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ND4 (NADH dehydrogenase, subunit 4 (complex I))

Identity

Other aliasMTND4
HGNC (Hugo) MT-ND4
LocusID (NCBI) 4538
Atlas_Id 49755
Location -  [Link to chromosome band ]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)MT-ND4   7459
Cards
Entrez_Gene (NCBI)ND4  4538  NADH dehydrogenase, subunit 4 (complex I)
AliasesMTND4
GeneCards (Weizmann)ND4
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]   [Sequence]  - [Contig_View]  ND4 [Vega]
TCGA cBioPortalND4
AceView (NCBI)ND4
Genatlas (Paris)ND4
WikiGenes4538
SOURCE (Princeton)ND4
Genetics Home Reference (NIH)ND4
Genomic and cartography
GoldenPath hg38 (UCSC)ND4  -  
GoldenPath hg19 (UCSC)ND4  -  
EnsemblND4 - [CytoView hg19]  ND4 - [CytoView hg38]
Mapping of homologs : NCBIND4 [Mapview hg19]  ND4 [Mapview hg38]
OMIM516003   535000   
Gene and transcription
Genbank (Entrez)-
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ND4
Gene ExpressionND4 [ NCBI-GEO ]   ND4 [ EBI - ARRAY_EXPRESS ]   ND4 [ SEEK ]   ND4 [ MEM ]
Gene Expression Viewer (FireBrowse)ND4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4538
GTEX Portal (Tissue expression)ND4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP03905   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP03905  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP03905
Splice isoforms : SwissVarP03905
Catalytic activity : Enzyme1.6.5.3 [ Enzyme-Expasy ]   1.6.5.31.6.5.3 [ IntEnz-EBI ]   1.6.5.3 [ BRENDA ]   1.6.5.3 [ KEGG ]   
PhosPhoSitePlusP03905
Domains : Interpro (EBI)NADH4_N    NADH_Q_OxRdtase_chainM/4    NADH_UbQ_OxRdtase    ND/Mrp_mem   
Domain families : Pfam (Sanger)Oxidored_q5_N (PF01059)    Proton_antipo_M (PF00361)   
Domain families : Pfam (NCBI)pfam01059    pfam00361   
Conserved Domain (NCBI)ND4
DMDM Disease mutations4538
Blocks (Seattle)ND4
SuperfamilyP03905
Peptide AtlasP03905
IPIIPI00008495   
Protein Interaction databases
DIP (DOE-UCLA)P03905
IntAct (EBI)P03905
BioGRIDND4
STRING (EMBL)ND4
ZODIACND4
Ontologies - Pathways
QuickGOP03905
Ontology : AmiGOresponse to hypoxia  in utero embryonic development  mitochondrial inner membrane  mitochondrial respiratory chain complex I  mitochondrial respiratory chain complex I  mitochondrial electron transport, NADH to ubiquinone  mitochondrial electron transport, NADH to ubiquinone  aging  NADH dehydrogenase (ubiquinone) activity  integral component of membrane  cerebellum development  mitochondrial respiratory chain complex I assembly  response to nicotine  response to ethanol  
Ontology : EGO-EBIresponse to hypoxia  in utero embryonic development  mitochondrial inner membrane  mitochondrial respiratory chain complex I  mitochondrial respiratory chain complex I  mitochondrial electron transport, NADH to ubiquinone  mitochondrial electron transport, NADH to ubiquinone  aging  NADH dehydrogenase (ubiquinone) activity  integral component of membrane  cerebellum development  mitochondrial respiratory chain complex I assembly  response to nicotine  response to ethanol  
NDEx NetworkND4
Atlas of Cancer Signalling NetworkND4
Wikipedia pathwaysND4
Orthology - Evolution
OrthoDB4538
Phylogenetic Trees/Animal Genes : TreeFamMT-ND4
HOVERGENP03905
HOGENOMP03905
Homologs : HomoloGeneND4
Homology/Alignments : Family Browser (UCSC)ND4
Gene fusions - Rearrangements
Fusion : QuiverND4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerND4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ND4
dbVarND4
ClinVarND4
1000_GenomesND4 
Exome Variant ServerND4
Genetic variants : HAPMAP4538
Genomic Variants (DGV)ND4 [DGVbeta]
DECIPHERND4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisND4 
Mutations
ICGC Data PortalMT-ND4 
TCGA Data PortalMT-ND4 
Broad Tumor PortalMT-ND4
OASIS PortalMT-ND4 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDMT-ND4
BioMutasearch ND4
DgiDB (Drug Gene Interaction Database)ND4
DoCM (Curated mutations)ND4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ND4 (select a term)
intoGenND4
Cancer3DND4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM516003    535000   
Orphanet
DisGeNETND4
MedgenND4
Genetic Testing Registry ND4
NextProtP03905 [Medical]
TSGene4538
GENETestsND4
Target ValidationND4
Huge Navigator MT-ND4 [HugePedia]
snp3D : Map Gene to Disease4538
BioCentury BCIQND4
ClinGenND4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4538
Chemical/Pharm GKB GenePA31263
Clinical trialND4
Miscellaneous
canSAR (ICR)ND4 (select the gene name)
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineND4
EVEXND4
GoPubMedND4
iHOPND4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:39:42 CEST 2018

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