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NDRG1 (N-myc downstream regulated 1)

Written2015-10Maria A Nagai, Flavia R Mangone
Discipline of Oncology, Department of Radiology and Oncology, Faculty of Medicine, University of São Paulo; Laboratory of Molecular Genetics, Center for Translational Research in Oncology, Cancer Institute of São Paulo, Av. Dr. Arnaldo, 251, CEP 01296-000, São Paulo, Brazil.
This article is an update of :
2009-10Michel Wissing, Nadine Rosmus, Michael Carducci, Sushant Kachhap
Johns Hopkins Medical Institute, The Sidney Kimmel Comprehensive Cancer Center, 1650 Orleans Street, CRB-I 162E, Baltimore, MD 21231, USA

(Note : for Links provided by Atlas : click)


Alias (NCBI)CAP43
HGNC Alias symbDRG1
HGNC Previous nameCAP43
LocusID (NCBI) 10397
Atlas_Id 41512
Location 8q24.22  [Link to chromosome band 8q24]
Location_base_pair Starts at 133237175 and ends at 133297252 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping NDRG1.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C18orf25 (18q21.1)::NDRG1 (8q24.22)DDX24 (14q32.12)::NDRG1 (8q24.22)ERG (21q22.2)::NDRG1 (8q24.22)
NDRG1 (8q24.22)::ATP2A2 (12q24.11)NDRG1 (8q24.22)::CSTF2 (Xq22.1)NDRG1 (8q24.22)::ERG (21q22.2)
NDRG1 (8q24.22)::FOXP1 (3p13)NDRG1 (8q24.22)::LPAR1 (9q31.3)NDRG1 (8q24.22)::NDRG1 (8q24.22)
NDRG1 (8q24.22)::NEAT1 (11q13.1)NDRG1 (8q24.22)::PLEKHA5 (12p12.3)NDRG1 (8q24.22)::SLC25A3 (12q23.1)
NDRG1 (8q24.22)::SNW1 (14q24.3)NDRG1 (8q24.22)::ST3GAL1 (8q24.22)NEDD8-MDP1 (14q12)::NDRG1 (8q24.22)
PSENEN (19q13.12)::NDRG1 (8q24.22)PTGS1 (9q33.2)::NDRG1 (8q24.22)PTMS (12p13.31)::NDRG1 (8q24.22)
PVT1 (8q24.21)::NDRG1 (8q24.22)


  DNA size: 64.85Kb; mRNA size: 3123 bp (NM_006096.3); 16 exons.
Description NDRG1 was mapped to human chromosome 8q24 and consists of 64,851 basepairs, starting at basepair 133,237,171 and ending at basepair 133,302,022 from the p-terminus. It is a member of the NDRG family, consisting of NDRG1, NDRG2, NDRG3 and NDRG4 (of which three isoforms exist: NDRG-4B, NDRG-4Bvar and NDRG-4H), which are part of the alpha/beta hydrolase superfamily. The members of the NDRG family share 52-65% amino acid identity. The promoter region of all NDRG family members contain CpG islands (Bandyopadhyay et al., 2004). NDRG1 downregulation has been correlated with DNA hypermethylation in some types of human cancer and cell lineages such as prostate, breast and gastric and also in sclerosis-affected brains (Li et al , 2015; Huynh et al , 2014; Han et al , 2013; Chang et al , 2013).
Transcription The DNA of NDRG1 contains 16 exons, see diagram for details about their location. The DNA encodes a 3.0 kb mRNA with a coding region of 1.185 kb.


