NCOA2 (nuclear receptor coactivator 2)

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NCOA2 (nuclear receptor coactivator 2)

Identity

Other names	GRIP1
	KAT13C
	NCoA-2
	SRC2
	TIF2
	bHLHe75
HGNC (Hugo)	NCOA2
LocusID (NCBI)	10499
Location	8q13.3
Location_base_pair	Starts at 71024267 and ends at 71316020 bp from pter ( according to hg19-Feb_2009)
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

Breakpoints

External links

	Nomenclature
HGNC (Hugo)	NCOA2 7669
Entrez_Gene (NCBI)	NCOA2 10499 nuclear receptor coactivator 2
	Cards
GeneCards (Weizmann)	NCOA2
Ensembl (Hinxton)	ENSG00000140396 [Gene_View] chr8:71024267-71316020 [Contig_View] NCOA2 [Vega]
AceView (NCBI)	NCOA2
Genatlas (Paris)	NCOA2
SOURCE (Stanford)	NM_006540
	Genomic and cartography
GoldenPath (UCSC)	NCOA2 - 8q13.3 chr8:71024267-71316020 - 8q13.3 [Description] (hg19-Feb_2009)
Ensembl	NCOA2 - 8q13.3 [CytoView]
Mapping of homologs : NCBI	NCOA2 [Mapview]
OMIM	601993
	Gene and transcription
Genbank (Entrez)	AK298528 AK308426 AW504723 BC092442 BC114383
RefSeq transcript (SRS)	NM_006540
RefSeq transcript (Entrez)	NM_006540
RefSeq genomic (SRS)	AC_000140 NC_000008 NC_018919 NT_008183 NW_001839132 NW_004929339
RefSeq genomic (Entrez)	AC_000140 NC_000008 NC_018919 NT_008183 NW_001839132 NW_004929339
Consensus coding sequences : CCDS (NCBI)	NCOA2
Cluster EST : Unigene	Hs.446678 [ SRS ] Hs.446678 [ NCBI ]
CGAP (NCI)	Hs.446678
Alternative Splicing : Fast-db (Paris)	GSHG0029636
Alternative Splicing Gallery	ENSG00000140396
Gene Expression	NCOA2 [ NCBI-GEO ] NCOA2 [ EBI - ARRAY_EXPRESS ]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	Q15596 (SRS) Q15596 (Uniprot)
NextProt	Q15596 [Medical]
With graphics : InterPro	Q15596
Splice isoforms : SwissVar	Q15596(Swissvar)
Domaine pattern : Prosite (SRS)	BHLH (PS50888) PAS (PS50112)
Domaine pattern : Prosite (Expaxy)	BHLH (PS50888) PAS (PS50112)
Domains : Interpro (SRS)	bHLH_dom DUF1518 Nuc_rcpt_coact Nuc_rcpt_coact_Ncoa-typ Nuclear_rcpt_coactivator PAC PAS PAS_fold SRC-1 Src1_rcpt_coact
Domains : Interpro (EBI)	bHLH_dom DUF1518 Nuc_rcpt_coact Nuc_rcpt_coact_Ncoa-typ Nuclear_rcpt_coactivator PAC PAS PAS_fold SRC-1 Src1_rcpt_coact
Related proteins : CluSTr	Q15596
Domain families : Pfam (SRS)	DUF1518 (PF07469) Nuc_rec_co-act (PF08815) PAS (PF00989) SRC-1 (PF08832)
Domain families : Pfam (Sanger)	DUF1518 (PF07469) Nuc_rec_co-act (PF08815) PAS (PF00989) SRC-1 (PF08832)
Domain families : Pfam (NCBI)	pfam07469 pfam08815 pfam00989 pfam08832
Domain families : Smart (EMBL)	HLH (SM00353) PAC (SM00086) PAS (SM00091)
DMDM	10499
Blocks (Seattle)	Q15596
PDB (SRS)	1GWQ 1GWR 1M2Z 1MV9 1MVC 1MZN 1P93 1T63 1T65 1UHL 1YOK 1ZDT 1ZDU 1ZKY 2AO6 2B1V 2B1Z 2B23 2FAI 2G44 2G5O 2P15 2P1T 2P1U 2P1V 2Q7J 2Q7L 2ZXZ 2ZY0 3A9E 3CLD 3DZU 3DZY 3E00 3E7C 3E94 3FUG 3GN8 3K22 3KWY 3KYT 3L0E 3L0J 3L0L 3O1D 3O1E 3OAP 3OZJ 3PCU 3PLZ 3Q95 3Q97 3R5M 3UP0 3UP3 4DOS 4E2J 4FHH 4FHI 4IA1 4IA2 4IA3 4IA7 4IQR 4IU7 4IUI 4IV2 4IV4 4IVW 4IVY 4IW6 4IW8 4IWC 4IWF
PDB (PDBSum)	1GWQ 1GWR 1M2Z 1MV9 1MVC 1MZN 1P93 1T63 1T65 1UHL 1YOK 1ZDT 1ZDU 1ZKY 2AO6 2B1V 2B1Z 2B23 2FAI 2G44 2G5O 2P15 2P1T 2P1U 2P1V 2Q7J 2Q7L 2ZXZ 2ZY0 3A9E 3CLD 3DZU 3DZY 3E00 3E7C 3E94 3FUG 3GN8 3K22 3KWY 3KYT 3L0E 3L0J 3L0L 3O1D 3O1E 3OAP 3OZJ 3PCU 3PLZ 3Q95 3Q97 3R5M 3UP0 3UP3 4DOS 4E2J 4FHH 4FHI 4IA1 4IA2 4IA3 4IA7 4IQR 4IU7 4IUI 4IV2 4IV4 4IVW 4IVY 4IW6 4IW8 4IWC 4IWF
PDB (IMB)	1GWQ 1GWR 1M2Z 1MV9 1MVC 1MZN 1P93 1T63 1T65 1UHL 1YOK 1ZDT 1ZDU 1ZKY 2AO6 2B1V 2B1Z 2B23 2FAI 2G44 2G5O 2P15 2P1T 2P1U 2P1V 2Q7J 2Q7L 2ZXZ 2ZY0 3A9E 3CLD 3DZU 3DZY 3E00 3E7C 3E94 3FUG 3GN8 3K22 3KWY 3KYT 3L0E 3L0J 3L0L 3O1D 3O1E 3OAP 3OZJ 3PCU 3PLZ 3Q95 3Q97 3R5M 3UP0 3UP3 4DOS 4E2J 4FHH 4FHI 4IA1 4IA2 4IA3 4IA7 4IQR 4IU7 4IUI 4IV2 4IV4 4IVW 4IVY 4IW6 4IW8 4IWC 4IWF
