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NDUFA8 (NADH:ubiquinone oxidoreductase subunit A8)

Identity

Alias_namesNADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8 (19kD, PGIV)
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa
Alias_symbol (synonym)PGIV
MGC793
Other aliasCI-19KD
CI-PGIV
HGNC (Hugo) NDUFA8
LocusID (NCBI) 4702
Atlas_Id 70762
Location 9q33.2  [Link to chromosome band 9q33]
Location_base_pair Starts at 122132466 and ends at 122159819 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CCDC180 (9q22.33) / NDUFA8 (9q33.2)LENG8 (19q13.42) / NDUFA8 (9q33.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NDUFA8   7692
Cards
Entrez_Gene (NCBI)NDUFA8  4702  NADH:ubiquinone oxidoreductase subunit A8
AliasesCI-19KD; CI-PGIV; PGIV
GeneCards (Weizmann)NDUFA8
Ensembl hg19 (Hinxton)ENSG00000119421 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000119421 [Gene_View]  chr9:122132466-122159819 [Contig_View]  NDUFA8 [Vega]
ICGC DataPortalENSG00000119421
TCGA cBioPortalNDUFA8
AceView (NCBI)NDUFA8
Genatlas (Paris)NDUFA8
WikiGenes4702
SOURCE (Princeton)NDUFA8
Genetics Home Reference (NIH)NDUFA8
Genomic and cartography
GoldenPath hg38 (UCSC)NDUFA8  -     chr9:122132466-122159819 -  9q33.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NDUFA8  -     9q33.2   [Description]    (hg19-Feb_2009)
EnsemblNDUFA8 - 9q33.2 [CytoView hg19]  NDUFA8 - 9q33.2 [CytoView hg38]
Mapping of homologs : NCBINDUFA8 [Mapview hg19]  NDUFA8 [Mapview hg38]
OMIM603359   
Gene and transcription
Genbank (Entrez)AF044953 AK301520 AK314135 BC001016 BU602971
RefSeq transcript (Entrez)NM_001318195 NM_014222
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NDUFA8
Cluster EST : UnigeneHs.495039 [ NCBI ]
CGAP (NCI)Hs.495039
Alternative Splicing GalleryENSG00000119421
Gene ExpressionNDUFA8 [ NCBI-GEO ]   NDUFA8 [ EBI - ARRAY_EXPRESS ]   NDUFA8 [ SEEK ]   NDUFA8 [ MEM ]
Gene Expression Viewer (FireBrowse)NDUFA8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4702
GTEX Portal (Tissue expression)NDUFA8
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51970   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51970  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51970
Splice isoforms : SwissVarP51970
PhosPhoSitePlusP51970
Domaine pattern : Prosite (Expaxy)CHCH (PS51808)   
Domains : Interpro (EBI)CHCH    NADH_Ub_cplx-1_asu_su-8   
Domain families : Pfam (Sanger)CHCH (PF06747)   
Domain families : Pfam (NCBI)pfam06747   
Conserved Domain (NCBI)NDUFA8
DMDM Disease mutations4702
Blocks (Seattle)NDUFA8
SuperfamilyP51970
Human Protein AtlasENSG00000119421
Peptide AtlasP51970
HPRD04525
IPIIPI00219034   IPI01011998   
Protein Interaction databases
DIP (DOE-UCLA)P51970
IntAct (EBI)P51970
FunCoupENSG00000119421
BioGRIDNDUFA8
STRING (EMBL)NDUFA8
ZODIACNDUFA8
Ontologies - Pathways
QuickGOP51970
Ontology : AmiGOmitochondrion  mitochondrial inner membrane  mitochondrial respiratory chain complex I  mitochondrial respiratory chain complex I  mitochondrial intermembrane space  mitochondrial electron transport, NADH to ubiquinone  mitochondrial electron transport, NADH to ubiquinone  NADH dehydrogenase (ubiquinone) activity  protein complex binding  mitochondrial respiratory chain complex I assembly  
Ontology : EGO-EBImitochondrion  mitochondrial inner membrane  mitochondrial respiratory chain complex I  mitochondrial respiratory chain complex I  mitochondrial intermembrane space  mitochondrial electron transport, NADH to ubiquinone  mitochondrial electron transport, NADH to ubiquinone  NADH dehydrogenase (ubiquinone) activity  protein complex binding  mitochondrial respiratory chain complex I assembly  
Pathways : KEGGOxidative phosphorylation    Non-alcoholic fatty liver disease (NAFLD)    Alzheimer's disease    Parkinson's disease    Huntington's disease   
NDEx NetworkNDUFA8
Atlas of Cancer Signalling NetworkNDUFA8
Wikipedia pathwaysNDUFA8
Orthology - Evolution
OrthoDB4702
GeneTree (enSembl)ENSG00000119421
Phylogenetic Trees/Animal Genes : TreeFamNDUFA8
HOVERGENP51970
HOGENOMP51970
Homologs : HomoloGeneNDUFA8
Homology/Alignments : Family Browser (UCSC)NDUFA8
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNDUFA8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NDUFA8
dbVarNDUFA8
ClinVarNDUFA8
1000_GenomesNDUFA8 
Exome Variant ServerNDUFA8
ExAC (Exome Aggregation Consortium)NDUFA8 (select the gene name)
Genetic variants : HAPMAP4702
Genomic Variants (DGV)NDUFA8 [DGVbeta]
DECIPHERNDUFA8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNDUFA8 
Mutations
ICGC Data PortalNDUFA8 
TCGA Data PortalNDUFA8 
Broad Tumor PortalNDUFA8
OASIS PortalNDUFA8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNDUFA8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNDUFA8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch NDUFA8
DgiDB (Drug Gene Interaction Database)NDUFA8
DoCM (Curated mutations)NDUFA8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NDUFA8 (select a term)
intoGenNDUFA8
Cancer3DNDUFA8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603359   
Orphanet
MedgenNDUFA8
Genetic Testing Registry NDUFA8
NextProtP51970 [Medical]
TSGene4702
GENETestsNDUFA8
Target ValidationNDUFA8
Huge Navigator NDUFA8 [HugePedia]
snp3D : Map Gene to Disease4702
BioCentury BCIQNDUFA8
ClinGenNDUFA8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4702
Chemical/Pharm GKB GenePA31498
Clinical trialNDUFA8
Miscellaneous
canSAR (ICR)NDUFA8 (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNDUFA8
EVEXNDUFA8
GoPubMedNDUFA8
iHOPNDUFA8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:32:26 CEST 2017

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