Note Molecular weight: 42,835 KDa, 394aa (NP_001128714.1)
Description NDRG1 is a ~ 43 kD protein, composed of 394 amino acids, with an iso-electric point of 5.7. NDRG1 has an alpha/beta hydrolase-fold motif, however, without a hydrolytic catalytic activity required to function as hydrolases. The protein has no apparent transmembrane domain (Kokame et al, 1996). NDRG1 has several phosphorylation sites, among others a phosphopantetheine attachment site, protein kinase C, casein kinase II, tyrosine kinase, protein kinase A and calmodulin kinase II. Experimental studies have demonstrated that NRDG1 is phosphorylated by Protein Kinase A and Calmodulin kinase II, and is also a physiological substrate of SGK1 and GSK-3-beta kinase (Figure 1), a kinase involved in cancer growth and progression. he C-terminal region of NDRG1 (residues 339-369) possess three tandem repeats of 10 amino acids, GTRSRSHTSE, (Zhou et al, 2001) not present in the other members of the NDRG family. These repeats with a histidine located between serine and threonine residues act as a binding site for metal ions such as nickel and copper (Zoroddu et al, 2001) (Figure 1). NDRG1 is also target for SOMOylation, preferentially by SUMO-2 isoform, in an acceptor site in residue Lys14. This modification does not affect the subcellular localization of NDRG1 but the protein stability by increasing protein ubiquitination and degradation (Lee and Kim, 2015) (Figure 1).
  Figure 1 - Schematic representation of the modular structure of NDRG1 - NDRG1 is target of phosphorylation by PKA, PKC, CaMKII. Residues that are phosphorylated by SGK1 and GSK3 and target of SUMOylation by SUMO-2 are indicated. PKA: Protein Kinase A; PKC: Protein Kinase C; CaMKII: Calmodulin Kinase II; SGK1: serum and glucocorticoid-regulated kinase 1; GSK3- Glycogen synthase kinase 3; SUMO-2: Small Ubiquitin-Like Modifier 2 .
Expression NDRG1 is relatively ubiquitously expressed in normal human cells, and especially highly expressed in prostate, brain, kidney, placenta, ovarian, thyroid, testicular and intestinal cells. NDRG1 is mostly found in epithelial cells. NDRG1 expression has been shown to be controlled by promoter CpG island methylation and histone acetylation. In addition, several transcription factors have been implicated in the NDRG1 transcriptional regulation, including homo- and heterodimers of MYC, MYCN and MAX, androgen receptor (AR), TP53, and HIF1A.
Localisation NDRG1 is primarily a cytoplasmic protein. 47.8% of the NDRG1 is expressed in the cytosol, 26.1% in the nucleus (such as in prostate epithelial cells), and 8.7% in the mitochondria (such as in proximal tubule cells in the kidney). NDRG1 is also found in the adherens junctions. Additionally, in intestinal and lactating breast epithelia NDRG1 is located in the plasma membrane. NDRG1 can also be found in vacuoles, the peroxisome, early and recycling endosomes, and the cytoskeleton.
Function The exact function of NDRG1 is still unclear. The expression of all members of the NDRG1 family has been correlated with different stages of differentiation from birth to adulthood. NDRG1 has been reported to be involved in different biological processes as cell proliferation, differentiation, development, and stress response (Ellen et al., 2008).
There is evidence that NDRG1 expression peaks in the G1 and G2/M phases, and is lowest in the S phase, and that this regulation might be associated to cell growth and differentiation. In fact, NDRG1 has been shown to up regulates p21/WAF1 (Kovacevic et al, 2013) and NDRG1 expression is downregulated under conditions of increased cell proliferation. NDRG1 is also described as a microtubule-associated protein, which may play an important role in maintaining spindle structure during cell division.
The function of NDRG1 may be controlled at least in part by phosphorylation. Phosphorylation at residues Ser330 and Thr346 by SGK-1 is involved in NF-κB signaling pathway inhibition probably affecting cell survival (Murakami et al, 2010).
NDRG1 has also been identified as a stress response gene, upregulated by homocysteine and hypoxia. Hif-1-dependent and independent mechanisms have been implicated in NDRG1 induction. It is also controlled by AP-1 transcription factors. When exposed to stress, for example hypoxia, NDRG1 may play a cytoprotective role in normal healthy cells.
