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NDUFA1 (NADH:ubiquinone oxidoreductase subunit A1)

Identity

Alias (NCBI)CI-MWFE
MC1DN12
MWFE
ZNF183
HGNC (Hugo) NDUFA1
HGNC Alias symbMWFE
CI-MWFE
HGNC Alias nameNADH:ubiquinone oxidoreductase (complex 1)
 type I dehydrogenase
 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1 (7.5kD, MWFE)
 complex I MWFE subunit
HGNC Previous nameNADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1 (7.5kD, MWFE)
 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
LocusID (NCBI) 4694
Atlas_Id 41516
Location Xq24  [Link to chromosome band Xq24]
Location_base_pair Starts at 119871832 and ends at 119876657 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NDUFA1 (Xq24) / SPRED2 (2p14)NFATC3 (16q22.1) / NDUFA1 (Xq24)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)NDUFA1   7683
Cards
Entrez_Gene (NCBI)NDUFA1    NADH:ubiquinone oxidoreductase subunit A1
AliasesCI-MWFE; MC1DN12; MWFE; ZNF183
GeneCards (Weizmann)NDUFA1
Ensembl hg19 (Hinxton)ENSG00000125356 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125356 [Gene_View]  ENSG00000125356 [Sequence]  chrX:119871832-119876657 [Contig_View]  NDUFA1 [Vega]
ICGC DataPortalENSG00000125356
TCGA cBioPortalNDUFA1
AceView (NCBI)NDUFA1
Genatlas (Paris)NDUFA1
SOURCE (Princeton)NDUFA1
Genetics Home Reference (NIH)NDUFA1
Genomic and cartography
GoldenPath hg38 (UCSC)NDUFA1  -     chrX:119871832-119876657 +  Xq24   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NDUFA1  -     Xq24   [Description]    (hg19-Feb_2009)
GoldenPathNDUFA1 - Xq24 [CytoView hg19]  NDUFA1 - Xq24 [CytoView hg38]
ImmunoBaseENSG00000125356
genome Data Viewer NCBINDUFA1 [Mapview hg19]  
OMIM300078   301020   
Gene and transcription
Genbank (Entrez)AB451304 AB451435 BC000266 BQ680674 CR456889
RefSeq transcript (Entrez)NM_004541
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NDUFA1
Alternative Splicing GalleryENSG00000125356
Gene ExpressionNDUFA1 [ NCBI-GEO ]   NDUFA1 [ EBI - ARRAY_EXPRESS ]   NDUFA1 [ SEEK ]   NDUFA1 [ MEM ]
Gene Expression Viewer (FireBrowse)NDUFA1 [ Firebrowse - Broad ]
GenevisibleExpression of NDUFA1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4694
GTEX Portal (Tissue expression)NDUFA1
Human Protein AtlasENSG00000125356-NDUFA1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15239   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15239  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15239
Splice isoforms : SwissVarO15239
PhosPhoSitePlusO15239
Domains : Interpro (EBI)NADH_Ub_cplx-1_asu_su-1   
Domain families : Pfam (Sanger)MWFE (PF15879)   
Domain families : Pfam (NCBI)pfam15879   
Conserved Domain (NCBI)NDUFA1
Blocks (Seattle)NDUFA1
PDB (RSDB)5XTC    5XTD    5XTH    5XTI   
PDB Europe5XTC    5XTD    5XTH    5XTI   
PDB (PDBSum)5XTC    5XTD    5XTH    5XTI   
PDB (IMB)5XTC    5XTD    5XTH    5XTI   
Structural Biology KnowledgeBase5XTC    5XTD    5XTH    5XTI   
SCOP (Structural Classification of Proteins)5XTC    5XTD    5XTH    5XTI   
CATH (Classification of proteins structures)5XTC    5XTD    5XTH    5XTI   
SuperfamilyO15239
Human Protein Atlas [tissue]ENSG00000125356-NDUFA1 [tissue]
Peptide AtlasO15239
HPRD02093
IPIIPI00005695   
Protein Interaction databases
DIP (DOE-UCLA)O15239
IntAct (EBI)O15239
BioGRIDNDUFA1
STRING (EMBL)NDUFA1
ZODIACNDUFA1
Ontologies - Pathways
QuickGOO15239
Ontology : AmiGOmitochondrion  mitochondrial inner membrane  mitochondrial respiratory chain complex I  mitochondrial respiratory chain complex I  mitochondrial respiratory chain complex I  cytosol  mitochondrial electron transport, NADH to ubiquinone  mitochondrial electron transport, NADH to ubiquinone  NADH dehydrogenase (ubiquinone) activity  integral component of membrane  mitochondrial membrane  mitochondrial respiratory chain complex I assembly  mitochondrial respiratory chain complex I assembly  
Ontology : EGO-EBImitochondrion  mitochondrial inner membrane  mitochondrial respiratory chain complex I  mitochondrial respiratory chain complex I  mitochondrial respiratory chain complex I  cytosol  mitochondrial electron transport, NADH to ubiquinone  mitochondrial electron transport, NADH to ubiquinone  NADH dehydrogenase (ubiquinone) activity  integral component of membrane  mitochondrial membrane  mitochondrial respiratory chain complex I assembly  mitochondrial respiratory chain complex I assembly  
Pathways : KEGGOxidative phosphorylation    Non-alcoholic fatty liver disease (NAFLD)    Alzheimer's disease    Parkinson's disease    Huntington's disease   
NDEx NetworkNDUFA1
Atlas of Cancer Signalling NetworkNDUFA1
Wikipedia pathwaysNDUFA1
Orthology - Evolution
OrthoDB4694
GeneTree (enSembl)ENSG00000125356
Phylogenetic Trees/Animal Genes : TreeFamNDUFA1
HOGENOMO15239
Homologs : HomoloGeneNDUFA1
Homology/Alignments : Family Browser (UCSC)NDUFA1
Gene fusions - Rearrangements
Fusion : QuiverNDUFA1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNDUFA1 [hg38]
dbVarNDUFA1
ClinVarNDUFA1
MonarchNDUFA1
1000_GenomesNDUFA1 
Exome Variant ServerNDUFA1
GNOMAD BrowserENSG00000125356
Varsome BrowserNDUFA1
Genomic Variants (DGV)NDUFA1 [DGVbeta]
DECIPHERNDUFA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNDUFA1 
Mutations
ICGC Data PortalNDUFA1 
TCGA Data PortalNDUFA1 
Broad Tumor PortalNDUFA1
OASIS PortalNDUFA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNDUFA1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNDUFA1
Mutations and Diseases : HGMDNDUFA1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch NDUFA1
DgiDB (Drug Gene Interaction Database)NDUFA1
DoCM (Curated mutations)NDUFA1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NDUFA1 (select a term)
intoGenNDUFA1
Cancer3DNDUFA1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300078    301020   
Orphanet369   
DisGeNETNDUFA1
MedgenNDUFA1
Genetic Testing Registry NDUFA1
NextProtO15239 [Medical]
GENETestsNDUFA1
Target ValidationNDUFA1
Huge Navigator NDUFA1 [HugePedia]
ClinGenNDUFA1 (curated)
Clinical trials, drugs, therapy
MyCancerGenomeNDUFA1
Protein Interactions : CTD
Pharm GKB GenePA31489
Pharm GKB PathwaysPA165948566   
PharosO15239
Clinical trialNDUFA1
Miscellaneous
canSAR (ICR)NDUFA1 (select the gene name)
HarmonizomeNDUFA1
DataMed IndexNDUFA1
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNDUFA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:28:31 CET 2021

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