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NCOA6 (nuclear receptor coactivator 6)

Identity

Alias_symbol (synonym)KIAA0181
RAP250
ASC2
AIB3
PRIP
TRBP
NRC
Other alias
HGNC (Hugo) NCOA6
LocusID (NCBI) 23054
Atlas_Id 41507
Location 20q11.22  [Link to chromosome band 20q11]
Location_base_pair Starts at 34714774 and ends at 34782404 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CHMP4B (20q11.22) / NCOA6 (20q11.22)NCOA6 (20q11.22) / GSS (20q11.22)NCOA6 (20q11.22) / NCOA6 (20q11.22)
NCOA6 (20q11.22) / PPIL4 (6q25.1)NCOA6 (20q11.22) / RALGAPA2 (20p11.23)NCOA6 (20q11.22) / SLC10A1 (14q24.2)
NCOA6 (20q11.22) / TCFL5 (20q13.33)NDE1 (16p13.11) / NCOA6 (20q11.22)PIGU (20q11.22) / NCOA6 (20q11.22)
PPP4R1L (20q13.32) / NCOA6 (20q11.22)PTTG1IP (21q22.3) / NCOA6 (20q11.22)ZNF343 (20p13) / NCOA6 (20q11.22)
NCOA6 20q11.22 / GSS 20q11.22NCOA6 20q11.22 / RALGAPA2 20p11.23NCOA6 20q11.22 / SLC10A1 14q24.2
NCOA6 20q11.22 / TCFL5 20q13.33PPP4R1L 20q13.32 / NCOA6 20q11.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NCOA6   15936
Cards
Entrez_Gene (NCBI)NCOA6  23054  nuclear receptor coactivator 6
AliasesAIB3; ASC2; NRC; PRIP; 
RAP250; TRBP
GeneCards (Weizmann)NCOA6
Ensembl hg19 (Hinxton)ENSG00000198646 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198646 [Gene_View]  chr20:34714774-34782404 [Contig_View]  NCOA6 [Vega]
ICGC DataPortalENSG00000198646
TCGA cBioPortalNCOA6
AceView (NCBI)NCOA6
Genatlas (Paris)NCOA6
WikiGenes23054
SOURCE (Princeton)NCOA6
Genetics Home Reference (NIH)NCOA6
Genomic and cartography
GoldenPath hg38 (UCSC)NCOA6  -     chr20:34714774-34782404 -  20q11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NCOA6  -     20q11.22   [Description]    (hg19-Feb_2009)
EnsemblNCOA6 - 20q11.22 [CytoView hg19]  NCOA6 - 20q11.22 [CytoView hg38]
Mapping of homologs : NCBINCOA6 [Mapview hg19]  NCOA6 [Mapview hg38]
OMIM605299   
Gene and transcription
Genbank (Entrez)AF128458 AF171667 AF177388 AF208227 AF245115
RefSeq transcript (Entrez)NM_001242539 NM_001318240 NM_014071
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NCOA6
Cluster EST : UnigeneHs.736403 [ NCBI ]
CGAP (NCI)Hs.736403
Alternative Splicing GalleryENSG00000198646
Gene ExpressionNCOA6 [ NCBI-GEO ]   NCOA6 [ EBI - ARRAY_EXPRESS ]   NCOA6 [ SEEK ]   NCOA6 [ MEM ]
Gene Expression Viewer (FireBrowse)NCOA6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23054
GTEX Portal (Tissue expression)NCOA6
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14686   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14686  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14686
Splice isoforms : SwissVarQ14686
PhosPhoSitePlusQ14686
Domains : Interpro (EBI)NCOA6_nucleic_acid-bd   
Domain families : Pfam (Sanger)Nucleic_acid_bd (PF13820)   
Domain families : Pfam (NCBI)pfam13820   
Conserved Domain (NCBI)NCOA6
DMDM Disease mutations23054
Blocks (Seattle)NCOA6
SuperfamilyQ14686
Human Protein AtlasENSG00000198646
Peptide AtlasQ14686
HPRD05599
IPIIPI00179071   IPI00873973   
Protein Interaction databases
DIP (DOE-UCLA)Q14686
IntAct (EBI)Q14686
FunCoupENSG00000198646
BioGRIDNCOA6
STRING (EMBL)NCOA6
ZODIACNCOA6
Ontologies - Pathways
QuickGOQ14686
Ontology : AmiGOchromatin binding  transcription coactivator activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  cytosol  DNA replication  DNA repair  DNA recombination  DNA-templated transcription, initiation  transcription initiation from RNA polymerase II promoter  cellular response to DNA damage stimulus  brain development  heart development  response to hormone  enzyme binding  myeloid cell differentiation  estrogen receptor binding  ligand-dependent nuclear receptor transcription coactivator activity  intracellular estrogen receptor signaling pathway  histone methyltransferase complex  glucocorticoid receptor signaling pathway  intracellular membrane-bounded organelle  cellular lipid metabolic process  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  retinoid X receptor binding  thyroid hormone receptor binding  