NDRG1 is upregulated during colon epithelial cell differentiation. It is positively or negatively regulated by hormones such as androgens and estradiol, respectively. Small molecules such as N-hydroxy-N'-phenol-octane-1,8-diotic acid diamide, calcium ionophores like BAPTA, metal ions such as Nickel and Cobalt, iron chelators and differentiating agents like retinoic acid induce NDRG1 expression. Additionally, NDRG1 is induced during cellular DNA damage and endoplasmic reticulum stress.
In the Schwann cells, NDRG1 is essential for myelin sheath maintenance. Hence, NDRG1 is a multifunctional protein with roles that may be tissue- and/or cell-type specific.
It has been found to be a Rab4a effector protein that recruits to the recycling endosomes in the Trans Golgi network by binding to the lipid phosphotidylinositol 4-phosphate (PI4P), where it plays a role in the recycling of E-cadherin. NDRG1 also interacts with HSP70. NDRG1 co-localizes with APO A-I and A-II, and may be involved in lipid transport.
Evidences obtained from global gene expression analysis of breast cell lines with high endogenous NDRG1 expression transduced with shRNA against NDRG1 suggested an involvement of NDRG1 with vesicle transport (Askautrud et al, 2014).
In cancer, NDRG1 is reported to be a metastasis suppressor gene which is downregulated in prostate, colon and breast cancers. However, up-regulation of NDRG1 has also been associated to poor prognosis in breast, renal, hepatocellular, and colorectal cancer, suggesting that it may play different role depending on cellular type and context (Nagai. et al, 2001; Nishie et al, 2001; Chua et al, 2007; Strzelczyk et al, 2009).
Signaling Pathways
The widespread localization of NDRG1 might impact its involvement with diverse signaling pathways. It has been demonstrated that NDRG1 interacts directly with NF-κB, PI3K/AKT/ mTOR, Ras/Raf/MEK/ERK, TGF-β; and Wnt/β-catenin pathways independently with each pathway or by promoting a crosstalk between them (Sun J et al, 2013). The nuclear translocation of the DNA binding subunit of NFκB, NFKB1 (p50), complexed with RelA is reduced by NDRG1 as a consequence of the induced degradation of IKBKB (IKK&beta), subunit of the IκB kinase complex (Hosoi et al, 2009). The effect of NDRG1 on NFκB signaling pathway seems to be dependent of phosphorylation at residues Ser330 and Thr346 by SGK1 (Murakami et al, 2010).
The expression of PTEN, a tumor suppressor gene described as inactivated in diverse types of human cancers, is also involved in tumor metastasis suppression and it was demonstrated that PTEN targets NDRG1 in a PI3K dependent manner. It was demonstrated that up regulation of PTEN increase the level of NDRG1 and the inhibition of PTEN by shRNA also inhibits NDRG1 expression. This blockage is reverted when the cells are treated with phospho-Akt inhibitor, evidencing a dependency of PI3K/AKT pathway (Bandyopadhyay, et al, 2004). In prostate epithelial cells NDRG1 expression increased phosphorylation of tumorigenic AKT, ERK1/2 and SMAD2L and decreased PTEN levels (Dixon et al, 2013). NDRG1 also has been associated to up-regulation of SMAD4 that is responsible for nuclear translocation of effector SMADs upon TGFβ receptor activation. Up regulation of SMAD4 has a dual role both in TGFβ signaling, intermediating the induction of p21, and also blocking Ras signaling pathway by inhibiting ERK phosphorylation (Kovacevic et al, 2013) (Figure 2).
