Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

NDC80 (NDC80, kinetochore complex component)

Identity

Alias_namesKNTC2
highly expressed in cancer, rich in leucine heptad repeats (yeast)
kinetochore associated 2
NDC80 kinetochore complex component homolog (S. cerevisiae)
Alias_symbol (synonym)HEC
HEC1
hsNDC80
TID3
Other aliasHsHec1
HGNC (Hugo) NDC80
LocusID (NCBI) 10403
Atlas_Id 41095
Location 18p11.32  [Link to chromosome band 18p11]
Location_base_pair Starts at 2571511 and ends at 2616635 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NDC80 (18p11.32) / NDC80 (18p11.32)NDC80 (18p11.32) / TTC39C (18q11.2)RPL18 (19q13.33) / NDC80 (18p11.32)
SMCHD1 (18p11.32) / NDC80 (18p11.32)NDC80 18p11.32 / TTC39C 18q11.2SMCHD1 18p11.32 / NDC80 18p11.32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NDC80   16909
Cards
Entrez_Gene (NCBI)NDC80  10403  NDC80, kinetochore complex component
AliasesHEC; HEC1; HsHec1; KNTC2; 
TID3; hsNDC80
GeneCards (Weizmann)NDC80
Ensembl hg19 (Hinxton)ENSG00000080986 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000080986 [Gene_View]  chr18:2571511-2616635 [Contig_View]  NDC80 [Vega]
ICGC DataPortalENSG00000080986
TCGA cBioPortalNDC80
AceView (NCBI)NDC80
Genatlas (Paris)NDC80
WikiGenes10403
SOURCE (Princeton)NDC80
Genetics Home Reference (NIH)NDC80
Genomic and cartography
GoldenPath hg38 (UCSC)NDC80  -     chr18:2571511-2616635 +  18p11.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NDC80  -     18p11.32   [Description]    (hg19-Feb_2009)
EnsemblNDC80 - 18p11.32 [CytoView hg19]  NDC80 - 18p11.32 [CytoView hg38]
Mapping of homologs : NCBINDC80 [Mapview hg19]  NDC80 [Mapview hg38]
OMIM607272   
Gene and transcription
Genbank (Entrez)AF017790 AK289396 AK313184 BC005239 BC010171
RefSeq transcript (Entrez)NM_006101
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NDC80
Cluster EST : UnigeneHs.414407 [ NCBI ]
CGAP (NCI)Hs.414407
Alternative Splicing GalleryENSG00000080986
Gene ExpressionNDC80 [ NCBI-GEO ]   NDC80 [ EBI - ARRAY_EXPRESS ]   NDC80 [ SEEK ]   NDC80 [ MEM ]
Gene Expression Viewer (FireBrowse)NDC80 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10403
GTEX Portal (Tissue expression)NDC80
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14777   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14777  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14777
Splice isoforms : SwissVarO14777
PhosPhoSitePlusO14777
Domains : Interpro (EBI)Kinetochore_Ndc80   
Domain families : Pfam (Sanger)Ndc80_HEC (PF03801)   
Domain families : Pfam (NCBI)pfam03801   
Conserved Domain (NCBI)NDC80
DMDM Disease mutations10403
Blocks (Seattle)NDC80
PDB (SRS)2IGP    2VE7    3IZ0   
PDB (PDBSum)2IGP    2VE7    3IZ0   
PDB (IMB)2IGP    2VE7    3IZ0   
PDB (RSDB)2IGP    2VE7    3IZ0   
Structural Biology KnowledgeBase2IGP    2VE7    3IZ0   
SCOP (Structural Classification of Proteins)2IGP    2VE7    3IZ0   
CATH (Classification of proteins structures)2IGP    2VE7    3IZ0   
SuperfamilyO14777
Human Protein AtlasENSG00000080986
Peptide AtlasO14777
HPRD06277
IPIIPI00005791   IPI00643791   
Protein Interaction databases
DIP (DOE-UCLA)O14777
IntAct (EBI)O14777
FunCoupENSG00000080986
BioGRIDNDC80
STRING (EMBL)NDC80
ZODIACNDC80
Ontologies - Pathways
QuickGOO14777
