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NDST1 (N-deacetylase and N-sulfotransferase 1)

Identity

Alias (NCBI)HSST
MRT46
NST1
HGNC (Hugo) NDST1
HGNC Alias symbNST1
HGNC Alias name[Heparan sulfate]-glucosamine N-sulfotransferase 1
 N-Deacetylase-N-sulfotransferase 1
 heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase 1
HGNC Previous nameHSST
HGNC Previous nameN-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
LocusID (NCBI) 3340
Atlas_Id 52611
Location 5q33.1  [Link to chromosome band 5q33]
Location_base_pair Starts at 150508131 and ends at 150558211 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARNT2 (15q25.1)::NDST1 (5q33.1)FAM168B (2q21.1)::NDST1 (5q33.1)NDST1 (5q33.1)::SEMA6A (5q23.1)
NDST1 (5q33.1)::TCOF1 (5q32)ARNT2 15q25.1::NDST1 5q33.1NDST1 5q33.1::TCOF1 5q32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)NDST1   7680
Cards
Entrez_Gene (NCBI)NDST1    N-deacetylase and N-sulfotransferase 1
AliasesHSST; MRT46; NST1
GeneCards (Weizmann)NDST1
Ensembl hg19 (Hinxton)ENSG00000070614 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000070614 [Gene_View]  ENSG00000070614 [Sequence]  chr5:150508131-150558211 [Contig_View]  NDST1 [Vega]
ICGC DataPortalENSG00000070614
TCGA cBioPortalNDST1
AceView (NCBI)NDST1
Genatlas (Paris)NDST1
SOURCE (Princeton)NDST1
Genetics Home Reference (NIH)NDST1
Genomic and cartography
GoldenPath hg38 (UCSC)NDST1  -     chr5:150508131-150558211 +  5q33.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NDST1  -     5q33.1   [Description]    (hg19-Feb_2009)
GoldenPathNDST1 - 5q33.1 [CytoView hg19]  NDST1 - 5q33.1 [CytoView hg38]
ImmunoBaseENSG00000070614
Genome Data Viewer NCBINDST1 [Mapview hg19]  
OMIM600853   616116   
Gene and transcription
Genbank (Entrez)AB209107 AK292448 AK293746 BC012888 BC015828
RefSeq transcript (Entrez)NM_001301063 NM_001543
Consensus coding sequences : CCDS (NCBI)NDST1
Gene ExpressionNDST1 [ NCBI-GEO ]   NDST1 [ EBI - ARRAY_EXPRESS ]   NDST1 [ SEEK ]   NDST1 [ MEM ]
Gene Expression Viewer (FireBrowse)NDST1 [ Firebrowse - Broad ]
GenevisibleExpression of NDST1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3340
GTEX Portal (Tissue expression)NDST1
Human Protein AtlasENSG00000070614-NDST1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52848   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP52848  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP52848
Catalytic activity : Enzyme2.8.2.8 [ Enzyme-Expasy ]   2.8.2.82.8.2.8 [ IntEnz-EBI ]   2.8.2.8 [ BRENDA ]   2.8.2.8 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP52848
Domains : Interpro (EBI)Heparan_SO4_deacetylase    NST/OST    P-loop_NTPase    Sulfotransferase_dom   
Domain families : Pfam (Sanger)HSNSD (PF12062)    Sulfotransfer_1 (PF00685)   
Domain families : Pfam (NCBI)pfam12062    pfam00685   
Conserved Domain (NCBI)NDST1
PDB (RSDB)1NST   
PDB Europe1NST   
PDB (PDBSum)1NST   
PDB (IMB)1NST   
Structural Biology KnowledgeBase1NST   
SCOP (Structural Classification of Proteins)1NST   
CATH (Classification of proteins structures)1NST   
SuperfamilyP52848
AlphaFold pdb e-kbP52848   
Human Protein Atlas [tissue]ENSG00000070614-NDST1 [tissue]
HPRD02912
Protein Interaction databases
DIP (DOE-UCLA)P52848
IntAct (EBI)P52848
BioGRIDNDST1
STRING (EMBL)NDST1
ZODIACNDST1
Ontologies - Pathways
QuickGOP52848
