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NCOR1 (nuclear receptor corepressor 1)

Identity

Alias_namesnuclear receptor co-repressor 1
Alias_symbol (synonym)N-CoR
hCIT529I10
TRAC1
hN-CoR
KIAA1047
<.TD>¼TD$WIDTH=80%>MGC104216
PPP1R109
Other aliasN-CoR1
HGNC (Hugo) NCOR1
LocusID (NCBI) 9611
Atlas_Id 41508
Location 17p12  [Link to chromosome band 17p12]
Location_base_pair Starts at 16091570 and ends at 16194639 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NCOR1 (17p12) / ACACA (17q12)NCOR1 (17p12) / ACER3 (11q13.5)NCOR1 (17p12) / FBXO3 (11p13)
NCOR1 (17p12) / LYN (8q12.1)NCOR1 (17p12) / RDX (11q22.3)NCOR1 (17p12) / RHOU (1q42.13)
NCOR1 (17p12) / RSF1 (11q14.1)NCOR1 (17p12) / SF3B1 (2q33.1)NCOR1 (17p12) / ZNF287 (17p11.2)
PAX5 (9p13.2) / NCOR1 (17p12)PHF21B (22q13.31) / NCOR1 (17p12)TTC19 (17p12) / NCOR1 (17p12)
NCOR1 17p12 / ACACA 17q12NCOR1 17p12 / ACER3 11q13.5NCOR1 17p12 / FBXO3 11p13
NCOR1 17p12 / RHOU 1q42.13NCOR1 17p12 / RSF1 11q14.1NCOR1 17p12 / ZNF287 17p11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Protein

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 8 ]
  ins(12;8)(p13;q11q21) ETV6/LYN
t(1;12)(p36;p13) ETV6/PRDM16
t(3;17)(q26;q12-21) TBL1XR1/RARA
t(8;9)(q24;p13) ?/MYC
t(9;13)(p12;q21) PAX5/DACH1
t(9;17)(p13;p12) PAX5/NCOR1
t(10;17)(p15;q21) ZMYND11/MBTD1
t(X;9)(q21;p13) PAX5/DACH2