  Figure 2 - Modulators and Biological functions of NDRG1 - NDRG1 is involved in a variety of signaling pathways been positively or negatively regulated. As a consequence, diverse biological processes are modulated. HIF1, hypoxia inducible factor 1; c-Myc, v-myc avian myelocytomatosis viral oncogene homolog; AR, Androgen receptor; E2, -17β-estradiol; AP1, activator protein-1, p53, tumor suppressor protein p53; PTEN, phosphatase and tensin homolog; VEGF, vascular endothelial growth factor; CXCL8 (IL-8), interleukin-8; p21, cyclin-dependent kinase inhibitor 1A; NFKB, nuclear factor of kappa light polypeptide gene enhancer in B-cells; pERK, extracellular signal-regulated kinases; SMAD4, SMAD family member 4; PI3K, phosphatidylinositol 3-kinase; AKT, v-akt murine thymoma viral oncogene homolog.
Homology NDRG1 amino acid sequence is 53% homologous to NDRG2, 62% to NDRG3, 62% to NDRG4, and 94% homologous to the mouse analog, Ndr-1 (also known as TDD5). NDRG1 homologs have been found in Helianthus, Caenorhabditis, Xenopus and Drosophilia.

Implicated in

Entity Prostatic adenocarcinoma, breast cancer, colorectal cancer, renal cell carcinoma, bladder carcinoma, pancreatic cancer, hepatocellular carcinoma, thyroid carcinoma, and glioma.
Prognosis The association of NDRG1 and prognosis of cancer patients is controversial. Some studies have found that downregulation of NDRG1 in cancer worsens the prognosis of cancer. There is an inverse relationship in the levels of NDRG1 expression and the Gleason grade of the tumor in prostate cancer. A high PTEN (a tumor suppressor which positively regulates NDRG1) and NDRG1 expression improves survival rates in patients with breast and prostate cancer. In patients with colorectal cancer, the 2 year survival rate for patients with high NDRG1-expression was 82.4%, while for patients with a low NDRG1-expression it was only 69.6%. In pancreatic cancer patients, the median survival time for patients with high NDRG1-expression was 24.7 months, while the median survival time for patients with low NDRG1-expression was only 10.9 months. High expression of NDRG1 in colon tumors was found to correlate with increased resistance to irinotecan.
On the other hand, the positivity for NDRG1 expression was associated to poor disease free and overall survival of breast cancer patients. Also, the positivity of NDRG1 protein observed in breast cancer patients is associated with important clinic-pathological variables for disease outcome, such as large tumor size, advanced clinical stage, lymph node metastasis and high tumor grade (SBR) (Nagai. et al, 2001). An inverse correlation of NDGR1 and ER and/or PR status has also been described (Leth-Larsen et al, 2009; Fotovati et al, 2006).
Increase in protein level has been observed in thyroid carcinomas. Thyroid lesions showed higher immunohistochemical staining of NDRG1 as compared to normal and benign thyroid lesions that was correlated with more advanced tumor stages. This increase of NDRG1 expression was correlated with more advanced TNM stage (stages III and IV) and an AMES high-risk category in patients with thyroid carcinoma (Gerhard et al, 2010).
In hepatocellular carcinoma upregulation of NDRG1 has been correlated with tumour aggressiveness and poor patients' survival (Chua et al., 2007).
NDRG1 has been associated to breast cancer cells differentiation both in vitro and in vivo. Endogenous expression of NDRG1 was associated to differentiation status of breast cancer cell lines and when these cells were treated with the cellular differentiation inducer, sodium butyrate, a concomitant increase of NDRG1 and β-casein, a marker of breast cell differentiation, expression was observed. Moreover, the blockage of NDRG1 expression was also followed by β-casein reduction. Also in breast cancer samples a close relationship between NDRG1 and β-casein was found (Fotovati et al, 2011).
NDRG1 has been considered as a possible biomarker to guide the decision of treatment of WHO grade II glioma patients. Time to reintervention, assessed for patients without immediate postoperative genotoxic treatment and known progression and survival status, was significantly longer in the high NDRG1 group. This group of tumors presented growth delay improving progression free surviva (Blaes et al, 2014).
