NDUFA4L2 (NDUFA4 mitochondrial complex associated like 2)

2017-04-01  

Identity

HGNC
LOCATION
12q13.3
LOCUSID
ALIAS
COXFA4L2,MISTRH,NUOMS
FUSION GENES

Other Information

Locus ID:

NCBI: 56901
HGNC: 29836
Ensembl: ENSG00000185633

Variants:

dbSNP: 56901
ClinVar: 56901
TCGA: ENSG00000185633
COSMIC: NDUFA4L2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185633ENST00000393825Q9NRX3
ENSG00000185633ENST00000393825A0A024RB39
ENSG00000185633ENST00000554503Q9NRX3
ENSG00000185633ENST00000554503A0A024RB39
ENSG00000185633ENST00000556732G3V560

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Oxidative phosphorylationKEGGko00190
Alzheimer's diseaseKEGGko05010
Huntington's diseaseKEGGko05016
Oxidative phosphorylationKEGGhsa00190
Alzheimer's diseaseKEGGhsa05010
Parkinson's diseaseKEGGhsa05012
Huntington's diseaseKEGGhsa05016
Metabolic pathwaysKEGGhsa01100
NADH dehydrogenase (ubiquinone) 1 alpha subcomplexKEGGhsa_M00146
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
NADH dehydrogenase (ubiquinone) 1 alpha subcomplexKEGGM00146

References

Pubmed IDYearTitleCitations
305382122018Integrated multi-omics characterization reveals a distinctive metabolic signature and the role of NDUFA4L2 in promoting angiogenesis, chemoresistance, and mitochondrial dysfunction in clear cell renal cell carcinoma.14
268194502016NDUFA4L2 Fine-tunes Oxidative Stress in Hepatocellular Carcinoma.12
267832872016Role of NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex 4-Like 2 in Clear Cell Renal Cell Carcinoma.8
274533282016NDUFA4L2 expression predicts poor prognosis in clear cell renal cell carcinoma patients.4
299538522018Induction of the mitochondrial NDUFA4L2 protein by HIF-1a regulates heart regeneration by promoting the survival of cardiac stem cell.2
307104122019Mitochondrial NDUFA4L2 protein promotes the vitality of lung cancer cells by repressing oxidative stress.1

Citation

Dessen P

NDUFA4L2 (NDUFA4 mitochondrial complex associated like 2)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56790/ndufa4l2