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NDUFB8 (NADH:ubiquinone oxidoreductase subunit B8)

Identity

Alias (NCBI)ASHI
CI-ASHI
MC1DN32
HGNC (Hugo) NDUFB8
HGNC Alias symbASHI
CI-ASHI
HGNC Alias namecomplex I ASHI subunit
HGNC Previous nameNADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8 (19kD, ASHI)
 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
LocusID (NCBI) 4714
Atlas_Id 49909
Location 10q24.31  [Link to chromosome band 10q24]
Location_base_pair Starts at 100523740 and ends at 100529871 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)NDUFB8   7703
Cards
Entrez_Gene (NCBI)NDUFB8    NADH:ubiquinone oxidoreductase subunit B8
AliasesASHI; CI-ASHI; MC1DN32
GeneCards (Weizmann)NDUFB8
Ensembl hg19 (Hinxton)ENSG00000166136 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166136 [Gene_View]  ENSG00000166136 [Sequence]  chr10:100523740-100529871 [Contig_View]  NDUFB8 [Vega]
ICGC DataPortalENSG00000166136
TCGA cBioPortalNDUFB8
AceView (NCBI)NDUFB8
Genatlas (Paris)NDUFB8
SOURCE (Princeton)NDUFB8
Genetics Home Reference (NIH)NDUFB8
Genomic and cartography
GoldenPath hg38 (UCSC)NDUFB8  -     chr10:100523740-100529871 -  10q24.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NDUFB8  -     10q24.31   [Description]    (hg19-Feb_2009)
GoldenPathNDUFB8 - 10q24.31 [CytoView hg19]  NDUFB8 - 10q24.31 [CytoView hg38]
ImmunoBaseENSG00000166136
Genome Data Viewer NCBINDUFB8 [Mapview hg19]  
OMIM602140   618252   
Gene and transcription
Genbank (Entrez)AA782554 AF044958 AF077028 AF115968 AI282606
RefSeq transcript (Entrez)NM_001284367 NM_001284368 NM_005004
Consensus coding sequences : CCDS (NCBI)NDUFB8
Gene ExpressionNDUFB8 [ NCBI-GEO ]   NDUFB8 [ EBI - ARRAY_EXPRESS ]   NDUFB8 [ SEEK ]   NDUFB8 [ MEM ]
Gene Expression Viewer (FireBrowse)NDUFB8 [ Firebrowse - Broad ]
GenevisibleExpression of NDUFB8 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4714
GTEX Portal (Tissue expression)NDUFB8
Human Protein AtlasENSG00000166136-NDUFB8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95169   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95169  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95169
PhosPhoSitePlusO95169
Domains : Interpro (EBI)NDUFB8    Ndufb8_metazoa   
Domain families : Pfam (Sanger)NDUF_B8 (PF05821)   
Domain families : Pfam (NCBI)pfam05821   
Conserved Domain (NCBI)NDUFB8
PDB (RSDB)5XTC    5XTD    5XTH    5XTI   
PDB Europe5XTC    5XTD    5XTH    5XTI   
PDB (PDBSum)5XTC    5XTD    5XTH    5XTI   
PDB (IMB)5XTC    5XTD    5XTH    5XTI   
Structural Biology KnowledgeBase5XTC    5XTD    5XTH    5XTI   
SCOP (Structural Classification of Proteins)5XTC    5XTD    5XTH    5XTI   
CATH (Classification of proteins structures)5XTC    5XTD    5XTH    5XTI   
SuperfamilyO95169
AlphaFold pdb e-kbO95169   
Human Protein Atlas [tissue]ENSG00000166136-NDUFB8 [tissue]
HPRD11886
Protein Interaction databases
DIP (DOE-UCLA)O95169
IntAct (EBI)O95169
BioGRIDNDUFB8
STRING (EMBL)NDUFB8
ZODIACNDUFB8
Ontologies - Pathways
QuickGOO95169
Ontology : AmiGOmitochondrion  mitochondrial inner membrane  mitochondrial respiratory chain complex I  mitochondrial respiratory chain complex I  mitochondrial respiratory chain complex I  mitochondrial respiratory chain complex I  mitochondrial matrix  endoplasmic reticulum  mitochondrial electron transport, NADH to ubiquinone  mitochondrial electron transport, NADH to ubiquinone  NADH dehydrogenase (ubiquinone) activity  integral component of membrane  mitochondrial respiratory chain complex I assembly  mitochondrial respiratory chain complex I assembly  
Ontology : EGO-EBImitochondrion  mitochondrial inner membrane  mitochondrial respiratory chain complex I  mitochondrial respiratory chain complex I  mitochondrial respiratory chain complex I  mitochondrial respiratory chain complex I  mitochondrial matrix  endoplasmic reticulum  mitochondrial electron transport, NADH to ubiquinone  mitochondrial electron transport, NADH to ubiquinone  NADH dehydrogenase (ubiquinone) activity  integral component of membrane  mitochondrial respiratory chain complex I assembly  mitochondrial respiratory chain complex I assembly  
Pathways : KEGGOxidative phosphorylation    Non-alcoholic fatty liver disease (NAFLD)    Alzheimer's disease    Parkinson's disease    Huntington's disease   
NDEx NetworkNDUFB8
Atlas of Cancer Signalling NetworkNDUFB8
Wikipedia pathwaysNDUFB8
Orthology - Evolution
OrthoDB4714
GeneTree (enSembl)ENSG00000166136
Phylogenetic Trees/Animal Genes : TreeFamNDUFB8
Homologs : HomoloGeneNDUFB8
Homology/Alignments : Family Browser (UCSC)NDUFB8
Gene fusions - Rearrangements
Fusion : QuiverNDUFB8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNDUFB8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NDUFB8
dbVarNDUFB8
ClinVarNDUFB8
MonarchNDUFB8
1000_GenomesNDUFB8 
Exome Variant ServerNDUFB8
GNOMAD BrowserENSG00000166136
Varsome BrowserNDUFB8
ACMGNDUFB8 variants
VarityO95169
Genomic Variants (DGV)NDUFB8 [DGVbeta]
DECIPHERNDUFB8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNDUFB8 
Mutations
ICGC Data PortalNDUFB8 
TCGA Data PortalNDUFB8 
Broad Tumor PortalNDUFB8
OASIS PortalNDUFB8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNDUFB8  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNDUFB8
Mutations and Diseases : HGMDNDUFB8
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNDUFB8
DgiDB (Drug Gene Interaction Database)NDUFB8
DoCM (Curated mutations)NDUFB8
CIViC (Clinical Interpretations of Variants in Cancer)NDUFB8
Cancer3DNDUFB8
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602140    618252   
Orphanet
DisGeNETNDUFB8
MedgenNDUFB8
Genetic Testing Registry NDUFB8
NextProtO95169 [Medical]
GENETestsNDUFB8
Target ValidationNDUFB8
Huge Navigator NDUFB8 [HugePedia]
ClinGenNDUFB8
Clinical trials, drugs, therapy
MyCancerGenomeNDUFB8
Protein Interactions : CTDNDUFB8
Pharm GKB GenePA31514
PharosO95169
Clinical trialNDUFB8
Miscellaneous
canSAR (ICR)NDUFB8
HarmonizomeNDUFB8
DataMed IndexNDUFB8
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNDUFB8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:22:24 CEST 2021

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