NCOA2 (nuclear receptor coactivator 2)

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NCOA2 (nuclear receptor coactivator 2)

Identity

Alias (NCBI)	GRIP1
	KAT13C
	NCoA-2
	SRC2
	TIF2
	bHLHe75
HGNC (Hugo)	NCOA2
HGNC Alias symb	TIF2
	GRIP1
	NCoA-2
	KAT13C
	bHLHe75
HGNC Alias name	glucocorticoid receptor interacting protein 1
LocusID (NCBI)	10499
Atlas_Id	141
Location	8q13.3 [Link to chromosome band 8q13]
Location_base_pair	Starts at 70109782 and ends at 70403808 bp from pter ( according to hg38-Dec_2013)

Fusion genes
(updated 2017)

Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

AHRR (5p15.33) / NCOA2 (8q13.3)	AKAP13 (15q25.3) / NCOA2 (8q13.3)	ETV6 (12p13.2) / NCOA2 (8q13.3)
GTF2I (7q11.23) / NCOA2 (8q13.3)	HEY1 (8q21.13) / NCOA2 (8q13.3)	HMGN3 (6q14.1) / NCOA2 (8q13.3)
KAT6A (8p11.21) / NCOA2 (8q13.3)	NCOA2 (8q13.3) / ARFGEF1 (8q13.2)	NCOA2 (8q13.3) / CAPZB (1p36.13)
NCOA2 (8q13.3) / HEY1 (8q21.13)	NCOA2 (8q13.3) / KAT6A (8p11.21)	NCOA2 (8q13.3) / KLHL28 (14q21.2)
NCOA2 (8q13.3) / LEPROTL1 (8p12)	NCOA2 (8q13.3) / MAP2K3 (17p11.2)	NCOA2 (8q13.3) / NCALD (8q22.3)
NCOA2 (8q13.3) / NCOA2 (8q13.3)	NCOA2 (8q13.3) / PTPRE (10q26.2)	NCOA2 (8q13.3) / RHOB (2p24.1)
NCOA2 (8q13.3) / RUNXBP2 ()	NCOA2 (8q13.3) / SLC35B4 (7q33)	NCOA2 (8q13.3) / SLC7A1 (13q12.3)
NCOA2 (8q13.3) / SNTG1 (8q11.21)	NCOA2 (8q13.3) / ST18 (8q11.23)	NCOA2 (8q13.3) / XKR9 (8q13.3)
NCOA2 (8q13.3) / ZNF704 (8q21.13)	PAX3 (2q36.1) / NCOA2 (8q13.3)	SH2D6 (2p11.2) / NCOA2 (8q13.3)
SRF (6p21.1) / NCOA2 (8q13.3)	TEAD1 (11p15.3) / NCOA2 (8q13.3)	THSD7B (2q22.1) / NCOA2 (8q13.3)
PAX3 NCOA2	NCOA2 8q13.3 / ARFGEF1 8q13.2	NCOA2 8q13.3 / LEPROTL1 8p12
NCOA2 8q13.3 / NCALD 8q22.3	NCOA2 8q13.3 / ST18 8q11.23	NCOA2 8q13.3 / XKR9 8q13.3
SH2D6 2p11.2 / NCOA2 8q13.3

Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

Breakpoints

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 4 ]

Indeterminate Dendritic Cell Tumor
inv(8)(p11q13) KAT6A/NCOA2
t(8;12)(q13;p13) ETV6/NCOA2
t(8;16)(p11;p13) KAT6A/CREBBP

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 20 ]

Soft Tissues: Alveolar rhabdomyosarcoma
Soft Tissues: Angiofibroma
Soft Tissues: Rhabdomyosarcoma
Soft tissue tumors: an overview
Soft Tissues: Alveolar rhabdomyosarcoma with t(2;2)(p23;q35) PAX3/NCOA1
GTF2I/NCOA2 ()
t(2;8)(p11;q13) SH2D6/NCOA2
t(2;8)(q36;q13) PAX3/NCOA2
t(6;8)(p21;q13) SRF/NCOA2
t(6;8)(q22;q13) VGLL2/NCOA2
t(8;8)(p12;q13) NCOA2/LEPROTL1
t(8;8)(q11;q13) NCOA2/ST18
LACTB2/NCOA2 (8q13)
NCOA2/ARFGEF1 (8q13)
NCOA2/XKR9 (8q13)
t(8;8)(q13;q21) NCOA2/ZNF704
t(8;8)(q13;q21) HEY1/NCOA2
t(8;8)(q13;q22) NCOA2/NCALD
t(8;11)(q13;p15) TEAD1/NCOA2
t(8;17)(q13;q21) NCOA2/ETV4

