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NCR3 (natural cytotoxicity triggering receptor 3)

Identity

Alias_namesLY117
lymphocyte antigen 117
Alias_symbol (synonym)1C7
NKp30
CD337
Other aliasMALS
HGNC (Hugo) NCR3
LocusID (NCBI) 259197
Atlas_Id 45913
Location 6p21.33  [Link to chromosome band 6p21]
Location_base_pair Starts at 31588883 and ends at 31592985 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PRRC2A (6p21.33) / NCR3 (6p21.33)PTK2 (8q24.3) / NCR3 (6p21.33)PRRC2A 6p21.33 / NCR3 6p21.33
PTK2 8q24.3 / NCR3 6p21.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NCR3   19077
Cards
Entrez_Gene (NCBI)NCR3  259197  natural cytotoxicity triggering receptor 3
Aliases1C7; CD337; LY117; MALS; 
NKp30
GeneCards (Weizmann)NCR3
Ensembl hg19 (Hinxton)ENSG00000204475 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000204475 [Gene_View]  chr6:31588883-31592985 [Contig_View]  NCR3 [Vega]
ICGC DataPortalENSG00000204475
TCGA cBioPortalNCR3
AceView (NCBI)NCR3
Genatlas (Paris)NCR3
WikiGenes259197
SOURCE (Princeton)NCR3
Genetics Home Reference (NIH)NCR3
Genomic and cartography
GoldenPath hg38 (UCSC)NCR3  -     chr6:31588883-31592985 -  6p21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NCR3  -     6p21.33   [Description]    (hg19-Feb_2009)
EnsemblNCR3 - 6p21.33 [CytoView hg19]  NCR3 - 6p21.33 [CytoView hg38]
Mapping of homologs : NCBINCR3 [Mapview hg19]  NCR3 [Mapview hg38]
OMIM609148   611550   
Gene and transcription
Genbank (Entrez)AB055881 AF031136 AF031137 AF031138 AJ223153
RefSeq transcript (Entrez)NM_001145466 NM_001145467 NM_147130
RefSeq genomic (Entrez)NC_000006 NC_018917 NG_021176 NT_113891 NT_167244 NT_167245 NT_167246 NT_167247 NT_167248 NT_167249
Consensus coding sequences : CCDS (NCBI)NCR3
Cluster EST : UnigeneHs.509513 [ NCBI ]
CGAP (NCI)Hs.509513
Alternative Splicing GalleryENSG00000204475
Gene ExpressionNCR3 [ NCBI-GEO ]   NCR3 [ EBI - ARRAY_EXPRESS ]   NCR3 [ SEEK ]   NCR3 [ MEM ]
Gene Expression Viewer (FireBrowse)NCR3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)259197
GTEX Portal (Tissue expression)NCR3
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14931   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14931  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14931
Splice isoforms : SwissVarO14931
PhosPhoSitePlusO14931
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_sub    Ig_V-set   
Domain families : Pfam (Sanger)V-set (PF07686)   
Domain families : Pfam (NCBI)pfam07686   
Domain families : Smart (EMBL)IG (SM00409)  
Conserved Domain (NCBI)NCR3
DMDM Disease mutations259197
Blocks (Seattle)NCR3
PDB (SRS)3NOI    3PV6   
PDB (PDBSum)3NOI    3PV6   
PDB (IMB)3NOI    3PV6   
PDB (RSDB)3NOI    3PV6   
Structural Biology KnowledgeBase3NOI    3PV6   
SCOP (Structural Classification of Proteins)3NOI    3PV6   
CATH (Classification of proteins structures)3NOI    3PV6   
SuperfamilyO14931
Human Protein AtlasENSG00000204475
Peptide AtlasO14931
HPRD11384
IPIIPI00384964   IPI00411498   IPI00011558   IPI00013125   IPI00032121   IPI00383788   IPI00985298   
Protein Interaction databases
DIP (DOE-UCLA)O14931
IntAct (EBI)O14931
FunCoupENSG00000204475
BioGRIDNCR3
STRING (EMBL)NCR3
ZODIACNCR3
Ontologies - Pathways
QuickGOO14931
Ontology : AmiGOimmune response-activating cell surface receptor signaling pathway  positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  receptor activity  receptor binding  protein binding  plasma membrane  integral component of plasma membrane  cell-cell adherens junction  inflammatory response  immune response  homophilic cell adhesion via plasma membrane adhesion molecules  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  cell recognition  natural killer cell activation  susceptibility to natural killer cell mediated cytotoxicity  protein homodimerization activity  positive regulation of natural killer cell mediated cytotoxicity  regulation of immune response  cell adhesion molecule binding  susceptibility to T cell mediated cytotoxicity  
Ontology : EGO-EBIimmune response-activating cell surface receptor signaling pathway  positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  receptor activity  receptor binding  protein binding  plasma membrane  integral component of plasma membrane  cell-cell adherens junction  inflammatory response  immune response  homophilic cell adhesion via plasma membrane adhesion molecules  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  cell recognition  natural killer cell activation  susceptibility to natural killer cell mediated cytotoxicity  protein homodimerization activity  positive regulation of natural killer cell mediated cytotoxicity  regulation of immune response  cell adhesion molecule binding  susceptibility to T cell mediated cytotoxicity  
Pathways : KEGGNatural killer cell mediated cytotoxicity   
NDEx NetworkNCR3
Atlas of Cancer Signalling NetworkNCR3
Wikipedia pathwaysNCR3
Orthology - Evolution
OrthoDB259197
GeneTree (enSembl)ENSG00000204475
Phylogenetic Trees/Animal Genes : TreeFamNCR3
HOVERGENO14931
HOGENOMO14931
Homologs : HomoloGeneNCR3
Homology/Alignments : Family Browser (UCSC)NCR3
Gene fusions - Rearrangements
Fusion : MitelmanPRRC2A/NCR3 [6p21.33/6p21.33]  [t(6;6)(p21;p21)]  
Fusion : MitelmanPTK2/NCR3 [8q24.3/6p21.33]  [t(6;8)(p21;q24)]  
Fusion: TCGAPRRC2A 6p21.33 NCR3 6p21.33 BRCA
Fusion: TCGAPTK2 8q24.3 NCR3 6p21.33 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNCR3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NCR3
dbVarNCR3
ClinVarNCR3
1000_GenomesNCR3 
Exome Variant ServerNCR3
ExAC (Exome Aggregation Consortium)NCR3 (select the gene name)
Genetic variants : HAPMAP259197
Genomic Variants (DGV)NCR3 [DGVbeta]
DECIPHERNCR3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNCR3 
Mutations
ICGC Data PortalNCR3 
TCGA Data PortalNCR3 
Broad Tumor PortalNCR3
OASIS PortalNCR3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNCR3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNCR3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NCR3
DgiDB (Drug Gene Interaction Database)NCR3
DoCM (Curated mutations)NCR3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NCR3 (select a term)
intoGenNCR3
Cancer3DNCR3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609148    611550   
Orphanet
MedgenNCR3
Genetic Testing Registry NCR3
NextProtO14931 [Medical]
TSGene259197
GENETestsNCR3
Target ValidationNCR3
Huge Navigator NCR3 [HugePedia]
snp3D : Map Gene to Disease259197
BioCentury BCIQNCR3
ClinGenNCR3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD259197
Chemical/Pharm GKB GenePA134883693
Clinical trialNCR3
Miscellaneous
canSAR (ICR)NCR3 (select the gene name)
Probes
Litterature
PubMed77 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNCR3
EVEXNCR3
GoPubMedNCR3
iHOPNCR3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:21:40 CEST 2017

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