NCOA2 (nuclear receptor coactivator 2)

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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
Donations are also welcome

NCOA2 (nuclear receptor coactivator 2)

Identity

Other names	GRIP1
	KAT13C
	NCoA-2
	SRC2
	TIF2
	bHLHe75
HGNC (Hugo)	NCOA2
LocusID (NCBI)	10499
Location	8q13.3
Location_base_pair	Starts at 71024267 and ends at 71316020 bp from pter ( according to hg19-Feb_2009)
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

Breakpoints

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias

11q23ChildAMLID1615

Other Solid tumors implicated (Data extracted from papers in the Atlas)

Solid Tumors	AmeloblastomID5945	MedulloblastomaID5065	rhabID5004	bladID5001	colonID5006

External links

	Nomenclature
HGNC (Hugo)	NCOA2 7669
	Cards
Entrez_Gene (NCBI)	NCOA2 10499 nuclear receptor coactivator 2
GeneCards (Weizmann)	NCOA2
Ensembl hg19 (Hinxton)	ENSG00000140396 [Gene_View] chr8:71024267-71316020 [Contig_View] NCOA2 [Vega]
Ensembl hg38 (Hinxton)	ENSG00000140396 [Gene_View] chr8:71024267-71316020 [Contig_View] NCOA2 [Vega]
ICGC DataPortal	ENSG00000140396
cBioPortal	NCOA2
AceView (NCBI)	NCOA2
Genatlas (Paris)	NCOA2
WikiGenes	10499
SOURCE (Princeton)	NCOA2
	Genomic and cartography
GoldenPath hg19 (UCSC)	NCOA2 - chr8:71024267-71316020 - 8q13.3 [Description] (hg19-Feb_2009)
GoldenPath hg38 (UCSC)	NCOA2 - 8q13.3 [Description] (hg38-Dec_2013)
Ensembl	NCOA2 - 8q13.3 [CytoView hg19] NCOA2 - 8q13.3 [CytoView hg38]
Mapping of homologs : NCBI	NCOA2 [Mapview hg19] NCOA2 [Mapview hg38]
OMIM	601993
	Gene and transcription
Genbank (Entrez)	AK298528 AK308426 AW504723 BC047111 BC092442
RefSeq transcript (Entrez)	NM_006540
RefSeq genomic (Entrez)	AC_000140 NC_000008 NC_018919 NT_008183 NW_001839132 NW_004929339
Consensus coding sequences : CCDS (NCBI)	NCOA2
Cluster EST : Unigene	Hs.595378 [ NCBI ]
CGAP (NCI)	Hs.595378
Alternative Splicing : Fast-db (Paris)	GSHG0029636
Alternative Splicing Gallery	ENSG00000140396
Gene Expression	NCOA2 [ NCBI-GEO ] NCOA2 [ SEEK ] NCOA2 [ MEM ]
SOURCE (Princeton)	Expression in : [Normal Tissue Atlas] [carcinoma Classsification] [NCI60]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	Q15596 (Uniprot)
NextProt	Q15596 [Medical]
With graphics : InterPro	Q15596
Splice isoforms : SwissVar	Q15596 (Swissvar)
Domaine pattern : Prosite (Expaxy)	BHLH (PS50888) PAS (PS50112)
Domains : Interpro (EBI)	bHLH_dom DUF1518 NCOA2 Nuc_rcpt_coact Nuc_rcpt_coact_Ncoa-typ Nuclear_rcpt_coactivator PAC PAS PAS_fold SRC-1 Src1_rcpt_coact
Related proteins : CluSTr	Q15596
Domain families : Pfam (Sanger)	DUF1518 (PF07469) Nuc_rec_co-act (PF08815) PAS (PF00989) SRC-1 (PF08832)
Domain families : Pfam (NCBI)	pfam07469 pfam08815 pfam00989 pfam08832
Domain families : Smart (EMBL)	HLH (SM00353) PAC (SM00086) PAS (SM00091)
