Atlas of Genetics and Cytogenetics in Oncology and Haematology

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NCOA2 (nuclear receptor coactivator 2)

Identity

Other namesGRIP1
KAT13C
NCoA-2
SRC2
TIF2
bHLHe75
HGNC (Hugo) NCOA2
LocusID (NCBI) 10499
Location 8q13.3
Location_base_pair Starts at 71024267 and ends at 71316020 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Breakpoints

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias 11q23ChildAMLID1615 11q23ID1030

Other Solid tumors implicated (Data extracted from papers in the Atlas)

Solid Tumors AmeloblastomID5945 MedulloblastomaID5065 rhab5004 rhabID5004 blad5001
bladID5001

External links

Nomenclature
HGNC (Hugo)NCOA2   7669
Cards
Entrez_Gene (NCBI)NCOA2  10499  nuclear receptor coactivator 2
GeneCards (Weizmann)NCOA2
Ensembl hg19 (Hinxton)ENSG00000140396 [Gene_View]  chr8:71024267-71316020 [Contig_View]  NCOA2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000140396 [Gene_View]  chr8:71024267-71316020 [Contig_View]  NCOA2 [Vega]
ICGC DataPortalENSG00000140396
cBioPortalNCOA2
AceView (NCBI)NCOA2
Genatlas (Paris)NCOA2
WikiGenes10499
SOURCE (Princeton)NCOA2
Genomic and cartography
GoldenPath hg19 (UCSC)NCOA2  -     chr8:71024267-71316020 -  8q13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NCOA2  -     8q13.3   [Description]    (hg38-Dec_2013)
EnsemblNCOA2 - 8q13.3 [CytoView hg19]  NCOA2 - 8q13.3 [CytoView hg38]
Mapping of homologs : NCBINCOA2 [Mapview hg19]  NCOA2 [Mapview hg38]
OMIM601993   
Gene and transcription
Genbank (Entrez)AK298528 AK308426 AW504723 BC047111 BC092442
RefSeq transcript (Entrez)NM_006540
RefSeq genomic (Entrez)AC_000140 NC_000008 NC_018919 NT_008183 NW_001839132 NW_004929339
Consensus coding sequences : CCDS (NCBI)NCOA2
Cluster EST : UnigeneHs.595378 [ NCBI ]
CGAP (NCI)Hs.595378
Alternative Splicing : Fast-db (Paris)GSHG0029636
Alternative Splicing GalleryENSG00000140396
Gene ExpressionNCOA2 [ NCBI-GEO ]     NCOA2 [ SEEK ]   NCOA2 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15596 (Uniprot)
NextProtQ15596  [Medical]
With graphics : InterProQ15596
Splice isoforms : SwissVarQ15596 (Swissvar)
Domaine pattern : Prosite (Expaxy)BHLH (PS50888)    PAS (PS50112)   
Domains : Interpro (EBI)bHLH_dom    DUF1518    NCOA2    Nuc_rcpt_coact    Nuc_rcpt_coact_Ncoa-typ    Nuclear_rcpt_coactivator    PAC    PAS    PAS_fold    SRC-1    Src1_rcpt_coact   
Related proteins : CluSTrQ15596
Domain families : Pfam (Sanger)DUF1518 (PF07469)    Nuc_rec_co-act (PF08815)    PAS (PF00989)    SRC-1 (PF08832)   
Domain families : Pfam (NCBI)pfam07469    pfam08815    pfam00989    pfam08832   
Domain families : Smart (EMBL)HLH (SM00353)  PAC (SM00086)  PAS (SM00091)  
DMDM Disease mutations10499
Blocks (Seattle)Q15596