Oncogenesis NDRG1 aberrant expression has been reported in different types of cancer, indication that it plays an important role in the tumorigenic process. However, both tumor suppressive and oncogenic functions have been demonstrated for NDRG1, suggesting an impact of its tissue specific function.
An inverse relationship exists between NDRG1 and the oncogenes N-myc and c-myc, suggesting that members of the MYC family suppress expression of NDRG1. Experimental evidence exist that both N-myc and c-myc downregulate NDRG1 gene expression by directly binding to NDRG1 promoter.
NDRG1 is downregulated in colon, breast, prostate and pancreatic neoplasms, by c-myc and N-myc transcription factors. In cancer cells, NDRG1 expression is consistent through all phases in the cell cycle, instead of the biphasic expression in normal cells. PTEN expression is positively related to NDRG1 expression. NDRG1 is induced in cancer cells by histone deacetylase inhibitors and DNA methyl transferase inhibitors indicating that NDRG1 is regulated by chromatin modulation and DNA methylation.
Although NDRG1 has been reported to be downregulated in a variety of cancers, it has been shown to be upregulated in hepatic, pancreatic and kidney cancers. Induction of NDRG1 in these tumors is speculated to be in response to tumor stress or hypoxia and NDRG1 is proposed as a marker of tumor hypoxia. However, in pancreatic cancer, cellular differentiation and not hypoxia was demonstrated to be the determining factor for NDRG1 expression. In renal cancer, induction of NDRG1 in the tumor tissue was restricted to infiltrating macrophages and not cancer cells.
NDRG1 is suggested to be an early target for p53. Loss of p53 expression in cancer is suggested to reduce NDRG1 expression. However, p53 knockout mice show expression of NDRG1, suggesting that there are other mechanisms regulating NDRG1 levels.
NDRG1 expression plays a role in vitro in primary tumor growth in prostate, breast, and bladder cancer: a higher expression of NDRG1 lowers the proliferation rates of these cancers. In pancreatic and bladder cancer cells, this reduction was proven in vivo: in pancreatic cells it was suggested that the reduced proliferation was caused by NDRG1 by modulating tumor stroma and angiogenesis. NDRG1 can recruit onto the recycling endosome in the Trans-Golgi network by binding to phosphotidylinositol 4-phosphate. There, NDRG1 may be involved in the transport of various cargo back to the cells' surface. At the molecular level, NDRG1 may stabilize the E-cadherin molecule by recycling it back to the cells' surface, thereby preventing tumor invasion.
Entity Hereditary Motor and Sensory Neuropathy-Lom (HMSNL) / Charcot-Marie-Tooth Disease (CMT 4D)
Note Autosomal recessive mutation in NDRG1 is responsible for HMSNL/CMT 4D inheritance. The Gypsy founder mutation, homozygote R148X, also called homozygote C564t is a causative mutation. In patients with CMT disease, apart from the R148X mutation, another disease-causing mutation was identified, namely IVS8-1G>A (g.2290787G>A), which results in skipping of exon 9. The homozygote phenotype of this mutation was very closely related to the phenotype of HMSNL patients.
An increased copy number (chr8: 134265065-134271319) covering NDRG's1 exons 6-8 was detected in CMT individual. Heterozygous individuals for the locus duplication are carriers for the disease while the homozygous are affected. Also, the presence of this duplication leads to a nonsense mutation at codon 223 affecting gene function (Okamoto et al, 2014).
Disease A hereditary autosomal recessive disease, caused by demyelination of peripheral nerves. It is the most common form of demyelinating Charcot-Marie-Tooth disease in the Roma population.
Prognosis Severe disability in adulthood. It begins consistently in the first decade of life with a gait disorder, followed by upper limb weakness in the second decade and, in most subjects, by deafness setting in in the third decade of life. Sensory loss affecting all modalities is present; both this and the motor involvement predominating distally in the limbs. Skeletal deformity, particularly foot deformities, are frequent.
