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NDE1 (nudE neurodevelopment protein 1)

Identity

Alias_namesnudE nuclear distribution gene E homolog 1 (A. nidulans)
nudE nuclear distribution E homolog 1 (A. nidulans)
Alias_symbol (synonym)nudE
FLJ20101
NDE
Other aliasHOM-TES-87
LIS4
MHAC
NUDE
NUDE1
HGNC (Hugo) NDE1
LocusID (NCBI) 54820
Atlas_Id 51506
Location 16p13.11  [Link to chromosome band 16p13]
Location_base_pair Starts at 15737124 and ends at 15820208 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
C9orf152 (9q31.3) / NDE1 (16p13.11)CBFB (16q22.1) / NDE1 (16p13.11)FANCC (9q22.32) / NDE1 (16p13.11)
H2AFY2 (10q22.1) / NDE1 (16p13.11)INS-IGF2 (11p15.5) / NDE1 (16p13.11)KCTD5 (16p13.3) / NDE1 (16p13.11)
NDE1 (16p13.11) / KMT2B (19q13.12)NDE1 (16p13.11) / LRRC26 (9q34.3)NDE1 (16p13.11) / LSS (21q22.3)
NDE1 (16p13.11) / NCOA6 (20q11.22)NDE1 (16p13.11) / NDE1 (16p13.11)NDE1 (16p13.11) / PDGFRB (5q32)
NDE1 (16p13.11) / REG3A (2p12)NDE1 (16p13.11) / TUBGCP3 (13q34)NFYC (1p34.2) / NDE1 (16p13.11)
PDGFRB (5q32) / NDE1 (16p13.11)ST6GALNAC1 (17q25.1) / NDE1 (16p13.11)TRIOBP (22q13.1) / NDE1 (16p13.11)
UBA52 (19p13.11) / NDE1 (16p13.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(5;16)(q32;p13) NDE1/PDGFRB