External links

	Nomenclature
HGNC (Hugo)	NCOA2 7669
	Cards
Entrez_Gene (NCBI)	NCOA2 10499 nuclear receptor coactivator 2
Aliases	GRIP1; KAT13C; NCoA-2; SRC2;
	TIF2; bHLHe75
GeneCards (Weizmann)	NCOA2
Ensembl hg19 (Hinxton)	ENSG00000140396 [Gene_View]
Ensembl hg38 (Hinxton)	ENSG00000140396 [Gene_View] ENSG00000140396 [Sequence] chr8:70109782-70403808 [Contig_View] NCOA2 [Vega]
ICGC DataPortal	ENSG00000140396
TCGA cBioPortal	NCOA2
AceView (NCBI)	NCOA2
Genatlas (Paris)	NCOA2
WikiGenes	10499
SOURCE (Princeton)	NCOA2
Genetics Home Reference (NIH)	NCOA2
	Genomic and cartography
GoldenPath hg38 (UCSC)	NCOA2 - chr8:70109782-70403808 - 8q13.3 [Description] (hg38-Dec_2013)
GoldenPath hg19 (UCSC)	NCOA2 - 8q13.3 [Description] (hg19-Feb_2009)
GoldenPath	NCOA2 - 8q13.3 [CytoView hg19] NCOA2 - 8q13.3 [CytoView hg38]
ImmunoBase	ENSG00000140396
genome Data Viewer NCBI	NCOA2 [Mapview hg19]
OMIM	601993
	Gene and transcription
Genbank (Entrez)	AI652063 AK298528 AK308426 AL712418 AW504723
RefSeq transcript (Entrez)	NM_001321703 NM_001321707 NM_001321711 NM_001321712 NM_001321713 NM_006540
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)	NCOA2
Alternative Splicing Gallery	ENSG00000140396
Gene Expression	NCOA2 [ NCBI-GEO ] NCOA2 [ EBI - ARRAY_EXPRESS ] NCOA2 [ SEEK ] NCOA2 [ MEM ]
Gene Expression Viewer (FireBrowse)	NCOA2 [ Firebrowse - Broad ]
Genevisible	Expression of NCOA2 in : [tissues] [cell-lines] [cancer] [perturbations]
BioGPS (Tissue expression)	10499
GTEX Portal (Tissue expression)	NCOA2
Human Protein Atlas	ENSG00000140396-NCOA2 [pathology] [cell] [tissue]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	Q15596 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction]
NextProt	Q15596 [Sequence] [Exons] [Medical] [Publications]
With graphics : InterPro	Q15596
Splice isoforms : SwissVar	Q15596
PhosPhoSitePlus	Q15596
Domaine pattern : Prosite (Expaxy)	BHLH (PS50888) PAS (PS50112)
Domains : Interpro (EBI)	bHLH_dom DUF1518 DUF4927 HLH_DNA-bd_sf NCOA2 Nuc_rcpt_coact Nuc_rcpt_coact_Ncoa-typ Nuc_rcpt_coact_Ncoa_int_sf Nuclear_rcpt_coactivator PAS PAS-like_dom_sf PAS_fold SRC/p160_LXXLL
Domain families : Pfam (Sanger)	DUF1518 (PF07469) DUF4927 (PF16279) Nuc_rec_co-act (PF08815) PAS (PF00989) SRC-1 (PF08832)
Domain families : Pfam (NCBI)	pfam07469 pfam16279 pfam08815 pfam00989 pfam08832
Domain families : Smart (EMBL)	DUF1518 (SM01151) HLH (SM00353) PAS (SM00091)
Conserved Domain (NCBI)	NCOA2
DMDM Disease mutations	10499
Blocks (Seattle)	NCOA2
