NDST4 (N-deacetylase and N-sulfotransferase 4)

2003-05-01  

Identity

HGNC
LOCATION
4q26
LOCUSID
ALIAS
N-HSST,N-HSST
FUSION GENES

Other Information

Locus ID:

NCBI: 64579
MIM: 615039
HGNC: 20779
Ensembl: ENSG00000138653

Variants:

dbSNP: 64579
ClinVar: 64579
TCGA: ENSG00000138653
COSMIC: NDST4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138653ENST00000264363Q9H3R1
ENSG00000138653ENST00000504854Q9H3R1
ENSG00000138653ENST00000613194Q9H3R1

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Glycosaminoglycan biosynthesis - heparan sulfate / heparinKEGGko00534
Glycosaminoglycan biosynthesis - heparan sulfate / heparinKEGGhsa00534
Metabolic pathwaysKEGGhsa01100
Glycosaminoglycan biosynthesis, heparan sulfate backboneKEGGhsa_M00059
Glycosaminoglycan biosynthesis, heparan sulfate backboneKEGGM00059
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Heparan sulfate/heparin (HS-GAG) metabolismREACTOMER-HSA-1638091
HS-GAG biosynthesisREACTOMER-HSA-2022928

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
239538522013Genome-wide association studies of maximum number of drinks.22
228435032012Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels.14
238256122013NDST4 is a novel candidate tumor suppressor gene at chromosome 4q26 and its genetic loss predicts adverse prognosis in colorectal cancer.12
203320992010A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.8
291581332018Characterization of heparan sulfate N-deacetylase/N-sulfotransferase isoform 4 using synthetic oligosaccharide substrates.0

Citation

Dessen P

NDST4 (N-deacetylase and N-sulfotransferase 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41515/ndst4