Atlas of Genetics and Cytogenetics in Oncology and Haematology

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NDRG4 (NDRG family member 4)

Identity

Alias_symbol (synonym)KIAA1180
SMAP-8
Other aliasBDM1
SMAP8
HGNC (Hugo) NDRG4
LocusID (NCBI) 65009
Atlas_Id 49948
Location 16q21  [Link to chromosome band 16q21]
Location_base_pair Starts at 58464822 and ends at 58513619 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MIR548AE2 (16q12.1) / NDRG4 (16q21)NDRG4 (16q21) / NDRG4 (16q21)ZNF776 (19q13.43) / NDRG4 (16q21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)NDRG4   14466
Cards
Entrez_Gene (NCBI)NDRG4  65009  NDRG family member 4
AliasesBDM1; SMAP-8; SMAP8
GeneCards (Weizmann)NDRG4
Ensembl hg19 (Hinxton)ENSG00000103034 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000103034 [Gene_View]  ENSG00000103034 [Sequence]  chr16:58464822-58513619 [Contig_View]  NDRG4 [Vega]
ICGC DataPortalENSG00000103034
TCGA cBioPortalNDRG4
AceView (NCBI)NDRG4
Genatlas (Paris)NDRG4
WikiGenes65009
SOURCE (Princeton)NDRG4
Genetics Home Reference (NIH)NDRG4
Genomic and cartography
GoldenPath hg38 (UCSC)NDRG4  -     chr16:58464822-58513619 +  16q21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NDRG4  -     16q21   [Description]    (hg19-Feb_2009)
GoldenPathNDRG4 - 16q21 [CytoView hg19]  NDRG4 - 16q21 [CytoView hg38]
Genome Data Viewer NCBINDRG4 [Mapview hg19]  
OMIM614463   
Gene and transcription
Genbank (Entrez)AB021172 AB033006 AB044944 AB044945 AB044946
RefSeq transcript (Entrez)NM_001130487 NM_001242833 NM_001242834 NM_001242835 NM_001242836 NM_001363869 NM_001378332 NM_001378333 NM_001378334 NM_001378335 NM_001378336 NM_001378337 NM_001378338 NM_001378339 NM_001378340 NM_001378341 NM_001378342 NM_001378343 NM_001378344 NM_001378345 NM_001378346 NM_001378347 NM_020465 NM_022910
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NDRG4
Alternative Splicing GalleryENSG00000103034
Gene ExpressionNDRG4 [ NCBI-GEO ]   NDRG4 [ EBI - ARRAY_EXPRESS ]   NDRG4 [ SEEK ]   NDRG4 [ MEM ]
Gene Expression Viewer (FireBrowse)NDRG4 [ Firebrowse - Broad ]
GenevisibleExpression of NDRG4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)65009
GTEX Portal (Tissue expression)NDRG4
Human Protein AtlasENSG00000103034-NDRG4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9ULP0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9ULP0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9ULP0
Splice isoforms : SwissVarQ9ULP0
PhosPhoSitePlusQ9ULP0
Domains : Interpro (EBI)AB_hydrolase    NDRG    NDRG4   
Domain families : Pfam (Sanger)Ndr (PF03096)   
Domain families : Pfam (NCBI)pfam03096   
Conserved Domain (NCBI)NDRG4
DMDM Disease mutations65009
SuperfamilyQ9ULP0
Human Protein Atlas [tissue]ENSG00000103034-NDRG4 [tissue]
Peptide AtlasQ9ULP0
HPRD14817
IPIIPI00745722   IPI00418960   IPI00217784   IPI00008269   IPI00644702   IPI01017932   IPI00910928   
Protein Interaction databases
DIP (DOE-UCLA)Q9ULP0
IntAct (EBI)Q9ULP0
FunCoupENSG00000103034
BioGRIDNDRG4
STRING (EMBL)NDRG4
ZODIACNDRG4
Ontologies - Pathways
QuickGOQ9ULP0
Ontology : AmiGOheart looping  molecular_function  protein binding  cytoplasm  cytoplasm  cytoplasm  mitochondrion  endoplasmic reticulum membrane  cytosol  signal transduction  brain development  visual learning  negative regulation of platelet-derived growth factor receptor signaling pathway  positive regulation of neuron projection development  negative regulation of smooth muscle cell migration  basolateral plasma membrane  cell differentiation  cell projection membrane  embryonic heart tube development  vesicle docking  negative regulation of smooth muscle cell proliferation  cardiac muscle cell proliferation  cell migration involved in heart development  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  regulation of endocytic recycling  
Ontology : EGO-EBIheart looping  molecular_function  protein binding  cytoplasm  cytoplasm  cytoplasm  mitochondrion  endoplasmic reticulum membrane  cytosol  signal transduction  brain development  visual learning  negative regulation of platelet-derived growth factor receptor signaling pathway  positive regulation of neuron projection development  negative regulation of smooth muscle cell migration  basolateral plasma membrane  cell differentiation  cell projection membrane  embryonic heart tube development  vesicle docking  negative regulation of smooth muscle cell proliferation  cardiac muscle cell proliferation  cell migration involved in heart development  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  regulation of endocytic recycling  
NDEx NetworkNDRG4
Atlas of Cancer Signalling NetworkNDRG4
Wikipedia pathwaysNDRG4
Orthology - Evolution
OrthoDB65009
GeneTree (enSembl)ENSG00000103034
Phylogenetic Trees/Animal Genes : TreeFamNDRG4
HOGENOMQ9ULP0
Homologs : HomoloGeneNDRG4
Homology/Alignments : Family Browser (UCSC)NDRG4
Gene fusions - Rearrangements
Fusion : QuiverNDRG4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNDRG4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NDRG4
dbVarNDRG4
ClinVarNDRG4
1000_GenomesNDRG4 
Exome Variant ServerNDRG4
GNOMAD BrowserENSG00000103034
Varsome BrowserNDRG4
Genetic variants : HAPMAP65009
Genomic Variants (DGV)NDRG4 [DGVbeta]
DECIPHERNDRG4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNDRG4 
Mutations
ICGC Data PortalNDRG4 
TCGA Data PortalNDRG4 
Broad Tumor PortalNDRG4
OASIS PortalNDRG4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNDRG4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNDRG4
Mutations and Diseases : HGMDNDRG4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutaselect NDRG4
DgiDB (Drug Gene Interaction Database)NDRG4
DoCM (Curated mutations)NDRG4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NDRG4 (select a term)
intoGenNDRG4
Cancer3DNDRG4 (select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614463   
Orphanet
DisGeNETNDRG4
MedgenNDRG4
Genetic Testing Registry NDRG4
NextProtQ9ULP0 [Medical]
TSGene65009
GENETestsNDRG4
Open Targets GeneticsENSG00000103034  [validation]
snp3D : Map Gene to Disease65009
BioCentury BCIQNDRG4
ClinGenNDRG4
Clinical trials, drugs, therapy
Protein Interactions : CTD65009
Pharm GKB GenePA31485
Clinical trialNDRG4
Miscellaneous
canSAR (ICR)NDRG4 (select the gene name)
HarmonizomeNDRG4
DataMed IndexNDRG4
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNDRG4
EVEXNDRG4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jul 11 20:01:56 CEST 2020
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