PDB (RSDB)	1GWQ 1GWR 1M2Z 1MV9 1MVC 1MZN 1P93 1T63 1T65 1UHL 1YOK 1ZDT 1ZDU 1ZKY 2AO6 2B1V 2B1Z 2B23 2FAI 2G44 2G5O 2LDC 2P15 2P1T 2P1U 2P1V 2Q7J 2Q7L 2YJD 2ZXZ 2ZY0 3A9E 3CLD 3DZU 3DZY 3E00 3E7C 3E94 3ERD 3FUG 3GN8 3K22 3K23 3KWY 3KYT 3L0E 3L0J 3L0L 3O1D 3O1E 3OAP 3OZJ 3PCU 3PLZ 3Q95 3R5M 3UP0 3UP3 4CSJ 4DOS 4E2J 4FHH 4FHI 4IA1 4IA2 4IA3 4IA7 4IQR 4IU7 4IUI 4IV2 4IV4 4IVW 4IVY 4IW6 4IW8 4IWC 4IWF 4K4J 4K6I 4M8E 4M8H 4NIE 4NQA 4OC7 4P6W 4P6X 4PLD 4PLE 4POH 4POJ 4PP3 4PP5 4PP6 4PPP 4PPS 4PXM 4Q0A 4Q13 4QE6 4QE8 4RFW 4RMC 4RMD 4RME 4RUO 4UDC 4UDD 4WG0 4ZN7 4ZN9 4ZNH 4ZNS 4ZNT 4ZNU 4ZNV 4ZNW 4ZO1 4ZSH 5APH 5APJ 5DI7 5DID 5DIE 5DIG 5DK9 5DKB 5DKE 5DKG 5DKS 5DL4 5DLR 5DMC 5DMF 5DP0 5DRJ 5DRM 5DTV 5DU5 5DUE 5DUG 5DUH 5DVS 5DVV 5DWE 5DWG 5DWI 5DWJ 5DX3 5DXB 5DXE 5DXG 5DXK 5DXM 5DXP 5DXQ 5DXR 5DY8 5DYB 5DYD 5DZ0 5DZ1 5DZ3 5DZH 5DZI 5E0W 5E0X 5E14 5E15 5E19 5E1C 5EC9 5EGV 5EHJ 5EI1 5EIT 5G3J 5G42 5G43 5G44 5G45 5G46 5G5W 5H1E 5HYR 5I4V 5IAW 5ICK 5KCC 5KCD 5KCE 5KCF 5KCT 5KCU 5KCW 5KD9 5KR9 5KRA 5KRC 5KRF 5KRH 5KRI 5KRJ 5KRK 5KRL 5KRM 5KRO 5L11 5LGA 5LYQ 5MK4 5NFP 5NFT 5NI5 5NI7 5NI8 5NIB 5Q17 5SYZ 5T1Z 5TLD 5TLF 5TLG 5TLL 5TLM 5TLO 5TLP 5TLT 5TLU 5TLV 5TLX 5TLY 5TM1 5TM2 5TM3 5TM4 5TM5 5TM6 5TM7 5TM8 5TM9 5TML 5TMM 5TMO 5TMQ 5TMR 5TMS 5TMT 5TMU 5TMV 5TMW 5TMZ 5TN1 5TN3 5TN4 5TN5 5TN6 5TN7 5TN8 5U2D 5UAN 5VB3 5VB5 5VB6 5VB7 5VQK 5VQL 5WGQ 5WZX 5XPL 5Y1J 5Y49 5YP5 5YXB 5YXD 5YXJ 5YXL 5Z12 6CZN 6D0F 6EL6 6EL7 6EL9 6ESN 6KKB 6KKE 6KNU 6KNV 6KNW 6OQX 6OQY 6OR1 6R7A 6R7J 6R7K 6SJM 6STI
PDB Europe	1GWQ 1GWR 1M2Z 1MV9 1MVC 1MZN 1P93 1T63 1T65 1UHL 1YOK 1ZDT 1ZDU 1ZKY 2AO6 2B1V 2B1Z 2B23 2FAI 2G44 2G5O 2LDC 2P15 2P1T 2P1U 2P1V 2Q7J 2Q7L 2YJD 2ZXZ 2ZY0 3A9E 3CLD 3DZU 3DZY 3E00 3E7C 3E94 3ERD 3FUG 3GN8 3K22 3K23 3KWY 3KYT 3L0E 3L0J 3L0L 3O1D 3O1E 3OAP 3OZJ 3PCU 3PLZ 3Q95 3R5M 3UP0 3UP3 4CSJ 4DOS 4E2J 4FHH 4FHI 4IA1 4IA2 4IA3 4IA7 4IQR 4IU7 4IUI 4IV2 4IV4 4IVW 4IVY 4IW6 4IW8 4IWC 4IWF 4K4J 4K6I 4M8E 4M8H 4NIE 4NQA 4OC7 4P6W 4P6X 4PLD 4PLE 4POH 4POJ 4PP3 4PP5 4PP6 4PPP 4PPS 4PXM 4Q0A 4Q13 4QE6 4QE8 4RFW 4RMC 4RMD 4RME 4RUO 4UDC 4UDD 4WG0 4ZN7 4ZN9 4ZNH 4ZNS 4ZNT 4ZNU 4ZNV 4ZNW 4ZO1 4ZSH 5APH 5APJ 5DI7 5DID 5DIE 5DIG 5DK9 5DKB 5DKE 5DKG 5DKS 5DL4 5DLR 5DMC 5DMF 5DP0 5DRJ 5DRM 5DTV 5DU5 5DUE 5DUG 5DUH 5DVS 5DVV 5DWE 5DWG 5DWI 5DWJ 5DX3 5DXB 5DXE 5DXG 5DXK 5DXM 5DXP 5DXQ 5DXR 5DY8 5DYB 5DYD 5DZ0 5DZ1 5DZ3 5DZH 5DZI 5E0W 5E0X 5E14 5E15 5E19 5E1C 5EC9 5EGV 5EHJ 5EI1 5EIT 5G3J 5G42 5G43 5G44 5G45 5G46 5G5W 5H1E 5HYR 5I4V 5IAW 5ICK 5KCC 5KCD 5KCE 5KCF 5KCT 5KCU 5KCW 5KD9 5KR9 5KRA 5KRC 5KRF 5KRH 5KRI 5KRJ 5KRK 5KRL 5KRM 5KRO 5L11 5LGA 5LYQ 5MK4 5NFP 5NFT 5NI5 5NI7 5NI8 5NIB 5Q17 5SYZ 5T1Z 5TLD 5TLF 5TLG 5TLL 5TLM 5TLO 5TLP 5TLT 5TLU 5TLV 5TLX 5TLY 5TM1 5TM2 5TM3 5TM4 5TM5 5TM6 5TM7 5TM8 5TM9 5TML 5TMM 5TMO 5TMQ 5TMR 5TMS 5TMT 5TMU 5TMV 5TMW 5TMZ 5TN1 5TN3 5TN4 5TN5 5TN6 5TN7 5TN8 5U2D 5UAN 5VB3 5VB5 5VB6 5VB7 5VQK 5VQL 5WGQ 5WZX 5XPL 5Y1J 5Y49 5YP5 5YXB 5YXD 5YXJ 5YXL 5Z12 6CZN 6D0F 6EL6 6EL7 6EL9 6ESN 6KKB 6KKE 6KNU 6KNV 6KNW 6OQX 6OQY 6OR1 6R7A 6R7J 6R7K 6SJM 6STI