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Breast: Ductal carcinoma


External links

Nomenclature
HGNC (Hugo)NCOR1   7672
Cards
Entrez_Gene (NCBI)NCOR1  9611  nuclear receptor corepressor 1
AliasesN-CoR; N-CoR1; PPP1R109; TRAC1; 
hN-CoR
GeneCards (Weizmann)NCOR1
Ensembl hg19 (Hinxton)ENSG00000141027 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000141027 [Gene_View]  chr17:16091570-16194639 [Contig_View]  NCOR1 [Vega]
ICGC DataPortalENSG00000141027
TCGA cBioPortalNCOR1
AceView (NCBI)NCOR1
Genatlas (Paris)NCOR1
WikiGenes9611
SOURCE (Princeton)NCOR1
Genetics Home Reference (NIH)NCOR1
Genomic and cartography
GoldenPath hg38 (UCSC)NCOR1  -     chr17:16091570-16194639 -  17p12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NCOR1  -     17p12   [Description]    (hg19-Feb_2009)
EnsemblNCOR1 - 17p12 [CytoView hg19]  NCOR1 - 17p12 [CytoView hg38]
Mapping of homologs : NCBINCOR1 [Mapview hg19]  NCOR1 [Mapview hg38]
OMIM600849   
Gene and transcription
Genbank (Entrez)AB028450 AB028451 AB028970 AF044209 AF087856
RefSeq transcript (Entrez)NM_001190438 NM_001190440 NM_006311
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NCOR1
Cluster EST : UnigeneHs.462323 [ NCBI ]
CGAP (NCI)Hs.462323
Alternative Splicing GalleryENSG00000141027
Gene ExpressionNCOR1 [ NCBI-GEO ]   NCOR1 [ EBI - ARRAY_EXPRESS ]   NCOR1 [ SEEK ]   NCOR1 [ MEM ]
Gene Expression Viewer (FireBrowse)NCOR1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9611
GTEX Portal (Tissue expression)NCOR1
Human Protein AtlasENSG00000141027-NCOR1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75376   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75376  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75376
Splice isoforms : SwissVarO75376
PhosPhoSitePlusO75376
Domaine pattern : Prosite (Expaxy)SANT (PS51293)   
Domains : Interpro (EBI)Homeobox-like    N-CoR_GPS2_interact    SANT/Myb    SANT_dom   
Domain families : Pfam (Sanger)GPS2_interact (PF15784)    Myb_DNA-binding (PF00249)   
Domain families : Pfam (NCBI)pfam15784    pfam00249   
Domain families : Smart (EMBL)SANT (SM00717)  
Conserved Domain (NCBI)NCOR1
DMDM Disease mutations9611
Blocks (Seattle)NCOR1
PDB (SRS)2EQR    3H52    3KMZ    3N00    4MDD    4WVD   
PDB (PDBSum)2EQR    3H52    3KMZ    3N00    4MDD    4WVD   
PDB (IMB)2EQR    3H52    3KMZ    3N00    4MDD    4WVD   
PDB (RSDB)2EQR    3H52    3KMZ    3N00    4MDD    4WVD   
Structural Biology KnowledgeBase2EQR    3H52    3KMZ    3N00    4MDD    4WVD   
SCOP (Structural Classification of Proteins)2EQR    3H52    3KMZ    3N00    4MDD    4WVD   
CATH (Classification of proteins structures)2EQR    3H52    3KMZ    3N00    4MDD    4WVD   
SuperfamilyO75376
Human Protein Atlas [tissue]ENSG00000141027-NCOR1 [tissue]
Peptide AtlasO75376
HPRD02911
IPIIPI00410351   IPI00939364   IPI00289344   IPI00790393   IPI00816631   IPI00978018   IPI00792418   IPI00793060   IPI00793653   IPI00794212   
Protein Interaction databases
DIP (DOE-UCLA)O75376
IntAct (EBI)O75376
FunCoupENSG00000141027
BioGRIDNCOR1
STRING (EMBL)NCOR1
ZODIACNCOR1
Ontologies - Pathways
QuickGOO75376
Ontology : AmiGOhistone deacetylase complex  negative regulation of transcription from RNA polymerase II promoter  negative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  RNA polymerase II activating transcription factor binding  transcription corepressor activity  transcription corepressor activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytosol  spindle microtubule  transcription from RNA polymerase II promoter  circadian rhythm  membrane  covalent chromatin modification  Sin3 complex  ligand-dependent nuclear receptor binding  transcriptional repressor complex  nuclear hormone receptor binding  histone deacetylase binding  transcription regulatory region DNA binding  cellular lipid metabolic process  negative regulation of JNK cascade  thyroid hormone receptor binding  spindle assembly  regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter  regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter  negative regulation of production of miRNAs involved in gene silencing by miRNA  regulation of fatty acid transport  
Ontology : EGO-EBIhistone deacetylase complex  negative regulation of transcription from RNA polymerase II promoter  negative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  RNA polymerase II activating transcription factor binding  transcription corepressor activity  transcription corepressor activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytosol  spindle microtubule &nb{p;transcription from RNA polymerase II promoter  circadian rhythm  membrane  covalent chromatin modification  Sin3 complex  ligand-dependent nuclear receptor binding  transcriptional repressor complex  nuclear hormone receptor binding  histone deacetylase binding  transcription regulatory region DNA binding  cellular lipid metabolic process  negative regulation of JNK cascade  thyroid hormone receptor binding  spindle assembly  regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter  regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter  negative regulation of production of miRNAs involved in gene silencing by miRNA  regulation of fatty acid transport  
Pathways : BIOCARTAControl of Gene Expression by Vitamin D Receptor [Genes]    Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) [Genes]   
Pathways : KEGGThyroid hormone signaling pathway    Transcriptional misregulation in cancer   
NDEx NetworkNCOR1
Atlas of Cancer Signalling NetworkNCOR1
Wikipedia pathwaysNCOR1
Orthology - Evolution
OrthoDB9611
GeneTree (enSembl)ENSG00000141027
Phylogenetic Trees/Animal Genes : TreeFamNCOR1
HOVERGENO75376
HOGENOMO75376
Homologs : HomoloGeneNCOR1
Homology/Alignments : Family Browser (UCSC)NCOR1
Gene fusions - Rearrangements
Fusion: TCGA_MDACCNCOR1 17p12 ACACA 17q12 BRCA
Fusion: TCGA_MDACCNCOR1 17p12 ACER3 11q13.5 BRCA
Fusion: TCGA_MDACCNCOR1 17p12 FBXO3 11p13 BRCA
Fusion: TCGA_MDACCNCOR1 17p12 RHOU 1q42.13 THCA
Fusion: TCGA_MDACCNCOR1 17p12 RSF1 11q14.1 BRCA
Fusion: TCGA_MDACCNCOR1 17p12 ZNF287 17p11.2 BRCA
Tumor Fusion PortalNCOR1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNCOR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NCOR1
dbVarNCOR1
ClinVarNCOR1
1000_GenomesNCOR1 
Exome Variant ServerNCOR1
ExAC (Exome Aggregation Consortium)ENSG00000141027
GNOMAD BrowserENSG00000141027
Genetic variants : HAPMAP9611
Genomic Variants (DGV)NCOR1 [DGVbeta]
DECIPHERNCOR1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNCOR1 
Mutations
ICGC Data PortalNCOR1 
TCGA Data PortalNCOR1 
Broad Tumor PortalNCOR1
OASIS PortalNCOR1 [ Somatic mutations - Copy number]
Cancer Gene: CensusNCOR1 
Somatic Mutations in Cancer : COSMICNCOR1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNCOR1
intOGen PortalNCOR1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NCOR1
DgiDB (Drug Gene Interaction Database)NCOR1
DoCM (Curated mutations)NCOR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NCOR1 (select a term)
intoGenNCOR1
Cancer3DNCOR1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600849   
Orphanet
DisGeNETNCOR1
MedgenNCOR1
Genetic Testing Registry NCOR1
NextProtO75376 [Medical]
TSGene9611
GENETestsNCOR1
Target ValidationNCOR1
Huge Navigator NCOR1 [HugePedia]
snp3D : Map Gene to Disease9611
BioCentury BCIQNCOR1
ClinGenNCOR1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9611
Chemical/Pharm GKB GenePA31477
Clinical trialNCOR1
Miscellaneous
canSAR (ICR)NCOR1 (select the gene name)
Probes
Litterature
PubMed269 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNCOR1
EVEXNCOR1
GoPubMedNCOR1
iHOPNCOR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:25:46 CET 2017

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