NDN (necdin, MAGE family member)

2009-11-01  

Identity

HGNC
LOCATION
15q11.2
LOCUSID
ALIAS
HsT16328,PWCR

Other Information

Locus ID:

NCBI: 4692
MIM: 602117
HGNC: 7675
Ensembl: ENSG00000182636

Variants:

dbSNP: 4692
ClinVar: 4692
TCGA: ENSG00000182636
COSMIC: NDN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182636ENST00000649030Q99608
ENSG00000182636ENST00000649030X5D982

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

References

Pubmed IDYearTitleCitations
93022651997The necdin gene is deleted in Prader-Willi syndrome and is imprinted in human and mouse.67
205389602010A candidate gene study of obstructive sleep apnea in European Americans and African Americans.30
152473302004Tissue-specific and imprinted epigenetic modifications of the human NDN gene.26
182726952008Necdin plays a role in the serotonergic modulation of the mouse respiratory network: implication for Prader-Willi syndrome.26
186604892008Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.26
129131182003A nuclear target for interleukin-1alpha: interaction with the growth suppressor necdin modulates proliferation and collagen expression.20
190587892009A common variant in DRD3 receptor is associated with autism spectrum disorder.19
159785862005Negative regulation of hypoxia inducible factor-1alpha by necdin.18
196266462009Necdin: a multi functional protein with potential tumor suppressor role?15
220462352011Necdin, a negative growth regulator, is a novel STAT3 target gene down-regulated in human cancer.12

Citation

Dessen P

NDN (necdin, MAGE family member)

Atlas Genet Cytogenet Oncol Haematol. 2009-11-01

Online version: http://atlasgeneticsoncology.org/gene/51233/ndn