PDB (RSDB)	1GWQ 1GWR 1M2Z 1MV9 1MVC 1MZN 1P93 1T63 1T65 1UHL 1YOK 1ZDT 1ZDU 1ZKY 2AO6 2B1V 2B1Z 2B23 2FAI 2G44 2G5O 2P15 2P1T 2P1U 2P1V 2Q7J 2Q7L 2ZXZ 2ZY0 3A9E 3CLD 3DZU 3DZY 3E00 3E7C 3E94 3FUG 3GN8 3K22 3KWY 3KYT 3L0E 3L0J 3L0L 3O1D 3O1E 3OAP 3OZJ 3PCU 3PLZ 3Q95 3Q97 3R5M 3UP0 3UP3 4DOS 4E2J 4FHH 4FHI 4IA1 4IA2 4IA3 4IA7 4IQR 4IU7 4IUI 4IV2 4IV4 4IVW 4IVY 4IW6 4IW8 4IWC 4IWF
Human Protein Atlas	ENSG00000140396
HPRD	09066
IPI	IPI00018251 IPI00985123 IPI00983197 IPI00976503 IPI00974076
	Protein Interaction databases
DIP (DOE-UCLA)	Q15596
IntAct (EBI)	Q15596
FunCoup	ENSG00000140396
REACTOME	NCOA2
Protein Interaction Database	10499
BioGRID	NCOA2
InParanoid	Q15596
Interologous Interaction database	Q15596
IntegromeDB	NCOA2
	Gene fusion - rearrangments
Rearrangement : COSMIC	HEY1 [8q21.13] - NCOA2 [8q13.3]
Rearrangement : COSMIC	PAX3 [2q36.1] - NCOA2 [8q13.3]
Translocation Breakpoints in Cancer : TICdb	NCOA2
	Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)	NCOA2
SNP (GeneSNP Utah)	NCOA2
SNP : HGBase	NCOA2
Genetic variants : HAPMAP	NCOA2
Somatic Mutations in Cancer : COSMIC	NCOA2
CONAN: Copy Number Analysis	NCOA2
Mutations and Diseases : HGMD	NCOA2
OMIM	601993
GENETests	601993
Disease Genetic Association	NCOA2
Huge Navigator	NCOA2 [HugePedia] NCOA2 [HugeCancerGEM]
Genomic Variants	NCOA2 NCOA2 [DGVbeta]
ClinVar	NCOA2
snp3D : Map Gene to Disease	10499
	General knowledge
Homologs : HomoloGene	NCOA2
Homology/Alignments : Family Browser (UCSC)	NCOA2
Phylogenetic Trees/Animal Genes : TreeFam	NCOA2
Chemical/Protein Interactions : CTD	10499
Chemical/Pharm GKB Gene	PA31471
Clinical trial	NCOA2
Cancer Resource (Charite)	ENSG00000140396
Ontology : AmiGO	negative regulation of transcription from RNA polymerase II promoter chromatin binding transcription coactivator activity histone acetyltransferase activity signal transducer activity protein binding nucleus nucleoplasm cytoplasm transcription, DNA-templated regulation of transcription, DNA-dependent ligand-dependent nuclear receptor binding ligand-dependent nuclear receptor transcription coactivator activity thyroid hormone receptor coactivator activity androgen receptor signaling pathway nuclear hormone receptor binding cellular lipid metabolic process small molecule metabolic process positive regulation of transcription from RNA polymerase II promoter protein dimerization activity
Ontology : EGO-EBI	negative regulation of transcription from RNA polymerase II promoter chromatin binding transcription coactivator activity histone acetyltransferase activity signal transducer activity protein binding nucleus nucleoplasm cytoplasm transcription, DNA-templated regulation of transcription, DNA-dependent ligand-dependent nuclear receptor binding ligand-dependent nuclear receptor transcription coactivator activity thyroid hormone receptor coactivator activity androgen receptor signaling pathway nuclear hormone receptor binding cellular lipid metabolic process small molecule metabolic process positive regulation of transcription from RNA polymerase II promoter protein dimerization activity
	Other databases
	Probes
	Litterature
PubMed	157 Pubmed reference(s) in Entrez
PubGene	NCOA2
iHOP	NCOA2

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S

Updated	01-2013	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Dec 3 19:40:36 CET 2013

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jlhuret@AtlasGeneticsOncology.org.

Atlas of Genetics and Cytogenetics in Oncology and Haematology

NCOA2 (nuclear receptor coactivator 2)

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to How to contribute