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NDUFS5 (NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase))

Identity

Alias_namesNADH dehydrogenase (ubiquinone) Fe-S protein 5 (15kD) (NADH-coenzyme Q reductase)
NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)
Alias_symbol (synonym)CI-15k
Other aliasCI15K
HGNC (Hugo) NDUFS5
LocusID (NCBI) 4725
Atlas_Id 70784
Location 1p34.3  [Link to chromosome band 1p34]
Location_base_pair Starts at 39491967 and ends at 39500308 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
EXOC4 (7q33) / NDUFS5 (1p34.3)NDUFS5 (1p34.3) / GRAMD1A (19q13.11)RLF (1p34.2) / NDUFS5 (1p34.3)
SHPRH (6q24.3) / NDUFS5 (1p34.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NDUFS5   7712
Cards
Entrez_Gene (NCBI)NDUFS5  4725  NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)
AliasesCI-15k; CI15K
GeneCards (Weizmann)NDUFS5
Ensembl hg19 (Hinxton)ENSG00000168653 [Gene_View]  chr1:39491967-39500308 [Contig_View]  NDUFS5 [Vega]
Ensembl hg38 (Hinxton)ENSG00000168653 [Gene_View]  chr1:39491967-39500308 [Contig_View]  NDUFS5 [Vega]
ICGC DataPortalENSG00000168653
TCGA cBioPortalNDUFS5
AceView (NCBI)NDUFS5
Genatlas (Paris)NDUFS5
WikiGenes4725
SOURCE (Princeton)NDUFS5
Genetics Home Reference (NIH)NDUFS5
Genomic and cartography
GoldenPath hg19 (UCSC)NDUFS5  -     chr1:39491967-39500308 +  1p34.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NDUFS5  -     1p34.3   [Description]    (hg38-Dec_2013)
EnsemblNDUFS5 - 1p34.3 [CytoView hg19]  NDUFS5 - 1p34.3 [CytoView hg38]
Mapping of homologs : NCBINDUFS5 [Mapview hg19]  NDUFS5 [Mapview hg38]
OMIM603847   
Gene and transcription
Genbank (Entrez)AF020352 AF047434 AF086268 AI244607 AK312188
RefSeq transcript (Entrez)NM_001184979 NM_004552
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_028193 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)NDUFS5
Cluster EST : UnigeneHs.632385 [ NCBI ]
CGAP (NCI)Hs.632385
Alternative Splicing GalleryENSG00000168653
Gene ExpressionNDUFS5 [ NCBI-GEO ]   NDUFS5 [ EBI - ARRAY_EXPRESS ]   NDUFS5 [ SEEK ]   NDUFS5 [ MEM ]
Gene Expression Viewer (FireBrowse)NDUFS5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4725
GTEX Portal (Tissue expression)NDUFS5
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43920   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43920  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43920
Splice isoforms : SwissVarO43920
PhosPhoSitePlusO43920
Domains : Interpro (EBI)NADH_UbQ_OxRdtase_FeS-su5   
Domain families : Pfam (Sanger)Ndufs5 (PF10200)   
Domain families : Pfam (NCBI)pfam10200   
Conserved Domain (NCBI)NDUFS5
DMDM Disease mutations4725
Blocks (Seattle)NDUFS5
SuperfamilyO43920
Human Protein AtlasENSG00000168653
Peptide AtlasO43920
HPRD11961
IPIIPI00220063   
Protein Interaction databases
DIP (DOE-UCLA)O43920
IntAct (EBI)O43920
FunCoupENSG00000168653
BioGRIDNDUFS5
STRING (EMBL)NDUFS5
ZODIACNDUFS5
Ontologies - Pathways
QuickGOO43920
Ontology : AmiGOmitochondrion  mitochondrial inner membrane  mitochondrial respiratory chain complex I  mitochondrial respiratory chain complex I  mitochondrial intermembrane space  mitochondrial electron transport, NADH to ubiquinone  NADH dehydrogenase (ubiquinone) activity  respiratory electron transport chain  mitochondrial respiratory chain complex I assembly  cellular metabolic process  small molecule metabolic process  
Ontology : EGO-EBImitochondrion  mitochondrial inner membrane  mitochondrial respiratory chain complex I  mitochondrial respiratory chain complex I  mitochondrial intermembrane space  mitochondrial electron transport, NADH to ubiquinone  NADH dehydrogenase (ubiquinone) activity  respiratory electron transport chain  mitochondrial respiratory chain complex I assembly  cellular metabolic process  small molecule metabolic process  
Pathways : KEGGOxidative phosphorylation    Non-alcoholic fatty liver disease (NAFLD)    Alzheimer's disease    Parkinson's disease    Huntington's disease   
NDEx NetworkNDUFS5
Atlas of Cancer Signalling NetworkNDUFS5
Wikipedia pathwaysNDUFS5
Orthology - Evolution
OrthoDB4725
GeneTree (enSembl)ENSG00000168653
Phylogenetic Trees/Animal Genes : TreeFamNDUFS5
HOVERGENO43920
HOGENOMO43920
Homologs : HomoloGeneNDUFS5
Homology/Alignments : Family Browser (UCSC)NDUFS5
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNDUFS5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NDUFS5
dbVarNDUFS5
ClinVarNDUFS5
1000_GenomesNDUFS5 
Exome Variant ServerNDUFS5
ExAC (Exome Aggregation Consortium)NDUFS5 (select the gene name)
Genetic variants : HAPMAP4725
Genomic Variants (DGV)NDUFS5 [DGVbeta]
DECIPHER (Syndromes)1:39491967-39500308  ENSG00000168653
CONAN: Copy Number AnalysisNDUFS5 
Mutations
ICGC Data PortalNDUFS5 
TCGA Data PortalNDUFS5 
Broad Tumor PortalNDUFS5
OASIS PortalNDUFS5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNDUFS5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNDUFS5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch NDUFS5
DgiDB (Drug Gene Interaction Database)NDUFS5
DoCM (Curated mutations)NDUFS5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NDUFS5 (select a term)
intoGenNDUFS5
Cancer3DNDUFS5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603847   
Orphanet
MedgenNDUFS5
Genetic Testing Registry NDUFS5
NextProtO43920 [Medical]
TSGene4725
GENETestsNDUFS5
Huge Navigator NDUFS5 [HugePedia]
snp3D : Map Gene to Disease4725
BioCentury BCIQNDUFS5
ClinGenNDUFS5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4725
Chemical/Pharm GKB GenePA31522
Clinical trialNDUFS5
Miscellaneous
canSAR (ICR)NDUFS5 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNDUFS5
EVEXNDUFS5
GoPubMedNDUFS5
iHOPNDUFS5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:34:45 CET 2017

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