PDB (SRS)1GWQ    1GWR    1M2Z    1MV9    1MVC    1MZN    1P93    1T63    1T65    1UHL    1YOK    1ZDT    1ZDU    1ZKY    2AO6    2B1V    2B1Z    2B23    2FAI    2G44    2G5O    2P15    2P1T    2P1U    2P1V    2Q7J    2Q7L    2ZXZ    2ZY0    3A9E    3CLD    3DZU    3DZY    3E00    3E7C    3E94    3ERD    3FUG    3GN8    3K22    3K23    3KWY    3KYT    3L0E    3L0J    3L0L    3O1D    3O1E    3OAP    3OZJ    3PCU    3PLZ    3Q95    3Q97    3R5M    3UP0    3UP3    4DOS    4E2J    4FHH    4FHI    4IA1    4IA2    4IA3    4IA7    4IQR    4IU7    4IUI    4IV2    4IV4    4IVW    4IVY    4IW6    4IW8    4IWC    4IWF    4K4J    4K6I    4M8E    4M8H    4NIE    4NQA    4P6W    4P6X   
PDB (PDBSum)1GWQ    1GWR    1M2Z    1MV9    1MVC    1MZN    1P93    1T63    1T65    1UHL    1YOK    1ZDT    1ZDU    1ZKY    2AO6    2B1V    2B1Z    2B23    2FAI    2G44    2G5O    2P15    2P1T    2P1U    2P1V    2Q7J    2Q7L    2ZXZ    2ZY0    3A9E    3CLD    3DZU    3DZY    3E00    3E7C    3E94    3ERD    3FUG    3GN8    3K22    3K23    3KWY    3KYT    3L0E    3L0J    3L0L    3O1D    3O1E    3OAP    3OZJ    3PCU    3PLZ    3Q95    3Q97    3R5M    3UP0    3UP3    4DOS    4E2J    4FHH    4FHI    4IA1    4IA2    4IA3    4IA7    4IQR    4IU7    4IUI    4IV2    4IV4    4IVW    4IVY    4IW6    4IW8    4IWC    4IWF    4K4J    4K6I    4M8E    4M8H    4NIE    4NQA    4P6W    4P6X   
PDB (IMB)1GWQ    1GWR    1M2Z    1MV9    1MVC    1MZN    1P93    1T63    1T65    1UHL    1YOK    1ZDT    1ZDU    1ZKY    2AO6    2B1V    2B1Z    2B23    2FAI    2G44    2G5O    2P15    2P1T    2P1U    2P1V    2Q7J    2Q7L    2ZXZ    2ZY0    3A9E    3CLD    3DZU    3DZY    3E00    3E7C    3E94    3ERD    3FUG    3GN8    3K22    3K23    3KWY    3KYT    3L0E    3L0J    3L0L    3O1D    3O1E    3OAP    3OZJ    3PCU    3PLZ    3Q95    3Q97    3R5M    3UP0    3UP3    4DOS    4E2J    4FHH    4FHI    4IA1    4IA2    4IA3    4IA7    4IQR    4IU7    4IUI    4IV2    4IV4    4IVW    4IVY    4IW6    4IW8    4IWC    4IWF    4K4J    4K6I    4M8E    4M8H    4NIE    4NQA    4P6W    4P6X   
PDB (RSDB)1GWQ    1GWR    1M2Z    1MV9    1MVC    1MZN    1P93    1T63    1T65    1UHL    1YOK    1ZDT    1ZDU    1ZKY    2AO6    2B1V    2B1Z    2B23    2FAI    2G44    2G5O    2P15    2P1T    2P1U    2P1V    2Q7J    2Q7L    2ZXZ    2ZY0    3A9E    3CLD    3DZU    3DZY    3E00    3E7C    3E94    3ERD    3FUG    3GN8    3K22    3K23    3KWY    3KYT    3L0E    3L0J    3L0L    3O1D    3O1E    3OAP    3OZJ    3PCU    3PLZ    3Q95    3Q97    3R5M    3UP0    3UP3    4DOS    4E2J    4FHH    4FHI    4IA1    4IA2    4IA3    4IA7    4IQR    4IU7    4IUI    4IV2    4IV4    4IVW    4IVY    4IW6    4IW8    4IWC    4IWF    4K4J    4K6I    4M8E    4M8H    4NIE    4NQA    4P6W    4P6X   
Human Protein AtlasENSG00000140396
Peptide AtlasQ15596
HPRD09066
IPIIPI00018251   IPI00985123   IPI00983197   IPI00976503   IPI00974076   
Protein Interaction databases
DIP (DOE-UCLA)Q15596
IntAct (EBI)Q15596
FunCoupENSG00000140396
BioGRIDNCOA2
IntegromeDBNCOA2
STRING (EMBL)NCOA2
Ontologies - Pathways
QuickGOQ15596