PDB (PDBSum)	1GWQ 1GWR 1M2Z 1MV9 1MVC 1MZN 1P93 1T63 1T65 1UHL 1YOK 1ZDT 1ZDU 1ZKY 2AO6 2B1V 2B1Z 2B23 2FAI 2G44 2G5O 2LDC 2P15 2P1T 2P1U 2P1V 2Q7J 2Q7L 2YJD 2ZXZ 2ZY0 3A9E 3CLD 3DZU 3DZY 3E00 3E7C 3E94 3ERD 3FUG 3GN8 3K22 3K23 3KWY 3KYT 3L0E 3L0J 3L0L 3O1D 3O1E 3OAP 3OZJ 3PCU 3PLZ 3Q95 3R5M 3UP0 3UP3 4CSJ 4DOS 4E2J 4FHH 4FHI 4IA1 4IA2 4IA3 4IA7 4IQR 4IU7 4IUI 4IV2 4IV4 4IVW 4IVY 4IW6 4IW8 4IWC 4IWF 4K4J 4K6I 4M8E 4M8H 4NIE 4NQA 4OC7 4P6W 4P6X 4PLD 4PLE 4POH 4POJ 4PP3 4PP5 4PP6 4PPP 4PPS 4PXM 4Q0A 4Q13 4QE6 4QE8 4RFW 4RMC 4RMD 4RME 4RUO 4UDC 4UDD 4WG0 4ZN7 4ZN9 4ZNH 4ZNS 4ZNT 4ZNU 4ZNV 4ZNW 4ZO1 4ZSH 5APH 5APJ 5DI7 5DID 5DIE 5DIG 5DK9 5DKB 5DKE 5DKG 5DKS 5DL4 5DLR 5DMC 5DMF 5DP0 5DRJ 5DRM 5DTV 5DU5 5DUE 5DUG 5DUH 5DVS 5DVV 5DWE 5DWG 5DWI 5DWJ 5DX3 5DXB 5DXE 5DXG 5DXK 5DXM 5DXP 5DXQ 5DXR 5DY8 5DYB 5DYD 5DZ0 5DZ1 5DZ3 5DZH 5DZI 5E0W 5E0X 5E14 5E15 5E19 5E1C 5EC9 5EGV 5EHJ 5EI1 5EIT 5G3J 5G42 5G43 5G44 5G45 5G46 5G5W 5H1E 5HYR 5I4V 5IAW 5ICK 5KCC 5KCD 5KCE 5KCF 5KCT 5KCU 5KCW 5KD9 5KR9 5KRA 5KRC 5KRF 5KRH 5KRI 5KRJ 5KRK 5KRL 5KRM 5KRO 5L11 5LGA 5LYQ 5MK4 5NFP 5NFT 5NI5 5NI7 5NI8 5NIB 5Q17 5SYZ 5T1Z 5TLD 5TLF 5TLG 5TLL 5TLM 5TLO 5TLP 5TLT 5TLU 5TLV 5TLX 5TLY 5TM1 5TM2 5TM3 5TM4 5TM5 5TM6 5TM7 5TM8 5TM9 5TML 5TMM 5TMO 5TMQ 5TMR 5TMS 5TMT 5TMU 5TMV 5TMW 5TMZ 5TN1 5TN3 5TN4 5TN5 5TN6 5TN7 5TN8 5U2D 5UAN 5VB3 5VB5 5VB6 5VB7 5VQK 5VQL 5WGQ 5WZX 5XPL 5Y1J 5Y49 5YP5 5YXB 5YXD 5YXJ 5YXL 5Z12 6CZN 6D0F 6EL6 6EL7 6EL9 6ESN 6KKB 6KKE 6KNU 6KNV 6KNW 6OQX 6OQY 6OR1 6R7A 6R7J 6R7K 6SJM 6STI
PDB (IMB)	1GWQ 1GWR 1M2Z 1MV9 1MVC 1MZN 1P93 1T63 1T65 1UHL 1YOK 1ZDT 1ZDU 1ZKY 2AO6 2B1V 2B1Z 2B23 2FAI 2G44 2G5O 2LDC 2P15 2P1T 2P1U 2P1V 2Q7J 2Q7L 2YJD 2ZXZ 2ZY0 3A9E 3CLD 3DZU 3DZY 3E00 3E7C 3E94 3ERD 3FUG 3GN8 3K22 3K23 3KWY 3KYT 3L0E 3L0J 3L0L 3O1D 3O1E 3OAP 3OZJ 3PCU 3PLZ 3Q95 3R5M 3UP0 3UP3 4CSJ 4DOS 4E2J 4FHH 4FHI 4IA1 4IA2 4IA3 4IA7 4IQR 4IU7 4IUI 4IV2 4IV4 4IVW 4IVY 4IW6 4IW8 4IWC 4IWF 4K4J 4K6I 4M8E 4M8H 4NIE 4NQA 4OC7 4P6W 4P6X 4PLD 4PLE 4POH 4POJ 4PP3 4PP5 4PP6 4PPP 4PPS 4PXM 4Q0A 4Q13 4QE6 4QE8 4RFW 4RMC 4RMD 4RME 4RUO 4UDC 4UDD 4WG0 4ZN7 4ZN9 4ZNH 4ZNS 4ZNT 4ZNU 4ZNV 4ZNW 4ZO1 4ZSH 5APH 5APJ 5DI7 5DID 5DIE 5DIG 5DK9 5DKB 5DKE 5DKG 5DKS 5DL4 5DLR 5DMC 5DMF 5DP0 5DRJ 5DRM 5DTV 5DU5 5DUE 5DUG 5DUH 5DVS 5DVV 5DWE 5DWG 5DWI 5DWJ 5DX3 5DXB 5DXE 5DXG 5DXK 5DXM 5DXP 5DXQ 5DXR 5DY8 5DYB 5DYD 5DZ0 5DZ1 5DZ3 5DZH 5DZI 5E0W 5E0X 5E14 5E15 5E19 5E1C 5EC9 5EGV 5EHJ 5EI1 5EIT 5G3J 5G42 5G43 5G44 5G45 5G46 5G5W 5H1E 5HYR 5I4V 5IAW 5ICK 5KCC 5KCD 5KCE 5KCF 5KCT 5KCU 5KCW 5KD9 5KR9 5KRA 5KRC 5KRF 5KRH 5KRI 5KRJ 5KRK 5KRL 5KRM 5KRO 5L11 5LGA 5LYQ 5MK4 5NFP 5NFT 5NI5 5NI7 5NI8 5NIB 5Q17 5SYZ 5T1Z 5TLD 5TLF 5TLG 5TLL 5TLM 5TLO 5TLP 5TLT 5TLU 5TLV 5TLX 5TLY 5TM1 5TM2 5TM3 5TM4 5TM5 5TM6 5TM7 5TM8 5TM9 5TML 5TMM 5TMO 5TMQ 5TMR 5TMS 5TMT 5TMU 5TMV 5TMW 5TMZ 5TN1 5TN3 5TN4 5TN5 5TN6 5TN7 5TN8 5U2D 5UAN 5VB3 5VB5 5VB6 5VB7 5VQK 5VQL 5WGQ 5WZX 5XPL 5Y1J 5Y49 5YP5 5YXB 5YXD 5YXJ 5YXL 5Z12 6CZN 6D0F 6EL6 6EL7 6EL9 6ESN 6KKB 6KKE 6KNU 6KNV 6KNW 6OQX 6OQY 6OR1 6R7A 6R7J 6R7K 6SJM 6STI
