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NDUFB4 (NADH:ubiquinone oxidoreductase subunit B4)

Identity

Alias_namesNADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4 (15kD, B15)
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa
Alias_symbol (synonym)B15
Other aliasCI-B15
HGNC (Hugo) NDUFB4
LocusID (NCBI) 4710
Atlas_Id 70775
Location 3q13.33  [Link to chromosome band 3q13]
Location_base_pair Starts at 120596281 and ends at 120602411 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NDUFB4 (3q13.33) / RPS11 (19q13.33)RPL11 (1p36.11) / NDUFB4 (3q13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NDUFB4   7699
Cards
Entrez_Gene (NCBI)NDUFB4  4710  NADH:ubiquinone oxidoreductase subunit B4
AliasesB15; CI-B15
GeneCards (Weizmann)NDUFB4
Ensembl hg19 (Hinxton)ENSG00000065518 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000065518 [Gene_View]  chr3:120596281-120602411 [Contig_View]  NDUFB4 [Vega]
ICGC DataPortalENSG00000065518
TCGA cBioPortalNDUFB4
AceView (NCBI)NDUFB4
Genatlas (Paris)NDUFB4
WikiGenes4710
SOURCE (Princeton)NDUFB4
Genetics Home Reference (NIH)NDUFB4
Genomic and cartography
GoldenPath hg38 (UCSC)NDUFB4  -     chr3:120596281-120602411 +  3q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NDUFB4  -     3q13.33   [Description]    (hg19-Feb_2009)
EnsemblNDUFB4 - 3q13.33 [CytoView hg19]  NDUFB4 - 3q13.33 [CytoView hg38]
Mapping of homologs : NCBINDUFB4 [Mapview hg19]  NDUFB4 [Mapview hg38]
OMIM603840   
Gene and transcription
Genbank (Entrez)AF044957 BC000855 BC034579 BC070285 BC146885
RefSeq transcript (Entrez)NM_001168331 NM_004547
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NDUFB4
Cluster EST : UnigeneHs.304613 [ NCBI ]
CGAP (NCI)Hs.304613
Alternative Splicing GalleryENSG00000065518
Gene ExpressionNDUFB4 [ NCBI-GEO ]   NDUFB4 [ EBI - ARRAY_EXPRESS ]   NDUFB4 [ SEEK ]   NDUFB4 [ MEM ]
Gene Expression Viewer (FireBrowse)NDUFB4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4710
GTEX Portal (Tissue expression)NDUFB4
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95168   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95168  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95168
Splice isoforms : SwissVarO95168
PhosPhoSitePlusO95168
Domains : Interpro (EBI)NADH_UbQ_OxRdtase_NDUFB4_su   
Domain families : Pfam (Sanger)NDUF_B4 (PF07225)   
Domain families : Pfam (NCBI)pfam07225   
Conserved Domain (NCBI)NDUFB4
DMDM Disease mutations4710
Blocks (Seattle)NDUFB4
SuperfamilyO95168
Human Protein AtlasENSG00000065518
Peptide AtlasO95168
HPRD11955
IPIIPI00220059   IPI00815735   IPI00980448   IPI00790949   
Protein Interaction databases
DIP (DOE-UCLA)O95168
IntAct (EBI)O95168
FunCoupENSG00000065518
BioGRIDNDUFB4
STRING (EMBL)NDUFB4
ZODIACNDUFB4
Ontologies - Pathways
QuickGOO95168
Ontology : AmiGOmitochondrion  mitochondrial inner membrane  mitochondrial respiratory chain complex I  mitochondrial respiratory chain complex I  mitochondrial electron transport, NADH to ubiquinone  mitochondrial electron transport, NADH to ubiquinone  response to oxidative stress  NADH dehydrogenase (ubiquinone) activity  integral component of membrane  nuclear membrane  mitochondrial respiratory chain complex I assembly  extracellular exosome  
Ontology : EGO-EBImitochondrion  mitochondrial inner membrane  mitochondrial respiratory chain complex I  mitochondrial respiratory chain complex I  mitochondrial electron transport, NADH to ubiquinone  mitochondrial electron transport, NADH to ubiquinone  response to oxidative stress  NADH dehydrogenase (ubiquinone) activity  integral component of membrane  nuclear membrane  mitochondrial respiratory chain complex I assembly  extracellular exosome  
Pathways : KEGGOxidative phosphorylation    Non-alcoholic fatty liver disease (NAFLD)    Alzheimer's disease    Parkinson's disease    Huntington's disease   
NDEx NetworkNDUFB4
Atlas of Cancer Signalling NetworkNDUFB4
Wikipedia pathwaysNDUFB4
Orthology - Evolution
OrthoDB4710
GeneTree (enSembl)ENSG00000065518
Phylogenetic Trees/Animal Genes : TreeFamNDUFB4
HOVERGENO95168
HOGENOMO95168
Homologs : HomoloGeneNDUFB4
Homology/Alignments : Family Browser (UCSC)NDUFB4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNDUFB4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NDUFB4
dbVarNDUFB4
ClinVarNDUFB4
1000_GenomesNDUFB4 
Exome Variant ServerNDUFB4
ExAC (Exome Aggregation Consortium)NDUFB4 (select the gene name)
Genetic variants : HAPMAP4710
Genomic Variants (DGV)NDUFB4 [DGVbeta]
DECIPHERNDUFB4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNDUFB4 
Mutations
ICGC Data PortalNDUFB4 
TCGA Data PortalNDUFB4 
Broad Tumor PortalNDUFB4
OASIS PortalNDUFB4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNDUFB4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNDUFB4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch NDUFB4
DgiDB (Drug Gene Interaction Database)NDUFB4
DoCM (Curated mutations)NDUFB4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NDUFB4 (select a term)
intoGenNDUFB4
Cancer3DNDUFB4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603840   
Orphanet
MedgenNDUFB4
Genetic Testing Registry NDUFB4
NextProtO95168 [Medical]
TSGene4710
GENETestsNDUFB4
Target ValidationNDUFB4
Huge Navigator NDUFB4 [HugePedia]
snp3D : Map Gene to Disease4710
BioCentury BCIQNDUFB4
ClinGenNDUFB4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4710
Chemical/Pharm GKB GenePA31510
Clinical trialNDUFB4
Miscellaneous
canSAR (ICR)NDUFB4 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNDUFB4
EVEXNDUFB4
GoPubMedNDUFB4
iHOPNDUFB4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:32:28 CEST 2017

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