Ontology : AmiGOGolgi membrane  cardiac septum development  protein binding  Golgi apparatus  glycosaminoglycan biosynthetic process  protein sulfation  inflammatory response  respiratory gaseous exchange by respiratory system  cell population proliferation  fibroblast growth factor receptor signaling pathway  heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process  [heparan sulfate]-glucosamine N-sulfotransferase activity  integral component of membrane  deacetylase activity  heparin biosynthetic process  forebrain development  midbrain development  aorta development  positive regulation of MAPK cascade  positive regulation of smoothened signaling pathway  embryonic neurocranium morphogenesis  embryonic viscerocranium morphogenesis  coronary vasculature development  heparan sulfate N-deacetylase activity  
Ontology : EGO-EBIGolgi membrane  cardiac septum development  protein binding  Golgi apparatus  glycosaminoglycan biosynthetic process  protein sulfation  inflammatory response  respiratory gaseous exchange by respiratory system  cell population proliferation  fibroblast growth factor receptor signaling pathway  heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process  [heparan sulfate]-glucosamine N-sulfotransferase activity  integral component of membrane  deacetylase activity  heparin biosynthetic process  forebrain development  midbrain development  aorta development  positive regulation of MAPK cascade  positive regulation of smoothened signaling pathway  embryonic neurocranium morphogenesis  embryonic viscerocranium morphogenesis  coronary vasculature development  heparan sulfate N-deacetylase activity  
Pathways : KEGGGlycosaminoglycan biosynthesis - heparan sulfate / heparin   
NDEx NetworkNDST1
Atlas of Cancer Signalling NetworkNDST1
Wikipedia pathwaysNDST1
Orthology - Evolution
OrthoDB3340
GeneTree (enSembl)ENSG00000070614
Phylogenetic Trees/Animal Genes : TreeFamNDST1
Homologs : HomoloGeneNDST1
Homology/Alignments : Family Browser (UCSC)NDST1
Gene fusions - Rearrangements
Fusion : MitelmanARNT2::NDST1 [15q25.1/5q33.1]  
Fusion : MitelmanNDST1::TCOF1 [5q33.1/5q32]  
Fusion : QuiverNDST1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNDST1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NDST1
dbVarNDST1
ClinVarNDST1
MonarchNDST1
1000_GenomesNDST1 
Exome Variant ServerNDST1
GNOMAD BrowserENSG00000070614
Varsome BrowserNDST1
ACMGNDST1 variants
VarityP52848
Genomic Variants (DGV)NDST1 [DGVbeta]
DECIPHERNDST1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNDST1 
Mutations
ICGC Data PortalNDST1 
TCGA Data PortalNDST1 
Broad Tumor PortalNDST1
OASIS PortalNDST1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNDST1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNDST1
Mutations and Diseases : HGMDNDST1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNDST1
DgiDB (Drug Gene Interaction Database)NDST1
DoCM (Curated mutations)NDST1
CIViC (Clinical Interpretations of Variants in Cancer)NDST1
Cancer3DNDST1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600853    616116   
Orphanet11804   
DisGeNETNDST1
MedgenNDST1
Genetic Testing Registry NDST1
NextProtP52848 [Medical]
GENETestsNDST1
Target ValidationNDST1
Huge Navigator NDST1 [HugePedia]
ClinGenNDST1
Clinical trials, drugs, therapy
MyCancerGenomeNDST1
Protein Interactions : CTDNDST1
Pharm GKB GenePA31486
PharosP52848
Clinical trialNDST1
Miscellaneous
canSAR (ICR)NDST1
HarmonizomeNDST1
ARCHS4NDST1
DataMed IndexNDST1
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNDST1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Sun Jan 16 18:24:23 CET 2022

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