NDUFA10 (NADH:ubiquinone oxidoreductase subunit A10)

2013-03-01  

Identity

HGNC
NDUFA10
LOCATION
2q37.3
LOCUSID
4705
ALIAS
CI-42KD,CI-42k,MC1DN22
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4705
MIM: 603835
HGNC: 7684
Ensembl: ENSG00000130414

Variants:

dbSNP: 4705
ClinVar: 4705
TCGA: ENSG00000130414
COSMIC: NDUFA10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130414ENST00000252711O95299
ENSG00000130414ENST00000252711A0A024R4B3
ENSG00000130414ENST00000307300O95299
ENSG00000130414ENST00000404554E7ESZ7
ENSG00000130414ENST00000407129Q8N1B9
ENSG00000130414ENST00000414580F8WEH0
ENSG00000130414ENST00000419408H7C2W5
ENSG00000130414ENST00000443626C9J6X0
ENSG00000130414ENST00000444548H7C1Y7
ENSG00000130414ENST00000448880H7C2X4
ENSG00000130414ENST00000620965A0A087WXC5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Oxidative phosphorylationKEGGko00190
Alzheimer's diseaseKEGGko05010
Huntington's diseaseKEGGko05016
Oxidative phosphorylationKEGGhsa00190
Alzheimer's diseaseKEGGhsa05010
Parkinson's diseaseKEGGhsa05012
Huntington's diseaseKEGGhsa05016
Metabolic pathwaysKEGGhsa01100
NADH dehydrogenase (ubiquinone) 1 alpha subcomplexKEGGhsa_M00146
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
NADH dehydrogenase (ubiquinone) 1 alpha subcomplexKEGGM00146
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.REACTOMER-HSA-163200
Respiratory electron transportREACTOMER-HSA-611105
Complex I biogenesisREACTOMER-HSA-6799198

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
373732642023An Exploration of the Coherent Effects between METTL3 and NDUFA10 on Alzheimer's Disease.6
373732642023An Exploration of the Coherent Effects between METTL3 and NDUFA10 on Alzheimer's Disease.6
357391872022Most mitochondrial dGTP is tightly bound to respiratory complex I through the NDUFA10 subunit.5
357391872022Most mitochondrial dGTP is tightly bound to respiratory complex I through the NDUFA10 subunit.5
341242422021Identifying Mitochondrial-Related Genes NDUFA10 and NDUFV2 as Prognostic Markers for Prostate Cancer through Biclustering.3
341242422021Identifying Mitochondrial-Related Genes NDUFA10 and NDUFV2 as Prognostic Markers for Prostate Cancer through Biclustering.3
224619102012FOXM1 induces a global methylation signature that mimics the cancer epigenome in head and neck squamous cell carcinoma.43
224619102012FOXM1 induces a global methylation signature that mimics the cancer epigenome in head and neck squamous cell carcinoma.43
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
193430462009Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.4
193430462009Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.4
189772412008Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey.28
190645712008Polymorphisms in mitochondrial genes and prostate cancer risk.22
189772412008Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey.28

Citation

Dessen P

NDUFA10 (NADH:ubiquinone oxidoreductase subunit A10)

Atlas Genet Cytogenet Oncol Haematol. 2013-03-01

Online version: http://atlasgeneticsoncology.org/gene/53210/ndufa10