Entity Atherosclerosis
Note Patients with HMSNL were found to have a high total cholesterol: HDL-C ratio.
Disease Atherosclerosis is an important factor for the development of cardiovascular diseases, like myocardial infarction and angina pectoris. NDRG1 contributes to HDL-C (high-density lipoprotein-cholesterol) levels most likely by its phosphopantetheine-binding domain interacting with the high-density lipoproteins apolipoprotein A-I and A-II


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Murakami Y, Hosoi F, Izumi H, Maruyama Y, Ureshino H, Watari K, Kohno K, Kuwano M, Ono M
Biochem Biophys Res Commun 2010 May 28;396(2):376-81
PMID 20416281
Prognostic value of NDRG1 and SPARC protein expression in breast cancer patients
Nagai MA, Gerhard R, Fregnani JH, Nonogaki S, Rierger RB, Netto MM, Soares FA
Breast Cancer Res Treat 2011 Feb;126(1):1-14
PMID 20369286
High expression of the Cap43 gene in infiltrating macrophages of human renal cell carcinomas
Nishie A, Masuda K, Otsubo M, Migita T, Tsuneyoshi M, Kohno K, Shuin T, Naito S, Ono M, Kuwano M
Clin Cancer Res 2001 Jul;7(7):2145-51
PMID 11448934
Exonic duplication CNV of NDRG1 associated with autosomal-recessive HMSN-Lom/CMT4D
Okamoto Y, Goksungur MT, Pehlivan D, Beck CR, Gonzaga-Jauregui C, Muzny DM, Atik MM, Carvalho CM, Matur Z, Bayraktar S, Boone PM, Akyuz K, Gibbs RA, Battaloglu E, Parman Y, Lupski JR
Genet Med 2014 May;16(5):386-94
PMID 24136616
Ndrg1-deficient mice exhibit a progressive demyelinating disorder of peripheral nerves.
Okuda T, Higashi Y, Kokame K, Tanaka C, Kondoh H, Miyata T.
Mol Cell Biol. 2004 May;24(9):3949-56.
PMID 15082788
Differential expression of the RTP/Drg1/Ndr1 gene product in proliferating and growth arrested cells.
Piquemal D, Joulia D, Balaguer P, Basset A, Marti J, Commes T.
Biochim Biophys Acta. 1999 Jul 8;1450(3):364-73.
PMID 10395947
Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family.
Qu X, Zhai Y, Wei H, Zhang C, Xing G, Yu Y, He F.
Mol Cell Biochem. 2002 Jan;229(1-2):35-44.
PMID 11936845
The regulation of hypoxic genes by calcium involves c-Jun/AP-1, which cooperates with hypoxia-inducible factor 1 in response to hypoxia.
Salnikow K, Kluz T, Costa M, Piquemal D, Demidenko ZN, Xie K, Blagosklonny MV.
Mol Cell Biol. 2002 Mar;22(6):1734-41.
PMID 11865053
Drg1 expression in 131 colorectal liver metastases: correlation with clinical variables and patient outcomes.
Shah MA, Kemeny N, Hummer A, Drobnjak M, Motwani M, Cordon-Cardo C, Gonen M, Schwartz GK.
Clin Cancer Res. 2005 May 1;11(9):3296-302.
PMID 15867226
N-myc-dependent repression of ndr1, a gene identified by direct subtraction of whole mouse embryo cDNAs between wild type and N-myc mutant.
Shimono A, Okuda T, Kondoh H.
Mech Dev. 1999 May;83(1-2):39-52.
PMID 10381566
NDRG1 is necessary for p53-dependent apoptosis.
Stein S, Thomas EK, Herzog B, Westfall MD, Rocheleau JV, Jackson RS 2nd, Wang M, Liang P.
J Biol Chem. 2004 Nov 19;279(47):48930-40. Epub 2004 Sep 17.