External links

Nomenclature
HGNC (Hugo)NDE1   17619
Cards
Entrez_Gene (NCBI)NDE1  54820  nudE neurodevelopment protein 1
AliasesHOM-TES-87; LIS4; MHAC; NDE; 
NUDE; NUDE1
GeneCards (Weizmann)NDE1
Ensembl hg19 (Hinxton)ENSG00000072864 [Gene_View]  chr16:15737124-15820208 [Contig_View]  NDE1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000072864 [Gene_View]  chr16:15737124-15820208 [Contig_View]  NDE1 [Vega]
ICGC DataPortalENSG00000072864
TCGA cBioPortalNDE1
AceView (NCBI)NDE1
Genatlas (Paris)NDE1
WikiGenes54820
SOURCE (Princeton)NDE1
Genetics Home Reference (NIH)NDE1
Genomic and cartography
GoldenPath hg19 (UCSC)NDE1  -     chr16:15737124-15820208 +  16p13.11   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NDE1  -     16p13.11   [Description]    (hg38-Dec_2013)
EnsemblNDE1 - 16p13.11 [CytoView hg19]  NDE1 - 16p13.11 [CytoView hg38]
Mapping of homologs : NCBINDE1 [Mapview hg19]  NDE1 [Mapview hg38]
OMIM605013   609449   614019   
Gene and transcription
Genbank (Entrez)AF124431 AK000108 AK025815 AK127927 BC001421
RefSeq transcript (Entrez)NM_001143979 NM_017668
RefSeq genomic (Entrez)NC_000016 NC_018927 NG_021210 NT_010393 NT_187607 NW_004929400
Consensus coding sequences : CCDS (NCBI)NDE1
Cluster EST : UnigeneHs.655378 [ NCBI ]
CGAP (NCI)Hs.655378
Alternative Splicing GalleryENSG00000072864
Gene ExpressionNDE1 [ NCBI-GEO ]   NDE1 [ EBI - ARRAY_EXPRESS ]   NDE1 [ SEEK ]   NDE1 [ MEM ]
Gene Expression Viewer (FireBrowse)NDE1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54820
GTEX Portal (Tissue expression)NDE1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NXR1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NXR1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NXR1
Splice isoforms : SwissVarQ9NXR1
PhosPhoSitePlusQ9NXR1
Domains : Interpro (EBI)NUDE_C   
Domain families : Pfam (Sanger)NUDE_C (PF04880)   
Domain families : Pfam (NCBI)pfam04880   
Conserved Domain (NCBI)NDE1
DMDM Disease mutations54820
Blocks (Seattle)NDE1
SuperfamilyQ9NXR1
Human Protein AtlasENSG00000072864
Peptide AtlasQ9NXR1
HPRD14815
IPIIPI00759601   IPI00014893   
Protein Interaction databases
DIP (DOE-UCLA)Q9NXR1
IntAct (EBI)Q9NXR1
FunCoupENSG00000072864
BioGRIDNDE1
STRING (EMBL)NDE1
ZODIACNDE1
Ontologies - Pathways
QuickGOQ9NXR1
Ontology : AmiGOG2/M transition of mitotic cell cycle  establishment of mitotic spindle orientation  kinetochore  condensed chromosome kinetochore  neuron migration  protein binding  centrosome  cytosol  kinesin complex  microtubule  microtubule nucleation  chromosome segregation  sister chromatid cohesion  mitotic centrosome separation  neuroblast proliferation  microtubule binding  microtubule binding  membrane  cell migration  protein domain specific binding  cerebral cortex development  spindle pole centrosome  cleavage furrow  identical protein binding  synapse  vesicle transport along microtubule  centrosome duplication  cell division  establishment of chromosome localization  centrosome localization  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  establishment of mitotic spindle orientation  kinetochore  condensed chromosome kinetochore  neuron migration  protein binding  centrosome  cytosol  kinesin complex  microtubule  microtubule nucleation  chromosome segregation  sister chromatid cohesion  mitotic centrosome separation  neuroblast proliferation  microtubule binding  microtubule binding  membrane  cell migration  protein domain specific binding  cerebral cortex development  spindle pole centrosome  cleavage furrow  identical protein binding  synapse  vesicle transport along microtubule  centrosome duplication  cell division  establishment of chromosome localization  centrosome localization  
NDEx NetworkNDE1
Atlas of Cancer Signalling NetworkNDE1
Wikipedia pathwaysNDE1
Orthology - Evolution
OrthoDB54820
GeneTree (enSembl)ENSG00000072864
Phylogenetic Trees/Animal Genes : TreeFamNDE1
HOVERGENQ9NXR1
HOGENOMQ9NXR1
Homologs : HomoloGeneNDE1
Homology/Alignments : Family Browser (UCSC)NDE1
Gene fusions - Rearrangements
Fusion : MitelmanNDE1/PDGFRB [16p13.11/5q32]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNDE1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NDE1
dbVarNDE1
ClinVarNDE1
1000_GenomesNDE1 
Exome Variant ServerNDE1
ExAC (Exome Aggregation Consortium)NDE1 (select the gene name)
Genetic variants : HAPMAP54820
Genomic Variants (DGV)NDE1 [DGVbeta]
DECIPHER (Syndromes)16:15737124-15820208  ENSG00000072864
CONAN: Copy Number AnalysisNDE1 
Mutations
ICGC Data PortalNDE1 
TCGA Data PortalNDE1 
Broad Tumor PortalNDE1
OASIS PortalNDE1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNDE1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNDE1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch NDE1
DgiDB (Drug Gene Interaction Database)NDE1
DoCM (Curated mutations)NDE1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NDE1 (select a term)
intoGenNDE1
Cancer3DNDE1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605013    609449    614019   
Orphanet837    4059    23446   
MedgenNDE1
Genetic Testing Registry NDE1
NextProtQ9NXR1 [Medical]
TSGene54820
GENETestsNDE1
Huge Navigator NDE1 [HugePedia]
snp3D : Map Gene to Disease54820
BioCentury BCIQNDE1
ClinGenNDE1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54820
Chemical/Pharm GKB GenePA128394673
Clinical trialNDE1
Miscellaneous
canSAR (ICR)NDE1 (select the gene name)
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNDE1
EVEXNDE1
GoPubMedNDE1
iHOPNDE1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:11:55 CEST 2017

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