Ontology : EGO-EBIchromatin binding  transcription coactivator activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  cytosol  DNA replication  DNA repair  DNA recombination  DNA-templated transcription, initiation  transcription initiation from RNA polymerase II promoter  cellular response to DNA damage stimulus  brain development  heart development  response to hormone  enzyme binding  myeloid cell differentiation  estrogen receptor binding  ligand-dependent nuclear receptor transcription coactivator activity  intracellular estrogen receptor signaling pathway  histone methyltransferase complex  glucocorticoid receptor signaling pathway  intracellular membrane-bounded organelle  cellular lipid metabolic process  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  retinoid X receptor binding  thyroid hormone receptor binding  
NDEx NetworkNCOA6
Atlas of Cancer Signalling NetworkNCOA6
Wikipedia pathwaysNCOA6
Orthology - Evolution
OrthoDB23054
GeneTree (enSembl)ENSG00000198646
Phylogenetic Trees/Animal Genes : TreeFamNCOA6
HOVERGENQ14686
HOGENOMQ14686
Homologs : HomoloGeneNCOA6
Homology/Alignments : Family Browser (UCSC)NCOA6
Gene fusions - Rearrangements
Fusion : MitelmanNCOA6/GSS [20q11.22/20q11.22]  
Fusion : MitelmanNCOA6/RALGAPA2 [20q11.22/20p11.23]  [t(20;20)(p11;q11)]  
Fusion : MitelmanNCOA6/SLC10A1 [20q11.22/14q24.2]  [t(14;20)(q24;q11)]  
Fusion : MitelmanNCOA6/TCFL5 [20q11.22/20q13.33]  [t(20;20)(q11;q13)]  
Fusion : MitelmanPIGU/NCOA6 [20q11.22/20q11.22]  [t(20;20)(q11;q11)]  
Fusion : MitelmanPPP4R1L/NCOA6 [20q13.32/20q11.22]  [t(20;20)(q11;q13)]  
Fusion: TCGANCOA6 20q11.22 GSS 20q11.22 BRCA
Fusion: TCGANCOA6 20q11.22 RALGAPA2 20p11.23 BRCA
Fusion: TCGANCOA6 20q11.22 SLC10A1 14q24.2 OV
Fusion: TCGANCOA6 20q11.22 TCFL5 20q13.33 LUAD
Fusion: TCGAPPP4R1L 20q13.32 NCOA6 20q11.22 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNCOA6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NCOA6
dbVarNCOA6
ClinVarNCOA6
1000_GenomesNCOA6 
Exome Variant ServerNCOA6
ExAC (Exome Aggregation Consortium)NCOA6 (select the gene name)
Genetic variants : HAPMAP23054
Genomic Variants (DGV)NCOA6 [DGVbeta]
DECIPHERNCOA6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNCOA6 
Mutations
ICGC Data PortalNCOA6 
TCGA Data PortalNCOA6 
Broad Tumor PortalNCOA6
OASIS PortalNCOA6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNCOA6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNCOA6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NCOA6
DgiDB (Drug Gene Interaction Database)NCOA6
DoCM (Curated mutations)NCOA6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NCOA6 (select a term)
intoGenNCOA6
Cancer3DNCOA6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605299   
Orphanet
MedgenNCOA6
Genetic Testing Registry NCOA6
NextProtQ14686 [Medical]
TSGene23054
GENETestsNCOA6
Target ValidationNCOA6
Huge Navigator NCOA6 [HugePedia]
snp3D : Map Gene to Disease23054
BioCentury BCIQNCOA6
ClinGenNCOA6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23054
Chemical/Pharm GKB GenePA31475
Clinical trialNCOA6
Miscellaneous
canSAR (ICR)NCOA6 (select the gene name)
Probes
Litterature
PubMed69 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNCOA6
EVEXNCOA6
GoPubMedNCOA6
iHOPNCOA6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:21:39 CEST 2017

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