DMDM Disease mutations	10499
Blocks (Seattle)	Q15596
PDB (SRS)	1GWQ 1GWR 1M2Z 1MV9 1MVC 1MZN 1P93 1T63 1T65 1UHL 1YOK 1ZDT 1ZDU 1ZKY 2AO6 2B1V 2B1Z 2B23 2FAI 2G44 2G5O 2P15 2P1T 2P1U 2P1V 2Q7J 2Q7L 2ZXZ 2ZY0 3A9E 3CLD 3DZU 3DZY 3E00 3E7C 3E94 3ERD 3FUG 3GN8 3K22 3K23 3KWY 3KYT 3L0E 3L0J 3L0L 3O1D 3O1E 3OAP 3OZJ 3PCU 3PLZ 3Q95 3Q97 3R5M 3UP0 3UP3 4DOS 4E2J 4FHH 4FHI 4IA1 4IA2 4IA3 4IA7 4IQR 4IU7 4IUI 4IV2 4IV4 4IVW 4IVY 4IW6 4IW8 4IWC 4IWF 4K4J 4K6I 4M8E 4M8H 4NIE 4NQA 4P6W 4P6X
PDB (PDBSum)	1GWQ 1GWR 1M2Z 1MV9 1MVC 1MZN 1P93 1T63 1T65 1UHL 1YOK 1ZDT 1ZDU 1ZKY 2AO6 2B1V 2B1Z 2B23 2FAI 2G44 2G5O 2P15 2P1T 2P1U 2P1V 2Q7J 2Q7L 2ZXZ 2ZY0 3A9E 3CLD 3DZU 3DZY 3E00 3E7C 3E94 3ERD 3FUG 3GN8 3K22 3K23 3KWY 3KYT 3L0E 3L0J 3L0L 3O1D 3O1E 3OAP 3OZJ 3PCU 3PLZ 3Q95 3Q97 3R5M 3UP0 3UP3 4DOS 4E2J 4FHH 4FHI 4IA1 4IA2 4IA3 4IA7 4IQR 4IU7 4IUI 4IV2 4IV4 4IVW 4IVY 4IW6 4IW8 4IWC 4IWF 4K4J 4K6I 4M8E 4M8H 4NIE 4NQA 4P6W 4P6X
PDB (IMB)	1GWQ 1GWR 1M2Z 1MV9 1MVC 1MZN 1P93 1T63 1T65 1UHL 1YOK 1ZDT 1ZDU 1ZKY 2AO6 2B1V 2B1Z 2B23 2FAI 2G44 2G5O 2P15 2P1T 2P1U 2P1V 2Q7J 2Q7L 2ZXZ 2ZY0 3A9E 3CLD 3DZU 3DZY 3E00 3E7C 3E94 3ERD 3FUG 3GN8 3K22 3K23 3KWY 3KYT 3L0E 3L0J 3L0L 3O1D 3O1E 3OAP 3OZJ 3PCU 3PLZ 3Q95 3Q97 3R5M 3UP0 3UP3 4DOS 4E2J 4FHH 4FHI 4IA1 4IA2 4IA3 4IA7 4IQR 4IU7 4IUI 4IV2 4IV4 4IVW 4IVY 4IW6 4IW8 4IWC 4IWF 4K4J 4K6I 4M8E 4M8H 4NIE 4NQA 4P6W 4P6X
PDB (RSDB)	1GWQ 1GWR 1M2Z 1MV9 1MVC 1MZN 1P93 1T63 1T65 1UHL 1YOK 1ZDT 1ZDU 1ZKY 2AO6 2B1V 2B1Z 2B23 2FAI 2G44 2G5O 2P15 2P1T 2P1U 2P1V 2Q7J 2Q7L 2ZXZ 2ZY0 3A9E 3CLD 3DZU 3DZY 3E00 3E7C 3E94 3ERD 3FUG 3GN8 3K22 3K23 3KWY 3KYT 3L0E 3L0J 3L0L 3O1D 3O1E 3OAP 3OZJ 3PCU 3PLZ 3Q95 3Q97 3R5M 3UP0 3UP3 4DOS 4E2J 4FHH 4FHI 4IA1 4IA2 4IA3 4IA7 4IQR 4IU7 4IUI 4IV2 4IV4 4IVW 4IVY 4IW6 4IW8 4IWC 4IWF 4K4J 4K6I 4M8E 4M8H 4NIE 4NQA 4P6W 4P6X
Human Protein Atlas	ENSG00000140396
Peptide Atlas	Q15596
HPRD	09066
IPI	IPI00018251 IPI00985123 IPI00983197 IPI00976503 IPI00974076
	Protein Interaction databases
DIP (DOE-UCLA)	Q15596
IntAct (EBI)	Q15596
FunCoup	ENSG00000140396
BioGRID	NCOA2
IntegromeDB	NCOA2
STRING (EMBL)	NCOA2
	Ontologies - Pathways
QuickGO	Q15596
Ontology : AmiGO	negative regulation of transcription from RNA polymerase II promoter chromatin binding transcription coactivator activity transcription coactivator activity histone acetyltransferase activity signal transducer activity protein binding nucleoplasm cytoplasm transcription, DNA-templated regulation of transcription, DNA-templated histone acetylation ligand-dependent nuclear receptor binding ligand-dependent nuclear receptor transcription coactivator activity thyroid hormone receptor coactivator activity androgen receptor signaling pathway nuclear hormone receptor binding cellular lipid metabolic process small molecule metabolic process positive regulation of transcription from RNA polymerase II promoter protein dimerization activity positive regulation of receptor activity
