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NDST2 (N-deacetylase and N-sulfotransferase 2)

Identity

Alias_namesN-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
Alias_symbol (synonym)NST2
HSST2
Other alias
HGNC (Hugo) NDST2
LocusID (NCBI) 8509
Atlas_Id 54492
Location 10q22.2  [Link to chromosome band 10q22]
Location_base_pair Starts at 73801911 and ends at 73811849 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NDST2 (10q22.2) / RUNX1 (21q22.12)NDST2 (10q22.2) / STAT3 (17q21.2)NDST2 (10q22.2) / ZSWIM8 (10q22.2)
NDST2 10q22.2 KIAA0913

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NDST2   7681
Cards
Entrez_Gene (NCBI)NDST2  8509  N-deacetylase and N-sulfotransferase 2
AliasesHSST2; NST2
GeneCards (Weizmann)NDST2
Ensembl hg19 (Hinxton)ENSG00000166507 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166507 [Gene_View]  chr10:73801911-73811849 [Contig_View]  NDST2 [Vega]
ICGC DataPortalENSG00000166507
TCGA cBioPortalNDST2
AceView (NCBI)NDST2
Genatlas (Paris)NDST2
WikiGenes8509
SOURCE (Princeton)NDST2
Genetics Home Reference (NIH)NDST2
Genomic and cartography
GoldenPath hg38 (UCSC)NDST2  -     chr10:73801911-73811849 -  10q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NDST2  -     10q22.2   [Description]    (hg19-Feb_2009)
EnsemblNDST2 - 10q22.2 [CytoView hg19]  NDST2 - 10q22.2 [CytoView hg38]
Mapping of homologs : NCBINDST2 [Mapview hg19]  NDST2 [Mapview hg38]
OMIM603268   
Gene and transcription
Genbank (Entrez)AB208870 AK293527 AK298957 AK300520 AK301251
RefSeq transcript (Entrez)NM_001330107 NM_003635
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NDST2
Cluster EST : UnigeneHs.654758 [ NCBI ]
CGAP (NCI)Hs.654758
Alternative Splicing GalleryENSG00000166507
Gene ExpressionNDST2 [ NCBI-GEO ]   NDST2 [ EBI - ARRAY_EXPRESS ]   NDST2 [ SEEK ]   NDST2 [ MEM ]
Gene Expression Viewer (FireBrowse)NDST2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8509
GTEX Portal (Tissue expression)NDST2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52849   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP52849  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP52849
Splice isoforms : SwissVarP52849
Catalytic activity : Enzyme2.8.2.8 [ Enzyme-Expasy ]   2.8.2.82.8.2.8 [ IntEnz-EBI ]   2.8.2.8 [ BRENDA ]   2.8.2.8 [ KEGG ]   
PhosPhoSitePlusP52849
Domains : Interpro (EBI)Heparan_SO4_deacetylase    P-loop_NTPase    Sulfotransferase_dom   
Domain families : Pfam (Sanger)HSNSD (PF12062)    Sulfotransfer_1 (PF00685)   
Domain families : Pfam (NCBI)pfam12062    pfam00685   
Conserved Domain (NCBI)NDST2
DMDM Disease mutations8509
Blocks (Seattle)NDST2
SuperfamilyP52849
Human Protein AtlasENSG00000166507
Peptide AtlasP52849
HPRD04465
IPIIPI00005600   IPI00737119   IPI01013963   IPI00644649   
Protein Interaction databases
DIP (DOE-UCLA)P52849
IntAct (EBI)P52849
FunCoupENSG00000166507
BioGRIDNDST2
STRING (EMBL)NDST2
ZODIACNDST2
Ontologies - Pathways
QuickGOP52849
Ontology : AmiGOGolgi membrane  glycosaminoglycan biosynthetic process  heparan sulfate proteoglycan biosynthetic process  [heparan sulfate]-glucosamine N-sulfotransferase activity  integral component of membrane  heparin biosynthetic process  N-acetylglucosamine deacetylase activity  
Ontology : EGO-EBIGolgi membrane  glycosaminoglycan biosynthetic process  heparan sulfate proteoglycan biosynthetic process  [heparan sulfate]-glucosamine N-sulfotransferase activity  integral component of membrane  heparin biosynthetic process  N-acetylglucosamine deacetylase activity  
Pathways : KEGGGlycosaminoglycan biosynthesis - heparan sulfate / heparin   
NDEx NetworkNDST2
Atlas of Cancer Signalling NetworkNDST2
Wikipedia pathwaysNDST2
Orthology - Evolution
OrthoDB8509
GeneTree (enSembl)ENSG00000166507
Phylogenetic Trees/Animal Genes : TreeFamNDST2
HOVERGENP52849
HOGENOMP52849
Homologs : HomoloGeneNDST2
Homology/Alignments : Family Browser (UCSC)NDST2
Gene fusions - Rearrangements
Fusion : MitelmanNDST2/RUNX1 [10q22.2/21q22.12]  
Fusion : MitelmanNDST2/ZSWIM8 [10q22.2/10q22.2]  [t(10;10)(q22;q22)]  
Fusion: TCGANDST2 10q22.2 KIAA0913 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNDST2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NDST2
dbVarNDST2
ClinVarNDST2
1000_GenomesNDST2 
Exome Variant ServerNDST2
ExAC (Exome Aggregation Consortium)NDST2 (select the gene name)
Genetic variants : HAPMAP8509
Genomic Variants (DGV)NDST2 [DGVbeta]
DECIPHERNDST2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNDST2 
Mutations
ICGC Data PortalNDST2 
TCGA Data PortalNDST2 
Broad Tumor PortalNDST2
OASIS PortalNDST2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNDST2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNDST2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NDST2
DgiDB (Drug Gene Interaction Database)NDST2
DoCM (Curated mutations)NDST2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NDST2 (select a term)
intoGenNDST2
Cancer3DNDST2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603268   
Orphanet
MedgenNDST2
Genetic Testing Registry NDST2
NextProtP52849 [Medical]
TSGene8509
GENETestsNDST2
Target ValidationNDST2
Huge Navigator NDST2 [HugePedia]
snp3D : Map Gene to Disease8509
BioCentury BCIQNDST2
ClinGenNDST2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8509
Chemical/Pharm GKB GenePA31487
Clinical trialNDST2
Miscellaneous
canSAR (ICR)NDST2 (select the gene name)
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNDST2
EVEXNDST2
GoPubMedNDST2
iHOPNDST2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:46:26 CEST 2017

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