Structural Biology KnowledgeBase	1GWQ 1GWR 1M2Z 1MV9 1MVC 1MZN 1P93 1T63 1T65 1UHL 1YOK 1ZDT 1ZDU 1ZKY 2AO6 2B1V 2B1Z 2B23 2FAI 2G44 2G5O 2LDC 2P15 2P1T 2P1U 2P1V 2Q7J 2Q7L 2YJD 2ZXZ 2ZY0 3A9E 3CLD 3DZU 3DZY 3E00 3E7C 3E94 3ERD 3FUG 3GN8 3K22 3K23 3KWY 3KYT 3L0E 3L0J 3L0L 3O1D 3O1E 3OAP 3OZJ 3PCU 3PLZ 3Q95 3R5M 3UP0 3UP3 4CSJ 4DOS 4E2J 4FHH 4FHI 4IA1 4IA2 4IA3 4IA7 4IQR 4IU7 4IUI 4IV2 4IV4 4IVW 4IVY 4IW6 4IW8 4IWC 4IWF 4K4J 4K6I 4M8E 4M8H 4NIE 4NQA 4OC7 4P6W 4P6X 4PLD 4PLE 4POH 4POJ 4PP3 4PP5 4PP6 4PPP 4PPS 4PXM 4Q0A 4Q13 4QE6 4QE8 4RFW 4RMC 4RMD 4RME 4RUO 4UDC 4UDD 4WG0 4ZN7 4ZN9 4ZNH 4ZNS 4ZNT 4ZNU 4ZNV 4ZNW 4ZO1 4ZSH 5APH 5APJ 5DI7 5DID 5DIE 5DIG 5DK9 5DKB 5DKE 5DKG 5DKS 5DL4 5DLR 5DMC 5DMF 5DP0 5DRJ 5DRM 5DTV 5DU5 5DUE 5DUG 5DUH 5DVS 5DVV 5DWE 5DWG 5DWI 5DWJ 5DX3 5DXB 5DXE 5DXG 5DXK 5DXM 5DXP 5DXQ 5DXR 5DY8 5DYB 5DYD 5DZ0 5DZ1 5DZ3 5DZH 5DZI 5E0W 5E0X 5E14 5E15 5E19 5E1C 5EC9 5EGV 5EHJ 5EI1 5EIT 5G3J 5G42 5G43 5G44 5G45 5G46 5G5W 5H1E 5HYR 5I4V 5IAW 5ICK 5KCC 5KCD 5KCE 5KCF 5KCT 5KCU 5KCW 5KD9 5KR9 5KRA 5KRC 5KRF 5KRH 5KRI 5KRJ 5KRK 5KRL 5KRM 5KRO 5L11 5LGA 5LYQ 5MK4 5NFP 5NFT 5NI5 5NI7 5NI8 5NIB 5Q17 5SYZ 5T1Z 5TLD 5TLF 5TLG 5TLL 5TLM 5TLO 5TLP 5TLT 5TLU 5TLV 5TLX 5TLY 5TM1 5TM2 5TM3 5TM4 5TM5 5TM6 5TM7 5TM8 5TM9 5TML 5TMM 5TMO 5TMQ 5TMR 5TMS 5TMT 5TMU 5TMV 5TMW 5TMZ 5TN1 5TN3 5TN4 5TN5 5TN6 5TN7 5TN8 5U2D 5UAN 5VB3 5VB5 5VB6 5VB7 5VQK 5VQL 5WGQ 5WZX 5XPL 5Y1J 5Y49 5YP5 5YXB 5YXD 5YXJ 5YXL 5Z12 6CZN 6D0F 6EL6 6EL7 6EL9 6ESN 6KKB 6KKE 6KNU 6KNV 6KNW 6OQX 6OQY 6OR1 6R7A 6R7J 6R7K 6SJM 6STI
SCOP (Structural Classification of Proteins)	1GWQ 1GWR 1M2Z 1MV9 1MVC 1MZN 1P93 1T63 1T65 1UHL 1YOK 1ZDT 1ZDU 1ZKY 2AO6 2B1V 2B1Z 2B23 2FAI 2G44 2G5O 2LDC 2P15 2P1T 2P1U 2P1V 2Q7J 2Q7L 2YJD 2ZXZ 2ZY0 3A9E 3CLD 3DZU 3DZY 3E00 3E7C 3E94 3ERD 3FUG 3GN8 3K22 3K23 3KWY 3KYT 3L0E 3L0J 3L0L 3O1D 3O1E 3OAP 3OZJ 3PCU 3PLZ 3Q95 3R5M 3UP0 3UP3 4CSJ 4DOS 4E2J 4FHH 4FHI 4IA1 4IA2 4IA3 4IA7 4IQR 4IU7 4IUI 4IV2 4IV4 4IVW 4IVY 4IW6 4IW8 4IWC 4IWF 4K4J 4K6I 4M8E 4M8H 4NIE 4NQA 4OC7 4P6W 4P6X 4PLD 4PLE 4POH 4POJ 4PP3 4PP5 4PP6 4PPP 4PPS 4PXM 4Q0A 4Q13 4QE6 4QE8 4RFW 4RMC 4RMD 4RME 4RUO 4UDC 4UDD 4WG0 4ZN7 4ZN9 4ZNH 4ZNS 4ZNT 4ZNU 4ZNV 4ZNW 4ZO1 4ZSH 5APH 5APJ 5DI7 5DID 5DIE 5DIG 5DK9 5DKB 5DKE 5DKG 5DKS 5DL4 5DLR 5DMC 5DMF 5DP0 5DRJ 5DRM 5DTV 5DU5 5DUE 5DUG 5DUH 5DVS 5DVV 5DWE 5DWG 5DWI 5DWJ 5DX3 5DXB 5DXE 5DXG 5DXK 5DXM 5DXP 5DXQ 5DXR 5DY8 5DYB 5DYD 5DZ0 5DZ1 5DZ3 5DZH 5DZI 5E0W 5E0X 5E14 5E15 5E19 5E1C 5EC9 5EGV 5EHJ 5EI1 5EIT 5G3J 5G42 5G43 5G44 5G45 5G46 5G5W 