Ontology : EGO-EBI	negative regulation of transcription from RNA polymerase II promoter chromatin binding transcription coactivator activity transcription coactivator activity histone acetyltransferase activity signal transducer activity protein binding nucleoplasm cytoplasm transcription, DNA-templated regulation of transcription, DNA-templated histone acetylation ligand-dependent nuclear receptor binding ligand-dependent nuclear receptor transcription coactivator activity thyroid hormone receptor coactivator activity androgen receptor signaling pathway nuclear hormone receptor binding cellular lipid metabolic process small molecule metabolic process positive regulation of transcription from RNA polymerase II promoter protein dimerization activity positive regulation of receptor activity
Pathways : KEGG	Thyroid hormone signaling pathway
Protein Interaction Database	NCOA2
DoCM (Curated mutations)	NCOA2
Wikipedia pathways	NCOA2
	Gene fusion - rearrangements
Rearrangement : COSMIC	PAX3 [2q36.1] - NCOA2 [8q13.3]
	Polymorphisms : SNP, variants
NCBI Variation Viewer	NCOA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)	NCOA2
dbVar	NCOA2
ClinVar	NCOA2
1000_Genomes	NCOA2
Exome Variant Server	NCOA2
SNP (GeneSNP Utah)	NCOA2
SNP : HGBase	NCOA2
Genetic variants : HAPMAP	NCOA2
Genomic Variants (DGV)	NCOA2 [DGVbeta]
	Mutations
ICGC Data Portal	ENSG00000140396
Cancer Gene: Census	NCOA2
Somatic Mutations in Cancer : COSMIC	NCOA2
CONAN: Copy Number Analysis	NCOA2
LOVD (Leiden Open Variation Database)	Whole genome datasets
LOVD (Leiden Open Variation Database)	LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)	LOVD 3.0 shared installation
Impact of mutations	[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor]
	Diseases
DECIPHER (Syndromes)	8:71024267-71316020
Mutations and Diseases : HGMD	NCOA2
OMIM	601993
Medgen	NCOA2
NextProt	Q15596 [Medical]
GENETests	NCOA2
Disease Genetic Association	NCOA2
Huge Navigator	NCOA2 [HugePedia] NCOA2 [HugeCancerGEM]
snp3D : Map Gene to Disease	10499
DGIdb (Drug Gene Interaction db)	NCOA2
	General knowledge
Homologs : HomoloGene	NCOA2
Homology/Alignments : Family Browser (UCSC)	NCOA2
Phylogenetic Trees/Animal Genes : TreeFam	NCOA2
Chemical/Protein Interactions : CTD	10499
Chemical/Pharm GKB Gene	PA31471
Clinical trial	NCOA2
Cancer Resource (Charite)	ENSG00000140396
	Other databases
	Probes
	Litterature
PubMed	163 Pubmed reference(s) in Entrez
CoreMine	NCOA2
GoPubMed	NCOA2
iHOP	NCOA2

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S

Updated	12-2014	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Feb 14 17:38:13 CET 2015

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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.