive regulation of female receptivity  positive regulation of transcription from RNA polymerase II promoter  retinoid X receptor binding  thyroid hormone receptor binding  protein dimerization activity  presynaptic active zone  DNA polymerase binding  cellular response to Thyroglobulin triiodothyronine  positive regulation of receptor activity  positive regulation of glucocorticoid receptor signaling pathway  
Pathways : KEGGThyroid hormone signaling pathway   
NDEx Network
Atlas of Cancer Signalling NetworkNCOA2
Wikipedia pathwaysNCOA2
Orthology - Evolution
OrthoDB10499
GeneTree (enSembl)ENSG00000140396
Phylogenetic Trees/Animal Genes : TreeFamNCOA2
Homologs : HomoloGeneNCOA2
Homology/Alignments : Family Browser (UCSC)NCOA2
Gene fusions - Rearrangements
Fusion: TCGANCOA2 8q13.3 ARFGEF1 8q13.2 BRCA
Fusion: TCGANCOA2 8q13.3 LEPROTL1 8p12 LUAD
Fusion: TCGANCOA2 8q13.3 NCALD 8q22.3 BRCA
Fusion: TCGANCOA2 8q13.3 ST18 8q11.23 SKCM
Fusion: TCGANCOA2 8q13.3 XKR9 8q13.3 LUAD
Fusion: TCGASH2D6 2p11.2 NCOA2 8q13.3 BLCA
Polymorphisms : SNP, variants
NCBI Variation ViewerNCOA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NCOA2
dbVarNCOA2
ClinVarNCOA2
1000_GenomesNCOA2 
Exome Variant ServerNCOA2
ExAC (Exome Aggregation Consortium)NCOA2 (select the gene name)
Genetic variants : HAPMAP10499
Genomic Variants (DGV)NCOA2 [DGVbeta]
Mutations
ICGC Data PortalNCOA2 
TCGA Data PortalNCOA2 
Broad Tumor PortalNCOA2
OASIS PortalNCOA2 [ Somatic mutations - Copy number]
Cancer Gene: CensusNCOA2 
Somatic Mutations in Cancer : COSMICNCOA2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NCOA2
DgiDB (Drug Gene Interaction Database)NCOA2
DoCM (Curated mutations)NCOA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NCOA2 (select a term)
intoGenNCOA2
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)8:71024267-71316020  ENSG00000140396
CONAN: Copy Number AnalysisNCOA2 
Mutations and Diseases : HGMDNCOA2
OMIM601993   
MedgenNCOA2
Genetic Testing Registry NCOA2
NextProtQ15596 [Medical]
TSGene10499
GENETestsNCOA2
Huge Navigator NCOA2 [HugePedia]
snp3D : Map Gene to Disease10499
BioCentury BCIQNCOA2
ClinGenNCOA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10499
Chemical/Pharm GKB GenePA31471
Clinical trialNCOA2
Miscellaneous
canSAR (ICR)NCOA2 (select the gene name)
Probes
Litterature
PubMed204 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNCOA2
EVEXNCOA2
GoPubMedNCOA2
iHOPNCOA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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