5H1E 5HYR 5I4V 5IAW 5ICK 5KCC 5KCD 5KCE 5KCF 5KCT 5KCU 5KCW 5KD9 5KR9 5KRA 5KRC 5KRF 5KRH 5KRI 5KRJ 5KRK 5KRL 5KRM 5KRO 5L11 5LGA 5LYQ 5MK4 5NFP 5NFT 5NI5 5NI7 5NI8 5NIB 5Q17 5SYZ 5T1Z 5TLD 5TLF 5TLG 5TLL 5TLM 5TLO 5TLP 5TLT 5TLU 5TLV 5TLX 5TLY 5TM1 5TM2 5TM3 5TM4 5TM5 5TM6 5TM7 5TM8 5TM9 5TML 5TMM 5TMO 5TMQ 5TMR 5TMS 5TMT 5TMU 5TMV 5TMW 5TMZ 5TN1 5TN3 5TN4 5TN5 5TN6 5TN7 5TN8 5U2D 5UAN 5VB3 5VB5 5VB6 5VB7 5VQK 5VQL 5WGQ 5WZX 5XPL 5Y1J 5Y49 5YP5 5YXB 5YXD 5YXJ 5YXL 5Z12 6CZN 6D0F 6EL6 6EL7 6EL9 6ESN 6KKB 6KKE 6KNU 6KNV 6KNW 6OQX 6OQY 6OR1 6R7A 6R7J 6R7K 6SJM 6STI
CATH (Classification of proteins structures)	1GWQ 1GWR 1M2Z 1MV9 1MVC 1MZN 1P93 1T63 1T65 1UHL 1YOK 1ZDT 1ZDU 1ZKY 2AO6 2B1V 2B1Z 2B23 2FAI 2G44 2G5O 2LDC 2P15 2P1T 2P1U 2P1V 2Q7J 2Q7L 2YJD 2ZXZ 2ZY0 3A9E 3CLD 3DZU 3DZY 3E00 3E7C 3E94 3ERD 3FUG 3GN8 3K22 3K23 3KWY 3KYT 3L0E 3L0J 3L0L 3O1D 3O1E 3OAP 3OZJ 3PCU 3PLZ 3Q95 3R5M 3UP0 3UP3 4CSJ 4DOS 4E2J 4FHH 4FHI 4IA1 4IA2 4IA3 4IA7 4IQR 4IU7 4IUI 4IV2 4IV4 4IVW 4IVY 4IW6 4IW8 4IWC 4IWF 4K4J 4K6I 4M8E 4M8H 4NIE 4NQA 4OC7 4P6W 4P6X 4PLD 4PLE 4POH 4POJ 4PP3 4PP5 4PP6 4PPP 4PPS 4PXM 4Q0A 4Q13 4QE6 4QE8 4RFW 4RMC 4RMD 4RME 4RUO 4UDC 4UDD 4WG0 4ZN7 4ZN9 4ZNH 4ZNS 4ZNT 4ZNU 4ZNV 4ZNW 4ZO1 4ZSH 5APH 5APJ 5DI7 5DID 5DIE 5DIG 5DK9 5DKB 5DKE 5DKG 5DKS 5DL4 5DLR 5DMC 5DMF 5DP0 5DRJ 5DRM 5DTV 5DU5 5DUE 5DUG 5DUH 5DVS 5DVV 5DWE 5DWG 5DWI 5DWJ 5DX3 5DXB 5DXE 5DXG 5DXK 5DXM 5DXP 5DXQ 5DXR 5DY8 5DYB 5DYD 5DZ0 5DZ1 5DZ3 5DZH 5DZI 5E0W 5E0X 5E14 5E15 5E19 5E1C 5EC9 5EGV 5EHJ 5EI1 5EIT 5G3J 5G42 5G43 5G44 5G45 5G46 5G5W 5H1E 5HYR 5I4V 5IAW 5ICK 5KCC 5KCD 5KCE 5KCF 5KCT 5KCU 5KCW 5KD9 5KR9 5KRA 5KRC 5KRF 5KRH 5KRI 5KRJ 5KRK 5KRL 5KRM 5KRO 5L11 5LGA 5LYQ 5MK4 5NFP 5NFT 5NI5 5NI7 5NI8 5NIB 5Q17 5SYZ 5T1Z 5TLD 5TLF 5TLG 5TLL 5TLM 5TLO 5TLP 5TLT 5TLU 5TLV 5TLX 5TLY 5TM1 5TM2 5TM3 5TM4 5TM5 5TM6 5TM7 5TM8 5TM9 5TML 5TMM 5TMO 5TMQ 5TMR 5TMS 5TMT 5TMU 5TMV 5TMW 5TMZ 5TN1 5TN3 5TN4 5TN5 5TN6 5TN7 5TN8 5U2D 5UAN 5VB3 5VB5 5VB6 5VB7 5VQK 5VQL 5WGQ 5WZX 5XPL 5Y1J 5Y49 5YP5 5YXB 5YXD 5YXJ 5YXL 5Z12 6CZN 6D0F 6EL6 6EL7 6EL9 6ESN 6KKB 6KKE 6KNU 6KNV 6KNW 6OQX 6OQY 6OR1 6R7A 6R7J 6R7K 6SJM 6STI
Superfamily	Q15596
Human Protein Atlas [tissue]	ENSG00000140396-NCOA2 [tissue]
Peptide Atlas	Q15596
HPRD	09066
IPI	IPI00018251 IPI00985123 IPI00983197 IPI00976503 IPI00974076
	Protein Interaction databases
DIP (DOE-UCLA)	Q15596
IntAct (EBI)	Q15596
FunCoup	ENSG00000140396
BioGRID	NCOA2
STRING (EMBL)	NCOA2
ZODIAC	NCOA2
	Ontologies - Pathways
QuickGO	Q15596