PMID 15377670
Identification of high-risk stage II colorectal tumors by combined analysis of the NDRG1 gene expression and the depth of tumor invasion
Strzelczyk B, Szulc A, Rzepko R, Kitowska A, Skokowski J, Szutowicz A, Pawelczyk T
Ann Surg Oncol 2009 May;16(5):1287-94
PMID 19259744
N-myc downregulated gene 1 is a phosphorylated protein in mast cells.
Sugiki T, Murakami M, Taketomi Y, Kikuchi-Yanoshita R, Kudo I.
Biol Pharm Bull. 2004 May;27(5):624-7.
PMID 15133234
Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors
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Carcinogenesis 2013 Sep;34(9):1943-54
PMID 23671130
Identification of NDRG1 as an early inducible gene during in vitro maturation of cultured mast cells.
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Biochem Biophys Res Commun. 2003 Jun 27;306(2):339-46.
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This paper should be referenced as such :
Maria A Nagai, Flavia R Mangone
NDRG1 (N-myc downstream regulated 1)
Atlas Genet Cytogenet Oncol Haematol. 2016;20(7):413-420.
Free journal version : [ pdf ]   [ DOI ]
History of this paper:
Wissing, M ; Rosmus, N ; Carducci, M ; Kachhap, S. NDRG1 (N-myc downstream regulated 1). Atlas Genet Cytogenet Oncol Haematol. 2010;14(8):776-780.

External links


HGNC (Hugo)NDRG1   7679
LRG (Locus Reference Genomic)LRG_258
Entrez_Gene (NCBI)NDRG1    N-myc downstream regulated 1
AliasesCAP43; CMT4D; DRG-1; DRG1; 
GeneCards (Weizmann)NDRG1
Ensembl hg19 (Hinxton)ENSG00000104419 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104419 [Gene_View]  ENSG00000104419 [Sequence]  chr8:133237175-133297252 [Contig_View]  NDRG1 [Vega]
ICGC DataPortalENSG00000104419
TCGA cBioPortalNDRG1
Genatlas (Paris)NDRG1
SOURCE (Princeton)NDRG1
Genetics Home Reference (NIH)NDRG1
Genomic and cartography
GoldenPath hg38 (UCSC)NDRG1  -     chr8:133237175-133297252 -  8q24.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NDRG1  -     8q24.22   [Description]    (hg19-Feb_2009)
GoldenPathNDRG1 - 8q24.22 [CytoView hg19]  NDRG1 - 8q24.22 [CytoView hg38]
Genome Data Viewer NCBINDRG1 [Mapview hg19]  
OMIM601455   605262   
Gene and transcription
Genbank (Entrez)AF004162 AF039944 AF147402 AF230380 AK091147
RefSeq transcript (Entrez)NM_001135242 NM_001258432 NM_001258433 NM_001374844 NM_001374845 NM_001374846 NM_001374847 NM_006096
Consensus coding sequences : CCDS (NCBI)NDRG1
Gene ExpressionNDRG1 [ NCBI-GEO ]   NDRG1 [ EBI - ARRAY_EXPRESS ]   NDRG1 [ SEEK ]   NDRG1 [ MEM ]
Gene Expression Viewer (FireBrowse)NDRG1 [ Firebrowse - Broad ]
GenevisibleExpression of NDRG1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10397
GTEX Portal (Tissue expression)NDRG1
Human Protein AtlasENSG00000104419-NDRG1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92597   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92597  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92597
Domains : Interpro (EBI)AB_hydrolase    NDRG    NDRG1   
Domain families : Pfam (Sanger)Ndr (PF03096)   
Domain families : Pfam (NCBI)pfam03096   
Conserved Domain (NCBI)NDRG1
AlphaFold pdb e-kbQ92597   
Human Protein Atlas [tissue]ENSG00000104419-NDRG1 [tissue]
Protein Interaction databases
IntAct (EBI)Q92597
Ontologies - Pathways