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  chromatin binding  transcription coactivator activity  transcription coactivator activity  histone acetyltransferase activity  signal transducer activity  protein binding  nucleoplasm  cytoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  histone acetylation  ligand-dependent nuclear receptor binding  ligand-dependent nuclear receptor transcription coactivator activity  thyroid hormone receptor coactivator activity  androgen receptor signaling pathway  nuclear hormone receptor binding  cellular lipid metabolic process  small molecule metabolic process  positive regulation of transcription from RNA polymerase II promoter  protein dimerization activity  positive regulation of receptor activity  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  chromatin binding  transcription coactivator activity  transcription coactivator activity  histone acetyltransferase activity  signal transducer activity  protein binding  nucleoplasm  cytoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  histone acetylation  ligand-dependent nuclear receptor binding  ligand-dependent nuclear receptor transcription coactivator activity  thyroid hormone receptor coactivator activity  androgen receptor signaling pathway  nuclear hormone receptor binding  cellular lipid metabolic process  small molecule metabolic process  positive regulation of transcription from RNA polymerase II promoter  protein dimerization activity  positive regulation of receptor activity  
Pathways : KEGGThyroid hormone signaling pathway   
Protein Interaction DatabaseNCOA2
DoCM (Curated mutations)NCOA2
Wikipedia pathwaysNCOA2
Gene fusion - rearrangements
Rearrangement : COSMICPAX3 [2q36.1]  -  NCOA2 [8q13.3]
Polymorphisms : SNP, variants
NCBI Variation ViewerNCOA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NCOA2
dbVarNCOA2
ClinVarNCOA2
1000_GenomesNCOA2 
Exome Variant ServerNCOA2
SNP (GeneSNP Utah)NCOA2
SNP : HGBaseNCOA2
Genetic variants : HAPMAPNCOA2
Genomic VariantsNCOA2  NCOA2 [DGVbeta]
Mutations
ICGC Data PortalENSG00000140396 
Cancer Gene: CensusNCOA2 
Somatic Mutations in Cancer : COSMICNCOA2 
CONAN: Copy Number AnalysisNCOA2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)8:71024267-71316020
Mutations and Diseases : HGMDNCOA2
OMIM601993   
MedgenNCOA2
NextProtQ15596 [Medical]
GENETestsNCOA2
Disease Genetic AssociationNCOA2
Huge Navigator NCOA2 [HugePedia]  NCOA2 [HugeCancerGEM]
snp3D : Map Gene to Disease10499
DGIdb (Drug Gene Interaction db)NCOA2
General knowledge
Homologs : HomoloGeneNCOA2
Homology/Alignments : Family Browser (UCSC)NCOA2
Phylogenetic Trees/Animal Genes : TreeFamNCOA2
Chemical/Protein Interactions : CTD10499
Chemical/Pharm GKB GenePA31471
Clinical trialNCOA2
Cancer Resource (Charite)ENSG00000140396
Other databases
Probes
Litterature
PubMed163 Pubmed reference(s) in Entrez
CoreMineNCOA2
GoPubMedNCOA2
iHOPNCOA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sun Dec 21 00:25:01 CET 2014
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