Ontology : AmiGOmitotic sister chromatid segregation  establishment of mitotic spindle orientation  mitotic cell cycle  chromosome, centromeric region  kinetochore  condensed chromosome kinetochore  condensed nuclear chromosome outer kinetochore  structural constituent of cytoskeleton  protein binding  nucleus  nucleoplasm  centrosome  cytosol  mitotic spindle organization  chromosome segregation  sister chromatid cohesion  attachment of spindle microtubules to kinetochore  membrane  Ndc80 complex  identical protein binding  cell division  metaphase plate congression  attachment of mitotic spindle microtubules to kinetochore  kinetochore organization  positive regulation of mitotic cell cycle spindle assembly checkpoint  positive regulation of protein localization to kinetochore  
Ontology : EGO-EBImitotic sister chromatid segregation  establishment of mitotic spindle orientation  mitotic cell cycle  chromosome, centromeric region  kinetochore  condensed chromosome kinetochore  condensed nuclear chromosome outer kinetochore  structural constituent of cytoskeleton  protein binding  nucleus  nucleoplasm  centrosome  cytosol  mitotic spindle organization  chromosome segregation  sister chromatid cohesion  attachment of spindle microtubules to kinetochore  membrane  Ndc80 complex  identical protein binding  cell division  metaphase plate congression  attachment of mitotic spindle microtubules to kinetochore  kinetochore organization  positive regulation of mitotic cell cycle spindle assembly checkpoint  positive regulation of protein localization to kinetochore  
NDEx NetworkNDC80
Atlas of Cancer Signalling NetworkNDC80
Wikipedia pathwaysNDC80
Orthology - Evolution
OrthoDB10403
GeneTree (enSembl)ENSG00000080986
Phylogenetic Trees/Animal Genes : TreeFamNDC80
HOVERGENO14777
HOGENOMO14777
Homologs : HomoloGeneNDC80
Homology/Alignments : Family Browser (UCSC)NDC80
Gene fusions - Rearrangements
Fusion : MitelmanNDC80/TTC39C [18p11.32/18q11.2]  
Fusion : MitelmanSMCHD1/NDC80 [18p11.32/18p11.32]  [t(18;18)(p11;p11)]  
Fusion: TCGANDC80 18p11.32 TTC39C 18q11.2 LUAD
Fusion: TCGASMCHD1 18p11.32 NDC80 18p11.32 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNDC80 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NDC80
dbVarNDC80
ClinVarNDC80
1000_GenomesNDC80 
Exome Variant ServerNDC80
ExAC (Exome Aggregation Consortium)NDC80 (select the gene name)
Genetic variants : HAPMAP10403
Genomic Variants (DGV)NDC80 [DGVbeta]
DECIPHERNDC80 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNDC80 
Mutations
ICGC Data PortalNDC80 
TCGA Data PortalNDC80 
Broad Tumor PortalNDC80
OASIS PortalNDC80 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNDC80  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNDC80
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NDC80
DgiDB (Drug Gene Interaction Database)NDC80
DoCM (Curated mutations)NDC80 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NDC80 (select a term)
intoGenNDC80
Cancer3DNDC80(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607272   
Orphanet
MedgenNDC80
Genetic Testing Registry NDC80
NextProtO14777 [Medical]
TSGene10403
GENETestsNDC80
Target ValidationNDC80
Huge Navigator NDC80 [HugePedia]
snp3D : Map Gene to Disease10403
BioCentury BCIQNDC80
ClinGenNDC80
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10403
Chemical/Pharm GKB GenePA162397359
Clinical trialNDC80
Miscellaneous
canSAR (ICR)NDC80 (select the gene name)
Probes
Litterature
PubMed98 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNDC80
EVEXNDC80
GoPubMedNDC80
iHOPNDC80
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:21:43 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.