Ontology : AmiGOprotein binding  nucleus  cytoplasm  cytoplasm  centrosome  cytosol  cytosol  microtubule  plasma membrane  adherens junction  signal transduction  microtubule binding  negative regulation of cell population proliferation  response to metal ion  microtubule cytoskeleton  DNA damage response, signal transduction by p53 class mediator  small GTPase binding  peripheral nervous system myelin maintenance  regulation of apoptotic process  gamma-tubulin binding  cadherin binding  cadherin binding  mast cell activation  perinuclear region of cytoplasm  recycling endosome membrane  extracellular exosome  cellular response to hypoxia  glutamatergic synapse  postsynapse organization  
Ontology : EGO-EBIprotein binding  nucleus  cytoplasm  cytoplasm  centrosome  cytosol  cytosol  microtubule  plasma membrane  adherens junction  signal transduction  microtubule binding  negative regulation of cell population proliferation  response to metal ion  microtubule cytoskeleton  DNA damage response, signal transduction by p53 class mediator  small GTPase binding  peripheral nervous system myelin maintenance  regulation of apoptotic process  gamma-tubulin binding  cadherin binding  cadherin binding  mast cell activation  perinuclear region of cytoplasm  recycling endosome membrane  extracellular exosome  cellular response to hypoxia  glutamatergic synapse  postsynapse organization  
REACTOMEQ92597 [protein]
REACTOME PathwaysR-HSA-6803205 [pathway]   
NDEx NetworkNDRG1
Atlas of Cancer Signalling NetworkNDRG1
Wikipedia pathwaysNDRG1
Orthology - Evolution
GeneTree (enSembl)ENSG00000104419
Phylogenetic Trees/Animal Genes : TreeFamNDRG1
Homologs : HomoloGeneNDRG1
Homology/Alignments : Family Browser (UCSC)NDRG1
Gene fusions - Rearrangements
Fusion : MitelmanNDRG1::ERG [8q24.22/21q22.2]  
Fusion : MitelmanNDRG1::FOXP1 [8q24.22/3p13]  
Fusion : MitelmanNDRG1::PLEKHA5 [8q24.22/12p12.3]  
Fusion : MitelmanNDRG1::SNW1 [8q24.22/14q24.3]  
Fusion : MitelmanNDRG1::ST3GAL1 [8q24.22/8q24.22]  
Fusion : MitelmanPVT1::NDRG1 [8q24.21/8q24.22]  
Fusion : COSMICNDRG1 [8q24.22]  -  ERG [21q22.2]  [fusion_1133]  [fusion_1135]  [fusion_1146]  
Fusion : QuiverNDRG1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNDRG1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NDRG1
Exome Variant ServerNDRG1
GNOMAD BrowserENSG00000104419
Varsome BrowserNDRG1
ACMGNDRG1 variants
Genomic Variants (DGV)NDRG1 [DGVbeta]
DECIPHERNDRG1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNDRG1 
ICGC Data PortalNDRG1 
TCGA Data PortalNDRG1 
Broad Tumor PortalNDRG1
OASIS PortalNDRG1 [ Somatic mutations - Copy number]
Cancer Gene: CensusNDRG1 
Somatic Mutations in Cancer : COSMICNDRG1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNDRG1
Mutations and Diseases : HGMDNDRG1
intOGen PortalNDRG1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
DgiDB (Drug Gene Interaction Database)NDRG1
DoCM (Curated mutations)NDRG1
CIViC (Clinical Interpretations of Variants in Cancer)NDRG1
NCG (London)NDRG1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
OMIM601455    605262   
Genetic Testing Registry NDRG1
NextProtQ92597 [Medical]
Target ValidationNDRG1
Huge Navigator NDRG1 [HugePedia]
Clinical trials, drugs, therapy
Protein Interactions : CTDNDRG1
Pharm GKB GenePA31482
Clinical trialNDRG1
DataMed IndexNDRG1
PubMed253 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Oct 8 21:23:30 CEST 2021

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