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NDST1 (N-deacetylase and N-sulfotransferase 1)

Identity

Alias_namesHSST
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
Alias_symbol (synonym)NST1
Other aliasMRT46
HGNC (Hugo) NDST1
LocusID (NCBI) 3340
Atlas_Id 52611
Location 5q33.1  [Link to chromosome band 5q33]
Location_base_pair Starts at 150497778 and ends at 150558211 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARNT2 (15q25.1) / NDST1 (5q33.1)FAM168B (2q21.1) / NDST1 (5q33.1)NDST1 (5q33.1) / SEMA6A (5q23.1)
NDST1 (5q33.1) / TCOF1 (5q32)ARNT2 15q25.1 / NDST1 5q33.1NDST1 5q33.1 / TCOF1 5q32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NDST1   7680
Cards
Entrez_Gene (NCBI)NDST1  3340  N-deacetylase and N-sulfotransferase 1
AliasesHSST; MRT46; NST1
GeneCards (Weizmann)NDST1
Ensembl hg19 (Hinxton)ENSG00000070614 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000070614 [Gene_View]  chr5:150497778-150558211 [Contig_View]  NDST1 [Vega]
ICGC DataPortalENSG00000070614
TCGA cBioPortalNDST1
AceView (NCBI)NDST1
Genatlas (Paris)NDST1
WikiGenes3340
SOURCE (Princeton)NDST1
Genetics Home Reference (NIH)NDST1
Genomic and cartography
GoldenPath hg38 (UCSC)NDST1  -     chr5:150497778-150558211 +  5q33.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NDST1  -     5q33.1   [Description]    (hg19-Feb_2009)
EnsemblNDST1 - 5q33.1 [CytoView hg19]  NDST1 - 5q33.1 [CytoView hg38]
Mapping of homologs : NCBINDST1 [Mapview hg19]  NDST1 [Mapview hg38]
OMIM600853   616116   
Gene and transcription
Genbank (Entrez)AB209107 AK292448 AK293746 BC012888 BC015828
RefSeq transcript (Entrez)NM_001301063 NM_001543
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NDST1
Cluster EST : UnigeneHs.222055 [ NCBI ]
CGAP (NCI)Hs.222055
Alternative Splicing GalleryENSG00000070614
Gene ExpressionNDST1 [ NCBI-GEO ]   NDST1 [ EBI - ARRAY_EXPRESS ]   NDST1 [ SEEK ]   NDST1 [ MEM ]
Gene Expression Viewer (FireBrowse)NDST1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3340
GTEX Portal (Tissue expression)NDST1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52848   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP52848  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP52848
Splice isoforms : SwissVarP52848
Catalytic activity : Enzyme2.8.2.8 [ Enzyme-Expasy ]   2.8.2.82.8.2.8 [ IntEnz-EBI ]   2.8.2.8 [ BRENDA ]   2.8.2.8 [ KEGG ]   
PhosPhoSitePlusP52848
Domains : Interpro (EBI)Heparan_SO4_deacetylase    P-loop_NTPase    Sulfotransferase_dom   
Domain families : Pfam (Sanger)HSNSD (PF12062)    Sulfotransfer_1 (PF00685)   
Domain families : Pfam (NCBI)pfam12062    pfam00685   
Conserved Domain (NCBI)NDST1
DMDM Disease mutations3340
Blocks (Seattle)NDST1
PDB (SRS)1NST   
PDB (PDBSum)1NST   
PDB (IMB)1NST   
PDB (RSDB)1NST   
Structural Biology KnowledgeBase1NST   
SCOP (Structural Classification of Proteins)1NST   
CATH (Classification of proteins structures)1NST   
SuperfamilyP52848
Human Protein AtlasENSG00000070614
Peptide AtlasP52848
HPRD02912
IPIIPI00784368   IPI00738468   IPI00922477   IPI00976542   IPI00981385   IPI00982523   
Protein Interaction databases
DIP (DOE-UCLA)P52848
IntAct (EBI)P52848
FunCoupENSG00000070614
BioGRIDNDST1
STRING (EMBL)NDST1
ZODIACNDST1
Ontologies - Pathways
QuickGOP52848
