NCR3LG1 (natural killer cell cytotoxicity receptor 3 ligand 1)

2011-05-01  

Identity

HGNC
NCR3LG1
LOCATION
11p15.1
LOCUSID
374383
ALIAS
B7-H6,B7H6,DKFZp686O24166

Other Information

Locus ID:

NCBI: 374383
MIM: 613714
HGNC: 42400
Ensembl: ENSG00000188211

Variants:

dbSNP: 374383
ClinVar: 374383
TCGA: ENSG00000188211
COSMIC: NCR3LG1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188211ENST00000338965Q68D85
ENSG00000188211ENST00000530403Q68D85

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
262416572015NKP30-B7-H6 Interaction Aggravates Hepatocyte Damage through Up-Regulation of Interleukin-32 Expression in Hepatitis B Virus-Related Acute-On-Chronic Liver Failure.7
195282592009The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans.0
214221702011Structure of the human activating natural cytotoxicity receptor NKp30 bound to its tumor cell ligand B7-H6.0
230661502012Mimicking an induced self phenotype by coating lymphomas with the NKp30 ligand B7-H6 promotes NK cell cytotoxicity.0
236870882013Induction of B7-H6, a ligand for the natural killer cell-activating receptor NKp30, in inflammatory conditions.0
242427032014B7-H6 protein expression has no prognostic significance in human gastric carcinoma.0
242756552014Homo-oligomerization of the activating natural killer cell receptor NKp30 ectodomain increases its binding affinity for cellular ligands.0
247807582014Metalloprotease-mediated tumor cell shedding of B7-H6, the ligand of the natural killer cell-activating receptor NKp30.0
250016512014Allogeneic and xenogeneic anti-tumor effect of callithrix jacchus natural killer cells is dependent on NKp30 and B7-H6 interaction.0
254007782014B7-H6 expression in non-small cell lung cancers.0

Citation

Dessen P

NCR3LG1 (natural killer cell cytotoxicity receptor 3 ligand 1)

Atlas Genet Cytogenet Oncol Haematol. 2011-05-01

Online version: http://atlasgeneticsoncology.org/gene/52208/ncr3lg1