Ontology : AmiGO	negative regulation of transcription by RNA polymerase II nuclear chromatin RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding chromatin binding transcription coactivator activity transcription coactivator activity protein binding nucleus nucleoplasm nucleoplasm cytoplasm regulation of transcription, DNA-templated regulation of glucose metabolic process bile acid and bile salt transport nuclear body nuclear receptor binding nuclear receptor binding aryl hydrocarbon receptor binding regulation of lipid metabolic process protein domain specific binding nuclear receptor transcription coactivator activity nuclear receptor transcription coactivator activity thyroid hormone receptor coactivator activity response to progesterone cellular response to hormone stimulus circadian regulation of gene expression protein-containing complex nuclear hormone receptor binding nuclear hormone receptor binding locomotor rhythm positive regulation of transcription by RNA polymerase II protein dimerization activity cellular response to Thyroglobulin triiodothyronine
Ontology : EGO-EBI	negative regulation of transcription by RNA polymerase II nuclear chromatin RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding chromatin binding transcription coactivator activity transcription coactivator activity protein binding nucleus nucleoplasm nucleoplasm cytoplasm regulation of transcription, DNA-templated regulation of glucose metabolic process bile acid and bile salt transport nuclear body nuclear receptor binding nuclear receptor binding aryl hydrocarbon receptor binding regulation of lipid metabolic process protein domain specific binding nuclear receptor transcription coactivator activity nuclear receptor transcription coactivator activity thyroid hormone receptor coactivator activity response to progesterone cellular response to hormone stimulus circadian regulation of gene expression protein-containing complex nuclear hormone receptor binding nuclear hormone receptor binding locomotor rhythm positive regulation of transcription by RNA polymerase II protein dimerization activity cellular response to Thyroglobulin triiodothyronine
Pathways : KEGG	Thyroid hormone signaling pathway
NDEx Network	NCOA2
Atlas of Cancer Signalling Network	NCOA2
Wikipedia pathways	NCOA2
	Orthology - Evolution
OrthoDB	10499
GeneTree (enSembl)	ENSG00000140396
Phylogenetic Trees/Animal Genes : TreeFam	NCOA2
HOGENOM	Q15596
Homologs : HomoloGene	NCOA2
Homology/Alignments : Family Browser (UCSC)	NCOA2
	Gene fusions - Rearrangements
Fusion : Mitelman	AHRR/NCOA2 [5p15.33/8q13.3]
Fusion : Mitelman	ETV6/NCOA2 [12p13.2/8q13.3]
Fusion : Mitelman	GTF2I/NCOA2 [7q11.23/8q13.3]
Fusion : Mitelman	HEY1/NCOA2 [8q21.13/8q13.3]
Fusion : Mitelman	KAT6A/NCOA2 [8p11.21/8q13.3]
Fusion : Mitelman	NCOA2/ARFGEF1 [8q13.3/8q13.2]
Fusion : Mitelman	NCOA2/LEPROTL1 [8q13.3/8p12]
Fusion : Mitelman	NCOA2/NCALD [8q13.3/8q22.3]
Fusion : Mitelman	NCOA2/ST18 [8q13.3/8q11.23]
Fusion : Mitelman	NCOA2/XKR9 [8q13.3/8q13.3]
