NDE1 (nudE neurodevelopment protein 1)

2010-06-01  

Identity

HGNC
LOCATION
16p13.11
LOCUSID
ALIAS
HOM-TES-87,LIS4,MHAC,NDE,NUDE,NUDE1
FUSION GENES

Other Information

Locus ID:

NCBI: 54820
MIM: 609449
HGNC: 17619
Ensembl: ENSG00000072864

Variants:

dbSNP: 54820
ClinVar: 54820
TCGA: ENSG00000072864
COSMIC: NDE1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000072864ENST00000396354Q9NXR1
ENSG00000072864ENST00000396354X5DR54
ENSG00000072864ENST00000396355Q9NXR1
ENSG00000072864ENST00000396355X5DR54
ENSG00000072864ENST00000570727I3L2S8
ENSG00000072864ENST00000572756I3L3G9
ENSG00000072864ENST00000572967I3L2T8
ENSG00000072864ENST00000573203I3L464
ENSG00000072864ENST00000573694I3L2R3
ENSG00000072864ENST00000574109I3L2R9
ENSG00000072864ENST00000576502I3L533
ENSG00000072864ENST00000577101I3L522

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
AURKA Activation by TPX2REACTOMER-HSA-8854518

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
215297512011Human mutations in NDE1 cause extreme microcephaly with lissencephaly [corrected].83
176007102007Cenp-F links kinetochores to Ndel1/Nde1/Lis1/dynein microtubule motor complexes.81
215297522011The essential role of centrosomal NDE1 in human cerebral cortex neurogenesis.62
200483382010Functional interplay between LIS1, NDE1 and NDEL1 in dynein-dependent organelle positioning.60
125564842003Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle.51
184693412008Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding.51
184693412008Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding.51
219114892011Mutually exclusive cytoplasmic dynein regulation by NudE-Lis1 and dynactin.49
189839802008DISC1, PDE4B, and NDE1 at the centrosome and synapse.44
200845192010Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging.41

Citation

Dessen P

NDE1 (nudE neurodevelopment protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-06-01

Online version: http://atlasgeneticsoncology.org/gene/51506/nde1