Ontology : AmiGOGolgi membrane  MAPK cascade  polysaccharide biosynthetic process  cardiac septum development  protein binding  glycosaminoglycan biosynthetic process  protein sulfation  inflammatory response  smoothened signaling pathway  respiratory gaseous exchange  fibroblast growth factor receptor signaling pathway  heparan sulfate proteoglycan biosynthetic process  [heparan sulfate]-glucosamine N-sulfotransferase activity  integral component of membrane  heparin biosynthetic process  forebrain development  midbrain development  aorta development  embryonic neurocranium morphogenesis  embryonic viscerocranium morphogenesis  N-acetylglucosamine deacetylase activity  coronary vasculature development  
Ontology : EGO-EBIGolgi membrane  MAPK cascade  polysaccharide biosynthetic process  cardiac septum development  protein binding  glycosaminoglycan biosynthetic process  protein sulfation  inflammatory response  smoothened signaling pathway  respiratory gaseous exchange  fibroblast growth factor receptor signaling pathway  heparan sulfate proteoglycan biosynthetic process  [heparan sulfate]-glucosamine N-sulfotransferase activity  integral component of membrane  heparin biosynthetic process  forebrain development  midbrain development  aorta development  embryonic neurocranium morphogenesis  embryonic viscerocranium morphogenesis  N-acetylglucosamine deacetylase activity  coronary vasculature development  
Pathways : KEGGGlycosaminoglycan biosynthesis - heparan sulfate / heparin   
NDEx NetworkNDST1
Atlas of Cancer Signalling NetworkNDST1
Wikipedia pathwaysNDST1
Orthology - Evolution
OrthoDB3340
GeneTree (enSembl)ENSG00000070614
Phylogenetic Trees/Animal Genes : TreeFamNDST1
HOVERGENP52848
HOGENOMP52848
Homologs : HomoloGeneNDST1
Homology/Alignments : Family Browser (UCSC)NDST1
Gene fusions - Rearrangements
Fusion : MitelmanARNT2/NDST1 [15q25.1/5q33.1]  [t(5;15)(q33;q25)]  
Fusion : MitelmanNDST1/TCOF1 [5q33.1/5q32]  [t(5;5)(q32;q33)]  
Fusion: TCGAARNT2 15q25.1 NDST1 5q33.1 PRAD
Fusion: TCGANDST1 5q33.1 TCOF1 5q32 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNDST1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NDST1
dbVarNDST1
ClinVarNDST1
1000_GenomesNDST1 
Exome Variant ServerNDST1
ExAC (Exome Aggregation Consortium)NDST1 (select the gene name)
Genetic variants : HAPMAP3340
Genomic Variants (DGV)NDST1 [DGVbeta]
DECIPHERNDST1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNDST1 
Mutations
ICGC Data PortalNDST1 
TCGA Data PortalNDST1 
Broad Tumor PortalNDST1
OASIS PortalNDST1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNDST1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNDST1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NDST1
DgiDB (Drug Gene Interaction Database)NDST1
DoCM (Curated mutations)NDST1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NDST1 (select a term)
intoGenNDST1
Cancer3DNDST1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600853    616116   
Orphanet11804   
MedgenNDST1
Genetic Testing Registry NDST1
NextProtP52848 [Medical]
TSGene3340
GENETestsNDST1
Huge Navigator NDST1 [HugePedia]
snp3D : Map Gene to Disease3340
BioCentury BCIQNDST1
ClinGenNDST1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3340
Chemical/Pharm GKB GenePA31486
Clinical trialNDST1
Miscellaneous
canSAR (ICR)NDST1 (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNDST1
EVEXNDST1
GoPubMedNDST1
iHOPNDST1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:28:16 CEST 2017

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