Fusion : Mitelman	NCOA2/ZNF704 [8q13.3/8q21.13]
Fusion : Mitelman	PAX3/NCOA2 [2q36.1/8q13.3]
Fusion : Mitelman	SH2D6/NCOA2 [2p11.2/8q13.3]
Fusion : Mitelman	SRF/NCOA2 [6p21.1/8q13.3]
Fusion : Mitelman	TEAD1/NCOA2 [11p15.3/8q13.3]
Fusion Portal	NCOA2 8q13.3 ARFGEF1 8q13.2 BRCA
Fusion Portal	NCOA2 8q13.3 LEPROTL1 8p12 LUAD
Fusion Portal	NCOA2 8q13.3 NCALD 8q22.3 BRCA
Fusion Portal	NCOA2 8q13.3 ST18 8q11.23 SKCM
Fusion Portal	NCOA2 8q13.3 XKR9 8q13.3 LUAD
Fusion Portal	SH2D6 2p11.2 NCOA2 8q13.3 BLCA
Fusion : Quiver	NCOA2
	Polymorphisms : SNP and Copy number variants
NCBI Variation Viewer	NCOA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)	NCOA2
dbVar	NCOA2
ClinVar	NCOA2
1000_Genomes	NCOA2
Exome Variant Server	NCOA2
GNOMAD Browser	ENSG00000140396
Varsome Browser	NCOA2
Genetic variants : HAPMAP	10499
Genomic Variants (DGV)	NCOA2 [DGVbeta]
DECIPHER	NCOA2 [patients] [syndromes] [variants] [genes]
CONAN: Copy Number Analysis	NCOA2
	Mutations
ICGC Data Portal	NCOA2
TCGA Data Portal	NCOA2
Broad Tumor Portal	NCOA2
OASIS Portal	NCOA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMIC	NCOA2 [overview] [genome browser] [tissue] [distribution]
Somatic Mutations in Cancer : COSMIC3D	NCOA2
Mutations and Diseases : HGMD	NCOA2
LOVD (Leiden Open Variation Database)	Whole genome datasets
LOVD (Leiden Open Variation Database)	LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)	LOVD 3.0 shared installation
BioMuta	search NCOA2
DgiDB (Drug Gene Interaction Database)	NCOA2
DoCM (Curated mutations)	NCOA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)	NCOA2 (select a term)
intoGen	NCOA2
Cancer3D	NCOA2(select the gene name)
Impact of mutations	[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
	Diseases
OMIM	601993
Orphanet
DisGeNET	NCOA2
Medgen	NCOA2
Genetic Testing Registry	NCOA2
NextProt	Q15596 [Medical]
TSGene	10499
GENETests	NCOA2
Target Validation	NCOA2
Huge Navigator	NCOA2 [HugePedia]
snp3D : Map Gene to Disease	10499
BioCentury BCIQ	NCOA2
ClinGen	NCOA2
	Clinical trials, drugs, therapy
Protein Interactions : CTD	10499
Pharm GKB Gene	PA31471
Clinical trial	NCOA2
	Miscellaneous
canSAR (ICR)	NCOA2 (select the gene name)
Harmonizome	NCOA2
DataMed Index	NCOA2
	Probes
	Litterature
PubMed	242 Pubmed reference(s) in Entrez
GeneRIFs	Gene References Into Functions (Entrez)
CoreMine	NCOA2
EVEX	NCOA2
GoPubMed	NCOA2

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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indexed on : Thu Jul 16 15:26:43 CEST 2020

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Atlas of Genetics and Cytogenetics in Oncology and Haematology

NCOA2 (nuclear receptor coactivator 2)

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to How to contribute